454 research outputs found
Global datasets of leaf photosynthetic capacity for ecological and earth system research
The maximum rate of Rubisco carboxylation (Vcmax) determines leaf photosynthetic capacity and is a key parameter for estimating the terrestrial carbon cycle, but its spatial information is lacking, hindering global ecological research. Here, we convert leaf chlorophyll content (LCC) retrieved from satellite data to Vcmax, based on plants’ optimal distribution of nitrogen between light harvesting and carboxylation pathways. We also derive Vcmax from satellite (GOME-2) observations of sun-induced chlorophyll fluorescence (SIF) as a proxy of leaf photosynthesis using a data assimilation technique. These two independent global Vcmax products agree well (r 2=0.79, RMSE=15.46 μmol m-2 s -1 25 , P<0.001) and compare well with 3672 ground-based measurements (r2=0.68, RMSE=13.55 μmol m-2 s -1 and P<0.001 for SIF; r2=0.55, RMSE=17.55 μmol m-2 s -1 and P<0.001 for LCC). The LCC-derived Vcmax product is also used to constrain the retrieval of Vcmax from TROPOMI SIF data to produce an optimized Vcmax product using both SIF and LCC information. The global distributions of these products are compatible with Vcmax computed from an ecological optimality theory using meteorological variables, but importantly reveal additional information on the influence of land cover, irrigation, soil pH and leaf nitrogen on leaf photosynthetic capacity. These satellite-based approaches and spatial Vcmax products are primed to play a major role in global ecosystem research. The three remote sensing Vcmax products based on SIF, LCC and SIF+LCC are available at https://doi.org/10.5281/zenodo.6466968 (Chen et al., 2020) and the code for implementing the ecological optimality theory is available at https://github.com/SmithEcophysLab/optimal_vcmax_R (Smith, 2020)
Immunomagnetic t-lymphocyte depletion (ITLD) of rat bone marrow using OX-19 monoclonal antibody
Graft versus host disease (GVHD) may be abrogated and host survival prolonged by in vitro depletion of T lymphocytes from bone marrow (BM) prior to allotransplantation. Using a mouse anti-rat pan T-lymphocyte monoclonal antibody (0×19) bound to monosized, magnetic, polymer beads, T lymphocytes were removed in vitro from normal bone marrow. The removal of the T lymphocytes was confirmed by flow cytometry. Injection of the T-lymphocyte-depleted bone marrow into fully allogeneic rats prevents the induction of GVHD and prolongs host survival. A highly efficient technique of T-lymphocyte depletion using rat bone marrow is described. It involves the binding of OX-19, a MoAb directed against all rat thy-mocytes and mature peripheral T lymphocytes, to monosized, magnetic polymer spheres. Magnetic separation of T lymphocytes after mixing the allogeneic bone marrow with the bead/OX-19 complex provides for a simple, rapid depletion of T lymphocytes from the bone marrow. In vitro studies using flow cytometry and the prevention of GVHD in a fully allogeneic rat bone marrow model have been used to demonstrate the effectiveness of the depletion procedure. © 1989 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted
SN 2016coi/ASASSN-16fp: An example of residual helium in a type Ic supernova?
The optical observations of Ic-4 supernova (SN) 2016coi/ASASSN-16fp, from
to days after explosion, are presented along with analysis
of its physical properties. The SN shows the broad lines associated with SNe
Ic-3/4 but with a key difference. The early spectra display a strong absorption
feature at \AA\ which is not seen in other SNe~Ic-3/4 at this
epoch. This feature has been attributed to He I in the literature. Spectral
modelling of the SN in the early photospheric phase suggests the presence of
residual He in a C/O dominated shell. However, the behaviour of the He I lines
are unusual when compared with He-rich SNe, showing relatively low velocities
and weakening rather than strengthening over time. The SN is found to rise to
peak d after core-collapse reaching a bolometric luminosity of Lp
\ergs. Spectral models, including the nebular epoch, show
that the SN ejected \msun\ of material, with \msun\ below
5000 \kms, and with a kinetic energy of erg. The
explosion synthesised \msun\ of 56Ni. There are significant
uncertainties in E(B-V)host and the distance however, which will affect Lp and
MNi. SN 2016coi exploded in a host similar to the Large Magellanic Cloud (LMC)
and away from star-forming regions. The properties of the SN and the
host-galaxy suggest that the progenitor had of \msun\
and was stripped almost entirely down to its C/O core at explosion.Comment: Accepted for publication in MNRAS. Updated to reflect the published
version, minor typographical changes onl
Semiparametric Multivariate Accelerated Failure Time Model with Generalized Estimating Equations
The semiparametric accelerated failure time model is not as widely used as
the Cox relative risk model mainly due to computational difficulties. Recent
developments in least squares estimation and induced smoothing estimating
equations provide promising tools to make the accelerate failure time models
more attractive in practice. For semiparametric multivariate accelerated
failure time models, we propose a generalized estimating equation approach to
account for the multivariate dependence through working correlation structures.
