18 research outputs found
Albiglutide and cardiovascular outcomes in patients with type 2 diabetes and cardiovascular disease (Harmony Outcomes): a double-blind, randomised placebo-controlled trial
- Author
- Abbas Jalal
- Abraham Sybil
- Ackert Jessica
- Adams Patricia
- Aggarwala Gaurav
- Aher Nutan
- Ahlqvist Jørn
- Ahn Chul Woo
- Akers Teresa
- Akhras Ronald
- Akhter Faiq
- Aksentyev Sergey
- Al Kawas Firas
- Alexander Karen
- Althouse Denise
- Altobelli Desma
- Alvarisqueta Andres
- Ambrosy Andrew
- Andersen James
- Andersen Ulla
- Anderson Michelle
- Anglade Moise
- Arbañil Hugo
- Arciszewska Malgorzata
- Argoud Georges
- Ariani Mehrdad
- Ashdji Reswan
- Avogaro Angelo
- Avramidis Iakovos
- Axthelm Christoph
- Aye Myint
- Babi Charleen
- Bachus Erasmus
- Baik Sei-Hyun
- Bailey Matt
- Bakhtari Ladan
- Baksi Arun
- Balasubramani Mathangi
- Baldovino Jorge
- Banach Marek
- Banerjee Subhash
- Bartlett Andrew
- Bartone Susan
- Baum Howard
- Bays Harold
- Bazhan Larysa
- Beasley Richard
- Beaudry Yves
- Beaulieu Gail
- Beboso Ronnie
- Bedard Jacques
- Beijerbacht Hugo Peter
- Belfort de Aguiar Renata
- Benjamin Sabrina
- Berger Dirk
- Berlingieri Joseph
- Berndtsson Blom Katarina
- Besada Diego
- Bethel M Angelyn
- Bhagwat Ravi
- Bhargava Anuj
- Bhosale Archana
- Bieler Tasso
- Bijata-Bronisz Renata
- Birkeland Kare
- Birkenfeld Andreas
- Blagden Mark
- Bloomfield Gerald
- Bode Bruce
- Boemi Massimo
- Bonadonna Riccardo
- Bondar Irina
- Bott Jochen
- Bousboulas Stavros
- Boye Alain
- Bratcher Christina
- Breneman Jody
- Briskin Toby
- Bristianou Magdalini
- Brockmyre Andrew
- Broughton Raymond
- Brown Judith
- Brown Kim
- Brychta Tomas
- Brønnum-Schou Jens
- Budhraja Madhusudan
- Bull Georgina
- Bundy Charles
- Burgess Lesley
- Busch Klaus
- Caca Karel
- Cadinot Didier
- Calderon Jorge
- Calella Pedro
- Califf Robert M
- Calvo Gómez Carlos
- Camacho Luis
- Cannon Kevin
- Cano Rodríguez Isidoro
- Cantero Maria Cecilia
- Carr Jewell
- Casson Ed
- Castaño Patricia
- Castro Conde Almudena
- Cathcart Harold
- Cavale Arvind
- Cech Vladimir
- Cequier Fillat Angel
- Cervantes-Escárcega Jose-Luis
- Cha Bong-Soo
- Chau Tuan
- Chaykin Louis
- Chehayeb Raja
- Chen David
- Chen Jung-Fu
- Chertkoff Alejandro
- Cheung Deanna
- Cheung Stephen
- Chevts Julia
- Chiang Chern-En
- Childress Richard
- Christian Tamra
- Chung Choon-Hee
- Coetzee Kathleen
- Cohen Allan
- Coker Rebecca
- Cole Joanna
- Collier Jeannie
- Condit Jonathan
- Consoli Agostino
- Conway James
- Cooksey Erin
- Cookson Tobias
- Cooper John
- Cooper Lauren
- Copland Allan
- Cornel Jan
- Cornett George Mitchell
- Crenier Laurent
- Cuadrado Jesus
- Cuatrecasas Cambra Guillem
- Cusson Jean
- D'Agostino Ralph B
- D'Agostino Ralph B.
- Daga Shruti
- Damyanova Velichka
- Dauber Ira
- Davila William
- Dawood Saleem
- De Armas Luis
- De Cosmo Salvatore
- De Loredo Luis
- De Teresa Parreño Luis
- de Álvaro Moreno Fernando
- Dean Julius
- Debroye Corinne
- Del Prato Stefano
- Del Prato Stefano
- Delgado Lista Javier
- Della Siega Anthony
- DeMets David
- Demidova Irina
- Derezinski Tadeusz
- Deshpande Sameer
- Detweiler Robert
- Devore Adam
- Di Bartolo Paolo
- Di Giovanna Michael
- Diaz Ernesto
- Dimitriadis Georgios
- Dimitrov Stefan
- Distiller Larry
- Dombrowski Keith
- Dominguez Andrea
- Domínguez Escribano José Ramón
- Donaldson Jill
- Donaubauer Torsten
- Dor Isaac
- Dotta Francesco
- Dreval Alexander
- Drummond Waymon
- Dumas Richard
- Dumbre Snehal
- Dungan Kathleen
- Durán García Santiago
- Duyck Francis
- Dvorakova Eva
- Dzongowski Peter
- Eagerton Donald
- Eapen Zubin
- Earl John
- Eaton Charles
- Ebo Geraldine
- Edelsberger Tomas
- Eliasson Bjorn
- Eliasson Ken
- Elisaf Moses
- Ellison Howard
- Elvira González Javier
- Emslie-Smith Alistair
- Endsley Patricia
- Enns Robert
- Erlinger Rudolf
- Ershova Olga
- Español Maria Vanesa
- Espinoza Augusto Dextre
- Farris Neil
- Ferguson Murdo
- Fernandez-Salazar Eva
- Fernández Rodríguez José María
- Fiel Thomas
- Finkelstein Hernan
- Firek Anthony
- First Brian
- Fleming John
- Flota-Cervera Luis Fernando
- Forgosh Les
- Frechtel Gustavo
- French William
- Fretes Jose
- Friedman Daniel
- Frontoni Simona
- Funke Klaus
- Fushtey Ivan
- Gadzinski Waldemar
- Gajek Jacek
- Galatius Søren
- Galetta Marianna
- Galstyan Gagik
- Gambineri Alessandra
- Gandy Winston
- Garcia Ronald
- Garganeeva Alla
- Garrido Santos Natalia
- Garrido Elizabeth
- Garvey Louisa
- Gaudet Daniel
- Gazzaruso Carmine
- Gentry Tracy
- Giaccari Andrea
- Gill Santosh
- Giorgino Francesco
- Goday Arno Alberto
- Godse Rupali
- Gomez Huelgas Ricardo
- Gonzales Rolando Vargas
- Gonzalez Joaquin
- González Juanatey José Ramón
- González-González José Gerardo
- Goodman Shaun
- Gordon Murray
- Gouet Didier
- Grachova Mariya
- Granger Christopher B
- Granger Christopher B.
- Green Fiona
- Green Jennifer B
- Green Jennifer B
- Greene Deb
- Greene Stephen
- Grondin Francois
- Grosskopf Josef
- Groutars Reginald G.E.J.
- Guerci Bruno
- Guice Michael
- Guimaraes Patricia
- Gulseth Hanne
- Gummadi Siva
- Gunstone Anthony
- Gupta Anil
- Gupta Milan
- Gupta Nikita
- Guttormsen Gaute
- Ha JuYoung
- Hackenyos Jonathan
- Haddock Trevorlyn
- Hagenow Andreas
- Hairston Kristen
- Hajdú Csaba
- Halciakova Katarina
- Halperin Frank
- Haluzik Martin
- Hamann Monika
- Hanson Lenita
- Haque Ghazala
- Harcsa Eleonóra
- Harris Tara
- Harrison Lindsay
- Harrison Rob
- Hartard Manfred
- Hartman Israel
- Heitner John
- Hejeebu Srini
- Henry Patrick
- Hereghty Belinda
- Hermany Paul
- Hernandez Mijares Antonio
- Hernandez Adrian F
- Hernandez Adrian F.
- Hernandez-Cassis Carlos
- Heymer Peter
- Hidalgo Horacio
- Higgins Alexander
- Hoek Boudewijn A
- Holman Rury
- Hoogslag Pieter A.M.
- Houle Pierre-Alain
- Hove Jens
- Howell Christina
- Hramiak Irene
- Huppertz Wolfgang
- Hutayanon Pisit
- Ibrahim Hassan
- Illies Gabriele
- Issa Basil
- Izmozherova Nadezhda
- Jackson-Voyzey Ewart
- Jacob Stephan
- Jacobs Shahram
- James Kourtnei
- James Rachel
- Jang Hak Chul
- Janmohamed Salim
- Janmohamed Salim
- Jarosz Marie
- Jenkins Wendy
- Jensen Jan Skov
- Jerjes-Díaz Carlos Sánchez
- Jiménez Díaz Víctor Alfonso
- Jintapakorn Woravut
- Jodar Gimeno Esteban
- Johnson Andrew
- Johnson David
- Johnson Megan
- Jones Michael
- Jones Nigel P
- Jones Nigel P
- Jordan Dedrick
- Joshi Parag
- Jung Thomas
- Kadgaonkar Neha
- Kahrmann Gerd
- Karetnikova Victoria
- Karka Mounika
- Karmalkar Anisha
- Kast Petra
- Kaster Steven
- Katerenchuk Vitaliy
- Kellerer Monika
- Kellum Daniel
- Kelly Aoife
- Kempe Hans-Peter
- Kessler Laurence
- Khandelwal Chaitali
- Kharakhulakh Marina
- Khariouzov Andrei
- Khokhlov Aleksandr
- Kim Chong-Jin
- Kim Christopher
- Kim Ellen
- Kim Hye Soon
- Kim In Joo
- Kirby William
- Klausmann Gerhard
- Klein Christiane
- Kleinecke-Pohl Uwe
- Kleinertz Klaus
- Klodawska Katarzyna
- Knouse Albert
- Kobalava Zhanna
- Kober Lars
- Koch Thorsten
- Kocsis Gyozo
- Kolls Brad
- Kong David
- Konyves Laszlo
- Kooy Adriaan
- Korpachev Vadym
- Kosch Christine
- Koshelskaya Olga
- Kosiborod Mikhail
- Koskinen Pekka
- Kosmacheva Elena
- Kostin Vladimir
- Kotsa Kalliopi
- Kouz Simon
- Kovacheva Snezhina
- Kovacs Christopher
- Koziolova Natalia
- Kragten Johannes A.
