924 research outputs found
Long-Term Outcomes in Children with Congenital Toxoplasmosis-A Systematic Review.
Even in the absence of manifestations at birth, children with congenital toxoplasmosis (CT) may develop serious long-term sequelae later in life. This systematic review aims to present the current state of knowledge to base an informed decision on how to optimally manage these pregnancies and children. For this, a systematic literature search was performed on 28 July 2022 in PubMed, CENTRAL, ClinicalTrials.gov, Google Scholar and Scopus to identify all prospective and retrospective studies on congenital toxoplasmosis and its long-term outcomes that were evaluated by the authors. We included 31 research papers from several countries. Virulent parasite strains, low socioeconomic status and any delay of treatment seem to contribute to a worse outcome, whereas an early diagnosis of CT as a consequence of prenatal screening may be beneficial. The rate of ocular lesions in treated children increases over time to 30% in European and over 70% in South American children and can be considerably reduced by early treatment in the first year of life. After treatment, new neurological manifestations are not reported, while ocular recurrences are observed in more than 50% of patients, with a mild to moderate impact on quality of life in European cohorts when compared to a significantly reduced quality of life in the more severely affected South American children. Though CT is rare and less severe in Europe when compared with South America, antenatal screening is the only effective way to diagnose and treat affected individuals at the earliest possible time in order to reduce the burden of disease and achieve satisfying outcomes
Corrigendum to âPollen-based paleoenvironmental and paleoclimatic change at Lake Ohrid (south-eastern Europe) during the past 500 kaâ published in Biogeosciences, 13, 1423â1437, 2016
In this corrigendum we report an updated pollen record from the Lake Ohrid DEEP site spanning the past 500 ka whereby we have reprocessed and re-analyzed 104 samples affected by chemical procedure problems that occurred in one palynological laboratory. Firstly, these samples were affected by the use of wrong containers, causing in- adequate settling of particles at the set centrifuging speed. Secondly, HCl and HF treatments were combined without the prescribed intermediate centrifuging and decanting steps. The inaccuracy in the protocol resulted in the loss of smaller pollen grains and in the overrepresentation of bisaccate ones in most of the re-analyzed samples. We therefore provide an updated set of figures with the new data and have revised the description of the results, discussion and conclusions re- ported in Sadori et al. (2016) where necessary. We stress that the majority of the original results and conclusions remain valid, while the recordsâ reliability and resolution have improved as 12 samples that had been omitted in the original study because of low count sums are now included in the revised dataset (Sadori et al., 2018)
Dromadaire
Autant que lâĂąne, auquel il est souvent associĂ©, le dromadaire est lâanimal caractĂ©ristique du Nord de lâAfrique, donc du monde berbĂšre. BĂȘte de somme, de trait, de course, lâimagerie populaire et touristique nâa surtout retenu de ce chameau Ă bosse unique, que la derniĂšre qualitĂ©Â : le mĂ©hari* touareg animal de selle, Ă©lancĂ©, Ă robe claire qui est particuliĂšrement photogĂ©nique surtout lorsquâil participe Ă une parade (ilĂ»Äan) ou lorsque, dans les temps rĂ©volus, il revenait dâun rezzou victori..
Pollen-based temperature and precipitation changes in the Ohrid Basin (western Balkans) between 160 and 70 ka
Our study aims to reconstruct climate changes that occurred at Lake Ohrid
(south-western Balkan Peninsula), the oldest extant lake in Europe, between
160 and 70 ka (covering part of marine isotope stage 6, MIS 6; all of MISÂ 5;
and the beginning of MISÂ 4). A multi-method approach, including the âModern
Analog Techniqueâ and the âWeighted Averaging Partial Least-Squares Regressionâ, is
applied to the high-resolution pollen sequence of the DEEP site, collected
from the central part of Lake Ohrid, to provide quantitative estimates of
climate and bioclimate parameters. This allows us to document climatic change
during the key periods of MISÂ 6 and MISÂ 5 in southern Europe, a region where
accurate climate reconstructions are still lacking for this time interval.
