Electromagnetic interactions GEneRalized (EIGER): algorithm abstraction and HPC implementation

Modern software development methods combined with key generalizations of standard computational algorithms enable the development of a new class of electromagnetic modeling tools. This paper describes current and anticipated capabilities of a frequency domain modeling code, EIGER, which has an extremely wide range of applicability. In addition, software implementation methods and high performance computing issues are discussed

Timing of maternal exposure and fetal sex determine the effects of low-level chemical mixture exposure on the fetal neuroendocrine system in sheep

We have shown that continuous maternal exposure to the complex mixture of environmental chemicals (ECs) found in human biosolids (sewage sludge), disrupts mRNA expression of genes crucial for development and long-term regulation of hypothalamo-pituitary gonadal (HPG) function in sheep. This study investigated whether exposure to ECs only during preconceptional period or only during pregnancy perturbed key regulatory genes within the hypothalamus and pituitary gland and whether these effects were different from chronic (life-long) exposure to biosolid ECs. The findings demonstrate that the timing and duration of maternal EC exposure influences the subsequent effects on the fetal neuroendocrine system in a sex-specific manner. Maternal exposure prior to conception or during pregnancy only, altered the expression of key fetal neuroendocrine regulatory systems such as GnRH and kisspeptin to a greater extent than when maternal exposure was ‘life-long’. Furthermore, hypothalamic gene expression was affected to a greater extent in males than in females, and following EC exposure, male fetuses expressed more “female-like” mRNA levels for some key neuroendocrine genes. This is the first study to show that “real-life” maternal exposure to low levels of a complex cocktail of chemicals prior to conception can subsequently affect the developing fetal neuroendocrine system. These findings demonstrate that the developing neuroendocrine system is sensitive to EC mixtures in a sex-dimorphic manner likely to predispose to reproductive dysfunction in later life

Supergeometry in locally covariant quantum field theory

In this paper we analyze supergeometric locally covariant quantum field theories. We develop suitable categories SLoc of super-Cartan supermanifolds, which generalize Lorentz manifolds in ordinary quantum field theory, and show that, starting from a few representation theoretic and geometric data, one can construct a functor A : SLoc --> S*Alg to the category of super-*-algebras which can be interpreted as a non-interacting super-quantum field theory. This construction turns out to disregard supersymmetry transformations as the morphism sets in the above categories are too small. We then solve this problem by using techniques from enriched category theory, which allows us to replace the morphism sets by suitable morphism supersets that contain supersymmetry transformations as their higher superpoints. We construct super-quantum field theories in terms of enriched functors eA : eSLoc --> eS*Alg between the enriched categories and show that supersymmetry transformations are appropriately described within the enriched framework. As examples we analyze the superparticle in 1|1-dimensions and the free Wess-Zumino model in 3|2-dimensions

Going chiral: overlap versus twisted mass fermions

We compare the behavior of overlap fermions, which are chirally invariant, and of Wilson twisted mass fermions at full twist in the approach to the chiral limit. Our quenched simulations reveal that with both formulations of lattice fermions pion masses of O(250 MeV) can be reached in practical applications. Our comparison is done at a fixed value of the lattice spacing a=0.123 fm. A number of quantities are measured such as hadron masses, pseudoscalar decay constants and quark masses obtained from Ward identities. We also determine the axial vector renormalization constants in the case of overlap fermions.Comment: 22 pages, 10 figure

Construction of Markov processes and associated multiplicative functionals from given harmonic measures

Let E be a noncompact locally compact second countable Hausdorff space. We consider the question when, given a family of finite nonzero measures on E that behave like harmonic measures associated with all relatively compact open sets in E (i.e. that satisfy a certain consistency condition), one can construct a Markov process on E and a multiplicative functional with values in [0, ∞) such that the hitting distributions of the process “inflated” by the multiplicative functional yield the given harmonic measures. We achieve this construction under weak continuity and local transience conditions on these measures that are natural in the theory of Markov processes, and a mild growth restriction on them. In particular, if the space E equipped with the measures satisfies the conditions of a harmonic space, such a Markov process and associated multiplicative functional exist. The result extends in a new direction the work of many authors, in probability and in axiomatic potential theory, on constructing Markov processes from given hitting distributions (i.e. from harmonic measures that have total mass no more than 1).Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/47657/1/440_2005_Article_BF01192513.pd

Electromagnetic Interactions GEneRalized (EIGER) - Algorithm abstraction and HPC implementation

