The Added Value of Water, Sanitation, and Hygiene Interventions to Mass Drug Administration for Reducing the Prevalence of Trachoma: A Systematic Review Examining

Trachoma is the leading cause of infectious blindness worldwide. The SAFE strategy, the World Health Organization-recommended method to eliminate blinding trachoma, combines developments in water, sanitation, surgery, and antibiotic treatment. Current literature does not focus on the comprehensive effect these components have on one another. The present systematic review analyzes the added benefit of water, sanitation, and hygiene education interventions to preventive mass drug administration of azithromycin for trachoma. Trials were identified from the PubMed database using a series of search terms. Three studies met the complete criteria for inclusion. Though all studies found a significant change in reduction of active trachoma prevalence, the research is still too limited to suggest the impact of the “F” and “E” components on trachoma prevalence and ultimately its effects on blindness

Optimal network topologies for local search with congestion

The problem of searchability in decentralized complex networks is of great importance in computer science, economy and sociology. We present a formalism that is able to cope simultaneously with the problem of search and the congestion effects that arise when parallel searches are performed, and obtain expressions for the average search cost--written in terms of the search algorithm and the topological properties of the network--both in presence and abscence of congestion. This formalism is used to obtain optimal network structures for a system using a local search algorithm. It is found that only two classes of networks can be optimal: star-like configurations, when the number of parallel searches is small, and homogeneous-isotropic configurations, when the number of parallel searches is large.Comment: 4 pages. Final version accepted in PR

Large-scale structural organization of social networks

The characterization of large-scale structural organization of social networks is an important interdisciplinary problem. We show, by using scaling analysis and numerical computation, that the following factors are relevant for models of social networks: the correlation between friendship ties among people and the position of their social groups, as well as the correlation between the positions of different social groups to which a person belongs.Comment: 5 pages, 3 figures, Revte

A cross-sectional study on levels of second-hand smoke in restaurants and bars in five cities in China

OBJECTIVES: To assess indoor second-hand smoke (SHS) exposure in restaurants and bars via PM(2.5) (fine particles 2.5 μm in diameter and smaller) level measurements in five cities in China. METHODS: The study was conducted from July to September in 2007 in Beijing, Xi'an, Wuhan, Kunming and Guiyang. Portable aerosol monitors were used to measure PM(2.5) concentrations in 404 restaurants and bars. The occupant density and the active smoker density were calculated for each venue sampled. RESULTS: Among the 404 surveyed venues, 23 had complete smoking bans, 9 had partial smoking bans and 313 (77.5%) were observed to have allowed smoking during sampling. The geometric mean of indoor PM(2.5) levels in venues with smoking observed was 208 μg/m(3) and 99 μg/m(3) in venues without observed smoking. When outdoor PM(2.5) levels were adjusted, indoor PM(2.5) levels in venues with smoking observed were consistently significantly higher than in venues without smoking observed (F=80.49, p<0.001). Indoor PM(2.5) levels were positively correlated with outdoor PM(2.5) levels (partial rho=0.37 p<0.001) and active smoker density (partial rho=0.34, p<0.001). CONCLUSIONS: Consistent with findings in other countries, PM(2.5) levels in smoking places are significantly higher than those in smoke-free places and are strongly related to the number and density of active smokers. These findings document the high levels of SHS in hospitality venues in China and point to the urgent need for comprehensive smoke-free laws in China to protect the public from SHS hazards, as called for in Article 8 of the Framework Convention on Tobacco Control, which was ratified by China in 2005

Percentile Queries in Multi-Dimensional Markov Decision Processes

Markov decision processes (MDPs) with multi-dimensional weights are useful to analyze systems with multiple objectives that may be conflicting and require the analysis of trade-offs. We study the complexity of percentile queries in such MDPs and give algorithms to synthesize strategies that enforce such constraints. Given a multi-dimensional weighted MDP and a quantitative payoff function $f$, thresholds $v_i$ (one per dimension), and probability thresholds $\alpha_i$, we show how to compute a single strategy to enforce that for all dimensions $i$, the probability of outcomes $\rho$ satisfying $f_i(\rho) \geq v_i$ is at least $\alpha_i$. We consider classical quantitative payoffs from the literature (sup, inf, lim sup, lim inf, mean-payoff, truncated sum, discounted sum). Our work extends to the quantitative case the multi-objective model checking problem studied by Etessami et al. in unweighted MDPs.Comment: Extended version of CAV 2015 pape

Models of stress fluctuations in granular media

We investigate in detail two models describing how stresses propagate and fluctuate in granular media. The first one is a scalar model where only the vertical component of the stress tensor is considered. In the continuum limit, this model is equivalent to a diffusion equation (where the r\^ole of time is played by the vertical coordinate) plus a randomly varying convection term. We calculate the response and correlation function of this model, and discuss several properties, in particular related to the stress distribution function. We then turn to the tensorial model, where the basic starting point is a wave equation which, in the absence of disorder, leads to a ray-like propagation of stress. In the presence of disorder, the rays acquire a diffusive width and the angle of propagation is shifted. A striking feature is that the response function becomes negative, which suggests that the contact network is mechanically unstable to very weak perturbations. The stress correlation function reveals characteristic features related to the ray-like propagation, which are absent in the scalar description. Our analytical calculations are confirmed and extended by a numerical analysis of the stochastic wave equation.Comment: 32 pages, latex, 18 figures and 6 diagram

'Moving on' through the locked ward system for women with intellectual disabilities

Background: The move to community support for all people with intellectual disabilities is an aspiration with international significance. In this article we draw on rich accounts from women with intellectual disabilities detained under the Mental Health Act (E&W) 1983 and staff at an National Health Service secure setting in England to explore how ‘moving on’ is defined and perceived. Methods: The study reports on an ethnographic study using the field-notes and the 26 semi-structured interviews with detained women and staff on three wards. Results: We first explore staff conceptions of moving on, which include behavioural change and utilising coping strategies. Then we discuss the areas of analysis that women discussed: taking back responsibility, success in arranged relationships, acceptance of regime and resistance to progression. Conclusion: The concepts of moving on were not determined by the women but by the service. We recommend further research which explores women’s own rehabilitation requirements