- Kravchun Nonna
- Kristiansen Ole Peter
- Krizova Jarmila
- Krzyzagorska Ewa
- Kulback Steven
- Kulkarni Mangesh
- Kumar Mariananda
- Kumar Rakesh
- Kumar Somesh
- Kumari Aditi
- Kuruvanka Tulsidas
- Kuzin Anatoly
- Labroo Ajay
- Lalau Jean-Daniel
- Landry Daniel
- Larin Oleksandr
- Larnefeldt Hans
- Lasswell William
- Lastuvka Jiri
- Lauder Steven
- Lauro Davide
- Lee Eun Young
- Lee Hyoung Woo
- Lee Kwan-Woo
- Lee Moon Kyu
- Leiter Lawrence A
- Leiter Lawrence A.
- Lentz John
- Lenzmeier Thomas
- Lesnov Victor
- Lewis David
- Li Wenyan
- Li Zhaoping
- Lieverse Aloysius G.
- Lif-Tiberg Cornelia
- Lillestol Michael
- Linderfalk Carina
- Lindsay Alistair
- Little Raymond
- Litvak Marcos
- Llamas Edmundo-Alfredo Bayram
- Lokhngina Yuliya
- Lombard Landman
- Longley Troy
- Lonn Eva
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- Lorimer Jamie
- Lorra Babette
- Lorraine Richard
- Loureyro Juan
- Lozanov Lachezar
- Lucas Morante Tomás
- Luedemann Joerg
- Luna Alejandro
- Lund Gustav
- Lund Per
- Lundman Pia
- Luttermann Matthias
- Lysenko Tatyana
- Maclean Malcolm
- Madej Andrzej
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- Maldonado Natacha
- Mandal Trisha
- Mandawat Aditya
- Mankovsky Boris
- Manrique Helard
- Marazuela Monica
- Margaritov Viktor
- Markov Valentin
- Marquess Marsha
- Martell Claros Nieves
- Mathews Robin
- Mathieu Chantal
- Mauricio Puente Didac
- Maxeiner Stephan
- Mayorov Alexander
- McGuire Darren
- McKeown-Biagas Cecilia
- McKnight John
- McLaughlin Patricia
- McMurray John J.V.
- McMurray John J.V.
- McNeill Robert
- Mehta Anand
- Mehta Rajendra
- Melchior Thomas
- Melidonis Andreas
- Melloni Chiara
- Mena Ribas Elena
- Merino Torres Juan Francisco
- Mezquita Raya Pedro
- Mhambrey Ankita
- Miekus Pawel
- Migdalis Ilias
- Mihaylova-Shumkova Rositsa
- Milek Karsten
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- Miller Diane
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- Mohr Gasparini Diego
- Moiseev Sergey
- Moodley Rajendran
- Moon Keon-Woong
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- Moran Joseph
- Morawski Emily
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- Mykhalchyshyn Galyna
- Myshanych Halyna
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- Nadar Venkatesh
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- Namgung June
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- Nischik Ruth
- Noronha Drusilla
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- Nyvad Ole
- O'Connell Ian
- O'Connor Thomas
- O'Mahony William
- Odio Alberto
- Oehrig-Pohl Edith
- Oleksyk Olga
- Olesinska-Mader Martyna
- Olsson Åke
- Oosthuysen Wessels
- Opiela Jaroslaw
- Ordoñez Sánchez Xavier
- Orio Silvia
- Orlenko Valeriia
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- Overton Robert
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- Pashkovska Nataliia
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- Patel Prashant
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- Patel Rajivkumar
- Patel Vickas
- Patil Ashwini P
- Patil Suradnya
- Patterson Catherine
- Pauker Zsolt
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- Pelayo-Orozco Emilia Susana
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- Perez Manghi Federico
- Perez Soto Isabel
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- Sigmon Kristina
- Sigmon Kristina N
- Silhova Elena
- Sinay Isaac
- Singh Narendra
- Sivalingam Kanagaratnam
- Sjöberg Folke
- Skokowska Ewa
- Smirnov Ivan
- Smith Paul
- Smith Peter
- Soffer Joseph
- Sokolova Nadezhda
- Solanki Sheetal
- Somerville Matthew
- Somerville Matthew C
- Soto González Alfonso
- Sowell Margaret
- Sposetti Georgina
- Srimahachota Suphot
- St-Maurice Francois
- Stankiewicz Andrzej
- Stasinska Teresa
- Stead Janet
- Steindorf Joerg
- Stewart Murray
- Stockhausen Juergen
- Stone Allegra
- Stonesifer Larry
- Storey Daniel
- Stoyanova Zhasmina
- Stuebler Petra
- Suh David
- Sukumaran Usha
- Swart Hendrik P.
- Sándor Vangel
- Söderberg Stefan
- Taeschner Heidrun
- Taft Lin
- Tahir Mohammed
- Tan Anjanette
- Tan Choon Beng Kathryn
- Tan Marilyn
- Taylon Alain
- Tentolouris Nikolaos
- Tews Dietrich
- Thakkar Maitreya
- Thomas Betsy
- Thorpe Karl
- Thorpe Karl M
- Thuan Jean-Francois
- Tien Kai Jen
- Tinahones Madueno Francisco
- Tirador Louie
- Tonolo Giancarlo
- Torres-Colores Jose Juan
- Torstensson Ingemar
- Trescoli Serrano Carlos
- Trevisan Roberto
- Tricoci Pierluigi
- Tripathy Devjit
- Trznadel-Morawska Iwona
- Tsapas Apostolos
- Tschoepe Diethelm
- Tseng Shih-Ting
- Tu Shih-Te
- Tugwell Barna
- Tzatzagou Glykeria
- Ulied Armiñana Angels
- Ulla Maria
- Urbanek Robin
- Uwaifo Gabriel
- Van Gaal Luc
- Vandyne Beth
- Vaphare Ashok
- Vasilevskaya Olga
- Vass Viktor
- Vedere Amarnath
- Vemulapalli Sreekanth
- Venugopal Chandra
- Verbovaya Nelli
- Vercammen Chris
- Verra Fernando
- Vidrio-Velázquez Maricela
- Viergever Eric P.
- Villagordoa-Mesa Juan
- Vishneva Elena
- Vizel Saul
- Vlasenko Maryna
- Vo Anthony
- Voinot Christel
- Vorobyev Sergey
- Vorokhobina Natalya
- Vouillarmet Julien
- Vrkoc Jan
- Wang Chih-Yuan
- Wang Ji-Hung
- Watson Anthony
- Watson David
- Welch Michelle
- Welker James
- White Alexander
- Wilhelm Karl
- Willis John
- Wilson Matt
- Wilson Tim
- Witek Robert
- Wium Cecilie
- Womer Terese
- Woo Vincent
- Wraight Ella
- Wynne Alan
- Xing Weibing
- Yamwong Sukit
- Yazdani Shahram
- Ye June
- Yoo Soon Jib
- Yordanov Victor
- Yu Jaemyung
- Zabalua Silvina
- Zaidman Cesar
- Zang Eddie
- Zanozina Olga
- Zeller-Stefan Helga
- Zhdanova Elena
- Zlova Tetiana
- Zubiate Carlos
- Zykova Tatyana
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2018
- Field of study
Background:
Glucagon-like peptide 1 receptor agonists differ in chemical structure, duration of action, and in their effects on clinical outcomes. The cardiovascular effects of once-weekly albiglutide in type 2 diabetes are unknown. We aimed to determine the safety and efficacy of albiglutide in preventing cardiovascular death, myocardial infarction, or stroke.
Methods:
We did a double-blind, randomised, placebo-controlled trial in 610 sites across 28 countries. We randomly assigned patients aged 40 years and older with type 2 diabetes and cardiovascular disease (at a 1:1 ratio) to groups that either received a subcutaneous injection of albiglutide (30–50 mg, based on glycaemic response and tolerability) or of a matched volume of placebo once a week, in addition to their standard care. Investigators used an interactive voice or web response system to obtain treatment assignment, and patients and all study investigators were masked to their treatment allocation. We hypothesised that albiglutide would be non-inferior to placebo for the primary outcome of the first occurrence of cardiovascular death, myocardial infarction, or stroke, which was assessed in the intention-to-treat population. If non-inferiority was confirmed by an upper limit of the 95% CI for a hazard ratio of less than 1·30, closed testing for superiority was prespecified. This study is registered with ClinicalTrials.gov, number NCT02465515.
Findings:
Patients were screened between July 1, 2015, and Nov 24, 2016. 10 793 patients were screened and 9463 participants were enrolled and randomly assigned to groups: 4731 patients were assigned to receive albiglutide and 4732 patients to receive placebo. On Nov 8, 2017, it was determined that 611 primary endpoints and a median follow-up of at least 1·5 years had accrued, and participants returned for a final visit and discontinuation from study treatment; the last patient visit was on March 12, 2018. These 9463 patients, the intention-to-treat population, were evaluated for a median duration of 1·6 years and were assessed for the primary outcome. The primary composite outcome occurred in 338 (7%) of 4731 patients at an incidence rate of 4·6 events per 100 person-years in the albiglutide group and in 428 (9%) of 4732 patients at an incidence rate of 5·9 events per 100 person-years in the placebo group (hazard ratio 0·78, 95% CI 0·68–0·90), which indicated that albiglutide was superior to placebo (p<0·0001 for non-inferiority; p=0·0006 for superiority). The incidence of acute pancreatitis (ten patients in the albiglutide group and seven patients in the placebo group), pancreatic cancer (six patients in the albiglutide group and five patients in the placebo group), medullary thyroid carcinoma (zero patients in both groups), and other serious adverse events did not differ between the two groups. There were three (<1%) deaths in the placebo group that were assessed by investigators, who were masked to study drug assignment, to be treatment-related and two (<1%) deaths in the albiglutide group.
