Characterization of >oil on copper> paintings by energy dispersive X-ray fluorescence spectrometry

Energy dispersive X-ray fluorescence is a common analytical tool for layer thickness measurements in quality control processes in the coating industry, but there are scarce microanalytical applications in order to ascertain semi-quantitative or quantitative information of painted layers. >Oil on copper> painting becomes a suitable material to be analysed by means of X-ray fluorescence spectrometry, due to the metallic nature of substrate and the possibility of applying layered models as used in coating industry. The aim of this work is to study the suitability of a quantitative energy dispersive X-ray fluorescence methodology for the assessment of the areal distribution of pigments and the characterization of painting methods on such kind of pictorial artworks. The method was calibrated using standard reference materials: dried droplets of monoelemental standard solutions laid on a metallic plate of copper. As an example of application, we estimated pigment mass distribution of two >oil on copper> paintings from the sixteenth and eighteenth centuries. Pictorial layers have been complementarily analysed by X-ray diffraction. Apart of the supporting media made of copper or brass, we could identify two different superimposed layers: (a) a preparation layer mainly composed by white lead and (b) the pictorial layer of variable composition depending on the pigments used by the artist on small areas of the painting surface. The areal mass distribution of the different elements identified in the painting pigments (Ca, Cr, Mn, Fe, Zn, Cd, Hg and Pb) have been determined by elemental mapping of some parts of the artworks. © 2011 Springer-Verlag.A. Pitarch gratefully acknowledges the Spanish Ministry of Education for the grant within the program of Formation of Graduate Stuff-FPU (reference AP2006-4591)Peer Reviewe

Joint interpretation of magnetotelluric, seismic, and well-log data in Hontomín (Spain)

Acknowledgements. This work is dedicated to the memory of Andrés Pérez-Estaún, brilliant scientist, colleague, and friend. The authors sincerely thank Ian Ferguson and an anonymous reviewer for their useful comments on the manuscript. Xènia Ogaya is currently supported in the Dublin Institute for Advanced Studies by a Science Foundation Ireland grant IRECCSEM (SFI grant 12/IP/1313). Juan Alcalde is funded by NERC grant NE/M007251/1, on interpretational uncertainty. Juanjo Ledo, Pilar Queralt and Alex Marcuello thank Ministerio de Economía y Competitividad and EU Feder Funds through grant CGL2014- 54118-C2-1-R. Funding for this Project has been partially provided by the Spanish Ministry of Industry, Tourism and Trade, through the CIUDEN-CSIC-Inst. Jaume Almera agreement (ALM-09-027: Characterization, Development and Validation of Seismic Techniques applied to CO2 Geological Storage Sites), the CIUDEN-Fundació Bosch i Gimpera agreement (ALM-09-009 Development and Adaptation of Electromagnetic techniques: Characterisation of Storage Sites) and the project PIERCO2 (Progress In Electromagnetic Research for CO2 geological reservoirs CGL2009-07604). The CIUDEN project is co-financed by the European Union through the Technological Development Plant of Compostilla OXYCFB300 Project (European Energy Programme for Recovery).Peer reviewedPublisher PD

Effects of Minimalist Footwear and Foot Strike Patterns on Plantar Pressure during a Prolonged Running

The use of minimalist shoes (MS) in running involves changes in running mechanics com pared to conventional shoes (CS), but there is still little research analysing the effects of this footwear on plantar pressure, which could help to understand some risk injury factors. Moreover, there are no studies examining the effects of a prolonged running and foot strike patterns on baropodometric variables in MS. Therefore, the aim of this study was to analyse the changes produced using MS on plantar pressure during a prolonged running, as well as its interaction with the time and foot strike pattern. Twenty-one experienced minimalist runners (age 38 ± 10 years, MS running experience 2 ± 1 years) ran with MS and CS for 30 min at 80% of their maximal aerobic speed, and mean pres sure, peak pressure, contact time, centre of pressure velocity, relative force and contact area were analysed using a pressure platform. Foot strike pattern and time were also considered as factors. The multivariable linear regression mixed models showed that the use of MS induced, at the end of a prolonged running, higher peak pressure (p = 0.008), lower contact time (p = 0.004) and lower contact area (p < 0.001) than using CS. Also, runners with forefoot strike pattern using MS, compared to midfoot and rearfoot patterns, showed higher mean and peak pressure (p < 0.001) and lower contact time and area (p < 0.05). These results should be considered when planning training for runners using MS, as higher peak pressure values when using this type of footwear could be a risk factor for the development of some foot injuries

Objetos de oro y epicampaniforme en la Cova del Gegant. Relaciones en la costa mediterránea de la Península Ibérica durante la Edad del Bronce

En este trabajo se analiza el estrato XXV de la Cova del Gegant (Sitges, Barcelona), adscrito a la Edad del Bronce, y se destaca la problemática cronológica de este período. En este yacimiento encontramos decoraciones epicampaniformes del "Grupo del Nordeste", tradicionalmente atribuidas a un Bronce Antiguo, un osario colectivo datado por C14 en el Bronce Medio, ornamentos en ámbar/resina de amplia cronología y dos piezas áureas, muy escasas en el nordeste de la Península Ibérica, que vinculamos con el episodio sepulcral. Las piezas arqueológicas y la serie de dataciones radiocarbónicas nos proporcionan datos importantes sobre las redes de intercambio y los desplazamientos a lo largo de la fachada mediterránea de la Península Ibérica durante la Edad de Bronce

