THE EVOLUTION OF GRENVILLE BASEMENT IN THE EASTERN GREAT SMOKY MOUNTAINS; CONSTRAINTS FROM U-PB ZIRCON GEOCHRONOLOGY, WHOLE ROCK SM-ND, AND FELDSPAR PB GEOCHEMISTRY

Identifying the crustal affinity of Grenville basement rocks in the Dellwood quadrangle, western NC, provides insight into the tectonic evolution of eastern Laurentia during Grenville orogenesis. U-Pb zircon geochronology of orthogneiss, augen gneiss, and mafic xenoliths in orthogneiss reveal magmatic pulses at 1130, 1180, and 1330 Ma and metamorphic episodes at 450 and 1040 Ma. Xenoliths in 1330 Ma orthogneiss are as old as 1382 Ma and represent the oldest component of Blue Ridge basement identified to-date. Feldspar Pb isotope values span a range between juvenile-Laurentian and southern-central Appalachian basement/Amazonia. Most Pb isotope data define an array consistent with crustal mixing between Laurentia and Amazonia, however, one xenolith has a unique Pb isotopic composition interpreted as Laurentian crust. Sm-Nd isotope data yield depleted mantle model ages ranging from 1.52 to 1.79 Ga (200 to 650 Ma older than their crystallization ages) indicating a broadly non-juvenile heritage for Dellwood basement. Three biotite gneiss samples contain detrital zircon grains derived from 1060, 1160, 1330, and 1750 Ma sources. Multiple magmatic zircon age populations, variable depleted mantle modelages, and regionally unique isotopic Pb signatures are evidence of protracted Grenville magmatism in the southern Appalachians involving both Laurentian and Amazonian crustal components

Stellar rotational periods in the planet hosting open cluster Praesepe

By using the dense coverage of the extrasolar planet survey project HATNet, we Fourier analyze 381 high-probability members of the nearby open cluster Praesepe (Beehive/M44/NGC 2632). In addition to the detection of 10 variables (of \delta Scuti and other types), we identify 180 rotational variables (including the two known planet hosts). This sample increases the number of known rotational variables in this cluster for spectral classes earlier than M by more than a factor of three. These stars closely follow a color/magnitude -- period relation from early F to late K stars. We approximate this relation by polynomials for an easier reference to the rotational characteristics in different colors. The total (peak-to-peak) amplitudes of the large majority (94%) of these variables span the range of 0.005 to 0.04 mag. The periods cover a range from 2.5 to 15 days. These data strongly confirm that Praesepe and the Hyades have the same gyrochronological ages. Regarding the two planet hosts, Pr0211 (the one with the shorter orbital period) has a rotational period that is ~2 days shorter than the one expected from the main rotational pattern in this cluster. This, together with other examples discussed in the paper, may hint that star-planet interaction via tidal dissipation can be significant in some cases in the rotational evolution of stars hosting Hot Jupiters.Comment: 17 pages, 13 figures, 5 tables; accepted for publication in MNRA

Factors Influencing Sleep Difficulty and Sleep Quantity in the Citizen Pscientist Psoriatic Cohort.

IntroductionSleep is essential for overall health and well-being, yet more than one-third of adults report inadequate sleep. The prevalence is higher among people with psoriasis, with up to 85.4% of the psoriatic population reporting sleep disruption. Poor sleep among psoriasis patients is particularly concerning because psoriasis is independently associated with many of the same comorbidities as sleep dysfunction, including cardiovascular disease, obesity, and depression. Given the high prevalence and serious consequences of disordered sleep in psoriasis, it is vital to understand the nature of sleep disturbance in this population. This study was designed to help meet this need by using survey data from Citizen Pscientist, an online patient portal developed by the National Psoriasis Foundation.MethodsOur analysis included 3118 participants who identified as having a diagnosis by a physician of psoriasis alone or psoriasis with psoriatic arthritis. Demographic information, psoriasis severity and duration, sleep apnea status, smoking and alcohol consumption, itch timing, and sleep characteristics were included. Two separate multivariate logistic regression models in STATA were used to determine whether the presence of psoriatic arthritis, age, gender, body mass index, comorbid sleep apnea, psoriasis severity, timing of worst itch, smoking status, or high-risk alcohol consumption were associated with sleep difficulty or low sleep quantity, defined by the American Academy of Sleep Medicine as less than 7 h of sleep per night on average.ResultsResults from the multivariate logistic regressions found that sleep difficulty was associated with psoriatic arthritis (OR 2.15, 95% CI [1.79-2.58]), female gender (2.03 [1.67-2.46]), obese body mass index (BMI ≥ 30) (1.25 [1.00-1.56]), sleep apnea (1.41 [1.07-1.86]), psoriasis severity of moderate (1.59 [1.30-1.94]) or severe (2.40 [1.87-3.08]), and smoking (1.60 [1.26-2.02]). Low sleep quantity was associated with obese BMI (1.62 [1.29-2.03]), sleep apnea (1.30 [1.01-1.68]), psoriasis severity of moderate (1.41 [1.16-1.72]) or severe (1.40 [1.11-1.76]), and smoking (1.62 [1.31-2.00]). Sleep difficulty and low sleep quantity were not associated with age, alcohol consumption, or timing of worst itch.ConclusionThese results are potentially meaningful in several aspects. We identify an important distinction between sleep difficulty and sleep quantity in psoriatic disease, whereby having psoriatic arthritis and being female are each associated with sleep difficulty despite no association with low sleep quantity. Furthermore, there is conflicting evidence from prior studies as to whether psoriasis severity is associated with sleep difficulty, but this well-powered, large study revealed a strong, graded relationship between psoriasis severity and both sleep difficulty and low sleep quantity. Overall, our results show that both sleep difficulty and low sleep quantity were associated with multiple factors in this analysis of a large psoriatic cohort. These findings suggest that dermatologists may gather clinically useful information by screening psoriatic patients for trouble sleeping and low sleep quantity to identify potential comorbidities and to more effectively guide disease management