Interpretation:
In patients with type 2 diabetes and cardiovascular disease, albiglutide was superior to placebo with respect to major adverse cardiovascular events. Evidence-based glucagon-like peptide 1 receptor agonists should therefore be considered as part of a comprehensive strategy to reduce the risk of cardiovascular events in patients with type 2 diabetes.
Funding:
GlaxoSmithKline
Genomic investigations of unexplained acute hepatitis in children
- Author
- Abdulla Amina
- Aebi Christoph
- Agbeko Rachel
- Aggelos Pefanis
- Agranoff Dan
- Agwuh Ken
- Agyeman Philipp
- Alba-Alejandre Irene
- Ali Ladan
- Alkema Wynand
- Allen Karen
- Alrabiah Dimah K.
- Amatya Puja
- Anderson Glenn
- Anderson Suzanne
- Andrade Catarina
- Andreani Julien
- Anpananthar Amutha
- Ansari Imran
- Antinao Diaz Juan F.
- Arif Tasnim
- Armstrong Diane
- Armstrong Jane A.
- Armstrong Lawrence
- Asgarian Zeinab
- Atkinson Laura
- Avcin Tadej
- Avramoska Tanja
- Baas Bryan
- Bahovec Natalija
- Baillie Kenneth
- Balode Anda
- Bamford Alasdair
- Barendregt A. M.
- Barral-Arca Ruth
- Barzdina Arta
- Barzdina Elza
- Basmaci Romain
- Bath David
- Bauchinger Sebastian
- Baumard Lucas
- Baumgart Hinrich
- Baxter Frances
- Bayzid Nadua
- Beer Sally
- Bell Ashley
- Bell Claire
- Bell Kathryn
- Bellini Arianna
- Bello Xabier
- Bellos Evangelos
- Benesch Martin
- Benesch Martin
- Bennet Joshua
- Berger Christoph
- Bernhard-Stirnemann Sara
- Beudeker Coco R.
- Beveridge Laura
- Bibi Sagida
- Bidlingmaier Christoph
- Biesbroek Giske
- Bijukchhe Sanjeev Man
- Billing Kyle
- Binder Alexander
- Binder Vera
- Birt Mark
- Bogovic Petra
- Bohmova Kristyna
- Bojang Kalifa
- Bont Louis J.
- Borensztajn Dorine M.
- Bories Pauline
- Branch Nicole
- Brengel-Pesce Karen
- Breuer Judith
- Broderick Claire
- Brotherton Helen
- Brown Julianne R.
- Brown Rachel
- Buddle Sarah
- Burling Sara
- Buschbeck Judith
- Cabello Laura
- Calle Irene Rivero
- Calvo-Bado Leo
- Campos Luis
- Candlish Janie
- Capozzi Lisa
- Carnota Sandra
- Caro Ivan
- Carrol Enitan D.
- Carson Gail
- Carter Michael
- Carter Michael J.
- Castellano Sergi
- Castro Maria Barreiro
- Cebey-López Miriam
- Ceesay Samba
- Celma Cristina
- Ceolotto Astrid
- Chan Adora
- Chand Meera
- Channon-Wells Samuel
- Charalambos Gogos
- Chikowore Primrose
- Chiurchiù Sara
- Chukkambotla Srikanth
- Chériaux Laura
- Clark Richard
- Clohisey Sara
- Cocklin Elizabeth
- Cohen Jonathan
- Cohen Laure
- Collings Kalvin
- Collins Emma
- Connon Maggie
- Cooray Samantha
- Cotillon Marie
- Counsell John R.
- Coutts Audrey
- Cresswell Fiona
- Crulley Stephen
- Cunnington Aubrey
- Curras-Tuala María José
- Czap Agata
- D'alessandro Umberto
- D?Souza Giselle
- Dall Anna
- Danekova Nevena
- Danhauser Katharina
- Darboe Saffiatou
- Darnell Sarah
- Daubney Esther
- Davis Francesca
- Davoust Juraté
- Dawson Joy
- de Groc Thibault
- de Groot Ronald
- de Haan L.
- de Jonge Marien I.
- de Silva Thushan
- de Tugny Alice
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- Ferguson Susie
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- van de Kuip Martijn
- van den Berg J. M.
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- van den Broek Bryan
- van der Flier Michiel
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- van der Velden Fabian J. S.
- van der Zee Carlijn
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- van Hensbroek Michael Boele
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- Waddington Simon N.
- Wallia Diane
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- Wang Shih-Min
- Ward Bryony
- Ward Catriona
- Watson Conall
- Weber Kathrin
- Wedderburn Catherine
- Wellings Lucy
- Wellman Paul
- Wham Murray
- White Deborah
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- Whittaker Elizabeth
- Whittaker Paul
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- Yeung Shunmay
- Zachariasse Joany
- Zaman Syed M. A.
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- Zavadska Dace
- Zennezini Chiozzi Riccardo
- Zenz Werner
- Zimmermann Elisa
- Zurl Christoph
- Zwerenz Manuela
- Publication venue
- Nature Research
- Publication date
- 30/03/2023
- Field of study
Since its first identification in Scotland, over 1,000 cases of unexplained paediatric hepatitis in children have been reported worldwide, including 278 cases in the UK1. Here we report an investigation of 38 cases, 66 age-matched immunocompetent controls and 21 immunocompromised comparator participants, using a combination of genomic, transcriptomic, proteomic and immunohistochemical methods. We detected high levels of adeno-associated virus 2 (AAV2) DNA in the liver, blood, plasma or stool from 27 of 28 cases. We found low levels of adenovirus (HAdV) and human herpesvirus 6B (HHV-6B) in 23 of 31 and 16 of 23, respectively, of the cases tested. By contrast, AAV2 was infrequently detected and at low titre in the blood or the liver from control children with HAdV, even when profoundly immunosuppressed. AAV2, HAdV and HHV-6 phylogeny excluded the emergence of novel strains in cases. Histological analyses of explanted livers showed enrichment for T cells and B lineage cells. Proteomic comparison of liver tissue from cases and healthy controls identified increased expression of HLA class 2, immunoglobulin variable regions and complement proteins. HAdV and AAV2 proteins were not detected in the livers. Instead, we identified AAV2 DNA complexes reflecting both HAdV-mediated and HHV-6B-mediated replication. We hypothesize that high levels of abnormal AAV2 replication products aided by HAdV and, in severe cases, HHV-6B may have triggered immune-mediated hepatic disease in genetically and immunologically predisposed children
Observation of gravitational waves from the coalescence of a 2.5−4.5 M⊙ compact object and a neutron star
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- Abac Adrian
- Abbott R.
- Abouelfettouh I.
- Acernese F.
- Ackley Kendall
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
- Adkins V. K.
- Afif Ismail M.
- Agarwal Deepali
- Agathos Michalis
- Aghaei Abchouyeh Maryam
- Aguiar Odylio D.
- Aguilar I.
- Aiello Lorenzo
- Ain Anirban
- Ajith Parameswaran
- Akcay Sarp
- Akseli Hannuksela Otto
- Akutsu Tomotada
- Al-Jodah Ammar
- Al-Shammari S.
- Albanesi Simone
- Alex iandolo Guido
- Alfaidi Reem Atallah E
- Allocca Annalisa
- Alléné C.
- Altin Paul
- Alvarez-Lopez Sofia
- Amato Alex
- Amez-Droz L.
- Amorosi A.
- Amra C.
- Ananyeva A.
- Anderson Stuart
- Anderson Warren G.
- Andia Manuel
- Ando M.
- Andrade T.
- Andrea Prodi Giovanni
- Andres Nicolas
- Andric Tomislav
- Andrés Vallejo Peña Sergio
- Andrés-Carcasona Marc
- Anglin J.
- Anne Bizouard Marie
- Ansoldi Stefano
- Antelis Javier M.
- Antier Sarah
- Antoni Ramis Vidal Felip
- Antonietta Palaia Maria
- Antonio Font Roda Jose
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- Yasui H.
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- Yelikar A. B.
- Yin X.
- Yokoyama Jun'ichi
- Yokozawa T.
- Yoo Jooheon
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- Zhao Yuhang
- Zheng Yanyan
- Zhong Haowen
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- Zhu Xingjiang
- Zhu Zong-Hong
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- Zucker M. E.
- Zweizig John
- Árpád Gergely László
- 劉 國欽
- 都丸 隆行
- Publication venue
- Publication date
- 23/04/2024
- Field of study
Ultralight vector dark matter search using data from the KAGRA O3GK run
- Author
- Abac A. G.
- Abbott R.
- Abe H.
- Abouelfettouh I.
- Acernese F.
- Ackley Kendall
- Adamcewicz Christian
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
- Adkins V. K.
- Adya V. B.
- Affeldt C.
- Afif Ismail M.
- Agarwal Deepali
- Agathos Michalis
- Aguiar Odylio D.
- Aguilar I.
- Aiello Lorenzo
- Ain Anirban
- Ajith Parameswaran
- Akseli Hannuksela Otto
- Akutsu Tomotada
- Al-Jodah Ammar
- Al-Shammari S.
- Albanesi S.
- Alberto Trani Alessandro
- Alfaidi Reem Atallah E
- Allocca Annalisa
- Alléné C.
- Altin Paul
- Alvarez-Lopez Sofia
- Amato Alex
- Amez-Droz L.
- Amorosi A.
- Amra C.
- Anand S.
- Ananyeva A.
- Anderson Stuart
- Anderson Warren G.
- Andia Manuel
- Ando M.
- Andrade T.
