Giant and reversible inverse barocaloric effects near room temperature in ferromagnetic MnCoGeB0.03

Hydrostatic pressure represents an inexpensive and practical method of driving caloric effects in brittle magnetocaloric materials, which display first-order magnetostructural phase transitions whose large latent heats are traditionally accessed using applied magnetic fields. Here, moderate changes of hydrostatic pressure are used to drive giant and reversible inverse barocaloric effects near room temperature in the notoriously brittle magnetocaloric material MnCoGeB0.03. The barocaloric effects compare favorably with those observed in barocaloric materials that are magnetic. The inevitable fragmentation provides a large surface for heat exchange with pressure-transmitting media, permitting good access to barocaloric effects in cooling devices.Peer ReviewedPostprint (author's final draft

Instructor versus Peer Attention Guidance in Online Learning Conversations

This paper reports a theory-driven experimental study for designing and evaluating two different forms of attention-guidance functionalities integrated into an anchored-discussion system. Using social constructivism as a motivating theory, we constructed a theoretical framework that emphasizes the importance of students’ attention allocation in online learning conversations and its influence on message quality and interaction patterns. The development of the functionalities, named faded instructor-led and peer-oriented attention guidance, aimed to direct students’ attention toward instructional materials’ central domain principles while offering them an open learning environment in which they could choose their own topics and express their own ideas. We evaluated the functionalities with heat map analysis, repeated measures general linear model analysis, and sequence analysis to assess the utility of the developed functionalities. Results show that attention guidance helped students more properly allocate their attention in online learning conversations. Furthermore, we found that the improved attention allocation led to better quality of students’ online learning conversations. We discuss implications for researchers and practitioners who wish to promote more fruitful online discussions

New Trade Models, Same Old Gains?

Micro-level data have had a profound influence on research in international trade over the last ten years. In many regards, this research agenda has been very successful. New stylized facts have been uncovered and new trade models have been developed to explain these facts. In this paper we investigate to what extent answers to new micro-level questions have affected answers to an old and central question in the field: how large are the welfare gains from trade? A crude summary of our results is: "So far, not much." (JEL F11, F12)

Polarimetric modeling and assessment of science cases for Giant Magellan Telescope-Polarimeter (GMT-Pol)

Polarization observations through the next-generation large telescopes will be invaluable for exploring the magnetic fields and composition of jets in AGN, multi-messenger transients follow-up, and understanding interstellar dust and magnetic fields. The 25m Giant Magellan Telescope (GMT) is one of the next-generation large telescopes and is expected to have its first light in 2029. The telescope consists of a primary mirror and an adaptive secondary mirror comprising seven circular segments. The telescope supports instruments at both Nasmyth as well as Gregorian focus. However, none of the first or second-generation instruments on GMT has the polarimetric capability. This paper presents a detailed polarimetric modeling of the GMT for both Gregorian and folded ports for astronomical B-K filter bands and a field of view of 5 arc minutes. At 500nm, The instrumental polarization is 0.1% and 3% for the Gregorian and folded port, respectively. The linear to circular crosstalk is 0.1% and 30% for the Gregorian and folded ports, respectively. The Gregorian focus gives the GMT a significant competitive advantage over TMT and ELT for sensitive polarimetry, as these telescopes support instruments only on the Nasmyth platform. We also discuss a list of polarimetric science cases and assess science case requirements vs. the modeling results. Finally, we discuss the possible routes for polarimetry with GMT and show the preliminary optical design of the GMT polarimeter.Comment: 13 pages, 5 figures,SPIE Optics + Photonics 2023 conference proceeding, Paper no 12690-2

Surface alignment, anchoring transitions, optical properties, and topological defects in the thermotropic nematic phase of organo-siloxane tetrapodes

We address the status of oxadiazole mesogens, C7 and C12, reported to show the biaxial nematic phase, by exploring material aspects (chemical stability, surface anchoring, optical and dielectric properties, topological defects) linked to the type of nematic order. We demonstrate that the isogyres splitting in conoscopic patterns of homeotropic state depends on sample thickness and is associated with variations of molecular tilt along the normal to substrates. We observe isolated topological point defects (boojums and hedgehogs), as well as nonsingular “escaped” disclinations pertinent only to the uniaxial nematic order. Our conclusion is that C7 and C12 feature only a uniaxial nematic phase and the apparent biaxiality is caused by surface effects

Evaluation of a seven gene mutational profile as a prognostic factor in a population-based study of clear cell renal cell carcinoma

