102 research outputs found
Dense gas in nearby galaxies XVI. The nuclear starburst environment in NGC4945
A multi-line millimeter-wave study of the nearby starburst galaxy NGC 4945
has been carried out using the Swedish-ESO Submillimeter Telescope (SEST). The
study covers the frequency range from 82 GHz to 354 GHz and includes 80
transitions of 19 molecules. 1.3 mm continuum data of the nuclear source are
also presented. A large number of molecular species indicate the presence of a
prominent high density interstellar gas component characterized by cm. Abundances of molecular species are calculated and
compared with abundances observed toward the starburst galaxies NGC 253 and M
82 and galactic sources. Apparent is an `overabundance' of HNC in the nuclear
environment of NGC 4945. While the HNC/HCN =1--0 line intensity ratio is
0.5, the HNC/HCN abundance ratio is 1. While HCN is subthermally
excited (8 K), CN is even less excited (3--4
K), indicating that it arises from a less dense gas component and that its
=2--1 line can be optically thin even though its =1--0 emission is
moderately optically thick. Overall, fractional abundances of NGC 4945 suggest
that the starburst has reached a stage of evolution that is intermediate
between those observed in NGC 253 and M 82. Carbon, nitrogen, oxygen and sulfur
isotope ratios are also determined. Within the limits of uncertainty, carbon
and oxygen isotope ratios appear to be the same in the nuclear regions of NGC
4945 and NGC 253. High O/O, low O/O and
N/N and perhaps also low S/S ratios appear to be
characteristic properties of a starburst environment in which massive stars
have had sufficient time to affect the isotopic composition of the surrounding
interstellar medium.Comment: 26 pages, 16 figures, accepted bt A&
Multi-stakeholder consensus on a target product profile for an HIV cure
Developing a cure for HIV is a global priority. Target product profiles are a tool commonly used throughout the drug development process to align interested parties around a clear set of goals or requirements for a potential product. Three distinct therapeutic modalities (combination therapies, ex-vivo gene therapy, and in-vivo gene therapy) for a target product profile for an HIV cure were identified. Using a process of expert face-to-face consultation and an online Delphi consultation, we found a high degree of agreement regarding the criteria for the optimum target product profile. Although the minimum attributes for a cure were debated, the broad consensus was that an acceptable cure need not be as safe and effective as optimally delivered antiretroviral therapy. An intervention that successfully cured a reasonable fraction of adults would be sufficient to advance to the clinic. These target product profiles will require further discussion and ongoing revisions as the field matures
Multi-stakeholder consensus on a target product profile for an HIV cure
Developing a cure for HIV is a global priority. Target product profiles are a tool commonly used throughout the drug development process to align interested parties around a clear set of goals or requirements for a potential product. Three distinct therapeutic modalities (combination therapies, ex-vivo gene therapy, and in-vivo gene therapy) for a target product profile for an HIV cure were identified. Using a process of expert face-to-face consultation and an online Delphi consultation, we found a high degree of agreement regarding the criteria for the optimum target product profile. Although the minimum attributes for a cure were debated, the broad consensus was that an acceptable cure need not be as safe and effective as optimally delivered antiretroviral therapy. An intervention that successfully cured a reasonable fraction of adults would be sufficient to advance to the clinic. These target product profiles will require further discussion and ongoing revisions as the field matures
Molecular excitation in the Interstellar Medium: recent advances in collisional, radiative and chemical processes
We review the different excitation processes in the interstellar mediumComment: Accepted in Chem. Re
The case for an HIV cure and how to get there
In light of the increasing global burden of new HIV infections, growing financial requirements, and shifting funding landscape, the global health community must accelerate the development and delivery of an HIV cure to complement existing prevention modalities. An effective curative intervention could prevent new infections, overcome the limitations of antiretroviral treatment, combat stigma and discrimination, and provide a sustainable financial solution for pandemic control. We propose steps to plan for an HIV cure now, including defining a target product profile and establishing the HIV Cure Africa Acceleration Partnership (HCAAP), a multidisciplinary public-private partnership that will catalyse and promote HIV cure research through diverse stakeholder engagement. HCAAP will convene stakeholders, including people living with HIV, at an early stage to accelerate the design, social acceptability, and rapid adoption of HIV-cure products
The CHESS chemical Herschel surveys of star forming regions: Peering into the protostellar shock L1157-B1. I. Shock chemical complexity
We present the first results of the unbiased survey of the L1157-B1 bow
shock, obtained with HIFI in the framework of the key program Chemical Herschel
surveys of star forming regions (CHESS). The L1157 outflow is driven by a
low-mass Class 0 protostar and is considered the prototype of the so-called
chemically active outflows. The bright blue-shifted bow shock B1 is the ideal
laboratory for studying the link between the hot (around 1000-2000 K) component
traced by H2 IR-emission and the cold (around 10-20 K) swept-up material. The
main aim is to trace the warm gas chemically enriched by the passage of a shock
and to infer the excitation conditions in L1157-B1. A total of 27 lines are
identified in the 555-636 GHz region, down to an average 3 sigma level of 30
mK. The emission is dominated by CO(5-4) and H2O(110-101) transitions, as
discussed by Lefloch et al. (2010). Here we report on the identification of
lines from NH3, H2CO, CH3OH, CS, HCN, and HCO+. The comparison between the
profiles produced by molecules released from dust mantles (NH3, H2CO, CH3OH)
and that of H2O is consistent with a scenario in which water is also formed in
the gas-phase in high-temperature regions where sputtering or grain-grain
collisions are not efficient. The high excitation range of the observed tracers
allows us to infer, for the first time for these species, the existence of a
warm (> 200 K) gas component coexisting in the B1 bow structure with the cold
and hot gas detected from ground
Social and ethical checkpoints for bottom-up synthetic biology, or protocells
An alternative to creating novel organisms through the traditional âtop-downâ approach to synthetic biology involves creating them from the âbottom upâ by assembling them from non-living components; the products of this approach are called âprotocells.â In this paper we describe how bottom-up and top-down synthetic biology differ, review the current state of protocell research and development, and examine the unique ethical, social, and regulatory issues raised by bottom-up synthetic biology. Protocells have not yet been developed, but many expect this to happen within the next five to ten years. Accordingly, we identify six key checkpoints in protocell development at which particular attention should be given to specific ethical, social and regulatory issues concerning bottom-up synthetic biology, and make ten recommendations for responsible protocell science that are tied to the achievement of these checkpoints
Smoke, curtains and mirrors: the production of race through time and title registration
This article analyses the temporal effects of title registration and their relationship to race. It traces the move away from the retrospection of pre-registry common law conveyancing and toward the dynamic, future-oriented Torrens title registration system. The Torrens system, developed in early colonial Australia, enabled the production of âcleanâ, fresh titles that were independent of their predecessors. Through a process praised by legal commentators for âcuringâ titles of their pasts, this system produces indefeasible titles behind its distinctive âcurtainâ and âmirrorâ, which function similarly to magiciansâ smoke and mirrors by blocking particular realities from view. In the case of title registries, those realities are particular histories of and relationships with land, which will not be protected by property law and are thus made precarious. Building on interdisciplinary work which theorises time as a social tool, I argue that Torrens title registration produces a temporal order which enables land market coordination by rendering some relationships with land temporary and making others indefeasible. This ordering of relationships with land in turn has consequences for the human subjects who have those relationships, cutting futures short for some and guaranteeing permanence to others. Engaging with Renisa Mawani and other critical race theorists, I argue that the categories produced by Torrens title registration systems materialise as race
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