Our results for the penultimate glacial show cold and dry conditions, while the onset of
the âlast interglacialâ is characterized by wet and warm conditions, with temperatures
higher than today (by ca. 2 âC). The Eemian also shows the well-known climatic
tri-partition in the Balkans, with an initial pre-temperate phase of abrupt warming
(128â121 ka), a central temperate phase with decreasing temperatures associated with
wet conditions (121â118 ka), followed by a post-temperate phase of progressive change
towards cold and dry conditions (118â112 ka).
After the Eemian, an alternation of four warm/wet periods with cold/dry
ones, likely related to the succession of Greenland stadials and cold events
known from the North Atlantic, occurred. The observed pattern is also
consistent with hydrological and isotopic data from the central
Mediterranean.
The Lake Ohrid climate reconstruction shows greater similarity with climate
patterns inferred from northern European pollen records than with southern
European ones, which is probably due to its intermediate position and the
mountainous setting. However, this hypothesis needs further testing as very
few climate reconstructions are available for southern Europe for this key
time period.</p
Agronomie Oasienne. Projet de Coopération Franco-Tunisien. Proposition d'un projet de Coopération technique : "Recherches pour le Développement de l'agriculture d'oasis dans le Sud Tunisien". Rapport de missions SynthÚse et propositions
Ce document est le résultat des missions réalisées au cours du premier semestre 1991 dans le cadre du projet d'appui à la recherche sur l'agriculture d'oasis en Tunisie. Il regroupe deux dossiers : - Rapports de missions et - SynthÚses et propositions. Dans la premiÚre partie du document, aprÚs une brÚve présentation du projet, 4 volets sont détaillés : - "Inventaire du patrimoine génétique Oasien", - "Protection des cultures", "Agronomie et Développement", et "Technologie post-récolte". La deuxiÚme partie du rapport présente les moyens, la programmation ainsi que le suivi et évaluation du proje
Danse
La danse tient incontestablement une place de choix dans la culture berbĂšre. PhĂ©nomĂšne essentiellement rural, il sâagit habituellement dâune manifestation dâun haut niveau esthĂ©tique, Ă la mise en scĂšne aussi symbolique que suggestive, sans doute liĂ©e Ă quelque thĂšme de fĂ©conditĂ© issu du fond des Ăąges. Exutoire commode, en tout cas, pour des populations menant une existence rude, elle ne peut laisser lâobservateur indiffĂ©rent. Au mieux, elle le charmera grĂące Ă son « mysticisme immanent » se ..
Deglacial and Holocene vegetation and climatic changes in the southern Central Mediterranean from a direct landâsea correlation
International audienceDespite a large number of studies, the long-term and millennial to centennial-scale climatic variability in the Mediterranean region during the last deglaciation and the Holocene is still debated, including in the southern Central Mediterranean. In this paper, we present a new marine pollen sequence (core MD04-2797CQ) from the Siculo-Tunisian Strait documenting the regional vegetation and climatic changes in the southern Central Mediterranean during the last deglaciation and the Holocene. The MD04-2797CQ marine pollen sequence shows that semi-desert plants dominated the vegetal cover in the southern Central Mediterranean between 18.2 and 12.3 ka cal BP, indicating prevailing dry conditions during the deglaciation, even during the Greenland Interstadial (GI)-1. Across the transition Greenland Stadial (GS)-1 -Holocene, Asteraceae-Poaceae steppe became dominant till 10.1 ka cal BP. This record underlines with no chronological ambiguity that even though temperatures increased, deficiency in moisture availability persisted into the early Holocene. Temperate trees and shrubs with heath underbrush or maquis expanded between 10.1 and 6.6 ka, corresponding to Sapropel 1 (S1) interval, while Mediterranean plants only developed from 6.6 ka onwards. These changes in vegetal cover show that the regional climate in southern Central Mediterranean was wetter during S1 and became drier during the mid-to late Holocene. Wetter conditions during S1 were likely due to increased winter precipitation while summers remained dry. We suggest, in agreement with published modeling experiments, that the early Holocene increased melting of the Laurentide Ice Sheet in conjunction with weak winter insolation played a major role in the development of winter precipitation maxima in the Mediterranean region in controlling the strength and position of the North Atlantic storm track. Finally, our data provide evidence for centennial-scale vegetation and climatic changes in the southern Central Mediterranean. During the wet early Holocene, alkenone-derived cooling episodes are synchronous with herbaceous composition changes that indicate muted changes in precipitation. In contrast, enhanced aridity episodes, as detected by strong reduction in trees and shrubs, are recorded during the mid-to late Holocene. We show that the impact of the Holocene cooling events on the Mediterranean hydroclimate depend on baseline climate states, i.e. insolation and ice sheet extent, shaping the response of the mid-latitude atmospheric circulation
