Minerva y la reformulación de la masculinidad en Cristalián de España de Beatriz Bernal

La literatura artúrica exhibe, por lo general, no sólo una visión patriarcal de las relaciones sociales, políticas y amorosas sino también una perspectiva masculinista de los personajes. Esta representación narrativa resalta el poder, protagonismo y virilidad de los héroes masculinos y, en contrapartida, la fragilidad y pasividad de los personajes femeninos. Este convencional patrón narrativo, no obstante, es reinventado y reformulado en el libro de caballerías Historia de los invictos y magnánimos caballeros don Cristalián de España, Príncipe de Trapisonda, y del Infante Lucescanio su hermano, hijos del famosísimo Emperador Lindedel de Trapisonda, compuesto en castellano por la autora Beatriz Bernal y publicado en 1545 en Valladolid. Este artículo estudia algunas de las estrategias utilizadas por la autora vallisoletana para componer un texto que desafía y se distancia de los modelos artúricos vigentes, ofreciendo al lector un mundo caballeresco sin géneros

Incremental validity of Emotional Intelligence Perceived in predicting well-being

El objetivo del presente trabajo fue valorar la relación entre Inteligencia Emocional Percibida (IEP), medida por la Escala del Metaconocimiento del Estado de Ánimo (TMMS), el bienestar subjetivo (SWS) y el optimismo/pesimismo disposicional. Además, valoramos si la IEP se puede considerar un adecuado predictor del bienestar subjetivo (SWS). Los participantes fueron 518 adultos, 434 mujeres y 84 hombres. Todos ellos respondieron de forma anónima medidas de satisfacción en la vida, afecto positivo y negativo, inteligencia emocional percibida y optimismo/pesimismo disposicional. Hemos utilizado el método de Johnson para valorar los pesos relativos de cada una de las variables predictoras en una regresión múltiple. Nuestros resultados señalan que dos dimensiones de IEP (Claridad y Reparación) son buenos predictores de SWS, mientras la tercera dimensión, Atención emocional, parece no ser un adecuado predictorThe aim of the present study was to assess the relationship between Perceived Emotional Intelligence (PEI) as measured by the Trait Meta-Mood Scale (TMMS), Subjective Well-Being (SWB), and dispositional optimism/pessimism. In addition, we assessed whether PEI can be considered an adequate predictor of the SWB. Participants were 518 adults, 434 males and 84 females who anonymously completed measures of satisfaction with life, positive and negative affect, perceived emotional intelligence, and dispositional optimism/pessimism. The Johnson’s method was used for estimating the relative weight of predictor variables in multiple regression. Our results support that two dimensions of PEI (Clarity and Repair) are good predictors of SWB, whereas the third dimension, Emotional Attention, seems not adequate as a predicto

New rhenium complexes with ciprofloxacin as useful models for understanding the properties of [99mTc]-ciprofloxacin radiopharmaceutical

Rhenium complexes with the antibiotic ciprofloxacin have been prepared to be studied as models of technetium radiopharmaceuticals. With this aim, the new rhenium complexes 1 {[ReO(Cpf)2]Cl}, 2 {[ReO(CpfH)2]Cl3} and 3 {fac-[Re(CO)3(H2O)(Cpf)]} with ciprofloxacin (CpfH=ciprofloxacin; Cpf=conjugated base of ciprofloxacin) have been synthesised and characterised by elemental analyses, IR, NMR ((1)H, (19)F and (13)C CP-MAS) spectroscopy, as well as MS measurements. All spectroscopic data are consistent with the coordination of ciprofloxacin in all these complexes through the carbonyl and the carboxylate oxygen atoms with the formation of a six member chelate ring. The study of a Tc-ciprofloxacin solution by ESI-MS reveals the presence of [TcO(Cpf)2](+) cations, which agrees with the hypothesis that complexes 1 and 2 can be seen as model rhenium complexes of this radiopharmaceutical. Antimicrobial and DNA gyrase inhibition studies performed with complexes 2 and 3 have shown a very similar behaviour between complex 2 and the free antibiotic, whereas complex 3 exhibit a lower antimicrobial activity. Based on a joint analysis of the data reported in the literature and the chemical and biological results obtained in this study, a tentative proposal to explain some aspects of the behaviour of Tc-ciprofloxacin radiopharmaceutical has been made

Multibiomarker approach to fipronil exposure in the fish Dicentrarchus labrax under two temperature regimes

