Parliamentary roll-call voting as a complex dynamical system:The case of Chile

A method is proposed to study the temporal variability of legislative roll-call votes in a parliament from the perspective of complex dynamical systems. We studied the Chilean Chamber of Deputies’ by analyzing the agreement ratio and the voting outcome of each vote over the last 19 years with a Recurrence Quantification Analysis and an entropy analysis (Sample Entropy). Two significant changes in the temporal variability were found: one in 2014, where the voting outcome became more recurrent and with less entropy, and another in 2018, where the agreement ratio became less recurrent and with higher entropy. These changes may be directly related to major changes in the Chilean electoral system and the composition of the Chamber of Deputies, given that these changes occurred just after the first parliamentary elections with non-compulsory voting (2013 elections) and the first elections with a proportional system in conjunction with an increase in the number of deputies (2017 elections) were held.</p

Contenido de minerales en suero, pelo de capa y pelo de cola de bovinos holstein, hereford, cebu y pardo suizo bajo diferentes condiciones ambientales y de manejo

Este trabajo fue reali2ado con objeto de comparar la composición mineral de pelo obtenido en diferente localización anatómica de bovinos de diferente raza y mantenidos bajo diferentes condiciones de manejo y alimentación, así como también comparar el con

The influence of controlled processes reasoning with Theory of Mind (ToM) in children with and without intellectual disabilities

La capacidad o mecanismo tácito de atribuir estados mentales a los otros y a uno mismo, con el objeto de anticipar, comprender y predecir la conducta, es conocida como Teoría de la Mente (ToM). Parte de la discusión se centra en comprender si este razonamiento es un proceso independiente o subordinado a los procesos ejecutivos de control consciente. En esta investigación se analiza el efecto de las funciones ejecutivas de control consciente en tareas de razonamiento con ToM, en niños con y sin discapacidad intelectual. La muestra la constituyen 30 niños con discapacidad intelectual y 20 niños sin discapacidad intelectual. Se hipotetizó que la habilidad para responder las preguntas de control, una operacionalización de las funciones ejecutivas de control consciente, se asocia más a las tareas de segundo orden que a las de primer orden, ya que estas requieren mayor carga representacional. Los resultados obtenidos, sugieren que los procesos de control consciente no sólo se asocian a las tareas que requieren una mayor carga representacional, sino a todas las tareas que requieren razonar con estados mentales, sean ellos de primer o segundo orden

La influencia de los procesos controlados en el razonamiento con Teoría de la Mente (ToM) en niños con y sin discapacidad intelectual

La capacidad o mecanismo tácito de atribuir estados mentales a los otros y a uno mismo, con el objeto de anticipar, comprender y predecir la conducta, es conocida como Teoría de la Mente (ToM). Parte de la discusión se centra en comprender si este razonamiento es un proceso independiente o subordinado a los procesos ejecutivos de control consciente. En esta investigación se analiza el efecto de las funciones ejecutivas de control consciente en tareas de razonamiento con ToM, en niños con y sin discapacidad intelectual. La muestra la constituyen 30 niños con discapacidad intelectual y 20 niños sin discapacidad intelectual. Se hipotetizó que la habilidad para responder las preguntas de control, una operacionalización de las funciones ejecutivas de control consciente, se asocia más a las tareas de segundo orden que a las de primer orden, ya que estas requieren mayor carga representacional. Los resultados obtenidos, sugieren que los procesos de control consciente no sólo se asocian a las tareas que requieren una mayor carga representacional, sino a todas las tareas que requieren razonar con estados mentales, sean ellos de primer o segundo orden

The nonlinearity of pupil diameter fluctuations in an insight task as criteria for detecting children who solve the problem from those who do not