Corrigendum to âPollen-based paleoenvironmental and paleoclimatic change at Lake Ohrid (south-eastern Europe) during the past 500 kaâ published in Biogeosciences, 13, 1423â1437, 2016
In this corrigendum we report an updated pollen record from the Lake Ohrid DEEP site spanning the past 500 ka whereby we have reprocessed and re-analyzed 104 samples affected by chemical procedure problems that occurred in one palynological laboratory. Firstly, these samples were affected by the use of wrong containers, causing in- adequate settling of particles at the set centrifuging speed. Secondly, HCl and HF treatments were combined without the prescribed intermediate centrifuging and decanting steps. The inaccuracy in the protocol resulted in the loss of smaller pollen grains and in the overrepresentation of bisaccate ones in most of the re-analyzed samples. We therefore provide an updated set of figures with the new data and have revised the description of the results, discussion and conclusions re- ported in Sadori et al. (2016) where necessary. We stress that the majority of the original results and conclusions remain valid, while the recordsâ reliability and resolution have improved as 12 samples that had been omitted in the original study because of low count sums are now included in the revised dataset (Sadori et al., 2018)
Orexinergic Input to Dopaminergic Neurons of the Human Ventral Tegmental Area
The mesolimbic reward pathway arising from dopaminergic (DA) neurons of the ventral tegmental area (VTA) has been
strongly implicated in reward processing and drug abuse. In rodents, behaviors associated with this projection are
profoundly influenced by an orexinergic input from the lateral hypothalamus to the VTA. Because the existence and
significance of an analogous orexigenic regulatory mechanism acting in the human VTA have been elusive, here we
addressed the possibility that orexinergic neurons provide direct input to DA neurons of the human VTA. Dual-label
immunohistochemistry was used and orexinergic projections to the VTA and to DA neurons of the neighboring substantia
nigra (SN) were analyzed comparatively in adult male humans and rats. Orexin B-immunoreactive (IR) axons apposed to
tyrosine hydroxylase (TH)-IR DA and to non-DA neurons were scarce in the VTA and SN of both species. In the VTA,
15.062.8% of TH-IR perikarya in humans and 3.260.3% in rats received orexin B-IR afferent contacts. On average, 0.2460.05 and 0.0560.005 orexinergic appositions per TH-IR perikaryon were detected in humans and rats, respectively. The majority(86â88%) of randomly encountered orexinergic contacts targeted the dendritic compartment of DA neurons. Finally, DA neurons of the SN also received orexinergic innervation in both species. Based on the observation of five times heavierorexinergic input to TH-IR neurons of the human, compared with the rat, VTA, we propose that orexinergic mechanism acting in the VTA may play just as important roles in reward processing and drug abuse in humans, as already established
well in rodents
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What have we learnt from palaeoclimate simulations?
There has been a gradual evolution in the way that palaeoclimate modelling and palaeoenvironmental data are used together to understand how the Earth System works, from an initial and largely descriptive phase through explicit hypothesis testing to diagnosis of underlying mechanisms. Analyses of past climate states are now regarded as integral to the evaluation of climate models, and have become part of the toolkit used to assess the likely realism of future projections. Palaeoclimate assessment has demonstrated that changes in large-scale features of climate that are governed by the energy and water balance show consistent responses to changes in forcing in different climate states, and these consistent responses are reproduced by climate models. However, state-of-the-art models are still largely unable to reproduce observed changes in climate at a regional scale reliably. While palaeoclimate analyses of state-of-the-art climate models suggest an urgent need for model improvement, much work is also needed on extending and improving palaeoclimate reconstructions and quantifying and reducing both numerical and interpretative uncertainties
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