Examining the Focus of SoTL Literature—Teaching and Learning?

Although the Scholarship of Teaching and Learning (SoTL) claims to focus on student learning, some have argued that SoTL studies often adopt a narrow view of learning and focus more on teaching than on learning. In this paper, we explore whether teaching is the primary focus of recent articles published from 2013-2017 in three international, self-identified SoTL journals: Teaching and Learning Inquiry: The ISSOTL Journal (TLI), The International Journal for the Scholarship of Teaching and Learning (ijSOTL), and The Journal of the Scholarship of Teaching and Learning (JoSoTL). Based on our analysis of the 299 empirical articles, we argue that they portray SoTL as a field focused primarily on teacher activity rather than student learning, despite efforts to broaden its scope

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

How can we help all students RISE? : A framework to create learning environments in higher education that will help all students grow as collaborative thinkers, partners, and leaders.

This collection of short essays utilizes a narrative approach to present the RISE framework, with four pillars centered on promoting student Resilience, Identity, Strength in Scholarship and Empowerment. Each short essay aims to draw attention to the spectrum of challenges that students currently face during their higher education journeys in Canada and what innovative solutions have been or could be implemented to address these adversities in accordance with RISE. The application of the framework to evaluate and reorient learning environments in Canadian higher education holds immense potential to help all students grow as collaborative thinkers, partners, and leaders that will leave academic settings well prepared for their life as leaders in their community.   Dans cet article qui rassemble de courts essais, nous utilisons une approche narrative pour présenter le cadre RISE en l’appuyant sur quatre piliers permettant de promouvoir la Résilience, l’Identité, la Solidité universitaire et l’Émancipation. Chacun des courts essais vise à mettre en relief, d’une part, l’éventail des défis auxquels les étudiants font face actuellement dans l’enseignement supérieur au Canada et, d’autre part, les solutions novatrices qui ont été mises en œuvre – ou qui pourraient l’être – pour s’attaquer à ces difficultés dans le contexte de RISE. L’application de ce cadre dans l’examen et la reconfiguration des environnements d’apprentissage de l’enseignement supérieur au Canada est pleine de promesses. Voilà qui pourrait aider tous les étudiants à devenir des penseurs collaboratifs, des partenaires et des leaders qui, lorsqu’ils quitteront l’université, seront prêts à agir comme des chefs de file de leur communauté

InterFrost Project Phase 2: Updated experiment design for validation of Cryohydrogeological codes (Frozen Inclusion)

International audienceRecent field and modelling studies indicate that a fully-coupled, multi-dimensional, thermo-hydraulic (TH) approach is required to accurately model the evolution of permafrost-impacted landscapes and groundwater systems. However, the relatively new and complex numerical codes being developed for coupled non-linear freeze-thaw systems require validation. This issue was first addressed within the InterFrost IPA Action Group, by means of an intercomparison of thirteen numerical codes for two-dimensional TH test cases (TH2 & TH3). The main results (cf. Grenier et al. 2018 and wiki.lsce.ipsl.fr/interfrost) demonstrate that these codes provide robust results for the test cases considered. The second phase of the InterFrost project is devoted to the simulation of a cold-room reference experiment based on test case TH2 (Frozen Inclusion). In a first implementation phase of the experimental setup, the initial frozen inclusion was inserted in the setup prior to the complete filling of the porous medium and the flow initiation. The thermal evolution of the system was monitored by thermistors located at the center of the initial inclusion and along the downgradient centerline. This setup provided optimal conditions to control the initial experiment geometries but resulted in slight differences in the initialization time for different experiments. We present a second implementation strategy that considers "in place" generation of an initial frozen inclusion through a cooling coil. The initial frozen inclusion is obtained after the initial cooling time and its initial thermal state is measured by means of an array of thermistors. In a second step, the flow is initiated, and the thermal evolution is monitored through an array of 11 thermistors (within the initial position and downgradient). The experimental setup and monitoring results as well as preliminary simulation results are presented. Derived results and conclusions from this exercise form the basis for the next phase within the InterFrost validation exercise. Grenier, C. et al. 2018. Groundwater flow and heat transport for systems undergoing freeze-thaw: Inter-comparison of numerical simulators for 2D test cases. Adv. Wat. Res. 114: 196-218

InterFrost Project Phase 2: Updated experiment design for validation of Cryohydrogeological codes (Frozen Inclusion)

22nd EGU General Assembly, held online 4-8 May, 2020International audienceRecent field and modelling studies indicate that a fully-coupled, multi-dimensional, thermo-hydraulic (TH) approach is required to accurately model the evolution of permafrost-impacted landscapes and groundwater systems. However, the relatively new and complex numerical codes being developed for coupled non-linear freeze-thaw systems require validation. This issue was first addressed within the InterFrost IPA Action Group, by means of an intercomparison of thirteen numerical codes for two-dimensional TH test cases (TH2 & TH3). The main results (cf. Grenier et al. 2018 and wiki.lsce.ipsl.fr/interfrost) demonstrate that these codes provide robust results for the test cases considered. The second phase of the InterFrost project is devoted to the simulation of a cold-room reference experiment based on test case TH2 (Frozen Inclusion). In a first implementation phase of the experimental setup, the initial frozen inclusion was inserted in the setup prior to the complete filling of the porous medium and the flow initiation. The thermal evolution of the system was monitored by thermistors located at the center of the initial inclusion and along the downgradient centerline. This setup provided optimal conditions to control the initial experiment geometries but resulted in slight differences in the initialization time for different experiments. We present a second implementation strategy that considers "in place" generation of an initial frozen inclusion through a cooling coil. The initial frozen inclusion is obtained after the initial cooling time and its initial thermal state is measured by means of an array of thermistors. In a second step, the flow is initiated, and the thermal evolution is monitored through an array of 11 thermistors (within the initial position and downgradient). The experimental setup and monitoring results as well as preliminary simulation results are presented. Derived results and conclusions from this exercise form the basis for the next phase within the InterFrost validation exercise. Grenier, C. et al. 2018. Groundwater flow and heat transport for systems undergoing freeze-thaw: Inter-comparison of numerical simulators for 2D test cases