- Andrea Prodi Giovanni
- Andres Nicolas
- Andric Tomislav
- Andrés-Carcasona Marc
- Anglin J.
- Anne Bizouard Marie
- Ansoldi S.
- Antelis Javier M.
- Antier Sarah
- Antoni Ramis Vidal Felip
- Antonietta Palaia Maria
- Antonio Font Roda Jose
- Aoumi M.
- Appavuravther E. Z.
- Appert S.
- Apple S. K.
- Arai Koji
- Araya Akito
- Araya Melody
- Areeda Joseph
- Argianas L. Granda
- Arif Shaikh Md
- Aritomi Naoki
- Armato F.
- Arnaud Nicolas
- Arogeti Megan
- Aronson Scott
- Arun K. G.
- Ashton Gregory
- Aso Yoichi
- Assiduo M.
- Aston S. M.
- Astone Pia
- Aubin Florian
- AVALLONE Guerino
- Babak Stanislav
- Badaracco Francesca
- Badger C.
- Bae Sangwook
- Bagnasco Stefano
- Bagui E.
- Bai Y.
- Baier Jeremy
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- De Rosa Rosario
- de rossi camilla
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- Fujimoto Hiroki
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- Wolfe N. E.
- Won Lee Hyung
- Won Seo Jin
- Wong D.
- Wong Henry T.
- Wright J. L.
- Wright Mick
- Wu Chien-Ming
- Wu David S.
- Wu Hsun-Chung
- Wysocki Daniel
- Xiao Liting
- Xu Victoria
- Xu Yumeng
- Yaala M. Ben
- Yadav Nikesh
- Yakovlev Alexey
- Yamamoto Hiroaki
- Yamamoto Kazuhiro
- Yamamoto M.
- Yamamoto Takahiro
- Yamamoto Takahiro S.
- Yamamura S.
- Yamazaki Ryo
- Yan S.
- Yan T.
- Yang F.
- Yang Fengwei
- Yang Kate Z.
- Yang L. -C.
- Yang Yi
- Yarbrough Zach
- Yeh S. -W.
- Yelikar A. B.
- Yeung S. M. C.
- Yin X.
- Yokoyama Jun'ichi
- Yokozawa T.
- Yoo Jooheon
- Yu Hang
- Yuzurihara Hirotaka
- Zadrożny A.
- Zahoor Jan Aasim
- Zannelli A. J.
- Zanolin M.
- Zeeshan M.
- Zelenova T.
- Zendri J. -P.
- Zeoli M.
- Zerrad M.
- Zevin Michael
- Zhang A. C.
- Zhang Jue
- Zhang L.
- Zhang Rui
- Zhang T.
- Zhang Ya
- Zhao C.
- Zhao Yue
- Zhao Yuhang
- Zheng Yanyan
- Zhong Haowen
- Zhong S.
- Zhou R.
- Zhu Zong-Hong
- Zucker M. E.
- Zweizig John
- Árpád Gergely László
- 劉 國欽
- 曹周键
- 都丸 隆行
- Publication venue
- Publication date
- 01/03/2024
- Field of study
Among the various candidates for dark matter (DM), ultralight vector DM can be probed by laser interferometric gravitational wave detectors through the measurement of oscillating length changes in the arm cavities. In this context, KAGRA has a unique feature due to differing compositions of its mirrors, enhancing the signal of vector DM in the length change in the auxiliary channels. Here we present the result of a search for U(1)B−L gauge boson DM using the KAGRA data from auxiliary length channels during the first joint observation run together with GEO600. By applying our search pipeline, which takes into account the stochastic nature of ultralight DM, upper bounds on the coupling strength between the U(1)B−L gauge boson and ordinary matter are obtained for a range of DM masses. While our constraints are less stringent than those derived from previous experiments, this study demonstrates the applicability of our method to the lower-mass vector DM search, which is made difficult in this measurement by the short observation time compared to the auto-correlation time scale of DM
Search for eccentric black hole coalescences during the third observing run of LIGO and Virgo
- Author
- Abac A. G.
- Abbott R.
- Abe H.
- Acernese F.
- Ackley Kendall
- Adamcewicz C.
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
- Adkins V. K.
- Adya V. B.
- Affeldt C.
- Afif Ismail M.
- Agarwal D.
- Agathos Michalis
- Aguiar Odylio D.
- Aguilar I.
- Aiello Lorenzo
- Ain Anirban
- Ajith Parameswaran
- Akseli Hannuksela Otto
- Akutsu Tomotada
- Al-Jodah Ammar
- Albanesi S.
- Alberto Trani Alessandro
- Alfaidi Reem Atallah E
- Allocca Annalisa
- Alléné C.
- Almualla M.
- Altin Paul
- Amato Alex
- Amez-Droz L.
- Amorosi A.
- Anand S.
- Ananyeva A.
- Andersen R.
- Anderson Stuart
- Anderson Warren G.
- Andia Manuel
- Ando M.
- Andrade T.
- Andrea Prodi Giovanni
- Andres Nicolas
- Andric Tomislav
- Andrés-Carcasona Marc
- Anne Bizouard Marie
- Ansoldi S.
- Antelis Javier M.
- Antier Sarah
- Antonio Font Roda Jose
- Aoumi M.
- Apostolatos T.
- Appavuravther E. Z.
- Appert S.
- Apple S. K.
- Arai Koji
- Araya Akito
- Araya Melody
- Areeda Joseph
- Arif Shaikh Md
- Aritomi Naoki
- Armato F.
- Arnaud Nicolas
- Arogeti Megan
- Aronson Scott
- Arun K. G.
- Ashton Gregory
- Aso Yoichi
- Assiduo M.
- Aston S. M.
- Astone Pia
- Aubin Florian
- Babak Stanislav
- Badalyan A.
- Badaracco Francesca
- Badger C.
- Bae Sangwook
- Bagnasco Stefano
- Bai Y.
- Baier Jeremy
- Bajpai Rishabh
- Baka T.
- Ball M.
- Ballardin G.
- Ballmer S. W.
- Baltus Grégory
- Banagiri Sharan
- Banerjee Biswajit
- Bankar Deepak
- Baral Pratyusava
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- Barker D.
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- Barone Fabrizio
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- Barsotti Lisa
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- Barta Dániel
- Barthelmy S. D.
- Barton Mark Andrew
- Bartos I.
- Basak Soummyadip
- Basalaev Artem
- Bassiri Riccardo
- Basti Andrea
- Bawaj Mateusz
- Baxi P.
- Bayley Joseph
- Baylor Amanda
- Bazzan M.
- Bedakihale V. M.
- Beirnaert Freija
- Bejger Michał
- Bell Angus
- Benedetto V.
- Beniwal D.
- Benoit William
- Bentley Joe
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- Berbel Marina
- Bergamin Fabio
- Berger Beverly
- Bernuzzi Sebastiano
- Beroiz Martin
- Berry Christopher P. L.
- Bersanetti Diego
- Bertolini A.
- Betzwieser Joseph
- Beveridge Damon
- Bevins Nathaniel
- Bhandare R.
- Bhandari A. V.
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- Bhattacharjee Dripta
- Bhaumik Shubhagata
- Bianchi A.
- Bilenko I. A.
- Bilicki Maciej
- Billingsley GariLynn
- Binetti Alberto
- Bini Sophie
- Birnholtz Ofek
- Biscans S.
- Bischi M.
- Biscoveanu Andrea Sylvia
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- Bitossi M.
- Blackburn Kent
- Blair C. D.
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- Boileau Guillaume
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- Bondarescu Ruxandra
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- Bonilla Carrasquel Edgard
- Bonilla G. S.
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- Bossilkov V.
- Boudart Vincent
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- Cagnoli Gianpietro
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- Chanial Pierre
- Chao Shiuh
- Chapman-Bird Christian
- Charlton E. L.
- Charlton Philip
- CHASSANDE-MOTTIN Eric
- Chastain L.
- Chatterjee Chayan
- Chatterjee Debarati
- Chatterjee Deep
- Chaturvedi M.
- Chaty Sylvain
- Chatziioannou Katerina
- Chen A.
- Chen A. H. -Y.
- Chen Dan
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- Chen Junxin
- Chen K. H.
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- Christensen Nelson
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- Ciani Giacomo
- Ciecieląg Paweł
- Cieślar Marek
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- Clara F.
- Clark James
- Clarke Teagan
- Clasey Essick Reed
- Claudio Diaz Mario
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- Coccia E.
- Codazzo Elena
- Cohadon Pierre-François
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- Concetta Tringali Maria
- Conti Livia
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- Corsi Alessandra
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- Cuoco E.
- Curyło M.
- Cusinato Marco
- D'Angelo Beatrice
- D'Antonio S.
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- D'Urso D.
- Dabadie P.
- Dal Canton Tito
- DALL'OSSO Simone
- Danilishin Stefan
- Danzmann K.
- Darroch K. E.
- Darsow-Fromm Christian
- Dartez L. P.
- Dasgupta A.
- Datta Sayantani
- Dattilo V.
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- Dave I.
- Davenport A.
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- De Rosa Rosario
- de rossi camilla
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- Del Pozzo W.
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- di giovanni Fabrizio
- Di Giovanni M.
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- Di Michele Alessandro
- Di Renzo Francesco
- DI. PALMA Irene
- Diab R.
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- Divyajyoti
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- Eddolls Graeme
- Edelman Bruce
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- Effler Anamaria
- Eichholz Johannes
- Einsle H.
- Eisenmann M.
- Eisenstein R. A.
- Ejlli Aldo
- Eka Setyawati Yoshinta
- Elizabeth Ramirez Guevara Karla
- Engelby E.
- Engl A. J.
- Erasmo Peña Arellano Fabián
- Errico L.
- error error
- error error
- error error
- error error
- Estellés Estrella Héctor
- Estevez Dimitri
- Etzel T.
- Evans C. R.
- Evans Matthew J.
- Evans T. M.
- Evstafyeva T.
- Ewing B. E.
