Factors affecting mortality in COVID-19 patients treated with tocilizumab

The aim of our study was to evaluate the risk factors associated with mortality in COVID-19 patients. During March 2020 to March 2022, 136 patients who were treated with tocilizumab in the service and intensive care unit due to Covid-19 pneumonia confirmed by Reverse-Transcriptase Polymerase Chain Reaction (RT-PCR) were retrospectively analyzed. While the mean age of the surviving group (n:70) was 54.4 years, for the dying group (n:66) it was 67.4 years. There was no significant difference in terms of gender in the surviving and dying patient groups (p:0.761). The time from hospital ization to tocilizumab treatment was significantly shorter among survivors (p=0.004), while patients who received tocilizumab in the intensive care unit exhibited a higher mortality rate. While the median Charlson Comorbidity Index (CCI) score was 0 in the surviving patients, it was 2 in the dying group. It was found that a 1-unit increase in CCI increased the mortality rate 1.416 times. Age, CCI, neutrophil, neutrophil-lymphocyte ratio (NLR), urea, and C reactive protein (CRP) were found to be independent risk factors for mortality. Patients with high white blood cell, lactate dehydrogenase, troponin, d-dimer, and low lymphocyte, total protein, albumin, and glomerular filtration rates had higher mortality rate. CCI, white blood cell, NLR, urea, LDH, troponin, d-dimer, CRP, lymphocyte, GFR, albumin and total protein basal values can be used as risk factors for death from Covid-19 disease. In addition, early initiation of tocilizumab therapy may reduce mortality rates

COMPARISON OF MULTIPLE CAMERA SEMI-AUTOMATIC SYSTEMS AND GLOBAL POSITIONING SYSTEM (GPS) AS DIFFERENT PLAYER TRACKING SYSTEMS IN FOOTBALL

Global positioning systems (GPS) as a wearable technology and multiple camera semi-automatic systems are two most popular technologies which aim to reveal physical performance of the players in both training and competitions. These technologies may have also specific contents in terms of benefits, advantages or disadvantages, and some recent studies have revealed the differences between these technologies. This paper aimed to discuss these technologies with respect to their benefits to practical application in light of the literature. The overall reliability and validity is good for both system especially in distance covered (Buchheit et al., 2014), Multiple camera semi-automatic systems due to having to predict some soccer events (corner kick, free kick, goals, penalties etc.) and providing same data about opponent team can be more useful than GPS in match analysis. On the other hand, GPS player tracking technology may become more useful in monitoring training loads since this system works independently of camera. Both systems have some limitations such as poor accuracy in computing high intensity running, acceleration, deceleration, and constant motion errors however these technologies have been developing so further innovations may overcome the limitations

Cytotoxic and bioactive properties of different color tulip flowers and degradation kinetic of tulip flower anthocyanins

This study was conducted to determine the potential use of anthocyanin-based extracts (ABEs) of wasted tulip flowers as food/drug colorants. For this aim, wasted tulip flowers were samples and analyzed for their bioactive properties and cytotoxicity. Total phenolic contents of the extracts of the claret red (126.55. mg of gallic acid equivalent (GAE)/g dry extract) and orange-red (113.76. mg GAE/g dry extract) flowers were the higher than those of the other tulip flowers. Total anthocyanin levels of the violet, orange-red, claret red and pink tulip flower extracts were determined as 265.04, 236.49, 839.08 and 404.45. mg pelargonidin 3-glucoside/kg dry extract, respectively and these levels were higher than those of the other flowers. The extracts were more effective for the inhibition of Listeria monocytogenes, Staphylococcus aureus and Yersinia enterocolitica compared to other tested bacteria. Additionally, the cytotoxic effects of five different tulip flower extracts on human breast adenocarcinoma (MCF-7) cell line were investigated. The results showed that the orange red, pink and violet extracts had no cytotoxic activity against MCF-7 cell lines while yellow and claret red extracts appeared to be toxic for the cells. Overall, the extracts of tulip flowers with different colors possess remarkable bioactive and cytotoxic properties. © 2013 Elsevier Ltd

Turner syndrome and associated problems in turkish children: A multicenter study

Objective: Turner syndrome (TS) is a chromosomal disorder caused by complete or partial X chromosome monosomy that manifests various clinical features depending on the karyotype and on the genetic background of affected girls. This study aimed to systematically investigate the key clinical features of TS in relationship to karyotype in a large pediatric Turkish patient population. Methods: Our retrospective study included 842 karyotype-proven TS patients aged 0-18 years who were evaluated in 35 different centers in Turkey in the years 2013-2014. Results: The most common karyotype was 45,X (50.7%), followed by 45,X/46,XX (10.8%), 46,X,i(Xq) (10.1%) and 45,X/46,X,i(Xq) (9.5%). Mean age at diagnosis was 10.2±4.4 years. The most common presenting complaints were short stature and delayed puberty. Among patients diagnosed before age one year, the ratio of karyotype 45,X was significantly higher than that of other karyotype groups. Cardiac defects (bicuspid aortic valve, coarctation of the aorta and aortic stenosi) were the most common congenital anomalies, occurring in 25% of the TS cases. This was followed by urinary system anomalies (horseshoe kidney, double collector duct system and renal rotation) detected in 16.3%. Hashimoto’s thyroiditis was found in 11.1% of patients, gastrointestinal abnormalities in 8.9%, ear nose and throat problems in 22.6%, dermatologic problems in 21.8% and osteoporosis in 15.3%. Learning difficulties and/or psychosocial problems were encountered in 39.1%. Insulin resistance and impaired fasting glucose were detected in 3.4% and 2.2%, respectively. Dyslipidemia prevalence was 11.4%. Conclusion: This comprehensive study systematically evaluated the largest group of karyotype-proven TS girls to date. The karyotype distribution, congenital anomaly and comorbidity profile closely parallel that from other countries and support the need for close medical surveillance of these complex patients throughout their lifespan. © Journal of Clinical Research in Pediatric Endocrinology