The marginal error distributions can be either identical as in sequential event
settings or different as in parallel event settings. Some regression
coefficients can be shared across margins as needed. The initial estimator is a
rank-based estimator with Gehan's weight, but obtained from an induced
smoothing approach with computation ease. The resulting estimator is consistent
and asymptotically normal, with a variance estimated through a multiplier
resampling method. In a simulation study, our estimator was up to three times
as efficient as the initial estimator, especially with stronger multivariate
dependence and heavier censoring percentage. Two real examples demonstrate the
utility of the proposed method
Global datasets of leaf photosynthetic capacity for ecological and earth system research
The maximum rate of Rubisco carboxylation (Vcmax) determines leaf photosynthetic capacity and is a key parameter for estimating the terrestrial carbon cycle, but its spatial information is lacking, hindering global ecological research. Here, we convert leaf chlorophyll content (LCC) retrieved from satellite data to Vcmax, based on plants' optimal distribution of nitrogen between light harvesting and carboxylation pathways. We also derive Vcmax from satellite (GOME-2) observations of sun-induced chlorophyll fluorescence (SIF) as a proxy of leaf photosynthesis using a data assimilation technique. These two independent global Vcmax products agree well (mol m−2 s−1, P<0.001) and compare well with 3672 ground-based measurements (mol m−2 s−1 and P<0.001 for SIF; mol m−2 s−1 and P<0.001 for LCC). The LCC-derived Vcmax product is also used to constrain the retrieval of Vcmax from TROPical Ozone Mission (TROPOMI) SIF data to produce an optimized Vcmax product using both SIF and LCC information. The global distributions of these products are compatible with Vcmax computed from an ecological optimality theory using meteorological variables, but importantly reveal additional information on the influence of land cover, irrigation, soil pH, and leaf nitrogen on leaf photosynthetic capacity. These satellite-based approaches and spatial Vcmax products are primed to play a major role in global ecosystem research. The three remote sensing Vcmax products based on SIF, LCC, and SIF+LCC are available at https://doi.org/10.5281/zenodo.6466968 (Chen et al., 2022), and the code for implementing the ecological optimality theory is available at https://github.com/SmithEcophysLab/optimal_vcmax_R and https://doi.org/10.5281/zenodo.5899564 (last access: 31 August 2022) (Smith et al., 2022)
The Curse of Online Friends: The Detrimental Effects of Online Social Network Usage on Well-Being
In the pursuit of happiness, it has been conventionally accepted that more friends would bring us a better quality of life. However, with the advent of social networking sites, unprecedented social influence has pervaded our daily lives. Across two studies we show that even though people feel more satisfied with their lives when they view the friends added on Facebook, reading friends’ posts reduces their well-being. This is because the more friends people have on Facebook, the more ostentatious information they see. The resultant drop in life satisfaction occurs because people fail to draw a connection between the number of friends and the amount of ostentatious information. Moreover, this decrease in life satisfaction is mediated by envy. We contribute to the literature on consumer well-being by identifying a novel and ubiquitous phenomenon of making social comparisons with hundreds of people, a phenomenon that arose with the advent of social networking and was previously outside the scope of social comparison literature
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Enhancing quantum efficiency of thin-film silicon solar cells by Pareto optimality
We present a composite design methodology for the simulation and optimization of the solar cell performance. Our method is based on the synergy of different computational techniques and it is especially designed for the thin-film cell technology. In particular, we aim to efficiently simulate light trapping and plasmonic effects to enhance the light harvesting of the cell. The methodology is based on the sequential application of a hierarchy of approaches: (a) full Maxwell simulations are applied to derive the photon’s scattering probability in systems presenting textured interfaces; (b) calibrated Photonic Monte Carlo is used in junction with the scattering matrices method to evaluate coherent and scattered photon absorption in the full cell architectures; (c) the results of these advanced optical simulations are used as the pair generation terms in model implemented in an effective Technology Computer Aided Design tool for the derivation of the cell performance; (d) the models are investigated by qualitative and quantitative sensitivity analysis algorithms, to evaluate the importance of the design parameters considered on the models output and to get a first order descriptions of the objective space; (e) sensitivity analysis results are used to guide and simplify the optimization of the model achieved through both Single Objective Optimization (in order to fully maximize devices efficiency) and Multi Objective Optimization (in order to balance efficiency and cost); (f) Local, Global and “Glocal” robustness of optimal solutions found by the optimization algorithms are statistically evaluated; (g) data-based Identifiability Analysis is used to study the relationship between parameters. The results obtained show a noteworthy improvement with respect to the quantum efficiency of the reference cell demonstrating that the methodology presented is suitable for effective optimization of solar cell devices
SN 2016coi/ASASSN-16fp: an example of residual helium in a type Ic supernova?
