Lineability, spaceability, and additivity cardinals for Darboux-like functions

We introduce the concept of maximal lineability cardinal number, mL(M), of a subset M of a topological vector space and study its relation to the cardinal numbers known as: additivity A(M), homogeneous lineability HL(M), and lineability L(M) of M. In particular, we will describe, in terms of L, the lineability and spaceability of the families of the following Darboux-like functions on R-n, n >= 1: extendable, Jones, and almost continuous function

Selected Reaction Monitoring (SRM) frente a Western Blot

We propose the SRM technology as a complementary method to the Western Blot for the detection and quantification of proteins in a sample. The technique Western Blot has its own limitations: i) only a protein-of-choice is detected, ignoring any non-relevant proteins, ii) the sensitivity of the technique depends on the specificity of the antibody and iii) Western Blot is expensive and time-consuming. The advantages of SRM with respect Western Blot are remarkable: i) you can detect up to hundreds of different proteins in a sample, ii) SRM is more sensitive, because just 50 copies of the target protein per cell are enough for the detection and iii) once it has been made an investment in the necessary machinery to develop this technique, the detection of proteins in a sample turns into a cheaper, faster, more specific and full-quantitative procedure, without the need of using antibodies. First of all, SRM requires the identification of little peptides, obtained by tryptic digestion, whose sequence must be unique for a single protein or isoform. There is software for that aim. Then, it’s necessary to create isotope-labeled peptides of that identified for acting as internal standards. That sample is introduced in a triple quadrupole mass spectrometer: it passes through a first quadrupole, which functions as a filter, where the fragments are selected, previously ionized, attending to the mass/charge (m/z) relation that correspond to that unique fragments of the protein of interest. In this first selection may be other peptides from other proteins, with the same m/z but with different sequence. To select those that are exclusive from the target protein, the fragments are moved to a second quadrupole, where they are fragmented again with a physical method, and so new smaller fragments are generated. All the new fragments are conduced to the third quadrupole, where just those which come from the protein of interest are selected, attending at their m/z again. The target peptide concentration is determined by measuring the observed signal response for the target peptide relative to that of the isotopic-labeled peptide, the concentration of which is calculated from a pre-determined calibration-response curve. Calibration curves have to be generated for each target peptide in the sample. Because SRM technology is increasing its use, there have been developed databases where the scientific community upload information about protocols and standards for each protein with the aim to facilitate the work to other researchers

Automating SLA-Driven API Development with SLA4OAI

The OpenAPI Specification (OAS) is the de facto standard to describe RESTful APIs from a functional perspective. OAS has been a success due to its simple model and the wide ecosystem of tools supporting the SLA-Driven API development lifecycle. Unfortunately, the current OAS scope ignores crucial information for an API such as its Service Level Agreement (SLA). Therefore, in terms of description and management of non-functional information, the disadvantages of not having a standard include the vendor lock-in and prevent the ecosystem to grow and handle extra functional aspects. In this paper, we present SLA4OAI, pioneering in extending OAS not only allowing the specification of SLAs, but also supporting some stages of the SLA-Driven API lifecycle with an open-source ecosystem. Finally, we validate our proposal having modeled 5488 limitations in 148 plans of 35 real-world APIs and show an initial interest from the industry with 600 and 1900 downloads and installs of the SLA Instrumentation Library and the SLA Engine.Ministerio de Economía y Competitividad TIN2015-70560-RMinisterio de Ciencia, Innovación y Universidades RTI2018-101204-B-C21Ministerio de Educación, Cultura y Deporte FPU15/0298

Complete or Partial Inflation Convergence in the EU?

This paper has one primary aim: to analyze whether there exists evidence in favor of inflation convergence, complete convergence, or common trends, partial convergence, within the European Union (EU). The analysis is done in a bivariate and multivariate framework, for traded and non-traded inflation rates, using sequential unit root tests, common trends analysis, and cointegration tests that allow for structural breaks. The results suggest that there is a di¤erent behavior between traded and non-traded inflation rates. In the bivariate framework, there is much stronger evidence of complete convergence for traded inflation rates than for non-traded inflation rates. In the multivariate framework, the complete convergence is only presented in the most tradeable inflation rate and there is a small number of common trends for the rest of traded inflation rates that suggests evidence of partial convergence in terms of long-run relationships. Finally, neither complete nor partial convergence is presented in the non-traded inflation rates.convergence, common trends, structural breaks, traded and nontraded inflation rates, European Union.

