A screening method for ranking chemicals by their fate and behaviour in the environment and potential toxic effects in humans following non-occupational exposure

A large number of chemicals are released intentionally or unintentionally into the environment each year. These include thousands of substances that are currently listed worldwide and several hundred new substances added annually (Mücke et al., 1986). When these compounds are used, they can reach microorganisms, plants, animals and man either in their original state or in the form of reaction and degradation products via air, water, soil or foodstuffs. Hence environmental chemicals can occur in practically all environmental compartments and ecosystems. It is not feasible to conduct assessments of human exposure and possible associated health effects for all chemicals. Even if the necessary resources were available, reliable data for a quantitative evaluation are likely to be absent in most cases. This has led to the development of schemes for prioritising compounds likely to be of environmental significance. Such schemes can be used to direct future research efforts towards the prioritised compounds. This study was commissioned by the Department of Health (DH) as part of a broader research activity that aims to identify key priority chemicals of concern to human health at routine levels of environmental exposure. The main pathways of human exposure are shown in Figure 1.1. A review of the principal prioritisation schemes used by different organisations to assess the significance of chemical release into the environment has been conducted by the MRC Institute for Environment and Health (IEH, 2003). This review showed that the approaches used by different organisations vary widely, depending on the initial reasons for which the schemes were developed. The basic information presented in the review was used to develop a simple screening method for ranking chemicals. The model used in this prioritisation scheme is outlined in Figure 1.2. The main purpose in developing the prioritisation scheme for DH was to develop a dedicated priority setting method capable of identifying chemicals in air, water, soil and foodstuffs that might pose a significant risk to human health following low level environmental exposure. The methodology was developed in order to identify compounds that required further assessment and those that had data gaps. More detailed risk assessments were conducted at a later stage on those compounds prioritised as being of high importancea. The screening methodology was developed for ‘existing chemicals’ as these are of greatest concern because data on their toxicity and/or fate and behaviour are often unknownb. The production of a priority list was designed to highlight compounds that required further regulatory measures to reduce exposure of the general population and for which an in-depth risk characterisation would be necessary to assist in the evaluation and implementation of activities for reducing environmental risks. This might include an assessment of the costs of such risks to human health and the costs of reduction measures. As the scheme also aimed to identify data gaps that might warrant further investigation, the application of default categories for chemicals with no data was also considered. The overall aim was to develop a screening methodology that is quick, clear and simple to use and that can easily be revised to take into account new information on compounds as and when it becomes available. a Benzene (IEH Report on Benzene in the Environment, R12); 4,6-dichlorocresol, hexachloro-1,3-butadiene, tetrachlorobenzene, 2,4,6-trichlorophenol (reports to DH; available from MRC Institute for Environment and Health b ‘Existing Substances’ are those that were placed in the European Union (EU) market before 1981. Prior to 1981 regulatory requirements were related to products intended for certain uses (e.g. veterinary medicines) and did not require assessment of the hazardous properties of any substance before they were released into the market. For substances placed on the market after 1981 (classified as ‘New Substances’) there is a legal requirement to conduct such assessments. Regulatory agencies require the collection of extensive documentation for safety before a chemical, for example, can be used in foods or commercial products. IEH Web Report W14, posted March 2004 at http://www.le.ac.uk/ieh/ 4 This report describes how physicochemical properties and toxicological data were incorporated into a screening model to assess the potential fate and transfer of chemicals between different environmental compartments and to predict the potential human exposure to toxic chemicals through the inhalation of contaminated air and the ingestion of water and food. It must be stressed, however, that the method devised is a simple screening process and that a more detailed assessment is necessary to determine the potential transfer through the foodchain of a chemical and the full extent of any adverse health effects. Sections 2 and 4 present the physicochemical properties, toxicological data and algorithms used to screen the compounds. Section 3 summarises the groups of chemicals that were included in the screening process. The results of the prioritisation scheme and comments on their limitations and constraints are presented in Section 5

The Rainbow Prim Algorithm for Selecting Putative Orthologous Protein Sequences

We present a selection method designed for eliminating species redundancy in clusters of putative orthologous sequences, to be applied as a post-processing procedure to pre-clustered data obtained from other methods. The algorithm can always zero-out the cluster redundancy while preserving the number of species of the original cluster

Pilot study and evaluation of a SMMR-derived sea ice data base

Data derived from the Nimbus 7 scanning multichannel microwave radiometer (SMMR) are discussed and the types of problems users have with satellite data are documented. The development of software for assessing the SMMR data is mentioned. Two case studies were conducted to verify the SMMR-derived sea ice concentrations and multi-year ice fractions. The results of a survey of potential users of SMMR data are presented, along with SMMR-derived sea ice concentration and multiyear ice fraction maps. The interaction of the Arctic atmosphere with the ice was studied using the Nimbus 7 SMMR. In addition, the characteristics of ice in the Arctic ocean were determined from SMMR data

Structure and tribological performance of diamond-like carbon based coatings for aerospace component processing

