A microfoundation for adaptability returns to schooling and technological complexity

In a frictional environment, technological complexity creates adaptability returns to schooling. This paper provides microfoundations to such an argument, and revisits the impacts of worker heterogeneity and risk aversion. In our model, firms and workers are located on a knowledge space. Education widens the measure of the knowledge subset that the worker embodies, while technological complexity expands the measure of the knowledge subset that is required to operate on the job. We find uncertainty with regard to the type of the future partner motivates schooling, while it inhibits technological complexity. When workers differ in scholastic ability, the welfare of a given group increases with the proportion of workers of this group. Finally, risk aversion motivates a precautionary demand for education, which in turn creates income risk through firms' technological choices.Education; Multi-dimensional skills; Frictions; Heterogeneity; Risk aversion

A microfoundation for adaptability returns to schooling and technological complexity

In a frictional environment, technological complexity creates adaptability returns to schooling. This paper provides microfoundations to such an argument, and revisits the impacts of worker heterogeneity and risk aversion. In our model, firms and workers are located on a knowledge space. Education widens the measure of the knowledge subset that the worker embodies, while technological complexity expands the measure of the knowledge subset that is required to operate on the job. We find uncertainty with regard to the type of the future partner motivates schooling, while it inhibits technological complexity. When workers differ in scholastic ability, the welfare of a given group increases with the proportion of workers of this group. Finally, risk aversion motivates a precautionary demand for education, which in turn creates income risk through firms' technological choices

Characterization and minimization of Glaser competitive homocoupling in Sonogashira porphyrin-based polycondensation

Abstract: A series of porphyrin-containing polymers exhibiting various degrees of Glaser-Hay coupling is reported. The Sonogashira polycondensation of ethynyl-porphyrin (EP) is found to be prone to intramolecular homo-coupling; a problem that appears underestimated in the literature. 1H NMR spectroscopy (using the β-protons as probes) permits to assess the ratio of Glaser vs. Sonogashira couplings. These homo-couplings bear dramatic consequences on the photophysical properties of the resulting polymers. Good conditions to perform Glaser-free Sonogashira polycondensations are provided and the optimization increases Mn (average molecular weight in number) from 9700 to 18900

Innate immune basis for rift valley fever susceptibility in mouse models

Rift Valley fever virus (RVFV) leads to varied clinical manifestations in animals and in humans that range from moderate fever to fatal illness, suggesting that host immune responses are important determinants of the disease severity. We investigated the immune basis for the extreme susceptibility of MBT/Pas mice that die with mild to acute hepatitis by day 3 post-infection compared to more resistant BALB/cByJ mice that survive up to a week longer. Lower levels of neutrophils observed in the bone marrow and blood of infected MBT/Pas mice are unlikely to be causative of increased RVFV susceptibility as constitutive neutropenia in specific mutant mice did not change survival outcome. However, whereas MBT/Pas mice mounted an earlier inflammatory response accompanied by higher amounts of interferon (IFN)-α in the serum compared to BALB/cByJ mice, they failed to prevent high viral antigen load. Several immunological alterations were uncovered in infected MBT/Pas mice compared to BALB/cByJ mice, including low levels of leukocytes that expressed type I IFN receptor subunit 1 (IFNAR1) in the blood, spleen and liver, delayed leukocyte activation and decreased percentage of IFN-γ-producing leukocytes in the blood. These observations are consistent with the complex mode of inheritance of RVFV susceptibility in genetic studies

Bourg-Charente – Le dérivant, fleuve Charente

Les investigations engagées en 2017 ont concerné deux secteurs : le lieu-dit le Dérivant (déjà prospecté en 2014 (Gailledreau 2014) et en 2016 (Gailledreau, Largier 2017) placé en rive gauche à moins d’un kilomètre en aval de Bourg-Charente et le lieu-dit Lépare inscrit dans un bras secondaire à une distance équivalente en amont du même village. La prospection dans le premier secteur, a débuté à partir du relief en plateau (se développant en rive gauche) sur lequel des bois et de nombreuses c..

