Superconductivity in TTF[Ni(dmit)2]2 films

We report on the observation of a superconducting transition in a fiber-like film of the TTF[Ni(dmit)2]2 phase electrodeposited on silicon substrates. Superconductivity is evidenced by a broad drop of the resistance below 0.8K under the application of a hydrostatic pressure of 7.7 kbar. Zero resistance is not reached due to the contribution of inter-fiber resistance. Superconductivity is confirmed by the application of a magnetic field perpendicular to the plane of the film. The critical field determined on the film is in agreement with that obtained in bulk single crystals

Tide-induced microseismicity in the Mertz glacier grounding area, East Antarctica

International audienceThe deployment of a seismic network along the Adélie and George V coasts in East Antarctica during the period 2009–2012 provides the opportunity to monitor cryoseismic activity and to obtain new insights on the relationship between tidal cycles and coastal glacier dynamics. Here we focus on records from a seismometer located on a rocky outcrop in the vicinity of the grounding line of the 35 km broad Mertz glacier, a major outflow of this region. We detect numerous icequakes (50,000 events within 10 months and up to 100 events/h) and demonstrate their clear tidal modulation. We suggest that they result from ice friction and fracturing around the rocky peak and from the glacier flexure in response to the falling and rising tides at its grounding area. We propose that such icequake monitoring could be used as a climate proxy since grounding lines are subject to migrate with sea level changes

Characterization of a Novel Compound That Stimulates STING-Mediated Innate Immune Activity in an Allele-Specific Manner.

The innate immune response to cytosolic DNA involves transcriptional activation of type I interferons (IFN-I) and proinflammatory cytokines. This represents the culmination of intracellular signaling pathways that are initiated by pattern recognition receptors that engage DNA and require the adaptor protein Stimulator of Interferon Genes (STING). These responses lead to the generation of cellular and tissue states that impair microbial replication and facilitate the establishment of long-lived, antigen-specific adaptive immunity. Ultimately this can lead to immune-mediated protection from infection but also to the cytotoxic T cell-mediated clearance of tumor cells. Intriguingly, pharmacologic activation of STING-dependent phenotypes is known to enhance both vaccine-associated immunogenicity and immune-based anti-tumor therapies. Unfortunately, the STING protein exists as multiple variant forms in the human population that exhibit differences in their reactivity to chemical stimuli and in the intensity of molecular signaling they induce. In light of this, STING-targeting drug discovery efforts require an accounting of protein variant-specific activity. Herein we describe a small molecule termed M04 that behaves as a novel agonist of human STING. Importantly, we find that the molecule exhibits a differential ability to activate STING based on the allelic variant examined. Furthermore, while M04 is inactive in mice, expression of human STING in mouse cells rescues reactivity to the compound. Using primary human cells in ex vivo assays we were also able to show that M04 is capable of simulating innate responses important for adaptive immune activation such as cytokine secretion, dendritic cell maturation, and T cell cross-priming. Collectively, this work demonstrates the conceivable utility of a novel agonist of human STING both as a research tool for exploring STING biology and as an immune potentiating molecule

Low-lying states and structure of the exotic 8^8He via direct reactions on the proton

International audienceThe structure of the light exotic nucleus 8He was investigated using direct reactions of the 8He SPIRAL beam on a proton-rich target. The (p,p') scattering to the Click to view the MathML source state, the (p,d)7He and (p,t)6He transfer reactions, were measured at the energy Elab=15.7 A.MeV. The light charged particles (p,d,t) were detected in the MUST Si-strip telescope array. The excitation spectrum of 8He was extracted from the (p,p') reaction. Above the known Click to view the MathML source excited state at 3.6 MeV, a second resonance was found around 5.4 MeV. The cross sections were analyzed within the coupled-reaction channels framework, using microscopic potentials. It is inferred that the 8He ground state has a more complex neutron-skin structure than suggested by previous α+4n models assuming a pure (1p3/2)4 configuration

Experimental evidence for subshell closure in 8^{8}He and indication of a resonant state in 7^{7}He below 1 MeV

NESTERThe spectroscopy of the unstable $^{8}$He and unbound $^{7}$He nuclei is investigated via the p($^{8}$He, d) transfer reaction with a 15.7A MeV $^{8}$He beam from the SPIRAL facility. The emitted deuterons were detected by the telescope array MUST. The results are analyzed within the coupled-channels Born approximation framework, and a spectroscopic factor $C^2$S=4.4±1.3 for neutron pickup to the $^{7}$He_g.s.$is deduced. This value is consistent with a full p3/2 subshell for$^{8}$He. Tentative evidence for the first excited state of$^{7}$He is found at$E^*$=0.9±0.5 MeV (width$\Gamma$=1.0±0.9 MeV). The second one is observed at a position compatible with previous measurements,$E^*$=2.9±0.1 MeV. Both are in agreement with previous separate measurements. The reproduction of the first excited state below 1 MeV would be a challenge for the most sophisticated nuclear theories