Copyright @ 2009 The Surface Science Society of JapanThis work examines diamond-like carbon (DLC) coatings deposited by plasma enhanced chemical vapour deposition (PECVD) as an environmentally friendly alternative to chromium plating in restoration of worn or damaged aircraft components. DLC coatings offer superior mechanical properties; however, high internal stresses and poor adhesion can prevent the deposition of thick films. This work examines a series of layered structures based on epoxy-resin interlayers with DLC applied as a surface film. Wear testing and examination with scanning electron microscopy and atomic force microscopy lead to the development of an optimum DLC/epoxy system with wear characteristics superior to those of chromium-plated steel. This new coating system has a great potential in restoring aircraft components in a more efficient and environmentally friendly manner.This work is funded via the Engineering and Physical Sciences Research Council (EPSRC)

Tuning the Hyperdrone

The HyperDrone is an instrument that generates acoustic waves taken from the data generated by seismic sensors across the surface of the entire globe. The data here is supplied by the Atomic Weapons Establishment Blacknest, Reading UK, which is part of the Comprehensive Test Ban Treaty Organisation (CTBTO) which monitors the ground for nuclear-scale explosions. This data is now contributing to other systems, such as early warning earthquake and tsunami alerts data.The entire network acts as a 'hyper' object, that is, a form which is too large (in scale of space/time etc), or too small in scale (of visibility etc), to be perceived by humans without the use of scientific systems. Data is arranged to be played back to generate resonance - a hyper 'drone' through the radome panel itself. The panel has been developed to work with a resonating geometric ‘tensegrity’ structure which was designed and made from aluminium and steel by Rob Smith during his artist residency at Wysing, where the Hyper Drone is currently located

Systemic approach to the management of infrastructure safety: Organizational items

This study deals with the organizational items within a systemic approach finalized to make the safety management of road infrastructures more sustainable at a scale of territory. In fact, the infrastructure safety is a very relevant topic in many states with structural systems built some decades ago. Beyond the inherent structural problems, other items are worthy to be investigated, such as, social, economic and organizational aspects. With this aim, the study describes a systemic approach finalized to make all the public and private stakeholders active actors in the management process by improving the organizational items: interaction and mode of governance. In detail, regarding a case study in an Italian region, the authors propose to take on the satellite-based information to investigate the structural safety problems of the infrastructures at a scale of territory. Along this issue, risk or alert maps are properly defined. Successively, useful suggestions are discussed with the focus to increase the interactions between the different actors for a better management of the safety. The recommendations are able to improve the governance mode and decision process with a more all-inclusive level of organization

Extinction of cue-evoked drug-seeking relies on degrading hierarchical instrumental expectancies

There has long been need for a behavioural intervention that attenuates cue-evoked drug-seeking, but the optimal method remains obscure. To address this, we report three approaches to extinguish cue-evoked drug-seeking measured in a Pavlovian to instrumental transfer design, in non-treatment seeking adult smokers and alcohol drinkers. The results showed that the ability of a drug stimulus to transfer control over a separately trained drug-seeking response was not affected by the stimulus undergoing Pavlovian extinction training in experiment 1, but was abolished by the stimulus undergoing discriminative extinction training in experiment 2, and was abolished by explicit verbal instructions stating that the stimulus did not signal a more effective response-drug contingency in experiment 3. These data suggest that cue-evoked drug-seeking is mediated by a propositional hierarchical instrumental expectancy that the drug-seeking response is more likely to be rewarded in that stimulus. Methods which degraded this hierarchical expectancy were effective in the laboratory, and so may have therapeutic potential

The evolution of density perturbations in f(R) gravity

We give a rigorous and mathematically well defined presentation of the Covariant and Gauge Invariant theory of scalar perturbations of a Friedmann-Lemaitre-Robertson-Walker universe for Fourth Order Gravity, where the matter is described by a perfect fluid with a barotropic equation of state. The general perturbations equations are applied to a simple background solution of R^n gravity. We obtain exact solutions of the perturbations equations for scales much bigger than the Hubble radius. These solutions have a number of interesting features. In particular, we find that for all values of n there is always a growing mode for the density contrast, even if the universe undergoes an accelerated expansion. Such a behaviour does not occur in standard General Relativity, where as soon as Dark Energy dominates, the density contrast experiences an unrelenting decay. This peculiarity is sufficiently novel to warrant further investigation on fourth order gravity models.Comment: 21 pages, 2 figures, typos corrected, submitted to PR

Listeria abdominal endograft infection miming pseudoaneurysm treated with in-situ aortic reconstruction: a case report

We report the case of a 72-year old man previously treated with an aortic endograft for an abdominal aortic aneurysm. After 3 years the patient developed a sepsis. Imaging and blood exams detected an endograft infection related to Listeria monocytogenes. Patients underwent endograft removal and in-situ aortic reconstruction with a cryopreserved allograft. A continuous antibacterial therapy has been established. One-month follow-up revealed the absence of clinically relevant infection with patency of the graft and absence of biochemical inflammatory markers