Renewable energy scenarios:exploring technology, acceptance and climate – options at the community-scale

Community-based renewable energy could play a key role in the transition to a low carbon society. This paper argues that given the right environmental and societal conditions, communities in the UK could source a high percentage of their electricity supply from a mixture of localised renewable electricity technologies. Here we use exploratory scenarios to assess demand and renewable electricity supply-side options at the community-scale for a location in Cumbria, UK. Three scenarios are presented, using narratives of how local demand and renewable electricity supply could be constructed under either existing or modified environmental and societal conditions. The three scenarios explored were ‘Current State of Play’, ‘Low Carbon Adjusted Society’ and ‘Reluctant Scenario’

Radio and X-ray observations of SN 2006jd: Another strongly interacting Type IIn supernova

We report four years of radio and X-ray monitoring of the Type IIn supernova SN 2006jd at radio wavelengths with the Very Large Array, Giant Metrewave Radio Telescope and Expanded Very Large Array; at X-ray wavelengths with {\em Chandra}, {\em XMM-Newton} and {\em Swift}-XRT. We assume that the radio and X-ray emitting particles are produced by shock interaction with a dense circumstellar medium. The radio emission shows an initial rise that can be attributed to free-free absorption by cool gas mixed into the nonthermal emitting region; external free-free absorption is disfavored because of the shape of the rising light curves and the low gas column density inferred along the line of sight to the emission region. The X-ray luminosity implies a preshock circumstellar density $\sim 10^6$ cm$^{-3}$ at a radius $r\sim 2\times 10^{16}$ cm, but the column density inferred from the photoabsorption of X-rays along the line of sight suggests a significantly lower density. The implication may be an asymmetry in the interaction. The X-ray spectrum shows Fe line emission at 6.9 keV that is stronger than is expected for the conditions in the X-ray emitting gas. We suggest that cool gas mixed into the hot gas plays a role in the line emission. Our radio and X-ray data both suggest the density profile is flatter than $r^{-2}$ because of the slow evolution of the unabsorbed emission.Comment: Accepted for publication in ApJ without any change

The Chandra view of the Largest Quasar Lens SDSS J1029+2623

We present results from Chandra observations of the cluster lens SDSS J1029+2623 at z_l=0.58, which is a gravitationally lensed quasar with the largest known image separation. We clearly detect X-ray emission both from the lensing cluster and the three lensed quasar images. The cluster has an X-ray temperature of kT = 8.1 (+2.0, -1.2) keV and bolometric luminosity of L_X = 9.6e44 erg s^-1. Its surface brightness is centered near one of the brightest cluster galaxies, and it is elongated East-West. We identify a subpeak North-West of the main peak, which is suggestive of an ongoing merger. Even so, the X-ray mass inferred from the hydrostatic equilibrium assumption appears to be consistent with the lensing mass from the Einstein radius of the system. We find significant absorption in the soft X-ray spectrum of the faintest quasar image, which can be caused by an intervening material at either the lens or source redshift. The X-ray flux ratios between the quasar images (after correcting for absorption) are in reasonable agreement with those at optical and radio wavelengths, and all the flux ratios are inconsistent with those predicted by simple mass models. This implies that microlensing effect is not significant for this system and dark matter substructure is mainly responsible for the anomalous flux ratios.Comment: 35 pages, 8 figures. Accepted for publication in Ap

X-ray, Optical, and Radio Observations of the Type II Supernovae 1999em and 1998S

Observations of the Type II-P (plateau) Supernova (SN) 1999em and Type IIn (narrow emission line) SN 1998S have enabled estimation of the profile of the SN ejecta, the structure of the circumstellar medium (CSM) established by the pre-SN stellar wind, and the nature of the shock interaction. SN 1999em is the first Type II-P detected at both X-ray and radio wavelengths. The Chandra X-ray data indicate non-radiative interaction of SN ejecta with a power-law density profile (rho \propto r^{-n} with n ~ 7) with a pre-SN wind with a low mass-loss rate of ~2 \times 10^{-6} M_sun/yr for a wind velocity of 10 km/sec, in agreement with radio mass-loss rate estimates. The Chandra data show an unexpected, temporary rise in the 0.4--2.0 keV X-ray flux at ~100 days after explosion. SN 1998S, at an age of >3 years, is still bright in X-rays and is increasing in flux density at cm radio wavelengths. Spectral fits to the Chandra data show that many heavy elements (Ne, Al, Si, S, Ar, and Fe) are overabundant with respect to solar values. We compare the observed elemental abundances and abundance ratios to theoretical calculations and find that our data are consistent with a progenitor mass of approximately 15-20 M_sun if the heavy element ejecta are radially mixed out to a high velocity. If the X-ray emission is from the reverse shock wave region, the supernova density profile must be moderately flat at a velocity ~10^4 km/sec, the shock front is non-radiative at the time of the observations, and the mass-loss rate is 1-2 \times 10^{-4} M_sun/yr for a pre-supernova wind velocity of 10 km/sec. This result is also supported by modeling of the radio emission which implies that SN 1998S is surrounded by a clumpy or filamentary CSM established by a high mass-loss rate, ~2 \times 10^{-4} M_sun/yr, from the pre-supernova star.Comment: 14 pages, 10 figures, accepted by ApJ, includes new data (one new obs. each of SN 1999em and SN 1998S), expanded discussion of spectral fit

