Understanding patterns of contraceptive use among never married Mexican American women

Background: Non-marital fertility differs considerably by race, ethnicity, and nativity. These differences arise largely from racial and ethnic disparities in contraceptive practices. Empirical work has not assessed the relative importance of the various mechanisms proposed to account for racial, ethnic, and nativity differences in contraceptive behavior among never married women. Objective: Our objective is to describe racial, ethnic, and nativity disparities in contraceptive practices and determine the relative importance of the various mechanisms proposed to explain those disparities among never married, non-cohabiting women. Methods: Pooling data from the 2006‒2010 and 2011‒2013 National Survey of Family Growth (NSFG), we compare the age- and parity-standardized patterns of contraceptive use among never married, non-cohabiting Mexican immigrants, US-born Mexican Americans, Blacks, and Whites. We also examine the extent to which socioeconomic characteristics, access to family planning, and attitudes towards family life give rise to group differences in patterns of contraceptive use. Results: Never married, non-cohabiting Whites are more likely than their minority counterparts to use very effective methods of contraception. Socioeconomic disparities explain some of the group differences in contraceptive practice. Differing levels of access to family planning also explain a significant portion of the difference in contraceptive practice between Whites and Mexican immigrants. Conclusions: Policies aimed at alleviating socioeconomic inequality and differential access to family planning services may be effective at reducing disparities in contraceptive use between White and non-White never married, non-cohabiting women, especially White/Mexican-immigrant differences

Adipocyte-specific protein tyrosine phosphatase 1B deletion increases lipogenesis, adipocyte cell size and is a minor regulator of glucose homeostasis

Peer reviewedPublisher PD

Three-Year Wilkinson Microwave Anisotropy Probe (WMAP) Observations: Temperature Analysis

We present new full-sky temperature maps in five frequency bands from 23 to 94 GHz, based on the first three years of the WMAP sky survey. The new maps, which are consistent with the first-year maps and more sensitive, incorporate improvements in data processing made possible by the additional years of data and by a more complete analysis of the polarization signal. These include refinements in the gain calibration and beam response models. We employ two forms of multi-frequency analysis to separate astrophysical foreground signals from the CMB, each of which improves on our first-year analyses. First, we form an improved 'Internal Linear Combination' map, based solely on WMAP data, by adding a bias correction step and by quantifying residual uncertainties in the resulting map. Second, we fit and subtract new spatial templates that trace Galactic emission; in particular, we now use low-frequency WMAP data to trace synchrotron emission. The WMAP point source catalog is updated to include 115 new sources. We derive the angular power spectrum of the temperature anisotropy using a hybrid approach that combines a maximum likelihood estimate at low l (large angular scales) with a quadratic cross-power estimate for l>30. Our best estimate of the CMB power spectrum is derived by averaging cross-power spectra from 153 statistically independent channel pairs. The combined spectrum is cosmic variance limited to l=400, and the signal-to-noise ratio per l-mode exceeds unity up to l=850. The first two acoustic peaks are seen at l=220.8 +- 0.7 and l=530.9 +- 3.8, respectively, while the first two troughs are seen at l=412.4 +- 1.9 and l=675.1 +- 11.1, respectively. The rise to the third peak is unambiguous; when the WMAP data are combined with higher resolution CMB measurements, the existence of a third acoustic peak is well established.Comment: 116 pgs, 24 figs. Accepted version of the 3-year paper as posted to http://lambda.gsfc.nasa.gov/product/map/dr2/map_bibliography.cfm in January 200

Anisotropy studies around the galactic centre at EeV energies with the Auger Observatory

Data from the Pierre Auger Observatory are analyzed to search for anisotropies near the direction of the Galactic Centre at EeV energies. The exposure of the surface array in this part of the sky is already significantly larger than that of the fore-runner experiments. Our results do not support previous findings of localized excesses in the AGASA and SUGAR data. We set an upper bound on a point-like flux of cosmic rays arriving from the Galactic Centre which excludes several scenarios predicting sources of EeV neutrons from Sagittarius $A$. Also the events detected simultaneously by the surface and fluorescence detectors (the `hybrid' data set), which have better pointing accuracy but are less numerous than those of the surface array alone, do not show any significant localized excess from this direction.Comment: Matches published versio

Genomic analysis of two phlebotomine sand fly vectors of Leishmania from the New and Old World.