Fipronil is a phenylpyrazole insecticide widely used to control pests in agriculture even though evidence of harmful side effects in non-target species has been reported. A comprehensive study on the effects of dietary administration of Regent®800WG (80 % fipronil) in European sea bass juveniles was carried out under two temperature regimes: a) natural conditions, and b) 3 °C above the natural temperature (an increase predicted for the NW Mediterranean by the end of this century). Fipronil was added to the fish food (10 mg fipronil /Kg feed) and the effects were studied at several time points including right before administration, 7 and 14 days after daily fipronil feed and one-week after the insecticide withdrawal from the diet (depuration period). A wide array of physiological and metabolic biomarkers including feeding rate, general condition indices, plasma and epidermal mucus metabolites, immune response, osmoregulation, detoxification and oxidative-stress markers and digestive enzymes were assessed. General linear models and principal component analyses indicated that regardless of water temperature, fipronil resulted in a significant alteration of several of the above listed biomarkers. Among them, glucose and lactate levels increased in plasma and decreased in epidermal mucus as indicators of a stress response. Similarly, a depletion in catalase activity and higher lipid peroxidation in liver of fipronil-exposed fish were also indicative of an oxidative-stress condition. Fipronil induced a time dependent inhibition of Cytochrome P450-related activities and an increase of phase II glutathione-S-transferase. Moreover, fipronil administration was able to reduce the hypo-osmoregulatory capability as shown by the increase of plasmatic osmolality and altered several digestive enzymes including trypsin, lipase, alpha amylase and maltase. Finally, analyses in bile and muscle confirmed the rapid clearance of fipronil but the persistence of the metabolite fipronil-sulfone in bile even after the 7-day depuration period. Altogether, the results reveal a notable impact of this compound on the physiological condition of the European sea bass. The results should be considered in future environmental risk assessment studies since fipronil could be hazardous to fish species, particularly those inhabiting estuarine ecosystems exposed to the discharge of agriculture runoffs where this pesticide is mainly used

Incremental validity of Emotional Intelligence Perceived in predicting well-being

El objetivo del presente trabajo fue valorar la relación entre Inteligencia Emocional Percibida (IEP), medida por la Escala del Metaconocimiento del Estado de Ánimo (TMMS), el bienestar subjetivo (SWS) y el optimismo/pesimismo disposicional. Además, valoramos si la IEP se puede considerar un adecuado predictor del bienestar subjetivo (SWS). Los participantes fueron 518 adultos, 434 mujeres y 84 hombres. Todos ellos respondieron de forma anónima medidas de satisfacción en la vida, afecto positivo y negativo, inteligencia emocional percibida y optimismo/pesimismo disposicional. Hemos utilizado el método de Johnson para valorar los pesos relativos de cada una de las variables predictoras en una regresión múltiple. Nuestros resultados señalan que dos dimensiones de IEP (Claridad y Reparación) son buenos predictores de SWS, mientras la tercera dimensión, Atención emocional, parece no ser un adecuado predictorThe aim of the present study was to assess the relationship between Perceived Emotional Intelligence (PEI) as measured by the Trait Meta-Mood Scale (TMMS), Subjective Well-Being (SWB), and dispositional optimism/pessimism. In addition, we assessed whether PEI can be considered an adequate predictor of the SWB. Participants were 518 adults, 434 males and 84 females who anonymously completed measures of satisfaction with life, positive and negative affect, perceived emotional intelligence, and dispositional optimism/pessimism. The Johnson’s method was used for estimating the relative weight of predictor variables in multiple regression. Our results support that two dimensions of PEI (Clarity and Repair) are good predictors of SWB, whereas the third dimension, Emotional Attention, seems not adequate as a predicto

Hard epoxy thermosets obtained via two sequential epoxy-amine condensations

A new family of dual-curable poly(ß-hydroxyamine ether) thermosets based on amine-epoxy formulations has been prepared and characterized. Both curing stages consist in an epoxy-amine polycondensation, each having different reactivity. Whereas the first one is carried out at relatively low temperature using an aliphatic flexible amine, the second is carried out at high temperature with a rigid aromatic amine. The sequentiality of the curing and the stability of the intermediate materials can be established in the basis of the different nucleophilicity of the amines used. The aromatic amine, with a weakly nucleophilic character, is not able to react with epoxides during the first stage at low temperature. The intermediate and final materials exhibit a wide range of properties, thanks to the different glass transition of both epoxy-amine networks, and can be tuned by changing the relative proportion of both diamines in the formulation. The participation of the epoxy resin in both curing stages ensures the homogeneity of the prepared materials, rendering them excellent candidates for applications such as adhesives or smart materials.Postprint (author's final draft