- Fabrizi Federica
- Faedi F.
- Fafone Viviana
- Fair H.
- Fairhurst Stephen
- Fan Pinchen
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- Farr Ben
- Farr Will M.
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- Favaro Giulio
- Favata Marc
- Fays Maxime
- Feicht J.
- Fejer M. M.
- Fenyvesi Edit
- Ferguson Deborah
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- Ferreira T. A.
- Fidecaro Francesco
- Fiori Alessio
- Fiori Irene
- Fishbach Maya
- Fisher R. P.
- Fittipaldi R.
- Fiumara V.
- Flaminio R.
- Fleischer Svenja
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- Floden E.
- Fong H.
- Fornal Bartosz
- Forsyth P. W. F.
- Franceschetti K.
- Francisco Nuño Siles José
- Franke A.
- Frasca S.
- Frasconi Franco
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- Freise Andreas
- Freitas Osvaldo
- Frey Raymond
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- Frolov V. V.
- Fujii S.
- Fukunaga I.
- Fulda P.
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- Gabella William
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- Gaetano Fronzé Gabriele
- Gair Jonathan
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- Gamba Rossella
- Ganapathy Dhruva
- Ganguly Apratim
- Gaonkar S. G.
- Garaventa Barbara
- Garcia-Bellido Juan
- García Quirós Cecilio
- García-Núñez C.
- Gardner James W.
- Gardner K. A.
- Gargiulo J.
- Garufi Fabio
- Gasbarra Claudio
- Gateley B.
- Gayathri V.
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- Gennai Alberto
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- Gerberding Oliver
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- Grado Aniello
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- GRANATA VERONICA.
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- Griggs Hannah
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- guetta dafne
- Guidi Gianluca
- Guimaraes A. R.
- Gulati H. K.
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- Guo Huaike
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- Hsu Shih-Chieh
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- Huang Y. T.
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- Hughey B.
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- Iwaya M.
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- Jacquet Pierre-Edouard
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- Jung Kihyun
- Junker Jonas
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- Kamiizumi Masahiro
- Kanda Nobuyuki
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- KARATHANASIS CHRISTOS.
- Karki Sudarshan
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- Kashyap R.
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- LIGO Collaboration
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- Wong Henry T.
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- Wu Chien-Ming
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- Wu Hsun-Chung
- Wysocki Daniel
- Xiao Liting
- Xu Victoria
- Yaala M. Ben
- Yadav Nikesh
- Yakovlev Alexey
- Yamamoto Hiroaki
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- Yeung S. M. C.
- Yeung T. Y.
- Yokoyama Jun'ichi
- Yokozawa T.
- Yoo Jooheon
- Yu Hang
- Yuzurihara Hirotaka
- Zadrożny A.
- Zahoor Jan Aasim
- Zannelli A. J.
- Zanolin M.
- Zeeshan M.
- Zelenova T.
- Zendri J. -P.
- Zevin Michael
- Zhang Jue
- Zhang L.
- Zhang Rui
- Zhang T.
- Zhang Ya
- Zhang Yanqi
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- Zhao Yue
- Zhao Yuhang
- Zheng Yanyan
- Zhong Haowen
- Zhou R.
- Zhu Zong-Hong
- Zimmerman Aaron
- Zucker M. E.
- Zweizig John
- Álvarez-López S.
- Árpád Gergely László
- 劉 國欽
- 曹周键
- 都丸 隆行
- Publication venue
- Publication date
- 01/08/2023
- Field of study
Despite the growing number of confident binary black hole coalescences observed through gravitational waves so far, the astrophysical origin of these binaries remains uncertain. Orbital eccentricity is one of the clearest tracers of binary formation channels. Identifying binary eccentricity, however, remains challenging due to the limited availability of gravitational waveforms that include effects of eccentricity. Here, we present observational results for a waveform-independent search sensitive to eccentric black hole coalescences, covering the third observing run (O3) of the LIGO and Virgo detectors. We identified no new high-significance candidates beyond those that were already identified with searches focusing on quasi-circular binaries. We determine the sensitivity of our search to high-mass (total mass M>70 M⊙) binaries covering eccentricities up to 0.3 at 15 Hz orbital frequency, and use this to compare model predictions to search results. Assuming all detections are indeed quasi-circular, for our fiducial population model, we place an upper limit for the merger rate density of high-mass binaries with eccentricities 0<e≤0.3 at 0.33 Gpc−3 yr−1 at 90\% confidence level
Cáparra : revista de innovación y experiencias educativas de los Centros de Profesores y Recursos de la Provincia de Cáceres
- Author
- Publication venue
- Publication date
- 01/01/2016
- Field of study
Se describe un proyecto, realizado siguiendo la metodología de aprendizaje basado en proyectos del CEIP Reyes Católicos de Guadalupe (Cáceres) que consistió en la realización en soporte digital y en papel, en inglés y en español, de folletos informativos para dar a conocer distintas ermitas, granjas y molinos de la Edad Media, en el entorno de GuadalupeES
Diagnóstico y tratamiento del dolor neuropático
- Author
- Agostino
- Aguilar-Luque
- Agustín Gómez De la Cámara
- Alonso
- Alonso
- Andrés Peña Arrebola
- Antonio Collado Cruz
- Antonio Martínez-Salio
- Attal
- Avelino Ferrero Méndez
- Backonja
- Backonja
- Baron
- Bennett
- Bennett
- Bernstein
- Beydoun
- Boivie
- Boswell
- Bouhassira
- Boureau
- Cardenas
- Cetas
- Cohen
- Collin
- Cruccu
- Cruccu
- Cruccu
- Cruccu
- Cruccu
- Deer
- Deuschl
- Dogra
- Dubinsky
- Dworkin
- Dworkin
- Dworkin
- Eisenberg
- Emilio Blanco Tarrío
- Enric Zamorano Bayarri
- Ertas
- Feder
- Finnerup
- Finnerup
- Forouzanfar
- Fredman
- Fromm
- Galer
- García-Larrea
- García-Larrea
- Gibson
- Gibson
- Gilron
- Gimbel
- Goldstein
- Gorson
- Gálvez
- Gálvez
- Hahn
- Hammark
- Harati
- Hempenstall
- Hunt
- Janig
- Jensen
- Joan Molet Teixidó
- Jordi Montero Homs
- Julio Pardo Fernández
- Khaliq
- Kieburtz
- Kochar
- Lefaucheur
- Lehmann
- Leijon
- Lesser
- Levendoglu
- Lima
- María Victoria Ribera Canudas
- Meier
- Miller
- Mirza
- Moisset
- Montero-Homs
- Moulin
- Myerson
- Nelson
- Nelson
- Nonaham
- Ochoa
- Owen
- Peyron
- Portenoy
- Pérez
- Rafael Gálvez Mateos
- Ragab
- Raja
- Raskin
- Raslan
- Rice
- Richter
- Romanelli
- Rosenstock
- Rowbotham
- Rowbotham
- Rowbotham
- Rowbotham
- Rull
- Saarto
- Sabatowski
- Schott
- Serra
- Siddall
- Simpson
- Sindou
- Sindrup
- Sindrup
- Sindrup
- Sindrup
- Sindrup
- Taylor
- Treede
- Truini
- Truini
- Tunks
- Turk
- Tölle
- Verdugo
- Vestergaard
- Vlcková-Moravcová
- Vranken
- Ware
- Watson
- Watson
- Watson
- Wiffen
- Wiffen
- Willer
- Wilton
- Wissel
- Woolf
- Zakrzewska
- Ángel Oteo-Álvaro
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
Evolution over Time of Ventilatory Management and Outcome of Patients with Neurologic Disease∗
- Author
- Abderrahim Azzouzi
- Abroug F.
- Achille Kouatchet
- Achim Lunkeit
- Adam Mikstacki
- Aguilera García
- Ahmed Sbihi
- Ai-Chin Cheng
- Ainhoa Rosselló
- Alain Mercat
- Alan Javier Zazu
- Alberto Belenguer
- Alberto Deicas
- Alberto Marino
- Alberto Soler
- Alejandro Algora
- Alejandro Arroliga
- Alejandro de la Serna
- Alejandro Gómez
- Alejandro Raimondi
- Alejandro Risso
- Alfonso Moreno
- Alfonso Muñoz
- Alfredo Padrón
- Alfredo Vasquez-Sandoval
- Ali Aydım Altunkan
- Ali Zeggwagh A.
- Aline Camile Yehia
- Alistair Nichol
- Allan Walkey
- Allison Bone
- Aloísio Marques do Nascimento
- Alvaro van Bommel
- Amalia Martínez de la Gandara
- Amber Monson
- Ambrogio Sansone
- Amee Patrawalla
- Amin P.
- Amine Ali Zeggwagh
- Amparo Ferrandiz
- Amy Waters
- Ana Carolina Caballero
- Ana Esther Trujillo
- Ana Villagrá
- Anders Aneman
- Andrea Gimenez
- Andrea Matte
- Andrea Neville Cracchiolo
- Andreas Schwartz
- Andreas Viehöfer
- Andrei Piontek
- Andrew Bersten
- Andrew Davies
- Andrew Davies
- Andrew Davies
- Andrew Steel
- Andrey Yaroshetskiy
- Anette Mortensen
- Anitha Shenoy
- Ankur Devendra Bhavsar
- Annunziata Mattei
- Anthony Saleh
- Antonina Pigna
- Antonino Giarratano
- Antonio Anzueto
- Antonio Braschi
- Antonio Corcione
- Antonio García-Jiménez
- Antonio Maestre
- Antonio Pesenti
- Antonio Raso
- Antonio Reyes
- Antonio Villa Delgado
- Antonio Viñuales
- Anzueto A.
- Arianna Boggero
- Ariel Chena
- Armando Pedulla'
- Arnaud W Thille
- Ashley Ellis
- Ashley Ellis
- Asisclo J Villagómez Ortiz
- Auke Reidinga
- Ayed Samia
- Barbara Tamowicz
- Barrios D.
