Topology-aware Quality-of-Service Support in Highly Integrated Chip Multiprocessors

Current design complexity trends, poor wire scalability, and power limitations argue in favor of highly modular onchip systems. Today’s state-of-the-art CMPs already feature up to a hundred discrete cores. With increasing levels of integration, CMPs with hundreds of cores, cache tiles, and specialized accelerators are anticipated in the near future. Meanwhile, server consolidation and cloud computing paradigms have emerged as profit vehicles for exploiting abundant resources of chip-multiprocessors. As multiple, potentially malevolent, users begin to share virtualized resources of a single chip, CMP-level quality-of-service (QOS) support becomes necessary to provide performance isolation, service guarantees, and security. This work takes a topology-aware approach to on-chip QOS. We propose to segregate shared resources, such as memory controllers and accelerators, into dedicated islands (shared regions) of the chip with full hardware QOS support. We rely on a richly connected Multidrop Express Channel (MECS) topology to connect individual nodes to shared regions, foregoing QOS support in much of the substrate and eliminating its respective overheads. We evaluate several topologies for the QOSenabled shared regions, focusing on the interaction between network-on-chip (NOC) and QOS metrics. We explore a new topology called Destination Partitioned Subnets (DPS), which uses a light-weight dedicated network for each destination node. On synthetic workloads, DPS nearly matches or outperforms other topologies with comparable bisection bandwidth in terms of performance, area overhead, energyefficiency, fairness, and preemption resilience.

Corneal confocal microscopy detects a reduction in corneal endothelial cells and nerve fibres in patients with acute ischemic stroke

YesEndothelial dysfunction and damage underlie cerebrovascular disease and ischemic stroke. We undertook corneal confocal microscopy (CCM) to quantify corneal endothelial cell and nerve morphology in 146 patients with an acute ischemic stroke and 18 age-matched healthy control participants. Corneal endothelial cell density was lower (P<0.001) and endothelial cell area (P<0.001) and perimeter (P<0.001) were higher, whilst corneal nerve fbre density (P<0.001), corneal nerve branch density (P<0.001) and corneal nerve fbre length (P=0.001) were lower in patients with acute ischemic stroke compared to controls. Corneal endothelial cell density, cell area and cell perimeter correlated with corneal nerve fber density (P=0.033, P=0.014, P=0.011) and length (P=0.017, P=0.013, P=0.008), respectively. Multiple linear regression analysis showed a signifcant independent association between corneal endothelial cell density, area and perimeter with acute ischemic stroke and triglycerides. CCM is a rapid non-invasive ophthalmic imaging technique, which could be used to identify patients at risk of acute ischemic stroke.Qatar National Research Fund Grant BMRP2003865

The microbiological diagnosis of tuberculous meningitis: results of Haydarpasa-1 study

We aimed to provide data on the diagnosis of tuberculous meningitis (TBM) in this largest case series ever reported. The Haydarpasa-1 study involved patients with microbiologically confirmed TBM in Albania, Croatia, Denmark, Egypt, France, Hungary, Iraq, Italy, Macedonia, Romania, Serbia, Slovenia, Syria and Turkey between 2000 and 2012. A positive culture, PCR or Ehrlich-Ziehl-Neelsen staining (EZNs) from the cerebrospinal fluid (CSF) was mandatory for inclusion of meningitis patients. A total of 506 TBM patients were included. The sensitivities of the tests were as follows: interferon- release assay (Quantiferon TB gold in tube) 90.2%, automated culture systems (ACS) 81.8%, Lowenstein Jensen medium (L-J) 72.7%, adenosine deaminase (ADA) 29.9% and EZNs 27.3%. CSF-ACS was superior to CSF L-J culture and CSF-PCR (p<0.05 for both). Accordingly, CSF L-J culture was superior to CSF-PCR (p<0.05). Combination of L-J and ACS was superior to using these tests alone (p<0.05). There were poor and inverse agreements between EZNs and L-J culture (=-0.189); ACS and L-J culture (=-0.172) (p<0.05 for both). Fair and inverse agreement was detected for CSF-ADA and CSF-PCR (=-0.299, p<0.05). Diagnostic accuracy of TBM was increased when both ACS and L-J cultures were used together. Non-culture tests contributed to TBM diagnosis to a degree. However, due to the delays in the diagnosis with any of the cultures, combined use of non-culture tests appears to contribute early diagnosis. Hence, the diagnostic approach to TBM should be individualized according to the technical capacities of medical institutions particularly in those with poor resources