Disruption of NIPBL/Scc2 in Cornelia de Lange Syndrome provokes cohesin genome-wide redistribution with an impact in the transcriptome

Cornelia de Lange syndrome (CdLS) is a rare disease affecting multiple organs and systems during development. Mutations in the cohesin loader, NIPBL/Scc2, were first described and are the most frequent in clinically diagnosed CdLS patients. The molecular mechanisms driving CdLS phenotypes are not understood. In addition to its canonical role in sister chromatid cohesion, cohesin is implicated in the spatial organization of the genome. Here, we investigate the transcriptome of CdLS patient-derived primary fibroblasts and observe the downregulation of genes involved in development and system skeletal organization, providing a link to the developmental alterations and limb abnormalities characteristic of CdLS patients. Genome-wide distribution studies demonstrate a global reduction of NIPBL at the NIPBL-associated high GC content regions in CdLS-derived cells. In addition, cohesin accumulates at NIPBL-occupied sites at CpG islands potentially due to reduced cohesin translocation along chromosomes, and fewer cohesin peaks colocalize with CTCF

Gold artifacts and Late Bell Beaker from Cova del Gegant: Interaction along the Mediterranean coastline of the Iberian Peninsula during Bronze Age

En este trabajo se analiza el estrato XXV de la Cova del Gegant (Sitges, Barcelona), adscrito a la Edad del Bronce, y se destaca la problemática cronológica de este período. En este yacimiento encontramos decoraciones epicampaniformes del “Grupo del Nordeste”, tradicionalmente atribuidas a un Bronce Antiguo, un osario colectivo datado por C14 en el Bronce Medio, ornamentos en ámbar/resina de amplia cronología y dos piezas áureas, muy escasas en el nordeste de la Península Ibérica, que vinculamos con el episodio sepulcral. Las piezas arqueológicas y la serie de dataciones radiocarbónicas nos proporcionan datos importantes sobre las redes de intercambio y los desplazamientos a lo largo de la fachada mediterránea de la Península Ibérica durante la Edad de Bronce.This paper presents archaeological layer XXV from Cova del Gegant (Sitges, Barcelona), ascribed to Bronze Age, and focuses on this period’s chronological issues. Cova del Gegant yielded Late Bell Beaker pottery featuring a decorative style akin to the “Northeastern Group” (generally ascribed to Early Bronze Age), human remains associated with a collective burial (radiocarbon dated to Middle Bronze Age), amber and/or resin ornaments, and two gold artifacts (very scarce in the NE of Iberian Peninsula). The archaeological artifacts and radiocarbon dating range provide important data concerning the exchange networks and movements along the Mediterranean coastline during Bronze Age.info:eu-repo/semantics/publishedVersio

Allogeneic Stem Cell Transplantation in Mantle Cell Lymphoma; Insights into Its Potential Role in the Era of New Immunotherapeutic and Targeted Therapies: The GETH/GELTAMO Experience

Allo-SCT is a curative option for selected patients with relapsed/refractory (R/R) MCL, but with significant NRM. We present the long-term results of patients receiving allo-SCT in Spain from March 1995 to February 2020. The primary endpoints were EFS, OS, and cumulative incidence (CI) of NRM, relapse, and GVHD. We included 135 patients, most (85%) receiving RIC. After a median follow-up of 68 months, 5-year EFS and OS were 47 and 50%, respectively. Overall and CR rates were 86 and 80%. The CI of relapse at 1 and 3 years were 7 and 12%. NRM at day 100 and 1 year were 17 and 32%. Previous ASCT and Grade 3-4 aGVHD were associated with a higher NRM. Grade 3-4 aGVHD, donor type (mismatch non-related), and the time-period 2006-2020 were independently related to worse EFS. Patients from 1995-2005 were younger, most from HLA-identical sibling donors, and were pretreated less. Our data confirmed that allo-SCT may be a curative option in R/R MCL with low a CI of relapse, although NRM is still high, being mainly secondary to aGVHD. The arrival of new, highly effective and low toxic immunotherapeutic or targeted therapies inevitably will relegate allo-SCT to those fit patients who fail these therapies, far away from the optimal timing of treatment

Crónicas de Jurisprudencia. Derechos Fundamentales y Libertades Púlbicas

Cónica de la jurisprudencia sobre derechos y libertades de los siguientes tribunales: Tribunal Europeo de Derechos Humanos, Tribunal de Justicia de la Unión Europea, Tribunal Constitucional, Tribunal SupremoFUNDACIÓ BOSCH I GIMPERA y Editorial Aranzadi (Thomson Reuters)2021-2

Crónicas de Jurisprudencia. Derechos Fundamentales y Libertades Púlbicas

Crónica de la jurisprudencia sobre derechos y libertades de los siguientes tribunales: Tribunal Europeo de Derechos Humanos, Tribunal de Justicia de la Unión Europea, Tribunal Constitucional, Tribunal SupremoFUNDACIÓ BOSCH I GIMPERA y Editorial Aranzadi (Thomson Reuters)2020-2

Crónicas de Jurisprudencia. Derechos Fundamentales y Libertades Púlbicas

Crónica de jurisprudencia sobre derechos y libertades de los siguientes tribunales: Tribunal Europeo de Derechos Humanos, Tribunal de Justicia de la Unión Europea, Tribunal Constitucional, Tribunal SupremoFUNDACIÓ BOSCH I GIMPERA y Editorial Aranzadi (Thomson Reuters)2021-2