1,289 research outputs found
A characterization of quadratic-multiplicative mappings
In the spirit of some earlier studies of Jean Dhombres, Roman Ger and
Ludwig Reich we discuss the alienation problem for quadratic and multiplicative
mappings
Proportion of various types of thyroid disorders among newborns with congenital hypothyroidism and normally located gland: A regional cohort study
Objective To determine the proportion of the various types of thyroid disorders among newborns detected by the neonatal TSH screening programme, with a normally located thyroid gland.Patients and methods Of the 882 575 infants screened in our centre between 1981 and 2002, 85 infants with a normally located gland had persistent elevation of serum TSH values (an incidence of 1/10 383). Six of these 85 patients were lost to follow-up and were therefore excluded from the study. During follow-up, patients were classified as having permanent or transient hypothyroidism.Results Among the 79 patients included in the study, transient (n = 30, 38% of cases) and permanent (n = 49, 62% of cases) congenital hypothyroidism (CH) was demonstrated during the follow-up at the age of 0.7 +/- 0.6 years and 2.6 +/- 1.8 years (P < 0.0001), respectively. The proportion of premature births was significantly higher in the group with transient CH (57%) than in the group with permanent CH (2%) (P < 0.0001). A history of iatrogenic iodine overload was identified during the neonatal period in 69% of transient cases. Among permanent CH cases (n = 49), patients were classified as having a goitre (n = 27, 55% of cases), a normal sized and shaped thyroid gland (n = 14, 29% of cases) or a hypoplastic gland (n = 8, 16% of cases). The latter patients demonstrated global thyroid hypoplasia (n = 3), a right hemithyroid (n = 2), hypoplasia of the left lobe (n = 2), or asymmetry in the location of the two lobes (n = 1). Patients with a normal sized and shaped thyroid gland showed a significantly less severe form of hypothyroidism than those with a goitre or a hypoplastic thyroid gland (P < 0.0002). Among permanent CH cases, those with a goitre (n = 27) had an iodine organification defect (n = 10), Pendred syndrome (n = 1), a defect of thyroglobulin synthesis (n = 8), or a defect of sodium iodine symporter (n = 1), and in seven patients no aetiology could be determined. Among permanent cases with a normal sized and shaped thyroid gland (n = 14), a specific aetiology was found in only one patient (pseudohypoparathyroidism) and two patients had Down's syndrome. Among those with a globally hypoplastic gland, a TSH receptor gene mutation was found in two patients.Conclusions A precise description of the phenotype can enhance our understanding of various forms of neonatal hypothyroidism as well as their prevalence and management. It also helps to identify cases of congenital hypothyroidism of unknown aetiology, which will need to be investigated in collaboration with molecular biologists
On the Orthogonal Stability of the Pexiderized Quadratic Equation
The Hyers--Ulam stability of the conditional quadratic functional equation of
Pexider type f(x+y)+f(x-y)=2g(x)+2h(y), x\perp y is established where \perp is
a symmetric orthogonality in the sense of Ratz and f is odd.Comment: 10 pages, Latex; Changed conten
Features of Muon Arrival Time Distributions of High Energy EAS at Large Distances From the Shower Axis
In view of the current efforts to extend the KASCADE experiment
(KASCADE-Grande) for observations of Extensive Air Showers (EAS) of primary
energies up to 1 EeV, the features of muon arrival time distributions and their
correlations with other observable EAS quantities have been scrutinised on
basis of high-energy EAS, simulated with the Monte Carlo code CORSIKA and using
in general the QGSJET model as generator. Methodically various correlations of
adequately defined arrival time parameters with other EAS parameters have been
investigated by invoking non-parametric methods for the analysis of
multivariate distributions, studying the classification and misclassification
probabilities of various observable sets. It turns out that adding the arrival
time information and the multiplicity of muons spanning the observed time
distributions has distinct effects improving the mass discrimination. A further
outcome of the studies is the feature that for the considered ranges of primary
energies and of distances from the shower axis the discrimination power of
global arrival time distributions referring to the arrival time of the shower
core is only marginally enhanced as compared to local distributions referring
to the arrival of the locally first muon.Comment: 24 pages, Journal Physics G accepte
Phi-values in protein folding kinetics have energetic and structural components
Phi-values are experimental measures of how the kinetics of protein folding
is changed by single-site mutations. Phi-values measure energetic quantities,
but are often interpreted in terms of the structures of the transition state
ensemble. Here we describe a simple analytical model of the folding kinetics in
terms of the formation of protein substructures. The model shows that
Phi-values have both structural and energetic components. In addition, it
provides a natural and general interpretation of "nonclassical" Phi-values
(i.e., less than zero, or greater than one). The model reproduces the
Phi-values for 20 single-residue mutations in the alpha-helix of the protein
CI2, including several nonclassical Phi-values, in good agreement with
experiments.Comment: 15 pages, 3 figures, 1 tabl
The contributions of diverse sense organs in the control of leg movement by a walking insect
Cruse H, Dean J, Suilmann M. The contributions of diverse sense organs in the control of leg movement by a walking insect. Journal of Comparative Physiology, A. 1984;154(5):695-705
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