InterFrost Project Phase 2: Updated experiment design for validation of Cryohydrogeological codes (Frozen Inclusion)

International audienceRecent field and modelling studies indicate that a fully-coupled, multi-dimensional, thermo-hydraulic (TH) approach is required to accurately model the evolution of permafrost-impacted landscapes and groundwater systems. However, the relatively new and complex numerical codes being developed for coupled non-linear freeze-thaw systems require validation. This issue was first addressed within the InterFrost IPA Action Group, by means of an intercomparison of thirteen numerical codes for two-dimensional TH test cases (TH2 & TH3). The main results (cf. Grenier et al. 2018 and wiki.lsce.ipsl.fr/interfrost) demonstrate that these codes provide robust results for the test cases considered. The second phase of the InterFrost project is devoted to the simulation of a cold-room reference experiment based on test case TH2 (Frozen Inclusion). In a first implementation phase of the experimental setup, the initial frozen inclusion was inserted in the setup prior to the complete filling of the porous medium and the flow initiation. The thermal evolution of the system was monitored by thermistors located at the center of the initial inclusion and along the downgradient centerline. This setup provided optimal conditions to control the initial experiment geometries but resulted in slight differences in the initialization time for different experiments. We present a second implementation strategy that considers "in place" generation of an initial frozen inclusion through a cooling coil. The initial frozen inclusion is obtained after the initial cooling time and its initial thermal state is measured by means of an array of thermistors. In a second step, the flow is initiated, and the thermal evolution is monitored through an array of 11 thermistors (within the initial position and downgradient). The experimental setup and monitoring results as well as preliminary simulation results are presented. Derived results and conclusions from this exercise form the basis for the next phase within the InterFrost validation exercise. Grenier, C. et al. 2018. Groundwater flow and heat transport for systems undergoing freeze-thaw: Inter-comparison of numerical simulators for 2D test cases. Adv. Wat. Res. 114: 196-218

InterFrost Project Phase 2: Updated experiment design for validation of Cryohydrogeological codes (Frozen Inclusion)

International audienceRecent field and modelling studies indicate that a fully-coupled, multi-dimensional, thermo-hydraulic (TH) approach is required to accurately model the evolution of permafrost-impacted landscapes and groundwater systems. However, the relatively new and complex numerical codes being developed for coupled non-linear freeze-thaw systems require validation. This issue was first addressed within the InterFrost IPA Action Group, by means of an intercomparison of thirteen numerical codes for two-dimensional TH test cases (TH2 & TH3). The main results (cf. Grenier et al. 2018 and wiki.lsce.ipsl.fr/interfrost) demonstrate that these codes provide robust results for the test cases considered. The second phase of the InterFrost project is devoted to the simulation of a cold-room reference experiment based on test case TH2 (Frozen Inclusion). In a first implementation phase of the experimental setup, the initial frozen inclusion was inserted in the setup prior to the complete filling of the porous medium and the flow initiation. The thermal evolution of the system was monitored by thermistors located at the center of the initial inclusion and along the downgradient centerline. This setup provided optimal conditions to control the initial experiment geometries but resulted in slight differences in the initialization time for different experiments. We present a second implementation strategy that considers "in place" generation of an initial frozen inclusion through a cooling coil. The initial frozen inclusion is obtained after the initial cooling time and its initial thermal state is measured by means of an array of thermistors. In a second step, the flow is initiated, and the thermal evolution is monitored through an array of 11 thermistors (within the initial position and downgradient). The experimental setup and monitoring results as well as preliminary simulation results are presented. Derived results and conclusions from this exercise form the basis for the next phase within the InterFrost validation exercise. Grenier, C. et al. 2018. Groundwater flow and heat transport for systems undergoing freeze-thaw: Inter-comparison of numerical simulators for 2D test cases. Adv. Wat. Res. 114: 196-218

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

Human cancer cells typically harbour multiple chromosomal aberrations, nucleotide substitutions and epigenetic modifications that drive malignant transformation. The Cancer Genome Atlas ( TCGA) pilot project aims to assess the value of large- scale multi- dimensional analysis of these molecular characteristics in human cancer and to provide the data rapidly to the research community. Here we report the interim integrative analysis of DNA copy number, gene expression and DNA methylation aberrations in 206 glioblastomas - the most common type of primary adult brain cancer - and nucleotide sequence aberrations in 91 of the 206 glioblastomas. This analysis provides new insights into the roles of ERBB2, NF1 and TP53, uncovers frequent mutations of the phosphatidylinositol- 3- OH kinase regulatory subunit gene PIK3R1, and provides a network view of the pathways altered in the development of glioblastoma. Furthermore, integration of mutation, DNA methylation and clinical treatment data reveals a link between MGMT promoter methylation and a hypermutator phenotype consequent to mismatch repair deficiency in treated glioblastomas, an observation with potential clinical implications. Together, these findings establish the feasibility and power of TCGA, demonstrating that it can rapidly expand knowledge of the molecular basis of cancer