Insights, characterized by sudden discoveries following unsuccessful problem-solving attempts, are fascinating phenomena. Dynamic systems perspectives argue that insight arises from self-organizing perceptual and motor processes. Entropy and fractal scaling are potential markers for emerging new and effective solutions. This study investigated whether specific features associated with self-organization in dynamical systems can distinguish between individuals who succeed and those who fail in solving insight tasks. To achieve this, we analyzed pupillary diameter fluctuations of children aged 6 to 12 during the 8-coin task, a well-established insight task. The participants were divided into two groups: successful (n = 24) and unsuccessful (n = 43) task completion. Entropy, determinism, recurrence ratio, and the β scaling exponent were estimated using Recurrence Quantification and Power Spectrum Density analyses. The results indicated that the solver group exhibited more significant uncertainty and lower predictability in pupillary diameter fluctuations before finding the solution. Recurrence Quantification Analysis revealed changes that went unnoticed by mean and standard deviation measures. However, the β scaling exponent did not differentiate between the two groups. These findings suggest that entropy and determinism in pupillary diameter fluctuations can identify early differences in problem-solving success. Further research is needed to determine the exclusive role of perceptual and motor activity in generating insights and investigate these results’ generalizability to other tasks and populations

Interdisciplinariedad e Intersectorialidad para la producción social del hábitat. Diseño participativo de un Asentamiento en Resistencia, Chaco.

El trabajo presenta una experiencia de práctica profesional interdisciplinaria, iniciada a partir de la firma de acuerdos de cooperación entre la Facultad de Arquitectura y Urbanismo de la Universidad Nacional del Nordeste (FAU-UNNE), la Facultad de Derecho, Ciencias Sociales y Políticas y el Instituto Superior de Servicio Social Remedios de Escalada de San Martín (ISSS). La propuesta de intervención surge a partir de la solicitud de un dirigente barrial del Centro de Promoción y Participación Comunitaria (CPyPC) del Asentamiento Soberanía, ubicado en la zona sur de la ciudad de Resistencia, capital de la Provincia del Chaco, a la cátedra Gestión y Desarrollo de la Vivienda Popular (GDVP) de la FAU, para la realización del reloteo[1] del asentamiento mencionado. La metodología participativa utilizada se implementa a través de talleres con el objetivo de: consolidar las relaciones vecinales, compartiendo y trabajando con los habitantes la problemática de la configuración espacial espontánea del barrio y los inconvenientes que eso conlleva para su inserción en la ciudad, logrando los consensos necesarios para el diseño del reloteo del sector. La coordinación de la intervención presenta carácter intersectorial, debido a la necesaria articulación por un lado, con el sector gubernamental, representado en el Instituto Provincial de Desarrollo Urbano y Vivienda (IPDUV), que implementa en nuestra provincia el Programa de Mejoramiento Barrial (PROMEBA) y, por otro, con el CPyPC y las 91 familias que integran el asentamiento. La experiencia tiene incidencia directa sobre tres aspectos: el acceso a la propiedad de la tierra, al posibilitar la regulación definitiva de cada lote; el acceso en carácter de beneficiarios al PROMEBA, al cumplimentar con las condiciones mínimas que exige el municipio para incorporarlo al catastro; y el fortalecimiento de la organización comunitaria del asentamiento. La vinculación con la producción social del hábitat en un contexto de extrema necesidad y conflictos sociales, atravesado por la práctica del trabajo interdisciplinario y por los procesos administrativos de los Organismos Públicos, implica la constante revisión de estrategias, que orienten procesos sociales superadores de los intereses particulares. [1] En Colombia, se denomina reloteo a la autorización para dividir, redistribuir o modificar el loteo de uno o más predios previamente urbanizados, para un mayor aprovechamiento, de conformidad con las normas que para el efecto establezcan el Plan de Ordenamiento Territorial y los instrumentos que lo desarrollen y complementen. En nuestro caso, es utilizado con una definición similar, pero para intervenir en predios con distintos grados de urbanización, debido a la ausencia de planificación de la ciudad por parte de las autoridades (Ministerio de Ambiente, Vivienda y Desarrollo Territorial, Decreto nº 564 de 2006, Licencias Urbanísticas)

Proposta sobre l’ordenació de la cirurgia bariàtrica en població adulta als hospitals públics de Catalunya