Evaluation of integrated care services in Catalonia:population-based and service-based real-life deployment protocols

BackgroundComprehensive assessment of integrated care deployment constitutes a major challenge to ensure quality, sustainability and transferability of both healthcare policies and services in the transition toward a coordinated service delivery scenario. To this end, the manuscript articulates four different protocols aiming at assessing large-scale implementation of integrated care, which are being developed within the umbrella of the regional project Nextcare (2016-2019), undertaken to foster innovation in technologically-supported services for chronic multimorbid patients in Catalonia (ES) (7.5M inhabitants).Whereas one of the assessment protocols is designed to evaluate population-based deployment of care coordination at regional level during the period 2011-2017, the other three are service-based protocols addressing: i) Home hospitalization; ii) Prehabilitation for major surgery; and, iii) Community-based interventions for frail elderly chronic patients. All three services have demonstrated efficacy and potential for health value generation. They reflect different implementation maturity levels. While full coverage of the entire urban health district of Barcelona-Esquerra (520k inhabitants) is the main aim of home hospitalization, demonstration of sustainability at Hospital Clinic of Barcelona constitutes the core goal of the prehabilitation service. Likewise, full coverage of integrated care services addressed to frail chronic patients is aimed at the city of Badalona (216k inhabitants).MethodsThe population-based analysis, as well as the three service-based protocols, follow observational and experimental study designs using a non-randomized intervention group (integrated care) compared with a control group (usual care) with a propensity score matching method. Evaluation of cost-effectiveness of the interventions using a Quadruple aim approach is a central outcome in all protocols. Moreover, multi-criteria decision analysis is explored as an innovative method for health delivery assessment. The following additional dimensions will also be addressed: i) Determinants of sustainability and scalability of the services; ii) Assessment of the technological support; iii) Enhanced health risk assessment; and, iv) Factors modulating service transferability.DiscussionThe current study offers a unique opportunity to undertake a comprehensive assessment of integrated care fostering deployment of services at regional level. The study outcomes will contribute refining service workflows, improving health risk assessment and generating recommendations for service selection.Trials registrationNCT03130283 (date released 04/06/2018), NCT03768050 (date released 12/05/2018), NCT03767387 (date released 12/05/2018).</p

Evaluation of integrated care services in Catalonia: population-based and service- based real-life deployment protocols

Background: Comprehensive assessment of integrated care deployment constitutes a major challenge to ensure quality, sustainability and transferability of both healthcare policies and services in the transition toward a coordinated service delivery scenario. To this end, the manuscript articulates four different protocols aiming at assessing large-scale implementation of integrated care, which are being developed within the umbrella of the regional project Nextcare (2016-2019), undertaken to foster innovation in technologically-supported services for chronic multimorbid patients in Catalonia (ES) (7.5 M inhabitants). Whereas one of the assessment protocols is designed to evaluate population-based deployment of care coordination at regional level during the period 2011-2017, the other three are service-based protocols addressing: i) Home hospitalization; ii) Prehabilitation for major surgery; and, iii) Community-based interventions for frail elderly chronic patients. All three services have demonstrated efficacy and potential for health value generation. They reflect different implementation maturity levels. While full coverage of the entire urban health district of Barcelona-Esquerra (520 k inhabitants) is the main aim of home hospitalization, demonstration of sustainability at Hospital Clinic of Barcelona constitutes the core goal of the prehabilitation service. Likewise, full coverage of integrated care services addressed to frail chronic patients is aimed at the city of Badalona (216 k inhabitants). Methods: The population-based analysis, as well as the three service-based protocols, follow observational and experimental study designs using a non-randomized intervention group (integrated care) compared with a control group (usual care) with a propensity score matching method. Evaluation of cost-effectiveness of the interventions using a Quadruple aim approach is a central outcome in all protocols. Moreover, multi-criteria decision analysis is explored as an innovative method for health delivery assessment. The following additional dimensions will also be addressed: i) Determinants of sustainability and scalability of the services; ii) Assessment of the technological support; iii) Enhanced health risk assessment; and, iv) Factors modulating service transferability. Discussion: The current study offers a unique opportunity to undertake a comprehensive assessment of integrated care fostering deployment of services at regional level. The study outcomes will contribute refining service workflows, improving health risk assessment and generating recommendations for service selection. Trials registration: NCT03130283 (date released 04/06/2018), NCT03768050 (date released 12/05/2018), NCT03767387 (date released 12/05/2018)