68 research outputs found
Targeted inactivation of hepatic Abca1 causes profound hypoalphalipoproteinemia and kidney hypercatabolism of apoA-I
- Author
- Publication venue
- 'American Society for Clinical Investigation'
- Publication date
- 01/01/2008
- Field of study
SLCO1B1*5 polymorphism (rs4149056) is associated with chemotherapy-induced amenorrhea in premenopausal women with breast cancer: a prospective cohort study
- Author
- A Valentini
- AM Wessels
- B Gerber
- Bernd Gerber
- C Bozza
- C Yoo
- Dirk Koczan
- E Lee
- E Link
- EA Elgindy
- Early Breast Cancer Trialists’ Collaborative Group
- F Faul
- G Singh
- H Joyce
- Hans-Jürgen Thiesen
- HCF Moore
- HI Su
- J König
- JM Walshe
- JP Bruin De
- JR Molina
- JR Perry
- K Takada
- L Wang
- LR Schover
- LR Treviño
- M Colvin
- M Niemi
- M Wong
- ME Abusief
- NH Turner
- P Munster
- P Ngamjanyaporn
- RA Anderson
- S Lee
- S Najafi
- Sarah Kempert
- SK Nigam
- SM Swain
- SM Swain
- Steffi Hartmann
- T Abe
- T Liu
- Toralf Reimer
- V Stearns
- WE Evans
- WM Deure van der
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Strategic partnering to improve community health worker programming and performance: features of a community-health system integrated approach
- Author
- A Haines
- A Mahbub
- A Renaud
- A Shankar
- A Teklehaimanot
- B Maggwa
- B Sircar
- C Debpuur
- C Delacollette
- D Berlan
- D Colvin
- D Frymus
- D Putnam
- D Walker
- Diana E. Frymus
- F Ayele
- G Mwai
- G Wangalwa
- G Yamey
- Global Health Workforce Alliance (GHWA)
- Global Health Workforce Alliance (GHWA)
- Global Health Workforce Alliance and World Health Organization
- Government of Rwanda
- H Nsona
- H Perry
- H Perry
- H Perry
- H Perry
- H Perry
- H Schneider
- Henry B. Perry
- J Christopher
- J Diaz
- J Dick
- J Frenk
- J Habicht
- J Meyer-Capps
- J Naimoli
- J Naimoli
- J Naimoli
- J Phillips
- J Phillips
- J Zakus
- James A. McCaffery
- John W. Townsend
- Joseph F. Naimoli
- K Bhattacharyya
- K Gilroy
- K Kallander
- K LeBan
- K Sadler
- K Tulenko
- L Altobelli
- L Crigler
- L Marquez
- L Nkonki
- L Pritchett
- L Ramiro
- M Clarke
- M Griffiths
- M Iwami
- M Mosquera
- M Rahman
- M Ro
- M Rogers
- P Berman
- P Berman
- P McNamara
- P Singh
- R Atun
- R Braun
- R Kanter
- S Ahmed
- S Arifeen
- S Frehywot
- S Hodgins
- S Isaac
- S Kane
- S Khan
- S Liberato
- S Robinson
- S Subramanian
- United Nations Children’s Fund
- World Health Organization
- World Health Organization
- World Health Organization
- World Health Organization
- X Kan
- Y Amare
- Z Bhutta
- Z Bhutta
- Z Hill
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Zinc homeostasis and signaling in health and diseases: Zinc signaling
- Author
- A Hsouna
- A Takeda
- A Takeda
- AB Lansdown
- AB Lansdown
- AH Shankar
- AL Prost
- AM Hosie
- AM Kim
- AQ Truong-Tran
- AS Prasad
- AS Prasad
- AS Prasad
- AS Prasad
- B Holst
- BD Gomperts
- BL Vallee
- BL Vallee
- C Andreini
- C Giunta
- C Hogstrand
- C Kitabayashi
- CA Blindauer
- CD Tran
- CD Tran
