Short photoperiod-induced decrease of histamine H3 receptors facilitates activation of hypothalamic neurons in the Siberian Hamster

Nonhibernating seasonal mammals have adapted to temporal changes in food availability through behavioral and physiological mechanisms to store food and energy during times of predictable plenty and conserve energy during predicted shortage. Little is known, however, of the hypothalamic neuronal events that lead to a change in behavior or physiology. Here we show for the first time that a shift from long summer-like to short inter-like photoperiod, which induces physiological adaptation to winter in the Siberian hamster, including a body weight decrease of up to 30%, increases neuronal activity in the dorsomedial region of the arcuate nucleus (dmpARC) assessed by electro physiological patch-clamping recording. Increased neuronal activity in short days is dependent on a photoperiod-driven down-regulation of H3 receptor expression and can be mimicked in long-day dmpARC neurons by the application of the H3 receptor antagonist, clobenproprit. Short-day activation of dmpARC neurons results in increased c-Fos expression. Tract tracing with the trans-synaptic retrograde tracer, pseudorabies virus, delivered into adipose tissue reveals a multisynaptic neuronal sympathetic outflow from dmpARC to white adipose tissue. These data strongly suggest that increased activity of dmpARC neurons, as a consequence of down-regulation of the histamine H3 receptor, contributes to the physiological adaptation of body weight regulation in seasonal photoperiod

Strange Quark Contributions to Parity-Violating Asymmetries in the Backward Angle G0 Electron Scattering Experiment

We have measured parity-violating asymmetries in elastic electron-proton and quasi-elastic electron-deuteron scattering at Q^2 = 0.22 and 0.63 GeV^2. They are sensitive to strange quark contributions to currents in the nucleon, and to the nucleon axial current. The results indicate strange quark contributions of < 10% of the charge and magnetic nucleon form factors at these four-momentum transfers. We also present the first measurement of anapole moment effects in the axial current at these four-momentum transfers.Comment: 5 pages, 2 figures, changed references, typo, and conten

Quarkonia Measurements by the CMS Experiment in pp and PbPb Collisions

Quarkonia have been studied in different collision system and energy in order to understand the effects of the hot and dense medium created in heavy-ion collisions. CMS is well suited to measure quarkonia decays to muons given the muon identification and charged particle tracking capability. We report here prompt, non-prompt J/\psi, and \Upsilon\ production measured by the CMS experiment in pp collisions at \sqrt{s}=7 TeV. In addition, the J/\psi\ and \Upsilon\ production in PbPb at \sqrt{s_{NN}}=2.76 TeV and pp collisions at the same per nucleon energy are measured and compared. Prompt and non-prompt J/\psi\ contributions are separated for the first time in heavy-ion collisions, as is the ground from the excited states in the \Upsilon\ family. Suppression in PbPb at \sqrt{s_{NN}}=2.76 TeV is quantified for prompt J/\psi, B->J/\psi, and \Upsilon(1S), as well as the relative suppression of \Upsilon(2S+3S) compared to \Upsilon(1S).Comment: 8 pages, 8 figures, Quark Matter 2011, plenar

Transverse Beam Spin Asymmetries at Backward Angles in Elastic Electron-Proton and Quasi-elastic Electron-Deuteron Scattering

We have measured the beam-normal single-spin asymmetries in elastic scattering of transversely polarized electrons from the proton, and performed the first measurement in quasi-elastic scattering on the deuteron, at backward angles (lab scattering angle of 108 degrees) for Q2 = 0.22 GeV^2/c^2 and 0.63 GeV^2/c^2 at beam energies of 362 MeV and 687 MeV, respectively. The asymmetry arises due to the imaginary part of the interference of the two-photon exchange amplitude with that of single photon exchange. Results for the proton are consistent with a model calculation which includes inelastic intermediate hadronic (piN) states. An estimate of the beam-normal single-spin asymmetry for the scattering from the neutron is made using a quasi-static deuterium approximation, and is also in agreement with theory

ϕ\phi Meson Production in In-In Collisions and the ϕ\phi Puzzle

The NA60 experiment measured dimuon production in In-In collisions at 158 AGeV. This paper presents a high statistics measurement of $\phi\to\mu\mu$ with the specific objective to provide insight on the $\phi$ puzzle, i.e. the difference in the inverse $T$ slopes and absolute yields measured by NA49 and NA50 in the kaon and lepton channel, respectively. Transverse momentum distributions were studied as a function of centrality. The slope parameter $T$ shows a rapid increase with centrality, followed by a saturation. Variations of $T$ with the fit range of the order of 15 MeV were observed, possibly as a consequence of radial flow. The $\phi$ meson yield normalized to the number of participants increases with centrality and is consistently higher than the yield measured by the NA49 experiment at any centrality.Comment: 4 Pages, 2 Figures. Proceedings of the 20$^{th}$ International Conference on Ultra-Relativistic Nucleus Nucleus Collision

Evidence for radial flow of thermal dileptons in high-energy nuclear collisions

The NA60 experiment at the CERN SPS has studied low-mass dimuon production in 158 AGeV In-In collisions. An excess of pairs above the known meson decays has been reported before. We now present precision results on the associated transverse momentum spectra. The slope parameter Teff extracted from the spectra rises with dimuon mass up to the rho, followed by a sudden decline above. While the initial rise is consistent with the expectations for radial flow of a hadronic decay source, the decline signals a transition to an emission source with much smaller flow. This may well represent the first direct evidence for thermal radiation of partonic origin in nuclear collisions.Comment: Accepted for publication in Physical Review Letter

