19 research outputs found

    Genome-Wide Interaction Analyses between Genetic Variants and Alcohol Consumption and Smoking for Risk of Colorectal Cancer

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    Genome-wide association studies (GWAS) have identified many genetic susceptibility loci for colorectal cancer (CRC). However, variants in these loci explain only a small proportion of familial aggregation, and there are likely additional variants that are associated with CRC susceptibility. Genome-wide studies of gene-environment interactions may identify variants that are not detected in GWAS of marginal gene effects. To study this, we conducted a genome-wide analysis for interaction between genetic variants and alcohol consumption and cigarette smoking using data from the Colon Cancer Family Registry (CCFR) and the Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO). Interactions were tested using logistic regression. We identified interaction between CRC risk and alcohol consumption and variants in the 9q22.32/HIATL1 (Pinteraction = 1.76×10−8; permuted pvalue 3.51x10-8) region. Compared to non-/occasional drinking light to moderate alcohol consumption was associated with a lower risk of colorectal cancer among individuals with rs9409565 CT genotype (OR, 0.82 [95% CI, 0.74±0.91]; P = 2.1×10−4) and TT genotypes (OR,0.62 [95% CI, 0.51±0.75]; P = 1.3×10−6) but not associated among those with the CC genotype (p = 0.059). No genome-wide statistically significant interactions were observed for smoking. If replicated our suggestive finding of a genome-wide significant interaction between genetic variants and alcohol consumption might contribute to understanding colorectal cancer etiology and identifying subpopulations with differential susceptibility to the effect of alcohol on CRC risk

    Preliminary studies show yield and quality potential of organic cotton

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    For three years (1993 to 1995), we monitored organically and conventionally managed cotton fields in Madera County, and measured pest and beneficial arthropod populations, plant growth and development parameters, nutrient status, plant density, yields and lint quality. Square (flower bud) retention was similar in the two systems, although western tarnished plant bugs (Lygus hesperus or lygus bugs) were significantly more abundant on several dates in the organic fields. On most dates, populations of the predatory insects Geocoris spp. were significantly higher in the organic than in the conventional fields. Lint yields were not significantly different for the two production systems in any of the three years, but were lower than county averages in all years. In 1994, lint quality in the two treatments differed in that color grades were more variable in the organic cotton bales. Late spring rains also affected planting success in each year and the shortened seasons in 1994 and 1995 generally kept yields in both treatments at or below two bales per acre

    Preliminary studies show yield and quality potential of organic cotton

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