Sexting entre adolescentes españoles: prevalencia y asociación con variables de personalidad

Antecedentes: el envío de contenidos sexuales (p.ej., fotos y vídeos) entre adolescentes a través de Internet y el teléfono móvil, o sexting, está recibiendo atención social creciente. Los objetivos de este estudio fueron: 1) analizar la prevalencia y tendencias por sexo y por edad del sexting entre adolescentes; y 2) examinar el perfil de personalidad de los adolescentes que participan en sexting. Método: participaron 3.223 adolescentes españoles entre 12 y 17 años (49,9% mujeres; edad media = 14,06, DT = 1,37) que completaron de forma anónima y voluntaria autoinformes sobre sexting y sobre los cinco grandes factores de personalidad. Resultados: la prevalencia total del sexting fue del 13,5%. La prevalencia fue del 3,4% a los 12 años y ascendió al 36,1% a los 17, mostrando una tendencia lineal creciente y significativa. En general, no se encontraron diferencias entre varones y mujeres. El perfil de personalidad de quienes se implicaron en sexting se caracterizó por una mayor Extraversión y Neuroticismo y por menor Amabilidad y Responsabilidad. Conclusiones: más allá que adoptar una perspectiva basada en los peligros del sexting, se hace necesario un enfoque educativo que enfatice el uso responsable e informado de las tecnologías de la información y la comunicaciónBackground: Voluntarily sending sexual content (e.g., photos, videos) among adolescents via the Internet and mobile phones, a phenomenon called sexting, is receiving increasing social and research attention. The aims of this study were: 1) to analyze the prevalence and trends of sexting among adolescents by gender and age and 2) to examine the personality profile of adolescents that participated in sexting. Method: The sample consisted of 3,223 Spanish adolescents from 12 to 17 years of age (49.9% female; mean age = 14.06, SD = 1.37) who anonymously and voluntarily completed self-report questionnaires on sexting and the big five personality factors. Results: The overall prevalence of sexting was 13.5%. The prevalence was 3.4% at 12 years old and increased to 36.1% at 17 years of age, showing a growing and significant linear trend. Overall, no differences were found between males and females. The personality profile of those involved in sexting was characterized by higher Extraversion and Neuroticism and by lower scores in Conscientiousness and Agreeableness. Conclusions: Given its high prevalence, beyond adopting a perspective based on the dangers of sexting, an educational approach that emphasizes responsible and informed use of information and communication technologies is necessary.Fil: Gámez Guadix, Manuel. Universidad Autónoma de Madrid; EspañaFil: de Santisteban, Patricia. Universidad Autónoma de Madrid; EspañaFil: Resett, Santiago Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Saavedra 15; Argentina. Universidad Nacional de Entre Ríos; Argentin

Fostering SLA-Driven API Specifications

Software architecture tendencies are shifting to a microservice paradigm. In this context, RESTful APIs are being established the standard of integration. API designer often identifies two key issues to be competitive in such growing market. On the one hand, the generation of accurate documentation of the behavior and capabilities of the API to promote its usage; on the other hand, the design of a pricing plan that fits into the potential API user’s needs. Besides the increasing number of API modeling alternatives is emerging, there is a lack of proposals on the definition of flexible pricing plans usually contained in the Service Level Agreements (SLAs). In this paper we propose two different modeling techniques for the description of SLA in a RESTful API context: iAgree and SLA4OAI.Ministerio de Economía y Competitividad TIN2015-70560-RJunta de Andalucía P12-TIC-1867Ministerio de Economía y Competitividad TIN2014-53986-RED

A Non-parametric reassessment of target zone nonlinearities: The Spanish Peseta/Deutsche Mark exchange rate

In this paper we present evidence concerning the existence of target zone nonlinearities in the Spanish Peseta/Deutsche Mark exchange rate using data with daily frequency for the period 1989-1996. Using a non-parametric technique, the Alternation Conditional Expectations (ACE) algorithm, we obtain evidence of the existence of non-linearities in both exchange rate and interest rate differential, with a functional form close to the non-linear effects given by the target zone model with realignment risk.Target zones, exchange rate, realignment risk, ACE algorithm