- Bas M Kors
- Begoña Balerdi
- Benoit Veber
- Bernabé Álvarez
- Bersten A.
- Bert Beishuizen
- Besbes Mohamed
- Bilge Çetin
- Bin Du
- Bin Du
- Bin Yu
- Bing Sun
- Birgitte Viebaek
- Bladimir Alejandro Gil
- Bo Broberg
- Bo Wang
- Boris Villamagua
- Brian Sherman
- Bruno Bonaccorsi Fernandino
- Bruno do Valle Pinheiro
- Bryan Beatty
- C Canevet
- Cakar N.
- Cameron Knott
- Camilo Pizarro
- Carlo Alberto Acosta
- Carlos Alberto Studart Gomes
- Carlos André Correia Casado
- Carlos Andrés Díaz
- Carlos Gallego
- Carlos Marian Crespo
- Carlos Robles-Arias
- Carmelo Dueñas
- Carmen Campos
- Carolina Gímenez-Esparza
- Carolina Lorencio
- Cartan Costello
- Catherine Simmonds
- Cayce Strength
- Cayetano Galetti
- Cecilia Carbayo
- Cecilia Hermosa
- Cecilia Pereyra
- Cesar Enciso
- Cezar Mihailescu
- Chabu Coronado
- Chafrina Marie Olay
- Chang Liu
- Chantal Hogan
- Charki Haimeur
- Chau Chin Man
- Chen Chin-Ming
- Chengmin Yu
- Cheromi Sittambalam
- Cheryl Cuzner
- Cheryl Ethier
- Chiara Verga
- Christian Frenkel
- Christian Putensen
- Christopher MacIsaac
- Christopher Spradley
- Chuanyun Qian
- Claire Cattigan
- Claire Reynolds
- Clara Laplaza Eva Regidor
- Clara Pacheco
- Claudia Diaz
- Claudia Olvera-Guzman
- Craig A Piquette
- Craig Cernosek
- Crissie De Spirito
- Crissie Despirito
- Cristian Casabella
- Cristian Cevallos
- Cristina Orlandi
- Cristina Santos
- César Antonio Maquilon
- César Aragón
- César Cruz Lozano
- César Pérez-Calvo
- Damian Violi
- Dana K Soetaert
- Daniel Duarte
- Daniel Fontaneda
- Daniel Vargas
- Daniel Weiss
- David Freire
- David Milliss
- Davide Chiumello
- Daxing Yu
- Debiao Song
- Deborah Barge
- Deborah Cook
- Deepak Govil
- Del-Sorbo L.
- Denice Wells
- Dennis Bergmans
- Dhruva Chaudhry
- Di Russo
- Diane Mackle
- Dianne Hill
- Dianne Stephens
- Dietrich Henzler
- Dimitros Matamis
- Dimple Tejwani
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- Do Danh Quynh
- Dolores Vila
- Dongpo Jiang
- Dorothée Carpentier
- Du B.
- Edgard Luna
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- Edgardo Nuñez
- Edoardo De Robertis
- Eduard Bootsma
- Eduardo Almeida
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- Edward Nicolayenko
- Eileen Gilder
- Elena Gallego
- Elena Parreño
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- Elisa Estenssoro
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- Elisha Matheson
- Ellen Kinkel
- Emily Stern
- Enrique Maraví
- Enrique Piacentini
- Erika Mannelli
- Erin Braden
- Erna Alberts
- Erwin J Oei
- Esteban A
- Eugenio Palazón
- Eva Benveniste
- Eva Manteiga
- Fabien Grelon
- Fabien Soulis
- Fabricio Picoita
- Fachun Zhou
- Falk Hildebrandt
- Fang Xu
- Farhad N Kapadia
- Fausto Fialho Moura
- Federica Antonicelli
- Federica Tallarini
- Federico Gordo
- Fekri Abroug
- Feng Li
- Fernando Antônio Botoni
- Fernando Fernández
- Fernando Lambert
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- Fernando Ríos
- Fernando Saldarini
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- Fernando Villarejo
- Fernando Villarejo
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- Forbes McGain
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- Frutos-Vivar F.
- Frédéric Bellec
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- Gabriel D Empaire
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- Gang Li
- Gary Kinasewitz
- Gary Kinasewitz
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- Giorgio Tulli
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- Pham Thi Van Anh
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- Raúl Lombardi
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- Ricardo Martinez Zubieta
- Ricardo Matos
- Rick McAllister
- Rios F.
- Robba C.
- Robert Fowler
- Robyn Klages
- Rodrigo E Gómez-Paz
- Roger Lamoglie
- Rogério de Castro Pereira
- Roland Schneider
- Rolf Dembinski
- Rolf Rossaint
- Rollin Roldán Mori
- Romano Tetamo
- Román Garrido
- Ronald Pairumani
- Ronnie Mantilla
- Rosa Luz López Martínez
- Rosa Sebastián
- Rosa Álvaro
- Rosalba Tufano
- Rosanna Del Giudice
- Rosanna Vaschetto
- Rosario Urbino
- Rovílson Lara
- Rovílson Lara
- Rubens Altair Amaral de Pádua
- Rubén Camargo
- Rui Moreno
- Rupesh Vakil
- Ryan Albert
- Sabriye Guvenc
- Salem Ould Zein
- Salvatore Maurizio Maggiore
- Samer Haj-Bakri
- Samir Abdelhadi
- Samir Sahu
- Samir Vermani
- Sando Chavarria
- Sangeeta Mehta
- Sanjay Dhanuka
- Santiago Ilutovich
- Sara Cabañes
- Schimdt Alejandra
- Sebastian Circo
- Sebastián E Mare
- Serena Azzari
- Serge Heines
- Sergio Cáceres
- Sergio Lasdica
- Seton Henderson
- Shawna Reddie
- Sheila Nainan Myatra
- Shelby Sutton
- Sheree Gare
- Shirley Nelson
- Shouhong Wang
- Silke Frenzel
- Silvia Mareque
- Silvina Borello
- Silvio A Ñamendys-Silva
- Simon J G Hockley
- Simona Beniczky
- Sindhaghatta Venkatram
- Sine Wichman
- Smyth Smith
- Soares M. A.
- Sofía García
- Soraya Puertas
- Srinivas Samavedam
- Stambouli Neji
- Steffen Appel
- Steffen Weber-Carstens
- Stephanie Lubchansky
- Stephen Lapinsky
- Steven Y Chang
- Stevens Salva
- Subhash Kumar Todi
- Sujoy Mukherjee
- Susan Gillen
- Susana Alves Ferreira
- Susana Moradillo
- Susana Temprano
- Susanne Andi Iversen
- Sutherasan Y.
- Sutrisno Gunawan
- Sylvia den Boer
- Tania Caf
- Tarek Dendane
- Tayfun Adanir
- Tejerina E. E.
- Teresa Mut
- Teresa Sánchez de Dios
- Thille A. W.
- Thomas Bein
- Thomas Lipp
- Thomas Moellhoff
- Thomas Steinke
- Thoralf Kerner
- Tiehe Qin
- Tim Coles
- Tim Houlihan
- Timothy D Girard
- Tom Cowlam
- Tony Sutherland
- Tony Williams
- Travis Parry
- Troy Browne
- Tumbass Volker
- Uli Strauch
- Umesh G
- Unase Büyükkoçak
- V J Cardenas Jr
- Valentín Parra
- Valerio Mangani
- Valery Subbotin
- Valle Pinheiro B.
- Valéria de Carvalho Magela
- Vanesa Ramírez
- Vicente Arraez
- Victoria Goñi
- Vincent John Scott
- Vito Marco Ranieri
- Vivek Joshi
- Wajdi Maazouzi
- Walter Brandt
- Walter Seyde
- Wanxia Li
- Wei He
- Wei Yu
- Wei Zhang
- Weihai Yao
- William Rodriguez-Cintron
- Winfried Schubert
- Wolfgang Baier
- Won-Yeon Lee
- Xi Zhu
- Xianyao Wan
- Xiaobo Huang
- Xue Wang
- Yalin Liu
- Yan Kang
- Yangong Chao
- Yaseen Arabi
- Yi Li
- Yi Yang
- Yogeet Kaur
- Yongjie Yin
- Young Suh G.
- Younsuck Koh
- Yu Bai
- Yuan Xu
- Yuhong Guo
- Yun Seong Kim
- Yunxuan Yue
- Zafer Dogan
- Zalatiel Maycotte Luna
- Zaza Cohen
- Zhengxuan Lv
- Zhenjie Hu
- Zhenyang He
- Zhicheng Zhang
- Zhihua Hu
- Zhixiang Li
- Zoltan Szentkereszty
- Zoraida Parra
- Zsolt Molnar
- Ángela Alonso
- Publication venue
- 'Ovid Technologies (Wolters Kluwer Health)'
- Publication date
- 01/11/2021
- Field of study
OBJECTIVES: To describe the changes in ventilator management over time in patients with neurologic disease at ICU admission and to estimate factors associated with 28-day hospital mortality. DESIGN: Secondary analysis of three prospective, observational, multicenter studies. SETTING: Cohort studies conducted in 2004, 2010, and 2016. PATIENTS: Adult patients who received mechanical ventilation for more than 12 hours. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Among the 20,929 patients enrolled, we included 4,152 (20%) mechanically ventilated patients due to different neurologic diseases. Hemorrhagic stroke and brain trauma were the most common pathologies associated with the need for mechanical ventilation. Although volume-cycled ventilation remained the preferred ventilation mode, there was a significant (p < 0.001) increment in the use of pressure support ventilation. The proportion of patients receiving a protective lung ventilation strategy was increased over time: 47% in 2004, 63% in 2010, and 65% in 2016 (p < 0.001), as well as the duration of protective ventilation strategies: 406 days per 1,000 mechanical ventilation days in 2004, 523 days per 1,000 mechanical ventilation days in 2010, and 585 days per 1,000 mechanical ventilation days in 2016 (p < 0.001). There were no differences in the length of stay in the ICU, mortality in the ICU, and mortality in hospital from 2004 to 2016. Independent risk factors for 28-day mortality were age greater than 75 years, Simplified Acute Physiology Score II greater than 50, the occurrence of organ dysfunction within first 48 hours after brain injury, and specific neurologic diseases such as hemorrhagic stroke, ischemic stroke, and brain trauma. CONCLUSIONS: More lung-protective ventilatory strategies have been implemented over years in neurologic patients with no effect on pulmonary complications or on survival. We found several prognostic factors on mortality such as advanced age, the severity of the disease, organ dysfunctions, and the etiology of neurologic disease
Bacterial etiology of community-acquired pneumonia in immunocompetent hospitalized patients and appropriateness of empirical treatment recommendations: an international point-prevalence study
- Author
- Abdulbaqi Zakeya
- Alarcón Hugo Cabello
- Aliberti S.
