Dynamic cloudlet assignment problem: A column generation approach

Major interest in network optimization is currently given to the integration of clusters of virtualization servers, also referred to as 'cloudlets', into mobile access networks for improved performance and reliability. Mobile access points (APs) are assigned (i.e., route their packets) to one or more cloudlets, with a cost in terms of latency for the users they provide connections to. Assignment of APs to cloudlet can be changed over time, with a cloudlet synchronization cost. We tackle the problem of the optimal assignment of APs to cloudlets over time, proposing dedicated mathematical models and column generation algorithms

Mouse and rat ultrasonic vocalizations in neuroscience and neuropharmacology: State of the art and future applications

Mice and rats emit ultrasonic vocalizations (USVs), which may express their arousal and emotional states, to communicate with each other. There is continued scientific effort to better understand the functions of USVs as a central element of the rodent behavioral repertoire. However, studying USVs is not only important because of their ethological relevance, but also because they are widely applied as a behavioral readout in various fields of biomedical research. In mice and rats, a large number of experimental models of brain disorders exist and studying the emission of USVs in these models can provide valuable information about the health status of the animals and the effectiveness of possible interventions, both environmental and pharmacological. This review (i) provides an updated overview of the contexts in which ultrasonic calling behaviour of mice and rats has particularly high translational value, and (ii) gives some examples of novel approaches and tools used for the analysis of USVs in mice and rats, combining qualitative and quantitative methods. The relevance of age and sex differences as well as the importance of longitudinal evaluations of calling and non-calling behaviour is also discussed. Finally, the importance of assessing the communicative impact of USVs in the receiver, that is, through playback studies, is highlighted

Forest landscape restoration in the drylands of Latin America

Forest Landscape Restoration (FLR) involves the ecological restoration of degraded forest landscapes, with the aim of benefiting both biodiversity and human well-being. We first identify four fundamental principles of FLR, based on previous definitions. We then critically evaluate the application of these principles in practice, based on the experience gained during an international, collaborative research project conducted in six dry forest landscapes of Latin America. Research highlighted the potential for FLR; tree species of high socioeconomic value were identified in all study areas, and strong dependence of local communities on forest resources was widely encountered, particularly for fuelwood. We demonstrated that FLR can be achieved through both passive and active restoration approaches, and can be cost-effective if the increased provision of ecosystem services is taken into account. These results therefore highlight the potential for FLR, and the positive contribution that it could make to sustainable development. However, we also encountered a number of challenges to FLR implementation, including the difficulty of achieving strong engagement in FLR activities among local stakeholders, lack of capacity for community-led initiatives, and the lack of an appropriate institutional and regulatory environment to support restoration activities. Successful implementation of FLR will require new collaborative alliances among stakeholders, empowerment and capacity building of local communities to enable them to fully engage with restoration activities, and an enabling public policy context to enable local people to be active participants in the decision making process. © 2012 by the author(s). Published here under license by the Resilience Alliance

Análise da recente alta internacional dos preços das commodities alimentares: previsão e mudança estrutural.

Este artigo tem como objetivo analisar a alta observada entre 2007 e 2011 nos preços das commodities de alimentação em âmbito internacional, tendo como motivação os efeitos prejudiciais que a elevação dos preços desse tipo de produto causa à segurança alimentar mundial. Por meio do método de Box e Jenkins (1976), busca-se estudar o comportamento dos preços nos meses que completam o ano de 2011 e, utilizando-se a análise de quebra estrutural, procura-se comprovar a quebra estrutural no período de maior alta. O estudo permite verificar que existe uma tendência de alta nos preços dos alimentos e de mudança estrutural na base de formação deles, evidenciando a necessidade de políticas públicas, em âmbito internacional, que assistam ao problema

Mobile Edge Cloud Network Design Optimization

Major interest is currently given to the integration of clusters of virtualization servers, also referred to as 'cloudlets' or 'edge clouds', into the access network to allow higher performance and reliability in the access to mobile edge computing services. We tackle the edge cloud network design problem for mobile access networks. The model is such that the virtual machines (VMs) are associated with mobile users and are allocated to cloudlets. Designing an edge cloud network implies first determining where to install cloudlet facilities among the available sites, then assigning sets of access points, such as base stations to cloudlets, while supporting VM orchestration and considering partial user mobility information, as well as the satisfaction of service-level agreements. We present link-path formulations supported by heuristics to compute solutions in reasonable time. We qualify the advantage in considering mobility for both users and VMs as up to 20% less users not satisfied in their SLA with a little increase of opened facilities. We compare two VM mobility modes, bulk and live migration, as a function of mobile cloud service requirements, determining that a high preference should be given to live migration, while bulk migrations seem to be a feasible alternative on delay-stringent tiny-disk services, such as augmented reality support, and only with further relaxation on network constraints