Volume CXIV, Number 4, November 7, 1996

Objective: Turner syndrome (TS) is a chromosomal disorder caused by complete or partial X chromosome monosomy that manifests various clinical features depending on the karyotype and on the genetic background of affected girls. This study aimed to systematically investigate the key clinical features of TS in relationship to karyotype in a large pediatric Turkish patient population.Methods: Our retrospective study included 842 karyotype-proven TS patients aged 0-18 years who were evaluated in 35 different centers in Turkey in the years 2013-2014.Results: The most common karyotype was 45,X (50.7%), followed by 45,X/46,XX (10.8%), 46,X,i(Xq) (10.1%) and 45,X/46,X,i(Xq) (9.5%). Mean age at diagnosis was 10.2±4.4 years. The most common presenting complaints were short stature and delayed puberty. Among patients diagnosed before age one year, the ratio of karyotype 45,X was significantly higher than that of other karyotype groups. Cardiac defects (bicuspid aortic valve, coarctation of the aorta and aortic stenosis) were the most common congenital anomalies, occurring in 25% of the TS cases. This was followed by urinary system anomalies (horseshoe kidney, double collector duct system and renal rotation) detected in 16.3%. Hashimoto's thyroiditis was found in 11.1% of patients, gastrointestinal abnormalities in 8.9%, ear nose and throat problems in 22.6%, dermatologic problems in 21.8% and osteoporosis in 15.3%. Learning difficulties and/or psychosocial problems were encountered in 39.1%. Insulin resistance and impaired fasting glucose were detected in 3.4% and 2.2%, respectively. Dyslipidemia prevalence was 11.4%.Conclusion: This comprehensive study systematically evaluated the largest group of karyotype-proven TS girls to date. The karyotype distribution, congenital anomaly and comorbidity profile closely parallel that from other countries and support the need for close medical surveillance of these complex patients throughout their lifespa

Impact of opioid-free analgesia on pain severity and patient satisfaction after discharge from surgery: multispecialty, prospective cohort study in 25 countries

Background: Balancing opioid stewardship and the need for adequate analgesia following discharge after surgery is challenging. This study aimed to compare the outcomes for patients discharged with opioid versus opioid-free analgesia after common surgical procedures.Methods: This international, multicentre, prospective cohort study collected data from patients undergoing common acute and elective general surgical, urological, gynaecological, and orthopaedic procedures. The primary outcomes were patient-reported time in severe pain measured on a numerical analogue scale from 0 to 100% and patient-reported satisfaction with pain relief during the first week following discharge. Data were collected by in-hospital chart review and patient telephone interview 1 week after discharge.Results: The study recruited 4273 patients from 144 centres in 25 countries; 1311 patients (30.7%) were prescribed opioid analgesia at discharge. Patients reported being in severe pain for 10 (i.q.r. 1-30)% of the first week after discharge and rated satisfaction with analgesia as 90 (i.q.r. 80-100) of 100. After adjustment for confounders, opioid analgesia on discharge was independently associated with increased pain severity (risk ratio 1.52, 95% c.i. 1.31 to 1.76; P < 0.001) and re-presentation to healthcare providers owing to side-effects of medication (OR 2.38, 95% c.i. 1.36 to 4.17; P = 0.004), but not with satisfaction with analgesia (beta coefficient 0.92, 95% c.i. -1.52 to 3.36; P = 0.468) compared with opioid-free analgesia. Although opioid prescribing varied greatly between high-income and low- and middle-income countries, patient-reported outcomes did not.Conclusion: Opioid analgesia prescription on surgical discharge is associated with a higher risk of re-presentation owing to side-effects of medication and increased patient-reported pain, but not with changes in patient-reported satisfaction. Opioid-free discharge analgesia should be adopted routinely

Ermenek Tahtacıları

Tahtacılar Türk toplumunda Alevilerin bir alt grubu olarak dikkat çekmektedir. bu makalede Ermenekde yaşayan insanların dini inançları ve uygulamaları hakkında bilgi verilmiştir. bu bağlamda, Tahtacılarda din inanç ve dini uygulamalar (doğum, sünnet, evlilik, ölüm) geleneksel Türk inançlarıyla ilişkisi tanımlayıcı ve objektif bir şekilde ele alınmıştır

Öğretim Teknolojileri ve Materyal Geliştirme Dersinin Hedeflerine Ulaşma Derecesi (Ankara Üniversitesi İlahiyat Fakültesi Öğretmenlik Programlarına Kayıtlı Öğrenciler Üzerinde Bir Araştırma)

An evaluation on the extent to reach the teaching technologies and improving materials course objectives. The purpose of this study is to evaluate the teaching technologies and improving materials course to reach its objectives in respect to students. To collect data, opinions of student have been taken by survey method. The results are: There isn’t a difference between male and female to reach course objectives. In the evaluation based upon item means, it was determinated that course objectives were reached at high degree. Some suppositions were produced in the part of discussions for the effective cours

Türk Kültüründe Yağmur Duası (Azatlı Kasabası Örneği)

“Prayer for Rain” has been a practice in almost all Turkish communities by now. It is well known and recognized that there are a common denominations among varies applications for this prayer among distinct Turkish communities. So it is a common phenomenon among these societies. Its various applications have been subject matters of different studies. In our study we carried out it as a case study in Azatlı town, Niğde, in which the original form of prayer for rain has been kep