A MIDI sequencer that widens access to the compositional possibilities of novel tunings

We present a new Dynamic Tonality MIDI sequencer, Hex, that aims to make sequencing music in and across a large variety of novel tunings as straightforward as sequencing in twelve-tone equal temperament. It replaces the piano roll used in conventional MIDI sequencers with a two-dimensional lattice roll in order to enable the intuitive visualization and dynamic manipulation of tuning. In conventional piano roll sequencers, a piano keyboard is displayed on the left side of the window, and white and black note lanes extend horizontally to the right, into which a user can draw a sequence of notes. Similarly, in Hex, a button lattice is displayed in its own pane on the left side of the window, and horizontal lines are drawn from the center of each note to the right. These lines function as generalized note lanes, just like in piano roll sequencers, but with the added benefit that each note lane's height is always proportional to its pitch, even if the user changes the tuning. The presence of the button lattice on the left side of the window illustrates exactly which buttons a performer would play in order to replicate the sequence when playing a physical button lattice instrument

Spectral tools for Dynamic Tonality and audio morphing

The analysis-resynthesis method used by the spectral toolbox allows the independent control of both frequency and amplitude for every partial in a given sound. The spectral toolbox begins by separating the 'signal' from the 'noise' which allows the peaks in the spectrum to be treated differently from the wide-band components. The spectral mapping technology is used to map the input to a fixed destination spectrum G like the SpT.Ntet routine maps all partials of the input sound to scale steps of the N-tone equal tempered scale that can be used to create sounds that are particularly appropriate for use in a given N-TET scale. Spectral morphing generates sound that moves smoothly between a source spectrum F and a destination spectrum G over a specified time t. A Dynamic Tonality synthesizer like Trans-FormSynth has a small number of parameters that enable many musically useful, and relatively, unexplored features like the continuous parameters α,β and γ move the tuning between a number of equal temperaments, non-equal temperaments and circulating temperaments

Does Bypass of the Proximal Small Intestine Impact Food Intake, Preference, and Taste Function in Humans? An Experimental Medicine Study Using the Duodenal-Jejunal Bypass Liner

The duodenal-jejunal bypass liner (Endobarrier) is an endoscopic treatment for obesity and type 2 diabetes mellitus (T2DM). It creates exclusion of the proximal small intestine similar to that after Roux-en-Y Gastric Bypass (RYGB) surgery. The objective of this study was to employ a reductionist approach to determine whether bypass of the proximal intestine is the component conferring the effects of RYGB on food intake and sweet taste preference using the Endobarrier as a research tool. A nested mechanistic study within a large randomised controlled trial compared the impact of lifestyle modification with vs. without Endobarrier insertion in patients with obesity and T2DM. Forty-seven participants were randomised and assessed at several timepoints using direct and indirect assessments of food intake, food preference and taste function. Patients within the Endobarrier group lost numerically more weight compared to the control group. Using food diaries, our results demonstrated similar reductions of food intake in both groups. There were no significant differences in food preference and sensory, appetitive reward, or consummatory reward domain of sweet taste function between groups or changes within groups. In conclusion, the superior weight loss seen in patients with obesity and T2DM who underwent the Endobarrier insertion was not due to a reduction in energy intake or change in food preferences