In this study, we investigate the influence of the seven genes (VHL, PBRM1, SETD2, BAP1, KDM5C, MTOR and TP53) most frequently mutated in clear cell renal cell cancer (ccRCC) on cancer-specific survival (CSS) in the prospective Netherlands Cohort Study on diet and cancer. DNA isolated from routinely archived formalin-fixed paraffin-embedded tumour blocks from 252 incident ccRCC cases was available for targeted next generation sequencing. Based on the sequencing quality and the completeness of information on clinical characteristics and follow-up, we could use 110 cases for survival analysis. The association with CSS for each mutated gene in these cases was tested using multivariable Cox proportional hazards models to estimate hazards ratios (HR) and confidence intervals (CIs), and we observed mutations in one or more of the seven genes in 64 out of 110 cases (58%). In the multivariable-adjusted analyses, mutations in VHL and PBRM1 were associated with better CSS (HRs (95% CI) 0.34 (0.13‒0.89) and 0.17 (0.04–0.66), respectively), although these results were not statistically significant after multiple testing correction. No association was observed for the other five genes, which may be attributable to limited power

Colossal reversible barocaloric effects in a plastic crystal mediated by lattice vibrations and ion diffusion

Solid-state methods for cooling and heating promise a more sustainable alternative to current compression cycles of greenhouse gases and inefficient fuel-burning heaters. Barocaloric effects (BCE) driven by hydrostatic pressure ($p$) are especially encouraging in terms of large adiabatic temperature changes ($|\Delta T| \sim 10$ K) and colossal isothermal entropy changes ($|\Delta S| \sim 100$ JK$^{-1}$kg$^{-1}$). However, BCE typically require large pressure shifts due to irreversibility issues, and sizeable $|\Delta T|$ and $|\Delta S|$ seldom are realized in a same material. Here, we demonstrate the existence of colossal and reversible BCE in LiCB$_{11}$H$_{12}$, a well-known solid electrolyte, near its order-disorder phase transition at $\approx 380$ K. Specifically, for $\Delta p \approx 0.23$ $(0.10)$ GPa we measured $|\Delta S_{\rm rev}| = 280$ $(200)$ JK$^{-1}$kg$^{-1}$ and $|\Delta T_{\rm rev}| = 32$ $(10)$ K, which individually rival with state-of-the-art barocaloric shifts obtained under similar pressure conditions. Furthermore, over a wide temperature range, pressure shifts of the order of $0.1$ GPa yield huge reversible barocaloric strengths of $\approx 2$ JK$^{-1}$kg$^{-1}$MPa$^{-1}$. Molecular dynamics simulations were carried out to quantify the role of lattice vibrations, molecular reorientations and ion diffusion on the disclosed colossal BCE. Interestingly, lattice vibrations were found to contribute the most to $|\Delta S|$ while the diffusion of lithium ions, despite adding up only slightly to the accompanying entropy change, was crucial in enabling the molecular order-disorder phase transition. Our work expands the knowledge on plastic crystals and should motivate the investigation of BCE in a variety of solid electrolytes displaying ion diffusion and concomitant molecular orientational disorder.Comment: 13 pages, 7 figure

What contributes to individual differences in brain structure?

Individual differences in adult human brain structure have been found to reveal a great deal of information about variability in behaviors, cognitive abilities and mental and physical health. Driven by such evidence, what contributes to individual variation in brain structure has gained accelerated attention as a research question. Findings thus far appear to support the notion that an individual’s brain architecture is determined largely by genetic and environmental influences. This review aims to evaluate the empirical literature on whether and how genes and the environment contribute to individual differences in brain structure. It first considers how genetic and environmental effects may separately contribute to brain morphology, by examining evidence from twin, genome-wide association, cross-sectional and longitudinal studies. Next, evidence for the influence of the complex interplay between genetic and environmental factors, characterized as gene-environment interactions and correlations, is reviewed. In evaluating the extant literature, this review will conclude that both genetic and environmental factors play critical roles in contributing to individual variability in brain structure

Screening for Chlamydia and Gonorrhea by Strand Displacement Amplification in Homeless Adolescents Attending Youth Shelters in Korea

We conducted the screening of sexually transmitted infections to define the prevalence of genital Chlamydia trachomatis and Neisseria gonorrhoeae infections and status of sexual risk behavior among homeless adolescents (10-19 yr old) in Korea. Adolescents who ran away from home and are under the care of youth shelters in ten cities in Korea served as the study population. Participants filled out a self-administered questionnaire related to sexuality. First-void urine was analyzed for chlamydial and gonococcal infection by strand displacement amplification (BDProbTecTMET, BD Diagnostic Systems, MD, U.S.A.). A total of 175 adolescents from 15 youth shelters took part in the study. Their median age was 16 yr, and 54.9% of them reported having sexual intercourse at least once. The prevalence of C. trachomatis and N. gonorrhoeae among homeless adolescents was 12.6% and 15.4%, respectively. Factors significantly associated with the infections were number of sexual partners during the past year and lifetime. This is the first community-based sexually transmitted infection (STI) screening among adolescent in Korea. Screening programs targeting sexually active adolescents are important for detection of STIs. They should be considered an alternative population-based surveillance system in order to control STIs nationally