Sub-kHz lasing of a CaF_2 Whispering Gallery Mode Resonator Stabilized Fiber Ring Laser

We utilize a high quality calcium fluoride whispering-gallery-mode resonator to stabilize a simple erbium doped fiber ring laser with an emission frequency of 196 THz (wavelenght 1530 nm) to a linewidth below 650 Hz. This corresponds to a relative stability of 3.3 x 10^(-12) over 16 \mus. In order to characterize the linewidth we use two identical self-built lasers and a commercial laser to determine the individual lasing linewidth via the three-cornered hat method.Comment: 4 pages, 3 figure

Protective Effects of Gynostemma pentaphyllum (var. Ginpent) against Lipopolysaccharide-Induced Inflammation and Motor Alteration in Mice

Gynostemma pentaphyllum (var. Ginpent) (GP) is a variety of Cucurbit with anti-inflammatory and antioxidant effects in patients. In this manuscript, the main components present in the dry extract of GP have been identified using Ultra High Performance Liquid Chromatography quadrupole-time-of-flight mass spectrometry (UHPLC/Q-TOF-MS). In addition, the anti-inflammatory action of GP was evaluated in animal models with acute peripheral inflammation and motor alteration induced by lipopolysaccharide. The results showed that GP dry extract is rich in secondary metabolites with potential antioxidant and anti-inflammatory properties. We found that the treatment with GP induced a recovery of motor function measured with the rotarod test and pole test, and a reduction in inflammatory cytokines such as interleukin-1\u3b2 and interleukin-6 measured with the ELISA test. The data collected in this study on the effects of GP in in vivo models may help integrate the therapeutic strategies of inflammatory-based disorders

Investigating cortical excitability and inhibition in patients with schizophrenia: A TMS-EEG study.

Transcranial magnetic stimulation (TMS) combined with electromyography (EMG) has widely been used as a non-invasive brain stimulation tool to assess excitation/inhibition (E/I) balance. E/I imbalance is a putative mechanism underlying symptoms in patients with schizophrenia. Combined TMS-electroencephalography (TMS-EEG) provides a detailed examination of cortical excitability to assess the pathophysiology of schizophrenia. This study aimed to investigate differences in TMS-evoked potentials (TEPs), TMS-related spectral perturbations (TRSP) and intertrial coherence (ITC) between patients with schizophrenia and healthy controls. TMS was applied over the motor cortex during EEG recording. Differences in TEPs, TRSP and ITC between the patient and healthy subjects were analysed for all electrodes at each time point, by applying multiple independent sample t-tests with a cluster-based permutation analysis to correct for multiple comparisons. Patients demonstrated significantly reduced amplitudes of early and late TEP components compared to healthy controls. Patients also showed a significant reduction of early delta (50-160 ms) and theta TRSP (30-250ms),followed by a reduction in alpha and beta suppression (220-560 ms; 190-420 ms). Patients showed a reduction of both early (50-110 ms) gamma increase and later (180-230 ms) gamma suppression. Finally, the ITC was significantly lower in patients in the alpha band, from 30 to 260 ms. Our findings support the putative role of impaired GABA-receptor mediated inhibition in schizophrenia impacting excitatory neurotransmission. Further studies can usefully elucidate mechanisms underlying specific symptoms clusters using TMS-EEG biometrics. [Abstract copyright: Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.

Transcranial evoked potentials can be reliably recorded with active electrodes

Electroencephalographic (EEG) signals evoked by transcranial magnetic stimulation (TMS) are usually recorded with passive electrodes (PE). Active electrode (AE) systems have recently become widely available; compared to PE, they allow for easier electrode preparation and a higher-quality signal, due to the preamplification at the electrode stage, which reduces electrical line noise. The performance between the AE and PE can differ, especially with fast EEG voltage changes, which can easily occur with TMS-EEG; however, a systematic comparison in the TMS-EEG setting has not been made. Therefore, we recorded TMS-evoked EEG potentials (TEPs) in a group of healthy subjects in two sessions, one using PE and the other using AE. We stimulated the left primary motor cortex and right medial prefrontal cortex and used two different approaches to remove early TMS artefacts, Independent Component Analysis and Signal Space Projection—Source Informed Recovery. We assessed statistical differences in amplitude and topography of TEPs, and their similarity, by means of the concordance correlation coefficient (CCC). We also tested the capability of each system to approximate the final TEP waveform with a reduced number of trials. The results showed that TEPs recorded with AE and PE do not differ in amplitude and topography, and only few electrodes showed a lower-than-expected CCC between the two methods of amplification. We conclude that AE are a viable solution for TMS-EEG recording