Early anthropogenic impact on Western Central African rainforests 2,600 y ago

A potential human footprint on Western Central African rainforests before the Common Era has become the focus of an ongoing controversy. Between 3,000 y ago and 2,000 y ago, regional pollen sequences indicate a replacement of mature rainforests by a forest–savannah mosaic including pioneer trees. Although some studies suggested an anthropogenic influence on this forest fragmentation, current interpretations based on pollen data attribute the ‘‘rainforest crisis’’ to climate change toward a drier, more seasonal climate. A rigorous test of this hypothesis, however, requires climate proxies independent of vegetation changes. Here we resolve this controversy through a continuous 10,500-y record of both vegetation and hydrological changes from Lake Barombi in Southwest Cameroon based on changes in carbon and hydrogen isotope compositions of plant waxes. δ¹³C-inferred vegetation changes confirm a prominent and abrupt appearance of C4 plants in the Lake Barombi catchment, at 2,600 calendar years before AD 1950 (cal y BP), followed by an equally sudden return to rainforest vegetation at 2,020 cal y BP. δD values from the same plant wax compounds, however, show no simultaneous hydrological change. Based on the combination of these data with a comprehensive regional archaeological database we provide evidence that humans triggered the rainforest fragmentation 2,600 y ago. Our findings suggest that technological developments, including agricultural practices and iron metallurgy, possibly related to the large-scale Bantu expansion, significantly impacted the ecosystems before the Common Era

Patient-reported outcomes and final overall survival results from the randomized phase 3 PENELOPE trial evaluating pertuzumab in low tumor human epidermal growth factor receptor 3 (HER3) mRNA-expressing platinum-resistant ovarian cancer

Introduction: The PENELOPE trial evaluated pertuzumab added to chemotherapy for biomarker-selected platinum-resistant ovarian cancer. As previously reported, pertuzumab did not statistically significantly improve progression-free survival (primary end point: HR 0.74, 95% CI 0.50 to 1.11), although results in the paclitaxel and gemcitabine cohorts suggested activity. Here, we report final overall survival and patient-reported outcomes. Patients and methods: Eligible patients had ovarian carcinoma that progressed during/within 6 months of completing ≥4 platinum cycles, low tumor human epidermal growth factor receptor 3 (HER3) mRNA expression, and ≤2 prior chemotherapy lines. Investigators selected single-agent topotecan, gemcitabine or weekly paclitaxel before patients were randomized to either placebo or pertuzumab (840→420 mg every 3 weeks), stratified by selected chemotherapy, prior anti-angiogenic therapy, and platinum-free interval. Final overall survival analysis (key secondary end point) was pre-specified after 129 deaths. Patient-reported outcomes (secondary end point) were assessed at baseline and every 9 weeks until disease progression. Results: At database lock (June 9, 2016), 130 (83%) of 156 randomized patients had died. Median follow-up was 27 months in the pertuzumab arm versus 26 months in the control arm. In the intent-to-treat population there was no overall survival difference between treatment arms (stratified HR 0.90, 95% CI 0.61 to 1.32; p=0.60). Results in subgroups defined by stratification factors indicated heterogeneity similar to previous progression-free survival results. Updated safety was similar to previously published results. Compliance with patient-reported outcomes questionnaire completion was >75% for all validated patient-reported outcomes measures. Pertuzumab demonstrated neither beneficial nor detrimental effects on patient-reported outcomes compared with placebo, except for increased diarrhea symptoms. Discussion: Consistent with the primary results, adding pertuzumab to chemotherapy for low tumor HER3 mRNA-expressing platinum-resistant ovarian cancer did not improve overall survival, but showed trends in some cohorts. Except for increased diarrhea symptoms, pertuzumab had no impact on patient-reported outcomes. ClinicalTrials.gov: ClinicalTrials.gov: NCT01684878

Search for a long lived component in the reaction U+U near the Coulomb barrier

Expérience GANILInternational audienceWe performed an experiment to search for a signature of a long living component in the collision of $^{238}$U + $^{238}$U between 6.09 and 7.35A MeV. The experiment was performed at GANIL using the spectrometer VAMOS, tuned for observing reactions with kinematics similar to fusion-fission events. Theoretical calculations indicate that if a long living component would exist for this reaction, the most probable fission channel of such a giant system would be via the emissionof quasi-lead nuclei. We detected events of such a category in the focal plane of VAMOS. These events present an excitation function growing as a function of the bombarding energy