Invasive Group A Streptococcal Infection in High School Football Players, New York City, 2003

After being notified that 2 high school football teammates were hospitalized with confirmed or suspected invasive group A streptococcal infections, we conducted an investigation of possible spread among other team members. This investigation highlights a need for guidelines on management of streptococcal and other infectious disease outbreaks in team sport settings

Pain, opioid tolerance and sensitisation to nociception in the neonate

Pain is commonplace in newborn infants. Opioid analgesics have become increasingly used to reduce different types of pain in neonates, including pain from surgery, medical procedures and chronic conditions. Adverse effects of opioids include respiratory depression, hypotension and tolerance. These adverse effects can be minimised by utilising specific administration techniques and constant monitoring. Recent studies have demonstrated that untreated pain can have long-term effects on infant pain behaviours months beyond the events, thus, opioid analgesics may have a beneficial role that extends beyond the immediate painful event(s)

Elucidating the mechanism of DNA-dependent ATP hydrolysis mediated by DNA-dependent ATPase A, a member of the SWI2/SNF2 protein family

The active DNA-dependent ATPase A domain (ADAAD), a member of the SWI2/SNF2 family, has been shown to bind DNA in a structure-specific manner, recognizing DNA molecules possessing double-stranded to single-stranded transition regions leading to ATP hydrolysis. Extending these studies we have delineated the structural requirements of the DNA effector for ADAAD and have shown that the single-stranded and double-stranded regions both contribute to binding affinity while the double-stranded region additionally plays a role in determining the rate of ATP hydrolysis. We have also investigated the mechanism of interaction of DNA and ATP with ADAAD and shown that each can interact independently with ADAAD in the absence of the other. Furthermore, the protein can bind to dsDNA as well as ssDNA molecules. However, the conformation change induced by the ssDNA is different from the conformational change induced by stem-loop DNA (slDNA), thereby providing an explanation for the observed ATP hydrolysis only in the presence of the double-stranded:single-stranded transition (i.e. slDNA)

Spatial Organization and Molecular Correlation of Tumor-Infiltrating Lymphocytes Using Deep Learning on Pathology Images

Beyond sample curation and basic pathologic characterization, the digitized H&E-stained images of TCGA samples remain underutilized. To highlight this resource, we present mappings of tumorinfiltrating lymphocytes (TILs) based on H&E images from 13 TCGA tumor types. These TIL maps are derived through computational staining using a convolutional neural network trained to classify patches of images. Affinity propagation revealed local spatial structure in TIL patterns and correlation with overall survival. TIL map structural patterns were grouped using standard histopathological parameters. These patterns are enriched in particular T cell subpopulations derived from molecular measures. TIL densities and spatial structure were differentially enriched among tumor types, immune subtypes, and tumor molecular subtypes, implying that spatial infiltrate state could reflect particular tumor cell aberration states. Obtaining spatial lymphocytic patterns linked to the rich genomic characterization of TCGA samples demonstrates one use for the TCGA image archives with insights into the tumor-immune microenvironment

The magnitude of the snow-sourced reactive nitrogen flux to the boundary layer in the Uintah Basin

Reactive nitrogen (Nr = NO, NO2, HONO) and volatile organic carbon emissions from oil and gas extraction activities play a major role in wintertime ground-level ozone exceedance events of up to 140 ppb in the Uintah Basin in eastern Utah. Such events occur only when the ground is snow covered, due to the impacts of snow on the stability and depth of the boundary layer and ultraviolet actinic flux at the surface. Recycling of reactive nitrogen from the photolysis of snow nitrate has been observed in polar and midlatitude snow, but snow-sourced reactive nitrogen fluxes in mid-latitude regions have not yet been quantified in the field. Here we present vertical profiles of snow nitrate concentration and nitrogen isotopes (δ15N) collected during the Uintah Basin Winter Ozone Study 2014 (UBWOS 2014), along with observations of insoluble light-absorbing impurities, radiation equivalent mean ice grain radii, and snow density that determine snow optical properties. We use the snow optical properties and nitrate concentrations to calculate ultraviolet actinic flux in snow and the production of Nr from the photolysis of snow nitrate. The observed δ15N(NO−3) is used to constrain modeled fractional loss of snow nitrate in a snow chemistry column model, and thus the source of Nr to the overlying boundary layer. Snow-surface δ15N(NO−3) measurements range from −5 to 10 ‰ and suggest that the local nitrate burden in the Uintah Basin is dominated by primary emissions from anthropogenic sources, except during fresh snowfall events, where remote NOx sources from beyond the basin are dominant. Modeled daily averaged snow-sourced Nr fluxes range from 5.6 to 71 × 107 molec cm−2s−1 over the course of the field campaign, with a maximum noontime value of 3.1 × 109 molec cm−2s−1. The top-down emission estimate of primary, anthropogenic NOx in Uintah and Duchesne counties is at least 300 times higher than the estimated snow NOx emissions presented in this study. Our results suggest that snow-sourced reactive nitrogen fluxes are minor contributors to the Nr boundary layer budget in the highly polluted Uintah Basin boundary layer during winter 2014