Cirugía bariátrica; Hospitales públicos; AdultosBariatric surgery; Public hospitals; AdultsCirurgia bariàtrica; Hospitals públics; AdultsL'objectiu és definir les indicacions de cirurgia bariàtrica en població adulta i disminuir la variabilitat entre centres hospitalaris; analitzar i definir els diferents nivells quirúrgics segons la complexitat de la cirurgia bariàtrica en població adulta; definir el seguiment a curt/mitjà i llarg termini de la postcirurgia bariàtrica en població adulta i establir els criteris i requeriments mínims dels centres hospitalaris per dur a terme cirurgia bariàtrica en població adulta. L’àmbit d’aplicació del consens és el Sistema sanitari integral d’utilització pública de Catalunya (SISCAT).El objetivo es definir las indicaciones de cirugía bariátrica en población adulta y disminuir la variabilidad entre centros hospitalarios; analizar y definir los diferentes niveles quirúrgicos segundos la complejidad de la cirugía bariátrica en población adulta; definir el seguimiento a corto/medio y largo plazo de la postcirugía bariátrica en población adulta y establecer los criterios y requerimientos mínimos de los centros hospitalarios para llevar a cabo cirugía bariátrica en población adulta. El ámbito de aplicación del consenso es el Sistema sanitario integral de utilización pública de Cataluña (SISCAT).The aim is to define the indications for bariatric surgery in the adult population and to decrease the variability between hospitals; analyze and define the different surgical levels according to the complexity of bariatric surgery in the adult population; define the short / medium and long-term follow-up of bariatric surgery in the adult population and establish the minimum criteria and requirements for hospitals to carry out bariatric surgery in the adult population. The scope of the consensus is the Comprehensive Health System for Public Use in Catalonia (SISCAT)

Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation.

Characterizing genetic influences on DNA methylation (DNAm) provides an opportunity to understand mechanisms underpinning gene regulation and disease. In the present study, we describe results of DNAm quantitative trait locus (mQTL) analyses on 32,851 participants, identifying genetic variants associated with DNAm at 420,509 DNAm sites in blood. We present a database of >270,000 independent mQTLs, of which 8.5% comprise long-range (trans) associations. Identified mQTL associations explain 15–17% of the additive genetic variance of DNAm. We show that the genetic architecture of DNAm levels is highly polygenic. Using shared genetic control between distal DNAm sites, we constructed networks, identifying 405 discrete genomic communities enriched for genomic annotations and complex traits. Shared genetic variants are associated with both DNAm levels and complex diseases, but only in a minority of cases do these associations reflect causal relationships from DNAm to trait or vice versa, indicating a more complex genotype–phenotype map than previously anticipated.C.L.R., G.D.S., G.S., J.L.M., K.B., M. Suderman, T.G.R. and T.R.G. are supported by the UK Medical Research Council (MRC) Integrative Epidemiology Unit at the University of Bristol (MC_UU_00011/1, MC_UU_00011/4, MC_UU_00011/5). C.L.R. receives support from a Cancer Research UK Programme grant (no. C18281/A191169). G.H. is funded by the Wellcome Trust and the Royal Society (208806/Z/17/Z). E.H. and J.M. were supported by MRC project grants (nos. MR/K013807/1 and MR/R005176/1 to J.M.) and an MRC Clinical Infrastructure award (no. MR/M008924/1 to J.M.). B.T.H. is supported by the Netherlands CardioVascular Research Initiative (the Dutch Heart Foundation, Dutch Federation of University Medical Centres, the Netherlands Organisation for Health Research and Development, and the Royal Netherlands Academy of Sciences) for the GENIUS project ‘Generating the best evidence-based pharmaceutical targets for atherosclerosis’ (CVON2011-19, CVON2017-20). J.T.B. was supported by the Economic and Social Research Council (grant no. ES/N000404/1). The present study was also supported by JPI HDHL-funded DIMENSION project (administered by the BBSRC UK, grant no. BB/S020845/1 to J.T.B., and by ZonMW the Netherlands, grant no. 529051021 to B.T.H). A.D.B. has been supported by a Wellcome Trust PhD Training Fellowship for Clinicians and the Edinburgh Clinical Academic Track programme (204979/Z/16/Z). J. Klughammer was supported by a DOC fellowship of the Austrian Academy of Sciences. Cohort-specific acknowledgements and funding are presented in the Supplementary Note

COVID-19 infection in adult patients with hematological malignancies: a European Hematology Association Survey (EPICOVIDEHA)

