EVN observations of 6.7-GHz methanol maser polarization in massive star-forming regions II. First statistical results

Magnetic fields have only recently been included in theoretical simulations of high-mass star formation. The simulations show that magnetic fields play an important role in the formation and dynamics of molecular outflows. Masers, in particular 6.7-GHz CH3OH masers, are the best probes of the magnetic field morphologies around massive young stellar objects on the smallest scales of 10-100 AU. This paper focuses on 4 massive young stellar objects, IRAS06058+2138-NIRS1, IRAS22272+6358A, S255-IR, and S231, which complement our previous 2012 sample (the first EVN group). From all these sources, molecular outflows have been detected in the past. Seven of the European VLBI Network antennas were used to measure the linear polarization and Zeeman-splitting of the 6.7-GHz CH3OH masers in the star-forming regions in this second EVN group. We detected a total of 128 CH3OH masing cloudlets. Fractional linear polarization (0.8%-11.3%) was detected towards 18% of the CH3OH masers in our sample. The linear polarization vectors are well ordered in all the massive young stellar objects. We measured significant Zeeman-splitting in IRAS06058+2138-NIRS1 (DVz=3.8+/-0.6 m/s) and S255-IR (DVz=3.2+/-0.7 m/s). By considering the 20 massive young stellar objects towards which the morphology of magnetic fields was determined by observing 6.7-GHz CH3OH masers in both hemispheres, we find no evident correlation between the linear distributions of CH3OH masers and the outflows or the linear polarization vectors. On the other hand, we present first statistical evidence that the magnetic field (on scales 10-100 AU) is primarily oriented along the large-scale outflow direction. Moreover, we empirically find that the linear polarization fraction of unsaturated CH3OH masers is P_l<4.5%.Comment: 13 pages, 8 figures, 7 tables, accepted by Astronomy & Astrophysic

Characterizing evolved Galactic stellar population: a challenge for astrometric measurements

Stars and planetary system

An investigation of the phase locking index for measuring of interdependency of cortical source signals recorded in the EEG

The phase locking index (PLI) was introduced to quantify in a statistical sense the phase synchronization of two signals. It has been commonly used to process biosignals. In this article, we investigate the PLI for measuring the interdependency of cortical source signals (CSSs) recorded in the Electroencephalogram (EEG). To this end, we consider simple analytical models for the mapping of simulated CSSs into the EEG. For these models, the PLI is investigated analytically and through numerical simulations. An evaluation is made of the sensitivity of the PLI to the amount of crosstalk between the sources through biological tissues of the head. It is found that the PLI is a useful interdependency measure for CSSs, especially when the amount of crosstalk is small. Another common interdependency measure is the coherence. A direct comparison of both measures has not been made in the literature so far. We assess the performance of the PLI and coherence for estimation and detection purposes based on, respectively, a normalized variance and a novel statistical measure termed contrast. Based on these performance measures, it is found that the PLI is similar or better than the CM in most cases. This result is also confirmed through analysis of EEGs recorded from epileptic patients

Geoeconomic variations in epidemiology, ventilation management, and outcomes in invasively ventilated intensive care unit patients without acute respiratory distress syndrome: a pooled analysis of four observational studies

