Does Social Media Use Increase Depressive Symptoms? A Reverse Causation Perspective

According to the World Health Organization (1), 264 million individuals worldwide suffer from depression—a condition characterized by feelings of low self-worth, impaired concentration, and disturbed sleep, among various other maladaptive symptoms (2). Adolescents between 13 and 18 years of age are also vulnerable (3), with a 52% increase in the prevalence of depression among adolescents from 2005 to 2017 (4). Depression is tied to many serious problems including failure to complete education, higher unplanned parenthood rates, poorer interpersonal relations, and heightened risk of substance abuse and suicidality (5–7).Published versionThis research was supported by the Ministry of Education Academy Research Fund Tier 1, awarded to AH by Singapore Management University (20-C242-SMU-001)

Development and Validation of a Risk Score for Chronic Kidney Disease in HIV Infection Using Prospective Cohort Data from the D:A:D Study

Ristola M. on työryhmien DAD Study Grp ; Royal Free Hosp Clin Cohort ; INSIGHT Study Grp ; SMART Study Grp ; ESPRIT Study Grp jäsen.Background Chronic kidney disease (CKD) is a major health issue for HIV-positive individuals, associated with increased morbidity and mortality. Development and implementation of a risk score model for CKD would allow comparison of the risks and benefits of adding potentially nephrotoxic antiretrovirals to a treatment regimen and would identify those at greatest risk of CKD. The aims of this study were to develop a simple, externally validated, and widely applicable long-term risk score model for CKD in HIV-positive individuals that can guide decision making in clinical practice. Methods and Findings A total of 17,954 HIV-positive individuals from the Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) study with >= 3 estimated glomerular filtration rate (eGFR) values after 1 January 2004 were included. Baseline was defined as the first eGFR > 60 ml/min/1.73 m2 after 1 January 2004; individuals with exposure to tenofovir, atazanavir, atazanavir/ritonavir, lopinavir/ritonavir, other boosted protease inhibitors before baseline were excluded. CKD was defined as confirmed (>3 mo apart) eGFR In the D:A:D study, 641 individuals developed CKD during 103,185 person-years of follow-up (PYFU; incidence 6.2/1,000 PYFU, 95% CI 5.7-6.7; median follow-up 6.1 y, range 0.3-9.1 y). Older age, intravenous drug use, hepatitis C coinfection, lower baseline eGFR, female gender, lower CD4 count nadir, hypertension, diabetes, and cardiovascular disease (CVD) predicted CKD. The adjusted incidence rate ratios of these nine categorical variables were scaled and summed to create the risk score. The median risk score at baseline was -2 (interquartile range -4 to 2). There was a 1: 393 chance of developing CKD in the next 5 y in the low risk group (risk score = 5, 505 events), respectively. Number needed to harm (NNTH) at 5 y when starting unboosted atazanavir or lopinavir/ritonavir among those with a low risk score was 1,702 (95% CI 1,166-3,367); NNTH was 202 (95% CI 159-278) and 21 (95% CI 19-23), respectively, for those with a medium and high risk score. NNTH was 739 (95% CI 506-1462), 88 (95% CI 69-121), and 9 (95% CI 8-10) for those with a low, medium, and high risk score, respectively, starting tenofovir, atazanavir/ritonavir, or another boosted protease inhibitor. The Royal Free Hospital Clinic Cohort included 2,548 individuals, of whom 94 individuals developed CKD (3.7%) during 18,376 PYFU (median follow-up 7.4 y, range 0.3-12.7 y). Of 2,013 individuals included from the SMART/ESPRIT control arms, 32 individuals developed CKD (1.6%) during 8,452 PYFU (median follow-up 4.1 y, range 0.6-8.1 y). External validation showed that the risk score predicted well in these cohorts. Limitations of this study included limited data on race and no information on proteinuria. Conclusions Both traditional and HIV-related risk factors were predictive of CKD. These factors were used to develop a risk score for CKD in HIV infection, externally validated, that has direct clinical relevance for patients and clinicians to weigh the benefits of certain antiretrovirals against the risk of CKD and to identify those at greatest risk of CKD.Peer reviewe

Brief mindfulness breathing exercises and working memory capacity: Findings from two experimental approaches

Mindfulness training has been extensively researched and found to elicit positive effects on cognitive performance, including working memory capacity. Benefits to cognitive function have been extended to brief mindfulness training as well. However, not much is known about its effect on working memory capacity. The current study examined the effects of a single 15-min session of mindful attention to breathing compared to a 15-min session of mind-wandering exercise in a within-subjects experimental design (Study 1; N = 82) and a between-subjects experimental design (Study 2; N = 424). Contrary to our hypotheses, in both experiments, we did not find any evidence that participants in the mindfulness condition outperform the control condition on an operation span task (Study 1) and a symmetry span task (Study 2). These results suggest that a single session of mindful practice may not be sufficient to enhance working memory capacity

A critical examination of the effectiveness of gratitude intervention on well-being outcomes: A within-person experimental daily diary approach

10.1080/17439760.2022.2154704The Journal of Positive Psychology186942-95

Problematic Smartphone Usage, Objective Smartphone Engagement, and Executive Functions: A Latent Variable Analysis

The negative consequences of smartphone usage have seen frequent discourse in popular media. While existing studies seek to resolve these debates in relation to executive functions, findings are still mixed, partly due to the lack of conceptual clarity, the use of self-reported measures, and task impurity. Addressing these limitations, the current multi-session study utilizes latent variable approaches to examine various smartphone usage, including objectively measured data-logged screen time and screen-checking, and 9 executive function tasks in 260 young adults. Our structural equation models showed no evidence that self-reported normative smartphone usage, objective screen time and objective screen-checking are associated with deficits in executive functions. Only self-reported problematic smartphone usage was associated with deficits in latent factor of task-switching. These findings shed light on the boundary conditions of the link between smartphone usage and executive functions and suggest that smartphone usage in moderation may not have inherent harms on cognitive functions

Anxiety disorders and executive functions: A three-level meta-analysis of reaction time and accuracy

Anxiety disorders, one of the most common classes of psychological disorders, have been shown to result in a decreased quality of life. Although some research suggests that anxiety disorders are linked to impairments in executive functioning, the inconsistency in the current literature yields an unclear conclusion on the relationship between the two. The current meta-analysis systematically investigated 55 records (N ​= ​4601; kReactionTime ​= ​44, kAccuracy ​= ​79) that compared various groups with anxiety disorders to healthy controls on executive function tasks. Overall, our meta-analysis showed that individuals with anxiety disorders exhibited significant deficits in performance efficiency (reaction times) on executive function tasks. However, we also found that individuals with anxiety disorders may outperform their healthy peers in performance effectiveness (task accuracy) in some conditions. Type of anxiety disorders, domain of executive functions, and mediation use were identified to moderate the overall relations between anxiety disorders and executive functioning. Nevertheless, the results were robust across important demographic and other clinical moderators (e.g., anxiety severity and comorbidity)

The effect of mere presence of smartphone on cognitive functions: A four-level meta-analysis

Ministry of Education, Singapore under its Academic Research Funding Tier