Suinocultura no Estado de Goiás: aplicação de um modelo de localização

Esta pesquisa teve como principal objetivo a análise da distribuição mais eficiente de granjas suinícolas no Estado de Goiás. O modelo de localização desenvolvido envolveu uma estrutura de programação inteira mista. Os fatores considerados para o objetivo do estudo foram os custos de transporte de grãos (milho e soja) até a granja, o custo de transporte de suínos até o abatedouro e o custo de transporte de carcaça de suíno até o mercado consumidor. Definiu-se como mercado consumidor o próprio Estado de Goiás, o Distrito Federal e os municípios de São Paulo, Rio de Janeiro e Belo Horizonte. Além disso, determinou-se também as ofertas de milho e soja de cada microrregião do Estado de Goiás, e o consumo per capita nacional de carne suína. Considerou-se três cenários, envolvendo níveis distintos de consumo per capita, sendo um o atual e os outros dois determinados de acordo com as perspectivas do setor.<br>The main purpose of this research work was to analyse the most efficient spatial distribution of pig production units in the state of Goiás. The model developed required a mixed integer programming structure. The factors considered in the model were: the grain transportation cost (corn and soybeans) from the source to the production unit, the cost of transporting the animals from the production unit to slaughterhouses and the carcass transportation cost from the slaughterhouse to retailers. The consumption market was spatialy defined as comprising the state of Goiás, the Distrito Federal and the counties of São Paulo, Rio de Janeiro and Belo Horizonte. Moreover, it was determined the supplies of corn and soybeans for each microregion in the state of Goiás and the national per capita pork consumption. Three scenarios, showing different per capita consumption levels, were considered. One of these is the current per capita consumption level and the two other were determined according to sector perspectives

Association of Apolipoprotein e with Intracerebral Hemorrhage Risk by Race/Ethnicity : A Meta-analysis

Importance: Genetic studies of intracerebral hemorrhage (ICH) have focused mainly on white participants, but genetic risk may vary or could be concealed by differing nongenetic coexposures in nonwhite populations. Transethnic analysis of risk may clarify the role of genetics in ICH risk across populations. Objective: To evaluate associations between established differences in ICH risk by race/ethnicity and the variability in the risks of apolipoprotein E (APOE) ϵ4 alleles, the most potent genetic risk factor for ICH. Design, Setting, and Participants: This case-control study of primary ICH meta-analyzed the association of APOE allele status on ICH risk, applying a 2-stage clustering approach based on race/ethnicity and stratified by a contributing study. A propensity score analysis was used to model the association of APOE with the burden of hypertension across race/ethnic groups. Primary ICH cases and controls were collected from 3 hospital- and population-based studies in the United States and 8 in European sites in the International Stroke Genetic Consortium. Participants were enrolled from January 1, 1999, to December 31, 2017. Participants with secondary causes of ICH were excluded from enrollment. Controls were regionally matched within each participating study. Main Outcomes and Measures: Clinical variables were systematically obtained from structured interviews within each site. APOE genotype was centrally determined for all studies. Results: In total, 13124 participants (7153 [54.5%] male with a median [interquartile range] age of 66 [56-76] years) were included. In white participants, APOE ϵ2 (odds ratio [OR], 1.49; 95% CI, 1.24-1.80; P <.001) and APOE ϵ4 (OR, 1.51; 95% CI, 1.23-1.85; P <.001) were associated with lobar ICH risk; however, within self-identified Hispanic and black participants, no associations were found. After propensity score matching for hypertension burden, APOE ϵ4 was associated with lobar ICH risk among Hispanic (OR, 1.14; 95% CI, 1.03-1.28; P =.01) but not in black (OR, 1.02; 95% CI, 0.98-1.07; P =.25) participants. APOE ϵ2 and ϵ4 did not show an association with nonlobar ICH risk in any race/ethnicity. Conclusions and Relevance: APOE ϵ4 and ϵ2 alleles appear to affect lobar ICH risk variably by race/ethnicity, associations that are confirmed in white individuals but can be shown in Hispanic individuals only when the excess burden of hypertension is propensity score-matched; further studies are needed to explore the interactions between APOE alleles and environmental exposures that vary by race/ethnicity in representative populations at risk for ICH