Phlebotomine sand flies are of global significance as important vectors of human disease, transmitting bacterial, viral, and protozoan pathogens, including the kinetoplastid parasites of the genus Leishmania, the causative agents of devastating diseases collectively termed leishmaniasis. More than 40 pathogenic Leishmania species are transmitted to humans by approximately 35 sand fly species in 98 countries with hundreds of millions of people at risk around the world. No approved efficacious vaccine exists for leishmaniasis and available therapeutic drugs are either toxic and/or expensive, or the parasites are becoming resistant to the more recently developed drugs. Therefore, sand fly and/or reservoir control are currently the most effective strategies to break transmission. To better understand the biology of sand flies, including the mechanisms involved in their vectorial capacity, insecticide resistance, and population structures we sequenced the genomes of two geographically widespread and important sand fly vector species: Phlebotomus papatasi, a vector of Leishmania parasites that cause cutaneous leishmaniasis, (distributed in Europe, the Middle East and North Africa) and Lutzomyia longipalpis, a vector of Leishmania parasites that cause visceral leishmaniasis (distributed across Central and South America). We categorized and curated genes involved in processes important to their roles as disease vectors, including chemosensation, blood feeding, circadian rhythm, immunity, and detoxification, as well as mobile genetic elements. We also defined gene orthology and observed micro-synteny among the genomes. Finally, we present the genetic diversity and population structure of these species in their respective geographical areas. These genomes will be a foundation on which to base future efforts to prevent vector-borne transmission of Leishmania parasites

The genetic mating system of a sea spider with male-biased sexual size dimorphism: evidence for paternity skew despite random mating success

Male-biased size dimorphism is usually expected to evolve in taxa with intense male–male competition for mates, and it is hence associated with high variances in male mating success. Most species of pycnogonid sea spiders exhibit female-biased size dimorphism, and are notable among arthropods for having exclusive male parental care of embryos. Relatively little, however, is known about their natural history, breeding ecology, and mating systems. Here we first show that Ammothella biunguiculata, a small intertidal sea spider, exhibits male-biased size dimorphism. Moreover, we combine genetic parentage analysis with quantitative measures of sexual selection to show that male body size does not appear to be under directional selection. Simulations of random mating revealed that mate acquisition in this species is largely driven by chance factors, although actual paternity success is likely non-randomly distributed. Finally, the opportunity for sexual selection (Is), an indirect metric for the potential strength of sexual selection, in A. biunguiculata males was less than half of that estimated in a sea spider with female-biased size dimorphism, suggesting the direction of size dimorphism may not be a reliable predictor of the intensity of sexual selection in this group. We highlight the suitability of pycnogonids as model systems for addressing questions relating parental investment and sexual selection, as well as the current lack of basic information on their natural history and breeding ecology

An upper limit to the photon fraction in cosmic rays above 10^19 eV from the Pierre Auger Observatory

An upper limit of 16% (at 95% c.l.) is derived for the photon fraction in cosmic rays with energies above 10^19 eV, based on observations of the depth of shower maximum performed with the hybrid detector of the Pierre Auger Observatory. This is the first such limit on photons obtained by observing the fluorescence light profile of air showers. This upper limit confirms and improves on previous results from the Haverah Park and AGASA surface arrays. Additional data recorded with the Auger surface detectors for a subset of the event sample, support the conclusion that a photon origin of the observed events is not favoured

History of clinical transplantation

The emergence of transplantation has seen the development of increasingly potent immunosuppressive agents, progressively better methods of tissue and organ preservation, refinements in histocompatibility matching, and numerous innovations is surgical techniques. Such efforts in combination ultimately made it possible to successfully engraft all of the organs and bone marrow cells in humans. At a more fundamental level, however, the transplantation enterprise hinged on two seminal turning points. The first was the recognition by Billingham, Brent, and Medawar in 1953 that it was possible to induce chimerism-associated neonatal tolerance deliberately. This discovery escalated over the next 15 years to the first successful bone marrow transplantations in humans in 1968. The second turning point was the demonstration during the early 1960s that canine and human organ allografts could self-induce tolerance with the aid of immunosuppression. By the end of 1962, however, it had been incorrectly concluded that turning points one and two involved different immune mechanisms. The error was not corrected until well into the 1990s. In this historical account, the vast literature that sprang up during the intervening 30 years has been summarized. Although admirably documenting empiric progress in clinical transplantation, its failure to explain organ allograft acceptance predestined organ recipients to lifetime immunosuppression and precluded fundamental changes in the treatment policies. After it was discovered in 1992 that long-surviving organ transplant recipient had persistent microchimerism, it was possible to see the mechanistic commonality of organ and bone marrow transplantation. A clarifying central principle of immunology could then be synthesized with which to guide efforts to induce tolerance systematically to human tissues and perhaps ultimately to xenografts

History of clinical transplantation

How transplantation came to be a clinical discipline can be pieced together by perusing two volumes of reminiscences collected by Paul I. Terasaki in 1991-1992 from many of the persons who were directly involved. One volume was devoted to the discovery of the major histocompatibility complex (MHC), with particular reference to the human leukocyte antigens (HLAs) that are widely used today for tissue matching.1 The other focused on milestones in the development of clinical transplantation.2 All the contributions described in both volumes can be traced back in one way or other to the demonstration in the mid-1940s by Peter Brian Medawar that the rejection of allografts is an immunological phenomenon.3,4 © 2008 Springer New York