The optical observations of Ic-4 supernova (SN) 2016coi/ASASSN-16fp, from ∼2 to ∼450 d after explosion, are presented along with analysis of its physical properties. The SN shows the broad lines associated with SNe Ic-3/4 but with a key difference. The early spectra display a strong absorption feature at ∼5400 Å which is not seen in other SNe Ic-3/4 at this epoch. This feature has been attributed to He I in the literature. Spectral modelling of the SN in the early photospheric phase suggests the presence of residual He in a C/O dominated shell. However, the behaviour of the He I lines is unusual when compared with He-rich SNe, showing relatively low velocities and weakening rather than strengthening over time. The SN is found to rise to peak ∼16 d after core-collapse reaching a bolometric luminosity of Lp∼3 × 1042 erg s−1. Spectral models, including the nebular epoch, show that the SN ejected 2.5–4 M⊙ of material, with ∼1.5 M⊙ below 5000 km s−1, and with a kinetic energy of (4.5–7) × 1051 erg. The explosion synthesized ∼0.14 M⊙ of 56Ni. There are significant uncertainties in E(B − V)host and the distance, however, which will affect Lp and MNi. SN 2016coi exploded in a host similar to the Large Magellanic Cloud (LMC) and away from star-forming regions. The properties of the SN and the host-galaxy suggest that the progenitor had MZAMS of 23–28 M⊙ and was stripped almost entirely down to its C/O core at explosion
Sources of variation in simulated ecosystem carbon storage capacity from the 5th Climate Model Intercomparison Project (CMIP5)
Ecosystem carbon (C) storage strongly regulates climate-C cycle feedback and is largely determined by both C residence time and C input from net primary productivity (NPP). However, spatial patterns of ecosystem C storage and its variation have not been well quantified in earth system models (ESMs), which is essential to predict future climate change and guide model development. We intended to evaluate spatial patterns of ecosystem C storage capacity simulated by ESMs as part of the 5th Climate Model Intercomparison Project (CMIP5) and explore the sources of multi-model variation from mean residence time (MRT) and/or C inputs. Five ESMs were evaluated, including C inputs (NPP and [gross primary productivity] GPP), outputs (autotrophic/heterotrophic respiration) and pools (vegetation, litter and soil C). ESMs reasonably simulated the NPP and NPP/GPP ratio compared with Moderate Resolution Imaging Spectroradiometer (MODIS) estimates except NorESM. However, all of the models significantly underestimated ecosystem MRT, resulting in underestimation of ecosystem C storage capacity. CCSM predicted the lowest ecosystem C storage capacity (~10 kg C m−2) with the lowest MRT values (14 yr), while MIROC-ESM estimated the highest ecosystem C storage capacity (~36 kg C m−2) with the longest MRT (44 yr). Ecosystem C storage capacity varied considerably among models, with larger variation at high latitudes and in Australia, mainly resulting from the differences in the MRTs across models. Our results indicate that additional research is needed to improve post-photosynthesis C-cycle modelling, especially at high latitudes, so that ecosystem C residence time and storage capacity can be appropriately simulated
Vitamin B6 catabolism and lung cancer risk:Results from the Lung Cancer Cohort Consortium (LC3)
Background Increased vitamin B6 catabolism related to inflammation, as measured by the PAr index (the ratio of 4-pyridoxic acid over the sum of pyridoxal and pyridoxal-5'-phosphate), has been positively associated with lung cancer risk in two prospective European studies. However, the extent to which this association translates to more diverse populations is not known. Materials and methods For this study, we included 5323 incident lung cancer cases and 5323 controls individually matched by age, sex, and smoking status within each of 20 prospective cohorts from the Lung Cancer Cohort Consortium. Cohort-specific odds ratios (ORs) and 95% confidence intervals (CIs) for the association between PAr and lung cancer risk were calculated using conditional logistic regression and pooled using random-effects models. Results PAr was positively associated with lung cancer risk in a dose-response fashion. Comparing the fourth versus first quartiles of PAr resulted in an OR of 1.38 (95% CI: 1.19-1.59) for overall lung cancer risk. The association between PAr and lung cancer risk was most prominent in former smokers (OR: 1.69, 95% CI: 1.36-2.10), men (OR: 1.60, 95% CI: 1.28-2.00), and for cancers diagnosed within 3 years of blood draw (OR: 1.73, 95% CI: 1.34-2.23). Conclusion Based on pre-diagnostic data from 20 cohorts across 4 continents, this study confirms that increased vitamin B6 catabolism related to inflammation and immune activation is associated with a higher risk of developing lung cancer. Moreover, PAr may be a pre-diagnostic marker of lung cancer rather than a causal factor
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