- Allen Karen S
- Almotairi Abdullah
- Ampazis Dimitrios
- Andersen Stine
- Angel Luis F
- Anseeuw Kurt
- Anzueto Antonio
- Aruj Patricia Karina
- Attorri Silvia
- Awokola Babatunde Ishola
- Aymerich Cristina Prat
- Bacha Zeina Aoun
- Barimboim Enrique
- Bashi Jules
- Battaglia S.
- Battaglia Salvatore
- Baunbæk-knudsen Gertrud
- Bergin Stephen P
- Bertrand Fabrice
- Bhatia Mohit
- Bilaceroglu Semra
- Birkun Alexei
- Blasi F.
- Bogdanović Nada
- Bogomolov Artemii
- Borderìas Luis
- Brito Veronica
- Brocovschii Victoria
- Brun-Buisson Christian
- Buitrago Ricardo
- Bukhary Ali
- Caeiro Juan Pablo
- Cambursano Victor Hugo
- Campbell Marion
- Carevic Vesna Vladic
- Carrabba Maria
- Carugati Manuela
- Casas Xavier
- Ceccato Adrian
- Ceriana Piero
- Chertcoff Julio
- Chipev Peter
- Chirita Daniela
- Christensen Anette Bro
- Cilloniz Catia
- Confalonieri Marco
- da Beira Cova
- Dalar Levent
- de Molina Rosa Malo
- de Montmollin Etienne
- De Rosa Marino
- de Vedia Lautaro
- del Castillo Juan González
- del la Torre Alicia Lacoma
- Del Prato Bruno
- Dhar Raja
- Dhasmana Devesh J
- Diaz-Brito Vicens
- Dietz Jessica
- Dimakou Katerina
- Djimon Marcel Zannou
- Dodo Balkissou Adamou
- Dreher Michael
- Dysart Claire E
- Díaz Ariel Cordon
- d’Arminio Monforte Antonella
- D’Souza George
- Edathodu Jameela
- El-Wahhab Ibrahim El-Said Abd
- Elahi Naheed
- Enani Abdullah Mushira Abdulaziz
- Encheva M.
- Encheva Milena
- Fantini R.
- Fantini Riccardo
- Fartoukh Muriel
- Fathy Amal
- Feldman Charles
- Fernández-Almira Maria Luisa
- Ferrão Cláudia
- Fiogbe Arnauld Attannon
- Fiorentino Giuseppe
- Franco-Sadud Ricardo A
- Francois Camille A
- Froes Felipe
- Gabrielli Barbra
- Gaga Mina
- Gallego M.
- Gallego Miguel
- Gammino Maria Antonia
- Ganaha Maria Cristina
- Garcia Noel Manuel Bordon
- García-Olivé Ignasi
- Garg Rajiv
- Garzón María I
- Gaspar-GarcÍa Inmaculada
- Golshani Keihan
- González Alicia Encabo
- Gori A.
- Hagel Stefan
- Hancock Carole
- HeitmannBødtger Uff e Christian
- Hill Adam T
- Hinojosa Cecilia I
- Hipskind John
- Holland Thomas L
- Hugo Bertrand
- Ion Chesov
- Ions Rhiannon
- Irfan Muhammad
- Jacobsson Marie-Laure Bouchy
- Jakopovic Marko
- Jankovic Mateja
- Jayaraj B S
- Jean-Marie Kayembe Ntumba
- Jensen Andreas Vestergaard
- Kaluzhenina Anna
- Keatings Vera M
- Kellie Susan M
- Kheir Fayez
- Kolditz Martin
- Koul Parvaiz A
- Krishnamurthy Shashi Bhaskara
- Kurahashi Kiyoyasu
- Lambert Sandra
- Landmeier Mark
- Lascar Florencia
- Leuschner P.
- Leuschner Pedro
- Leuschner Pedro
- Levine Stephanie M
- Lois Manuel
- Lopardo Gustavo
- Luna Carlos M
- Lötsch Felix
- Mahesh P A
- Malberti Alessio Gerardo
- Maor Yasmin
- Marcos Pedro J
- Marin-Corral J.
- Martin-Loeches Ignacio
- Martínez Elena Laserna
- Mateyo Kondwelani John
- Matkovic Zinka
- Medenica Milic
- Meier Garnet
- Meireles Mariana
- Meisinger Matthias
- Memon Jawed Ulhadi
- Menendez R.
- Menzella Francesco
- Menéndez Rosario
- Messika Jonathan
- Meyer Christian Niels
- Mihsra Deebya Raj
- Milani Giuseppe
- Milenkovic Branislava
- Minarowski Lukasz
- Miteva Darina
- Mitrecic Ivan
- Mohamed Nazik Eltayeb
- Morcillo Nora
- Morsy Nesreen Elsayed
- Moyano Silvia
- Nair Girish B
- Narayan Kiran Vishnu
- Nava Stefano
- Neves João
- Ngahane Mbatchou
- Noda Julio
- Nouér Simone Aranha
- Nwankwo Ogonna N O
- Olufunlola Adefuye Bolanle
- Olumide Segaolu
- Palmiero Gerardo
- PandoSandova Ana
- Papapetrou Dimosthenis
- Pascual-Guardia S.
- Patel Hemali
- Paternina Fernando Jose Pereira
- Pensotti Claudia
- Pereyra Betiana
- Pesut Dragica
- Petersen Pelle Trier
- Petkova Diana
- Petrino Roberta
- Pletz Mathias W
- Pujol Jordi Almirall
- Ravara Sofia B
- Rello Jordi
- Restrepo M. I.
- Reyes Katherine
- Rico Carlos Andres Bustamante
- Ridgeon Elliott
- Rodrigo-Troyano Ana
- Rodriguez-Cintron William
- Roger Dodo
- Rossi Paolo
- Rudran Banu
- Ruiz-Buitrago S.
- Ruiz-Buitrago Silvia
- Rupp Jan
- Rusu Doina
- Saito Shigeki
- Sanz Francisco
- Scapellato Pablo Gustavo
- Schaberg Tom
- Shafiek Hanaa
- Shah Ray D
- Shah Sonali
- Shen Ning
- Shrestha Poojan
- Siaw-Lartey Beatrice
- Sibila Oriol
- Skeemer Julie
- Sobh Eman
- Solé-Violán Jordi
- Soni Nilam J
- Sorino Claudio
- Sotgiu G.
- Spielmanns Marc
- Stagnaro Juan Pablo
- Steinhilber Gundi
- Strahilevitz Jacob
- Sukhija Kunal
- Szymon Skoczyński
- Tartara Silvina
- Tattevin Pierre
- Thalhammer Florian
- Toma Cristina
- Torra Ester Vendrell
- Torres Antoni
- Tsigou Evdoxia
- Tulio Fernando Di
- Udnur Hirennappa B
- Ugalde Daniel Barajas
- Ukwaja Kingsley N
- Uranga Ane
- van Boven Job FM
- Van Braeckel Eva
- van de Garde E M W
- Victoria Patricia Javaloyes
- Villegas José F
- Vincent Jean Louis
- Whitaker Paul
- Whitlow K Scott
- Woltmann Gerrit
- Wunderink Richard G.