Background: Geoeconomic variations in epidemiology, the practice of ventilation, and outcome in invasively ventilated intensive care unit (ICU) patients without acute respiratory distress syndrome (ARDS) remain unexplored. In this analysis we aim to address these gaps using individual patient data of four large observational studies. Methods: In this pooled analysis we harmonised individual patient data from the ERICC, LUNG SAFE, PRoVENT, and PRoVENT-iMiC prospective observational studies, which were conducted from June, 2011, to December, 2018, in 534 ICUs in 54 countries. We used the 2016 World Bank classification to define two geoeconomic regions: middle-income countries (MICs) and high-income countries (HICs). ARDS was defined according to the Berlin criteria. Descriptive statistics were used to compare patients in MICs versus HICs. The primary outcome was the use of low tidal volume ventilation (LTVV) for the first 3 days of mechanical ventilation. Secondary outcomes were key ventilation parameters (tidal volume size, positive end-expiratory pressure, fraction of inspired oxygen, peak pressure, plateau pressure, driving pressure, and respiratory rate), patient characteristics, the risk for and actual development of acute respiratory distress syndrome after the first day of ventilation, duration of ventilation, ICU length of stay, and ICU mortality. Findings: Of the 7608 patients included in the original studies, this analysis included 3852 patients without ARDS, of whom 2345 were from MICs and 1507 were from HICs. Patients in MICs were younger, shorter and with a slightly lower body-mass index, more often had diabetes and active cancer, but less often chronic obstructive pulmonary disease and heart failure than patients from HICs. Sequential organ failure assessment scores were similar in MICs and HICs. Use of LTVV in MICs and HICs was comparable (42\ub74% vs 44\ub72%; absolute difference \u20131\ub769 [\u20139\ub758 to 6\ub711] p=0\ub767; data available in 3174 [82%] of 3852 patients). The median applied positive end expiratory pressure was lower in MICs than in HICs (5 [IQR 5\u20138] vs 6 [5\u20138] cm H2O; p=0\ub70011). ICU mortality was higher in MICs than in HICs (30\ub75% vs 19\ub79%; p=0\ub70004; adjusted effect 16\ub741% [95% CI 9\ub752\u201323\ub752]; p&lt;0\ub70001) and was inversely associated with gross domestic product (adjusted odds ratio for a US$10 000 increase per capita 0\ub780 [95% CI 0\ub775\u20130\ub786]; p&lt;0\ub70001). Interpretation: Despite similar disease severity and ventilation management, ICU mortality in patients without ARDS is higher in MICs than in HICs, with a strong association with country-level economic status. Funding: No funding

Planet formation imager: Project update

The Planet Formation Imager (PFI) is a near- and mid-infrared interferometer project with the driving science goal of imaging directly the key stages of planet formation, including the young proto-planets themselves. Here, we will present an update on the work of the Science Working Group (SWG), including new simulations of dust structures during the assembly phase of planet formation and quantitative detection efficiencies for accreting and non-accreting young exoplanets as a function of mass and age. We use these results to motivate two reference PFI designs consisting of a) twelve 3m telescopes with a maximum baseline of 1.2km focused on young exoplanet imaging and b) twelve 8m telescopes optimized for a wider range of young exoplanets and protoplanetary disk imaging out to the 150K H2O ice line. Armed with 4 x 8m telescopes, the ESO/VLTI can already detect young exoplanets in principle and projects such as MATISSE, Hi-5 and Heimdallr are important PFI pathfinders to make this possible. We also discuss the state of technology development needed to make PFI more affordable, including progress towards new designs for inexpensive, small field-of-view, large aperture telescopes and prospects for Cubesat-based space interferometry

Death in hospital following ICU discharge: insights from the LUNG SAFE study

Background: To determine the frequency of, and factors associated with, death in hospital following ICU discharge to the ward. Methods: The Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE study was an international, multicenter, prospective cohort study of patients with severe respiratory failure, conducted across 459 ICUs from 50 countries globally. This study aimed to understand the frequency and factors associated with death in hospital in patients who survived their ICU stay. We examined outcomes in the subpopulation discharged with no limitations of life sustaining treatments (‘treatment limitations’), and the subpopulations with treatment limitations. Results: 2186 (94%) patients with no treatment limitations discharged from ICU survived, while 142 (6%) died in hospital. 118 (61%) of patients with treatment limitations survived while 77 (39%) patients died in hospital. Patients without treatment limitations that died in hospital after ICU discharge were older, more likely to have COPD, immunocompromise or chronic renal failure, less likely to have trauma as a risk factor for ARDS. Patients that died post ICU discharge were less likely to receive neuromuscular blockade, or to receive any adjunctive measure, and had a higher pre- ICU discharge non-pulmonary SOFA score. A similar pattern was seen in patients with treatment limitations that died in hospital following ICU discharge. Conclusions: A significant proportion of patients die in hospital following discharge from ICU, with higher mortality in patients with limitations of life-sustaining treatments in place. Non-survivors had higher systemic illness severity scores at ICU discharge than survivors. Trial Registration: ClinicalTrials.gov NCT02010073