Circumstellar Emission from Type Ib and Ic Supernovae

The presumed Wolf-Rayet star progenitors of Type Ib/c supernovae have fast, low density winds and the shock waves generated by the supernova interaction with the wind are not expected to be radiative at typical times of observation. The injected energy spectrum of radio emitting electrons typically has an observed index p=3, which is suggestive of acceleration in cosmic ray dominated shocks. The early, absorbed part of the radio light curves can be attributed to synchrotron self-absorption, which leads to constraints on the magnetic field in the emitting region and on the circumstellar density. The range of circumstellar densities inferred from the radio emission is somewhat broader than that for Galactic Wolf-Rayet stars, if similar efficiencies of synchrotron emission are assumed in the extragalactic supernovae. For the observed and expected ranges of circumstellar densities to roughly overlap, a high efficiency of magnetic field production in the shocked region is required (epsilon_B ~ 0.1). For the expected densities around a Wolf-Rayet star, a nonthermal mechanism is generally required to explain the observed X-ray luminosities of Type Ib/c supernovae. Although the inverse Compton mechanism can explain the observed X-ray emission from SN 2002ap if the wind parameters are taken from the radio model, the mechanism is not promising for other supernovae unless the postshock magnetic energy density is much smaller than the electron energy density. In some cases another mechanism is definitely needed and we suggest that it is X-ray synchrotron emission in a case where the shock wave is cosmic ray dominated so that the electron energy spectrum flattens at high energy. More comprehensive X-ray observations of a Type Ib/c supernova are needed to determine whether this suggestion is correct.Comment: 31 pages, 2 figures, ApJ, accepted, corrected typ

Near-Infrared Photometry of the Type IIn SN 2005ip: The Case for Dust Condensation

Near-infrared photometric observations of the Type IIn SN 2005ip in NGC 2906 reveal large fluxes (>1.3 mJy) in the K_s-band over more than 900 days. While warm dust can explain the late-time K_s-band emission of SN 2005ip, the nature of the dust heating source is ambiguous. Shock heating of pre-existing dust by post-shocked gas is unlikely because the forward shock is moving too slowly to have traversed the expected dust-free cavity by the time observations first reveal the K_s emission. While an infrared light echo model correctly predicts a near-infrared luminosity plateau, heating dust to the observed temperatures of ~1400-1600 K at a relatively large distance from the supernova (> 10^{18} cm) requires an extraordinarily high early supernova luminosity (~1 X 10^{11} L_solar). The evidence instead favors condensing dust in the cool, dense shell between the forward and reverse shocks. Both the initial dust temperature and the evolutionary trend towards lower temperatures are consistent with this scenario. We infer that radiation from the circumstellar interaction heats the dust. While this paper includes no spectroscopic confirmation, the photometry is comparable to other SNe that do show spectroscopic evidence for dust formation. Observations of dust formation in SNe are sparse, so these results provide a rare opportunity to consider SNe Type IIn as dust sources.Comment: 11 pages, 6 figures, 3 tables, Accepted for Publication to ApJ: January 20, 200

Reproducibility of telomere length assessment: an international collaborative study

BACKGROUND: Telomere length is a putative biomarker of ageing, morbidity and mortality. Its application is hampered by lack of widely applicable reference ranges and uncertainty regarding the present limits of measurement reproducibility within and between laboratories. METHODS: We instigated an international collaborative study of telomere length assessment: 10 different laboratories, employing 3 different techniques [Southern blotting, single telomere length analysis (STELA) and real-time quantitative PCR (qPCR)] performed two rounds of fully blinded measurements on 10 human DNA samples per round to enable unbiased assessment of intra- and inter-batch variation between laboratories and techniques. RESULTS: Absolute results from different laboratories differed widely and could thus not be compared directly, but rankings of relative telomere lengths were highly correlated (correlation coefficients of 0.63-0.99). Intra-technique correlations were similar for Southern blotting and qPCR and were stronger than inter-technique ones. However, inter-laboratory coefficients of variation (CVs) averaged about 10% for Southern blotting and STELA and more than 20% for qPCR. This difference was compensated for by a higher dynamic range for the qPCR method as shown by equal variance after z-scoring. Technical variation per laboratory, measured as median of intra- and inter-batch CVs, ranged from 1.4% to 9.5%, with differences between laboratories only marginally significant (P = 0.06). Gel-based and PCR-based techniques were not different in accuracy. CONCLUSIONS: Intra- and inter-laboratory technical variation severely limits the usefulness of data pooling and excludes sharing of reference ranges between laboratories. We propose to establish a common set of physical telomere length standards to improve comparability of telomere length estimates between laboratories

No evidence that protein truncating variants in BRIP1 are associated with breast cancer risk: implications for gene panel testing.