- Xu Jin-fu
- Yangui Ferdaous
- Yilmaz Ufuk
- Yum Ho Kee
- Zanforlin Alessandro
- Zuñiga Omar Ceballos
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2020
- Field of study
An accurate knowledge of the epidemiology of community-acquired pneumonia (CAP) is key for selecting appropriate antimicrobial treatments. Very few etiological studies assessed the appropriateness of empiric guideline recommendations at a multinational level. This study aims at the following: (i) describing the bacterial etiologic distribution of CAP and (ii) assessing the appropriateness of the empirical treatment recommendations by clinical practice guidelines (CPGs) for CAP in light of the bacterial pathogens diagnosed as causative agents of CAP. Secondary analysis of the GLIMP, a point-prevalence international study which enrolled adults hospitalized with CAP in 2015. The analysis was limited to immunocompetent patients tested for bacterial CAP agents within 24 h of admission. The CAP CPGs evaluated included the following: the 2007 and 2019 American Thoracic Society/Infectious Diseases Society of America (ATS/IDSA), the European Respiratory Society (ERS), and selected country-specific CPGs. Among 2564 patients enrolled, 35.3% had an identifiable pathogen. Streptococcus pneumoniae (8.2%) was the most frequently identified pathogen, followed by Pseudomonas aeruginosa (4.1%) and Klebsiella pneumoniae (3.4%). CPGs appropriately recommend covering more than 90% of all the potential pathogens causing CAP, with the exception of patients enrolled from Germany, Pakistan, and Croatia. The 2019 ATS/IDSA CPGs appropriately recommend covering 93.6% of the cases compared with 90.3% of the ERS CPGs (p < 0.01). S. pneumoniae remains the most common pathogen in patients hospitalized with CAP. Multinational CPG recommendations for patients with CAP seem to appropriately cover the most common pathogens and should be strongly encouraged for the management of CAP patients.info:eu-repo/semantics/publishedVersio
Prevalence and Etiology of Community-acquired Pneumonia in Immunocompromised Patients
- Author
- Abdulsemed Kedir Abdella
- Alarcón Hugo Cabello
- Aliberti Stefano
- Allen Karen S
- Almotairi Abdullah
- Alvarado Ezequiel
- Aman Mohamed
- Ampazis Dimitrios
- Andersen Stine
- Angel Luis F
- Anseeuw Kurt
- Anzueto Antonio
- Aruj Patricia Karina
- Attorri Silvia
- Awokola Babatunde Ishola
- Aymerich Cristina Prat
- Bacha Zeina Aoun
- Balkissou Adamou Dodo
- Barimboim Enrique
- Bashi Jules
- Battaglia Salvatore
- Baunbæk-Knudsen Gertrud
- Bella Abdelhaleem
- Bergin Stephen P
- Bertrand Fabrice
- Bhatia Mohit
- Bilaceroglu Semra
- Birkun Alexei
- Blasi Francesco
- Bogdanović Nada
- Bogomolov Artemii
- Borderìas Luis
- Brito Veronica
- Brocovschii Victoria
- Brun-Buisson Christian
- Buitrago Ricardo
- Bukhary Zakeya Abdulbaqi Ali
- Bødtger Uffe Christian Heitmann
- Caeiro Juan Pablo
- Cambursano Victor Hugo
- Campbell Marion
- Carevic Vesna Vladic
- Carone Mauro
- Carrabba Maria
- Carugati Manuela
- Casas Xavier
- Cazaux A
- Ceccato Adrian
- Ceriana Piero
- Cetrangolo Antonio A
- Chertcoff Julio
- Chipev Peter
- Chirita Daniela
- Christensen Anette Bro
- Cilloniz Catia
- Comel Andrea
- Confalonieri Marco
- Creutz Petra
- Dalar Levent
- de la Torre Alicia Lacoma
- de Molina Rosa Malo
- de Montmollin Etienne
- de Vedia Lautaro
- del Castillo Juan González
- Dhar Raja
- Dhasmana Devesh J
- Di Pasquale Marta Francesca
- Diaz-Brito Vicens
- Dietz Jessica
- Dimakou Katerina
- Djimon Marcel Zannou
- Dodo Roger
- Dorobat Carmen Mihaela
- Dreher Michael
- Dysart Claire E
- Díaz Ariel Cordon
- D’Souza George
- Ebruke Bernard
- Edathodu Jameela
- El-Wahhab Ibrahim El-Said Abd
- Elahi Naheed
- Enani Abdullah Mushira Abdulaziz
- Encheva Milena
- Fantini Riccardo
- Fartoukh Muriel
- Fathy Amal
- Feldman Charles
- Feneley Andrew
- Fernández-Almira Maria Luisa
- Ferrão Cláudia
- Fiogbe Arnauld Attannon
- Fiorentino Giuseppe
- Franco-Sadud Ricardo A
- Francois Camille A
- Franzetti Fabio
- Froes Felipe
- Gabrielli Barbra
- Gaga Mina
- Gallego Miguel
- Gammino Maria Antonia
- Ganaha Maria Cristina
- Garcia Noel Manuel Bordon
- García-Olivé Ignasi
- Garg Rajiv
- Garzón María I
- Gaspar-GarcÍa Inmaculada
- GLIMP Investigators [missing]
- Golshani Keihan
- González del Castillo Juan
- González Alicia Encabo
- Gramegna Andrea
- Hagel Stefan
- Hancock Carole
- Hill Adam T
- Hinojosa Cecilia I
- Hipskind John
- Holland Thomas L
- Ion Chesov
- Ions Rhiannon
- Irfan Muhammad
- Jacobsson Marie-Laure Bouchy
- Jakopovic Marko
- Jankovic Mateja
- Jayaraj B S
- Jensen Andreas Vestergaard
- Kaimakamis Evangelos
- Kaluzhenina Anna
- Kant Surya
- Keatings Vera M
- Kellie Susan M
- Kheir Fayez
- Khoury Abdo
- Kolditz Martin
- Koul Parvaiz A
- Krishnamurthy Shashi Bhaskara
- Kurahashi Kiyoyasu
- Labra Lucía
- Lambert Sandra
- Landmeier Mark
- Lascar Florencia
- Leuschner Pedro
- Leuschner Pedro
- Levine Stephanie M
- Limaye Sneha
- Lois Manuel
- Lopardo Gustavo
- Luna Carlos M
- Lötsch Felix
- Mahesh P A
- Malberti Alessio Gerardo
- Maor Yasmin
- Marcos Pedro J
- Martin-Loeches Ignacio
- Martínez Elena Laserna
- Mateyo Kondwelani John
- Matkovic Zinka
- Medenica Milic
- Meier Garnet
- Meireles Mariana
- Meisinger Matthias
- Memon Jawed Ulhadi
- Menzella Francesco
- Menéndez Rosario
- Messika Jonathan
- Meyer Christian Niels
- Mihsra Deebya Raj
- Milani Giuseppe
- Milenkovic Branislava
- Minarowski Lukasz
- Miteva Darina
- Mitrecic Ivan
- Mohamed Nazik Eltayeb
- Monforte Antonella d’Arminio
- Monge Elisa
- Morcillo Nora
- Morosi Manuela
- Morsy Nesreen Elsayed
- Moyano Silvia
- Nair Girish B
- Narayan Kiran Vishnu
- Nava Stefano
- Neves João
- Ngahane Bertrand Hugo Mbatchou
- Niederlausitz Klinikum
- Noda Julio
- Noriega Lorena
- Nouér Simone Aranha
- Ntumba Jean-Marie Kayembe
- Nwankwo Ogonna N O
- Olufunlola Adefuye Bolanle
- Olumide Segaolu
- Palmiero Gerardo
- Pando-Sandoval Ana
- Papapetrou Dimosthenis
- Patel Hemali
- Patella Vincenzo
- Paternina Fernando Jose Pereira
- Pensotti Claudia
- Pereyra Betiana
- Pesut Dragica
- Petersen Pelle Trier
- Petkova Diana
- Petrino Roberta
- Pletz Mathias W
- Prato Bruno Del
- Pujol Jordi Almirall
- Radovanovic Dejan
- Ravara Sofia B
- Rello Jordi
- Restrepo Marcos I
- Reyes Katherine
- Reyes Luis F
- Rico Carlos Andres Bustamante
- Ridgeon Elliott
- Rodrigo-Troyano Ana
- Rodriguez-Cintron William
- Rosa Marino De
- Rossi Paolo
- Rudran Banu
- Ruiz-Buitrago Silvia
- Rupp Jan
- Rupp Jan
- Rusu Doina
- Saito Shigeki
- Salvi Sundeep
- Sanz Francisco
- Scapellato Pablo Gustavo
- Scarlata Simone
- Schaberg Tom
- Shafiek Hanaa
- Shah Ray D
- Shah Sonali
- Shen Ning
- Shrestha Poojan
- Siaw-Lartey Beatrice
- Sibila Oriol
- Singanayagam Anika
- Skeemer Julie
- Sobh Eman
- Solé-Violán Jordi
- Soni Nilam J
- Sorino Claudio
- Sotgiu Giovanni
- Spielmanns Marc
- Stagnaro Juan Pablo
- Steinhilber Gundi
- Strahilevitz Jacob
- Sukhija Kunal
- Suttorp Norton
- Swarnakar Rajesh
- Szymon Skoczyński
- Tartara Silvina
- Tattevin Pierre
- Terraneo Silvia
- Thalhammer Florian
- Toma Cristina
- Torra Ester Vendrell
- Torres Antoni
- Totten Vicken
- Tsigou Evdoxia
- Tulio Fernando Di
- Udnur Hirennappa B
- Ugalde Daniel Barajas
- Ukwaja Kingsley N
- Uranga Ane
- van Boven Job F M
- Van Braeckel Eva
- van de Garde E M W
- Victoria Patricia Javaloyes
- Villegas José F
- Vincent Jean Louis
- Whitaker Paul
- Whitlow K Scott
- Woltmann Gerrit
- Wunderink Richard G
- Xu Jin-fu
- Yangui Ferdaous
- Yilmaz Ufuk
- Yone Eric Walter Pefura
- Youzguin Alexander
- Yum Ho Kee
- Zanforlin Alessandro
- Zuñiga Omar Ceballos
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2019
- Field of study
BACKGROUND:
The correct management of immunocompromised patients with pneumonia is debated. We evaluated the prevalence, risk factors, and characteristics of immunocompromised patients coming from the community with pneumonia.
METHODS:
We conducted a secondary analysis of an international, multicenter study enrolling adult patients coming from the community with pneumonia and hospitalized in 222 hospitals in 54 countries worldwide. Risk factors for immunocompromise included AIDS, aplastic anemia, asplenia, hematological cancer, chemotherapy, neutropenia, biological drug use, lung transplantation, chronic steroid use, and solid tumor.
RESULTS:
At least 1 risk factor for immunocompromise was recorded in 18% of the 3702 patients enrolled. The prevalences of risk factors significantly differed across continents and countries, with chronic steroid use (45%), hematological cancer (25%), and chemotherapy (22%) the most common. Among immunocompromised patients, community-acquired pneumonia (CAP) pathogens were the most frequently identified, and prevalences did not differ from those in immunocompetent patients. Risk factors for immunocompromise were independently associated with neither Pseudomonas aeruginosa nor non-community-acquired bacteria. Specific risk factors were independently associated with fungal infections (odds ratio for AIDS and hematological cancer, 15.10 and 4.65, respectively; both P = .001), mycobacterial infections (AIDS; P = .006), and viral infections other than influenza (hematological cancer, 5.49; P < .001).
CONCLUSIONS:
Our findings could be considered by clinicians in prescribing empiric antibiotic therapy for CAP in immunocompromised patients. Patients with AIDS and hematological cancer admitted with CAP may have higher prevalences of fungi, mycobacteria, and noninfluenza viruses