Modern software development methods combined with key generalizations of standard computational algorithms enable the development of a new class of electromagnetic modeling tools. This paper describes current and anticipated capabilities of a frequency domain modeling code, EIGER, which has an extremely wide range of applicability. In addition, software implementation methods and high performance computing issues are discussed

Hausdorff dimension of operator semistable L\'evy processes

Let $X=\{X(t)\}_{t\geq0}$ be an operator semistable L\'evy process in \rd with exponent $E$, where $E$ is an invertible linear operator on \rd and $X$ is semi-selfsimilar with respect to $E$. By refining arguments given in Meerschaert and Xiao \cite{MX} for the special case of an operator stable (selfsimilar) L\'evy process, for an arbitrary Borel set B\subseteq\rr_+ we determine the Hausdorff dimension of the partial range $X(B)$ in terms of the real parts of the eigenvalues of $E$ and the Hausdorff dimension of $B$.Comment: 23 page

Effects of environmental pollutants on the reproduction and welfare of ruminants

Anthropogenic pollutants comprise a wide range of synthetic organic compounds and heavy metals, which are dispersed throughout the environment, usually at low concentrations. Exposure of ruminants, as for all other animals, is unavoidable and while the levels of exposure to most chemicals are usually too low to induce any physiological effects, combinations of pollutants can act additively or synergistically to perturb multiple physiological systems at all ages but particularly in the developing foetus. In sheep, organs affected by pollutant exposure include the ovary, testis, hypothalamus and pituitary gland and bone. Reported effects of exposure include changes in organ weight and gross structure, histology and gene and protein expression but these changes are not reflected in changes in reproductive performance under the conditions tested. These results illustrate the complexity of the effects of endocrine disrupting compounds on the reproductive axis, which make it difficult to extrapolate between, or even within, species. Effects of pollutant exposure on the thyroid gland, immune, cardiovascular and obesogenic systems have not been shown explicitly, in ruminants, but work on other species suggests that these systems can also be perturbed. It is concluded that exposure to a mixture of anthropogenic pollutants has significant effects on a wide variety of physiological systems, including the reproductive system. Although this physiological insult has not yet been shown to lead to a reduction in ruminant gross performance, there are already reports indicating that anthropogenic pollutant exposure can compromise several physiological systems and may pose a significant threat to both reproductive performance and welfare in the longer term. At present, many potential mechanisms of action for individual chemicals have been identified but knowledge of factors affecting the rate of tissue exposure and of the effects of combinations of chemicals on physiological systems is poor. Nevertheless, both are vital for the identification of risks to animal productivity and welfare

Análise morfológica e funcional do processo espermatogênico em cobaios (Cavia porcellus) da pré-puberdade até a pós-puberdade

Este estudo descreveu as análises morfológica e funcional do processo espermatogênico em cobaios (Cavia porcellus) de cinco (S5); seis (S6); nove (S9) e onze (S11) semanas de idade (N=5/grupo). Os aspectos analisados incluíram a contagem das populações celulares presentes no estádio 1 do ciclo do epitélio seminífero (CES), eficiência das mitoses espermatogoniais (RMi), produção meiótica (RMe), rendimento geral da espermatogênese (RGE), índice de células de Sertoli (ICS) e capacidade de suporte das células de Sertoli (CSCS). Os resultados mostraram que número médio de espermatogônias A, espermatócitos primários em pré-leptóteno/leptóteno, espermatócitos primários em paquíteno, células espermatogênicas totais e células de Sertoli mostraram variações numéricas em função da idade, entretanto, não detectadas estatisticamente, enquanto espermátides arredondadas aumentaram significativamente na puberdade e depois se estabilizaram. A produção espermatogênica de cobaios de 5 a 11 semanas não atingiu o ponto de estabilização e o RMi, RMe, RGE, ICS e CSCS mostraram variação numérica significativa em função da idade. Os resultados demonstraram que Cavia porcellus na pós-puberdade 2 são um modelo experimental vantajoso para estudos de processos de reconhecimento homólogos, alinhamento, e sinapses durante a prófase meiótica; o rendimento intrínseco da espermatogênese em cobaios é semelhante ao relatado para ratos Wistar, pacas e cutias (Dasyprocta sp.) e menor do que em preás, enquanto que a eficiência funcional das células de Sertoli é superior a de cutias e ratos Wistar e inferior à de pacas, rato espinhoso e catetos. Concluiu-se que em cobaios a espermatogênese está completamente estabelecida na semana 6 de idade, indicando a fase púbere do desenvolvimento sexual, e até a semana 11 eles não atingiram a produção espermática diária máxima e, portanto, a maturidade sexual