Awareness On Recent Trends of Global Climate Change

Climate change is defined as a change in the statistical properties of meteorological variables, which are considered over a long period of time, regardless of the cause. Modern climate change is mainly dominated by human influences, which is now large enough to exceed the bounds of natural variability. The main sources of global climate change are human induced changes in the atmospheric composition. Changes to the climate system is observed at a global scale through measurement of temperature at the surface in the middle of the atmosphere, increased sea level, increased sea surface temperature, increased ocean heat content and water vapour in the atmosphere. The decrease in polar ice sheet, decreased global sea ice content, and the net decrease in glacier volumes were all observed. The aim of the study is to assess the recent trends of global climate change & create awareness among the public based on the topic. A questionnaire comprising 15 questions was circulated among 100 participants with the aid of an online survey platform. The data collection was performed using Google forms. The statistical analysis was done using SPSS software. When inquired about the awareness of the risks of global warming, 99% of the participants responded positively. It was observed that, according to the participants’ opinion, global climate change is too late to be prevented or reduced. 80% of the participants believe that a technological breakthrough would influence climate change and global warming rates. The participants of the survey were questioned whether global warming was linked to extreme weather events like hurricanes et cetera, and 96% of the participants responded positively. When they were questioned about their awareness and impacts of global climate change on the future, the majority responded that it would result in rise in sea levels, as well as a rise in global temperature. The recent trends of global climate change was studied, surveyed and demonstrated that this climate change has a vast impact on the future. It must be reduced to maximum to avoid complex circumstances in the future

Fibro-inflammatory recovery and type 2 diabetes remission following a low calorie diet but not exercise training: A secondary analysis of the DIASTOLIC randomised controlled trial

AimsTo investigate the relationship between fibro-inflammatory biomarkers and cardiovascular structure/function in people with Type 2 Diabetes (T2D) compared to healthy controls and the effect of two lifestyle interventions in T2D.MethodsData were derived from the DIASTOLIC randomised controlled trial (RCT) and includes a comparison between those with T2D and the matched healthy volunteers recruited at baseline. Adults with T2D without cardiovascular disease (CVD) were randomized to a 12-week intervention either: (1) exercise training, (2) a low-energy (∼810 kcal/day) meal-replacement plan (MRP) or (3) standard care. Principal Component and Fisher's linear discriminant analysis were used to investigate the relationships between MRI acquired cardiovascular outcomes and fibro-inflammatory biomarkers in cases versus controls and pre- and post-intervention in T2D.ResultsAt baseline, 83 people with T2D (mean age 50.5 ± 6.4; 58% male) and 36 healthy controls (mean age 48.6 ± 6.2; 53% male) were compared and 76 people with T2D completed the RCT for pre- post-analysis. Compared to healthy controls, subjects with T2D had adverse cardiovascular remodelling and a fibro-inflammatory profile (20 differentially expressed biomarkers). The 3D data visualisations showed almost complete separation between healthy controls and those with T2D, and a marked shift towards healthy controls following the MRP (15 biomarkers significantly changed) but not exercise training.ConclusionsFibro-inflammatory pathways and cardiovascular structure/function are adversely altered before the onset of symptomatic CVD in middle-aged adults with T2D. The MRP improved the fibro-inflammatory profile of people with T2D towards a more healthy status. Long-term studies are required to assess whether these changes lead to continued reverse cardiac remodelling and prevent CVD

Association of Quantitative and Qualitative Dermatoglyphic Variable and DNA Polymorphism in Female Breast Cancer Population

Objective: To investigate the association between dermatoglyphics and the DNA repair genetic variants in female breast carcinoma. Methodology: The distinct dermatoglyphic variables include ≥ six whorls, Finger ridge counts, A-B Ridge Count, ATD angle and Pattern intensity Index are analyzed for its association with the DNA repair variants namely XRCC1 Arg194Trp, XRCC3Thr241Met, ERCC4Arg 415Gln, and ERCC5 Asp1104His. The statistical procedure used to analyze the frequency of association is odds ratio and relative risk ratio. Result:The results suggests that the relative risk is about 2 to 4 times with statistical significance for breast cancer and high risk group for the genes XRCC1 Arg194Trp, ERCC4 Arg 415 Gln, ERCC5 Asp1104His in their dominant model in both breast cancer and high risk group for six or more whorls, Pattern Intensity Index, A-B RC. Conclusion: It can be suggested that dermal ridges can be used as an effective biomarker of genomic instability in breast cancer