Background: Patients with hematological malignancies (HM) are at high risk of mortality from SARS-CoV-2 disease 2019 (COVID-19). A better understanding of risk factors for adverse outcomes may improve clinical management in these patients. We therefore studied baseline characteristics of HM patients developing COVID-19 and analyzed predictors of mortality. Methods: The survey was supported by the Scientific Working Group Infection in Hematology of the European Hematology Association (EHA). Eligible for the analysis were adult patients with HM and laboratory-confirmed COVID-19 observed between March and December 2020. Results: The study sample includes 3801 cases, represented by lymphoproliferative (mainly non-Hodgkin lymphoma n = 1084, myeloma n = 684 and chronic lymphoid leukemia n = 474) and myeloproliferative malignancies (mainly acute myeloid leukemia n = 497 and myelodysplastic syndromes n = 279). Severe/critical COVID-19 was observed in 63.8% of patients (n = 2425). Overall, 2778 (73.1%) of the patients were hospitalized, 689 (18.1%) of whom were admitted to intensive care units (ICUs). Overall, 1185 patients (31.2%) died. The primary cause of death was COVID-19 in 688 patients (58.1%), HM in 173 patients (14.6%), and a combination of both COVID-19 and progressing HM in 155 patients (13.1%). Highest mortality was observed in acute myeloid leukemia (199/497, 40%) and myelodysplastic syndromes (118/279, 42.3%). The mortality rate significantly decreased between the first COVID-19 wave (March–May 2020) and the second wave (October–December 2020) (581/1427, 40.7% vs. 439/1773, 24.8%, p value < 0.0001). In the multivariable analysis, age, active malignancy, chronic cardiac disease, liver disease, renal impairment, smoking history, and ICU stay correlated with mortality. Acute myeloid leukemia was a higher mortality risk than lymphoproliferative diseases. Conclusions: This survey confirms that COVID-19 patients with HM are at high risk of lethal complications. However, improved COVID-19 prevention has reduced mortality despite an increase in the number of reported cases.EPICOVIDEHA has received funds from Optics COMMITTM (COVID-19 Unmet Medical Needs and Associated Research Extension) COVID-19 RFP program by GILEAD Science, United States (Project 2020-8223)

Effectiveness of an intervention for improving drug prescription in primary care patients with multimorbidity and polypharmacy:Study protocol of a cluster randomized clinical trial (Multi-PAP project)

This study was funded by the Fondo de Investigaciones Sanitarias ISCIII (Grant Numbers PI15/00276, PI15/00572, PI15/00996), REDISSEC (Project Numbers RD12/0001/0012, RD16/0001/0005), and the European Regional Development Fund ("A way to build Europe").Background: Multimorbidity is associated with negative effects both on people's health and on healthcare systems. A key problem linked to multimorbidity is polypharmacy, which in turn is associated with increased risk of partly preventable adverse effects, including mortality. The Ariadne principles describe a model of care based on a thorough assessment of diseases, treatments (and potential interactions), clinical status, context and preferences of patients with multimorbidity, with the aim of prioritizing and sharing realistic treatment goals that guide an individualized management. The aim of this study is to evaluate the effectiveness of a complex intervention that implements the Ariadne principles in a population of young-old patients with multimorbidity and polypharmacy. The intervention seeks to improve the appropriateness of prescribing in primary care (PC), as measured by the medication appropriateness index (MAI) score at 6 and 12months, as compared with usual care. Methods/Design: Design:pragmatic cluster randomized clinical trial. Unit of randomization: family physician (FP). Unit of analysis: patient. Scope: PC health centres in three autonomous communities: Aragon, Madrid, and Andalusia (Spain). Population: patients aged 65-74years with multimorbidity (≥3 chronic diseases) and polypharmacy (≥5 drugs prescribed in ≥3months). Sample size: n=400 (200 per study arm). Intervention: complex intervention based on the implementation of the Ariadne principles with two components: (1) FP training and (2) FP-patient interview. Outcomes: MAI score, health services use, quality of life (Euroqol 5D-5L), pharmacotherapy and adherence to treatment (Morisky-Green, Haynes-Sackett), and clinical and socio-demographic variables. Statistical analysis: primary outcome is the difference in MAI score between T0 and T1 and corresponding 95% confidence interval. Adjustment for confounding factors will be performed by multilevel analysis. All analyses will be carried out in accordance with the intention-to-treat principle. Discussion: It is essential to provide evidence concerning interventions on PC patients with polypharmacy and multimorbidity, conducted in the context of routine clinical practice, and involving young-old patients with significant potential for preventing negative health outcomes. Trial registration: Clinicaltrials.gov, NCT02866799Publisher PDFPeer reviewe