Thermal dileptons at SPS energies

Clear signs of excess dileptons above the known sources were found at the SPS since long. However, a real clarification of these observations was only recently achieved by NA60, measuring dimuons with unprecedented precision in 158A GeV, In-In collisions. The excess mass spectrum in the region M<1 GeV is consistent with a dominant contribution from pi+pi- -> rho -> mu+mu- annihilation. The associated rho spectral function shows a strong broadening, but essentially no shift in mass. In the region M>1 GeV, the excess is found to be prompt, not due to enhanced charm production. The inverse slope parameter Teff associated with the transverse momentum spectra rises with mass up to the rho, followed by a sudden decline above. While the initial rise, coupled to a hierarchy in hadron freeze-out, points to radial flow of a hadronic decay source, the decline above signals a transition to a low-flow source, presumably of partonic origin. The mass spectra show at low transverse momenta the steep rise towards low masses characteristic for Planck-like radiation. The polarization of the excess referred to the Collins Soper frame is found to be isotropic. All observations are consistent with the interpretation of the excess as thermal radiation.Comment: Prepared for 20th International Conference on Ultra-Relativistic Nucleus-Nucleus Collisions: Quark Matter 2008 (QM2008), Jaipur, India, 4-10 Feb. 200

Invloed van de koolzuur- en zuurstofspanning op enkele uiterlijke kenmerken, groeiverschijnselen, lage temperatuur bederf en ademhaling van witlofkroppen

N-truncated Aβ(4-42) is highly abundant in Alzheimer disease (AD) brain and was the first Aβ peptide discovered in AD plaques. However, a possible role in AD aetiology has largely been neglected. In the present report, we demonstrate that Aβ(4-42) rapidly forms aggregates possessing a high aggregation propensity in terms of monomer consumption and oligomer formation. Short-term treatment of primary cortical neurons indicated that Aβ(4-42) is as toxic as pyroglutamate Aβ(3-42) and Aβ(1-42). In line with these findings, treatment of wildtype mice using intraventricular Aβ injection induced significant working memory deficits with Aβ(4-42), pyroglutamate Aβ(3-42) and Aβ(1-42). Transgenic mice expressing Aβ(4-42) (Tg4-42 transgenic line) developed a massive CA1 pyramidal neuron loss in the hippocampus. The hippocampus-specific expression of Aβ(4-42) correlates well with age-dependent spatial reference memory deficits assessed by the Morris water maze test. Our findings indicate that N-truncated Aβ(4-42) triggers acute and long-lasting behavioral deficits comparable to AD typical memory dysfunction

NA60 results on thermal dimuons

The NA60 experiment at the CERN SPS has measured muon pairs with unprecedented precision in 158A GeV In-In collisions. A strong excess of pairs above the known sources is observed in the whole mass region 0.2<M<2.6 GeV. The mass spectrum for M<1 GeV is consistent with a dominant contribution from pi+pi- -> rho -> mu+mu- annihilation. The associated rho spectral function shows a strong broadening, but essentially no shift in mass. For M>1 GeV, the excess is found to be prompt, not due to enhanced charm production, with pronounced differences to Drell-Yan pairs. The slope parameter Teff associated with the transverse momentum spectra rises with mass up to the rho, followed by a sudden decline above. The rise for M<1 GeV is consistent with radial flow of a hadronic emission source. The seeming absence of significant flow for M>1 GeV and its relation to parton-hadron duality is discussed in detail, suggesting a dominantly partonic emission source in this region. A comparison of the data to the present status of theoretical modeling is also contained. The accumulated empirical evidence, including also a Planck-like shape of the mass spectra at low pT and the lack of polarization, is consistent with a global interpretation of the excess dimuons as thermal radiation. We conclude with first results on omega in-medium effects.Comment: 10 pages, 12 figures, submitted to Eur. Phys. J.

Study of the electromagnetic transition form-factors in \eta -> \mu^+\mu^-\gamma and \omega -> \mu^+\mu^-\pi^0 decays with NA60

The NA60 experiment at the CERN SPS has studied low-mass muon pairs in 158A GeV In-In collisions. The mass and pT spectra associated with peripheral collisions can quantitatively be described by the known neutral meson decays. The high data quality has allowed to remeasure the electromagnetic transition form factors of the Dalitz decays \eta -> \mu^+\mu^-\gamma and \omega -> \mu^+\mu^-\pi^0. Using the usual pole approximation F = (1-M_{\mu\mu}^{2}/\Lambda^{2})^{-1} for the form factors, we find \Lambda^{-2} (in GeV^{-2}) to be 1.95+-0.17(stat.)+-0.05(syst.) for the \eta and 2.24+-0.06(stat.)+-0.02(syst.) for the \omega. While the values agree with previous results from the Lepton-G experiment, the errors are greatly improved, confirming now on the level of 10\sigma the strong enhancement of the \omega form factor beyond the expectation from vector meson dominance. An improved value of the branching ratio BR(\omega -> \mu^+\mu^-\pi^0) = [1.73+-0.25(stat.)+-0.14(syst.)]*10^{-4} has been obtained as a byproduct.Comment: Submitted to Phys. Lett.