Release kinetics from nano-inclusion-based and affinity-based hydrogels: A comparative study

In this study, we compare the release mechanisms from nanocomposite hydrogels. Liposomes made of different compositions of 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) and 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine (DPPC), nanogels made of chitosan-hyaluronic acid association and crosslinked nanogels made of Nisopropylacrylamide (NIPAM) and different ratios of methacrylic acid (MAA) were embedded in acrylamide hydrogels with a model drug, either sulforhodamine B or rhodamine 6G. Liposomes demonstrated the capacity to release their payload over 10 days while NIPAM nanogels and chitosan nanogels released within one or two days. We found that liposomes embedded in hydrogels presented two distinctive release mechanisms, a diffusive burst and a slower “sub-diffusive” release. Both nanogels on the other side presented no observable nor defined affinity-based release mechanism due to presence of salts, completely screening electrostatic interactions. The present work highlights critical points related to the release mechanisms from nanocomposite hydrogels as drug delivery devices or as biomedical tools for tissue engineering or regenerative medicine

Benchmark, les réseaux sociaux en bibliothèque : étude comparative

Assurer une présence sur les réseaux sociaux est aujourd’hui incontournable pour les bibliothèques d’une certaine taille. Cette démarche permet de toucher un public étendu, d’assurer une médiation vers ses ressources et celles de ses partenaires, de développer la participation des usagers, et de montrer la connexion entre l’établissement et son quartier. La bibliothèque de la Canopée souhaite assurer une forte présence sur les réseaux sociaux.Il en est de même pour la bibliothèque en préfiguration du Carré Saint-Lazare. Cette étude à un instant T doit servir de base pour déterminer quelles sont les plateformes sociales les plus intéressantes dans une bibliothèque de lecture publique. Les fonctionnalités, l’attrait de certains réseaux évoluant à la hausse ou à la baisse entraînera une réévaluation possible de ce benchmark. Etude coordonnée par la préfiguration de la bibliothèque Canopée et rédigée par : Pierre-Marie Augereau, Cyrille Engel, Romain Gaillard, Ophélie Hamot-Béchay, Capucine Liébeaux (préfiguration Canopée), Soizic Cadio (préfiguration Saint-Lazare

Innate immune basis for rift valley fever susceptibility in mouse models

Rift Valley fever virus (RVFV) leads to varied clinical manifestations in animals and in humans that range from moderate fever to fatal illness, suggesting that host immune responses are important determinants of the disease severity. We investigated the immune basis for the extreme susceptibility of MBT/Pas mice that die with mild to acute hepatitis by day 3 post-infection compared to more resistant BALB/cByJ mice that survive up to a week longer. Lower levels of neutrophils observed in the bone marrow and blood of infected MBT/Pas mice are unlikely to be causative of increased RVFV susceptibility as constitutive neutropenia in specific mutant mice did not change survival outcome. However, whereas MBT/Pas mice mounted an earlier inflammatory response accompanied by higher amounts of interferon (IFN)-α in the serum compared to BALB/cByJ mice, they failed to prevent high viral antigen load. Several immunological alterations were uncovered in infected MBT/Pas mice compared to BALB/cByJ mice, including low levels of leukocytes that expressed type I IFN receptor subunit 1 (IFNAR1) in the blood, spleen and liver, delayed leukocyte activation and decreased percentage of IFN-γ-producing leukocytes in the blood. These observations are consistent with the complex mode of inheritance of RVFV susceptibility in genetic studies

Laminar Python: tools for cortical depth-resolved analysis of high-resolution brain imaging data in Python

Increasingly available high-resolution brain imaging data require specialized processing tools that can leverage their anatomical detail and handle their size. Here, we present user-friendly Python tools for cortical depth resolved analysis in such data. Our implementation is based on the CBS High-Res Brain Processing framework, and aims to make high-resolution data processing tools available to the broader community

Publisher Correction: An engineered human Fc domain that behaves like a pH-toggle switch for ultra-long circulation persistence.

An amendment to this paper has been published and can be accessed via a link at the top of the paper