BACKGROUND: BRCA1 interacting protein C-terminal helicase 1 (BRIP1) is one of the Fanconi Anaemia Complementation (FANC) group family of DNA repair proteins. Biallelic mutations in BRIP1 are responsible for FANC group J, and previous studies have also suggested that rare protein truncating variants in BRIP1 are associated with an increased risk of breast cancer. These studies have led to inclusion of BRIP1 on targeted sequencing panels for breast cancer risk prediction. METHODS: We evaluated a truncating variant, p.Arg798Ter (rs137852986), and 10 missense variants of BRIP1, in 48 144 cases and 43 607 controls of European origin, drawn from 41 studies participating in the Breast Cancer Association Consortium (BCAC). Additionally, we sequenced the coding regions of BRIP1 in 13 213 cases and 5242 controls from the UK, 1313 cases and 1123 controls from three population-based studies as part of the Breast Cancer Family Registry, and 1853 familial cases and 2001 controls from Australia. RESULTS: The rare truncating allele of rs137852986 was observed in 23 cases and 18 controls in Europeans in BCAC (OR 1.09, 95% CI 0.58 to 2.03, p=0.79). Truncating variants were found in the sequencing studies in 34 cases (0.21%) and 19 controls (0.23%) (combined OR 0.90, 95% CI 0.48 to 1.70, p=0.75). CONCLUSIONS: These results suggest that truncating variants in BRIP1, and in particular p.Arg798Ter, are not associated with a substantial increase in breast cancer risk. Such observations have important implications for the reporting of results from breast cancer screening panels.The COGS project is funded through a European Commission's Seventh Framework Programme grant (agreement number 223175 - HEALTH-F2-2009-223175). BCAC is funded by Cancer Research UK [C1287/A10118, C1287/A12014] and by the European Community´s Seventh Framework Programme under grant agreement number 223175 (grant number HEALTH-F2-2009-223175) (COGS). Funding for the iCOGS infrastructure came from: the European Community's Seventh Framework Programme under grant agreement n° 223175 (HEALTH-F2-2009-223175) (COGS), Cancer Research UK (C1287/A10118, C1287/A 10710, C12292/A11174, C1281/A12014, C5047/A8384, C5047/A15007, C5047/A10692, C8197/A16565), the National Institutes of Health (CA128978) and Post-Cancer GWAS initiative (1U19 CA148537, 1U19 16 CA148065 and 1U19 CA148112 - the GAME-ON initiative), the Department of Defense (W81XWH-10-1- 0341), the Canadian Institutes of Health Research (CIHR) for the CIHR Team in Familial Risks of Breast Cancer, Komen Foundation for the Cure, the Breast Cancer Research Foundation, and the Ovarian Cancer Research Fund. This study made use of data generated by the Wellcome Trust Case Control consortium. Funding for the project was provided by the Wellcome Trust under award 076113. The results published here are in part based upon data generated by The Cancer Genome Atlas Project established by the National Cancer Institute and National Human Genome Research Institute.This is the author accepted manuscript. The final version is available from BMJ Group at http://dx.doi.org/10.1136/jmedgenet-2015-103529

Breast cancer risk variants at 6q25 display different phenotype associations and regulate ESR1, RMND1 and CCDC170.

We analyzed 3,872 common genetic variants across the ESR1 locus (encoding estrogen receptor α) in 118,816 subjects from three international consortia. We found evidence for at least five independent causal variants, each associated with different phenotype sets, including estrogen receptor (ER(+) or ER(-)) and human ERBB2 (HER2(+) or HER2(-)) tumor subtypes, mammographic density and tumor grade. The best candidate causal variants for ER(-) tumors lie in four separate enhancer elements, and their risk alleles reduce expression of ESR1, RMND1 and CCDC170, whereas the risk alleles of the strongest candidates for the remaining independent causal variant disrupt a silencer element and putatively increase ESR1 and RMND1 expression.This is the author accepted manuscript. The final version is available from Nature Publishing Group via http://dx.doi.org/10.1038/ng.352