Identification of citrullinated α-enolase as a candidate autoantigen in rheumatoid arthritis

Antibodies against citrullinated proteins are highly specific for rheumatoid arthritis (RA), but little is understood about their citrullinated target antigens. We have detected a candidate citrullinated protein by immunoblotting lysates of monocytic and granulocytic HL-60 cells treated with peptidylarginine deiminase. In an initial screen of serum samples from four patients with RA and one control, a protein of molecular mass 47 kDa from monocytic HL-60s reacted with sera from the patients, but not with the serum from the control. Only the citrullinated form of the protein was recognised. The antigen was identified by tandem mass spectrometry as α-enolase, and the positions of nine citrulline residues in the sequence were determined. Serum samples from 52 patients with RA and 40 healthy controls were tested for presence of antibodies against citrullinated and non-citrullinated α-enolase by immunoblotting of the purified antigens. Twenty-four sera from patients with RA (46%) reacted with citrullinated α-enolase, of which seven (13%) also recognised the non-citrullinated protein. Six samples from the controls (15%) reacted with both forms. α-Enolase was detected in the RA joint, where it co-localised with citrullinated proteins. The presence of antibody together with expression of antigen within the joint implicates citrullinated α-enolase as a candidate autoantigen that could drive the chronic inflammatory response in RA

Access to shops: The views of low-income shoppers

Concern is mounting as the retail stranglehold upon access to food grows. Research on the implications of restructuring retailing and health inequality has failed to involve low-income consumers in this debate. This paper reports on an exercise conducted for the UK Government's, Social Exclusion Unit's Policy Action Team on Access to Shops. The survey provides a useful baseline of the views of low-income groups in England. The choices that people on low income can make were found to be dominated by certain factors such as income and, most importantly, transport. Consumers reported varying levels of satisfaction with retail provision. The findings suggest gaps between what people have, what they want and what the planning process does and does not offer them. Better policy and processes are needed to include and represent the interests of low-income groups

Problems and Paradoxes in Economic and Social Policies of Modern Welfare States

Relationships between economic growth rates and the expansion of welfare expenditures in Western nations are examined. The point is made that real gross national product grew rapidly from about 1959 until about 1973, but that since 1973 it has either grown slowly or not at all, while welfare expenditures and entitlements have continued to escalate. Forecasts of a variety of important economic variables in these countries for the near term are presented and discussed, and it is concluded that despite the current modest economic improvement, difficulties in funding welfare states will continue throughout the remainder of the 1980s. Some consideration is given to problems in welfare states to the end of the century, and further difficulties in funding and managing these states are forecast for this period as well. Problems of welfare states are not regarded as short-term by-products of maladjustments experienced in the Western world in the last 10 years but rather as long-term characteristics.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/67103/2/10.1177_000271628547900102.pd

Social quality and Brexit in Stoke-on-Trent, England

In this article, we seek to provide a social quality–led analysis of some of the conditions that led to the UK population’s collective decision to leave the European Union in June 2016. We draw on interview data collected between 2010 and 2012 to argue that while not predictable, the seeds of the Brexit vote are well rooted in the conditions experienced by many of the working classes in Britain’s most deprived postindustrial communities. We argue that the ongoing decline in economic security, effective enfranchisement, social inclusion, and social empowerment have all had profound consequences for working-class communities and that the outcome of the Brexit vote was rooted, at least in part, in their subjective experiences and disenchantment forged in this ongoing decline

Tony Blair and John Howard: comparative predominance and 'Institution Stretch' in the UK and Australia

It has recently been argued that the UK premier enjoys a level of executive power unavailable to US presidents, but how does he or she compare to another prime minister operating within a broadly similar system? Commonalities of intra-executive influence and capacity exist under the premierships in the UK and Australia. Discrete institutional constraints and deviations are evident, but trends and similarities in resource capacity can be clearly identified. These include: the growth of the leaders' office; broadening and centralising of policy advice and media operations; and strengthening of the role and function of ministerial advisers. I contend that this amounts to 'institution stretch', with new structures, processes and practices becoming embedded in the political system by the incumbents. © 2007 The Author. Journal compilation © 2007 Political Studies Association

Looking for the women in Baron and Taylor's (1969) Educational administration and the social sciences

A search for women in Baron and Taylor's (1969) Educational administration and the social sciences [London: The Athlone Press] using feminist poststructural discourse analysis (FPDA) has revealed a changing discourse about gendered educational administration over the course of 50 years. Whilst few women are featured in the text itself, citations of women's writing surface the historical contributions of women as headmistresses and public servants. Women who have cited the text since its publication have challenged gendered theory and academic writing conventions. FPDA is used to explore the gendered educational administration discourse through the intertextuality of academic writing. Fluctuations between powerfulness and powerlessness are revealed depending on the socio-political context and women's circumstances

The hand of accounting and accountancy firms in deepening income and wealth inequalities and the economic crisis: Some evidence

This paper looks at the economic crisis in the UK. It argues that everyday accounting practices are deeply implicated in the inequitable distribution of income and wealth, a major cause of the economic crisis engulfing the neoliberal economies. Without adequate purchasing power middle and low income households cannot make the purchases necessary for a sustained revival of the economic activity. Accounting calculations and discourses play a major role in the determination of wages and taxes. They prioritise the interests of capital over labour and the state and have systematically eroded labour's share of the gross domestic product. At the same time, despite a massive growth in corporate profitability, the UK state's share of the national wealth in the form of tax revenues has also declined. It is argued that accounting practices which label payment of wages to labour and payment of taxes to the state as ?costs? amplify capitalist concerns about private appropriation of surpluses and have played a major role in assigning such payments to negative spaces. Through the sale of tax avoidance schemes to corporations and wealthy elites, accountancy firms have facilitated a skewed distribution of income of wealth and further constrained the state's capacity to reflate the economy. Consequently, the tax burdens on the less well-off have increased and further eroded their purchasing power and possibilities of building a sustainable economy