Efficacy of vaginal weights in pelvic floor dysfunction: A systematic review and meta-analysis

Pelvic floor dysfunction (PFD) affects women's quality of life because the pelvic floor muscles are unable to contract and relax properly. Kegel exercise is the first line of treatment for PFD, while vaginal cones with weights have recently been used for pelvic floor strengthening. When compared to alternative treatments, various studies have evaluated the effectiveness of vaginal weights or cones in treating PFD. However, there are controversial conclusions reached when the effectiveness of vaginal weights is compared in various ways. The purpose of this study was determine the effectiveness of vaginal weights compared with other interventions in reducing the symptoms of PFD. Using various databases, an extensive literature search was conducted, and a randomised control trial examining the usefulness of vaginal weights in PFD was identified. PRISMA guidelines were used to synthesize the data. The risk of bias tools were used to assess the quality of the selected studies. Results suggest that vaginal cones are effective in treating PFD. However, when it was compared with other treatment modalities, no significant differences were found. Hence, the results are equivocal and cannot be generalized

Protein profile study of pap smear and cervix biopsy tissues using high performance liquid chromatography (HPLC)-laser induced fluorescence (LIF)

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Integrated multi-omics analysis reveals the molecular interplay between circadian clocks and cancer pathogenesis

Abstract Circadian rhythms (CRs) are fundamental biological processes that significantly impact human well-being. Disruption of these rhythms can trigger insufficient neurocognitive development, insomnia, mental disorders, cardiovascular diseases, metabolic dysfunctions, and cancer. The field of chronobiology has increased our understanding of how rhythm disturbances contribute to cancer pathogenesis, and how circadian timing influences the efficacy of cancer treatments. As the circadian clock steadily gains recognition as an emerging factor in tumorigenesis, a thorough and comprehensive multi-omics analysis of CR genes/proteins has never been performed. To shed light on this, we performed, for the first time, an integrated data analysis encompassing genomic/transcriptomic alterations across 32 cancer types (n = 10,918 tumors) taken from the PanCancer Atlas, unfavorable prognostic protein analysis, protein–protein interactomics, and shortest distance score pathways to cancer hallmark phenotypes. This data mining strategy allowed us to unravel 31 essential CR-related proteins involved in the signaling crossroad between circadian rhythms and cancer. In the context of drugging the clock, we identified pharmacogenomic clinical annotations and drugs currently in late phase clinical trials that could be considered as potential cancer therapeutic strategies. These findings highlight the diverse roles of CR-related genes/proteins in the realm of cancer research and therapy

Fibro-inflammatory recovery and type 2 diabetes remission following a low calorie diet but not exercise training: a secondary analysis of the DIASTOLIC randomised controlled trial

To investigate the relationship between fibro-inflammatory biomarkers and cardiovascular structure/function in people with Type 2 Diabetes (T2D) compared to healthy controls and the effect of two lifestyle interventions in T2D. Data were derived from the DIASTOLIC randomised controlled trial (RCT) and includes a comparison between those with T2D and the matched healthy volunteers recruited at baseline. Adults with T2D without cardiovascular disease (CVD) were randomized to a 12-week intervention either: 1) exercise training, 2) a low-energy (∼810 kcal/day) meal-replacement plan (MRP) or 3) standard care. Principal Component and Fisher's linear discriminant analysis were used to investigate the relationships between MRI acquired cardiovascular outcomes and fibro-inflammatory biomarkers in cases versus controls and pre-and post-intervention in T2D. At baseline, 83 people with T2D (mean age 50.5 ± 6.4; 58% male) and 36 healthy controls (mean age 48.6 ± 6.2; 53 % male) were compared and 76 people with T2D completed the RCT for pre- post-analysis. Compared to healthy controls, subjects with T2D had adverse cardiovascular remodelling and a fibro-inflammatory profile (20 differentially expressed biomarkers). The 3D data visualisations showed almost complete separation between healthy controls and those with T2D, and a marked shift towards healthy controls following the MRP (15 biomarkers significantly changed) but not exercise training. Fibro-inflammatory pathways and cardiovascular structure/function are adversely altered before the onset of symptomatic CVD in middle-aged adults with T2D. The MRP improved the fibro-inflammatory profile of people with T2D towards a more healthy status. Long-term studies are required to assess whether these changes lead to continued reverse cardiac remodelling and prevent CVD.</p