- CJ Fahrni
- CJ Frederickson
- CL Keen
- CW Christine
- DA Andersson
- DE Baranano
- DG Stathakis
- DJ Eide
- DK Perry
- DL Brautigan
- DU Spahl
- E Bettelli
- E Bettelli
- E Bossy-Wetzel
- E Pirev
- F Chimienti
- F Chimienti
- F Wang
- G Fernandes
- G Riccioni
- GK Andrews
- H Haase
- H Haase
- H Haase
- H Hu
- H Kitamura
- H Maske
- H Ogura
- H Sakurai
- H Sharir
- H Takano
- I Lengyel
- II Ivanov
- J Dufner-Beattie
- J Dufner-Beattie
- J Pielage
- J Qian
- J Raulin
- JA Park
- JH Weiss
- JR Schwartz
- K Hirzel
- K Inoue
- K Inoue
- K Inoue
- K Inoue
- K Kabu
- K Kikuchi
- K Murakami
- K Nishida
- K Thambiayya
- K Vogt
- K Wang
- Keigo Nishida
- KH Ibs
- KM Taylor
- KM Taylor
- KM Taylor
- L Besser
- L Huang
- L Huang
- L Rink
- LD Pound
- LH Ho
- M Doren Van
- M Hershfinkel
- M Margoshes
- M Murakami
- M Nishihara
- M Penkowa
- M Richter
- M Richter
- M Veldhoen
- Masaaki Murakami
- ML Mayer
- N Kagara
- NA Begum
- P Legendre
- P Lichtlen
- PA Adlard
- PD Zalewski
- PJ Fraker
- R Sladek
- RA Colvin
- RD Palmiter
- RD Palmiter
- S Corbalan-Garcia
- S Hojyo
- S Hou
- S Kury
- S Pal
- S Sumalekshmy
- S Ueno
- S Yamasaki
- S Yamashita
- S Yasuda
- Satoru Yamasaki
- SL Kelleher
- SL Sensi
- SR Hubbard
- SY Assaf
- T Fujii
- T Fukada
- T Fukada
- T Hirano
- T Hirano
- T Jirakulaporn
- T Kambe
- T Kambe
- T Ohkawara
- T Suzuki
- TB Cole
- TF Xu
- TG Smart
- Toshio Hirano
- Toshiyuki Fukada
- V Bulow von
- V Lopantsev
- VE Reeve
- W Chowanadisai
- W Maret
- W Maret
- W Maret
- WG Telford
- WR Mathews
- X Xie
- Y Kanayama
- Y Li
- Y Zhang
- YM Lu
- Publication venue
- Springer-Verlag
- Publication date
- 01/01/2011
- Field of study
The essential trace element zinc (Zn) is widely required in cellular functions, and abnormal Zn homeostasis causes a variety of health problems that include growth retardation, immunodeficiency, hypogonadism, and neuronal and sensory dysfunctions. Zn homeostasis is regulated through Zn transporters, permeable channels, and metallothioneins. Recent studies highlight Zn’s dynamic activity and its role as a signaling mediator. Zn acts as an intracellular signaling molecule, capable of communicating between cells, converting extracellular stimuli to intracellular signals, and controlling intracellular events. We have proposed that intracellular Zn signaling falls into two classes, early and late Zn signaling. This review addresses recent findings regarding Zn signaling and its role in physiological processes and pathogenesis
Global patient outcomes after elective surgery: prospective cohort study in 27 low-, middle- and high-income countries.
- Author
- Ab Majid MA
- Ab Rahman AS
- Ab Rahman R
- Abayasinghe C
- Abbott T
- Abdullah NH
- Abdur-Rahman L
- Abeloos J
- Abernethy C
- Abidin UN
- Abrunhosa A
- Absar M
- Adam S
- Adams D
- Adams G
- Adamson M
- Adekola O
- Adelaja Y
- Ademola A
- Adenekan A
- Adenike O
- Adeolu AA
- Adetoye A
- Adewale B
- Adigun T
- Adolfsson A
- Aflori L
- Africander C
- Afshari A
- Agarwal V
- Agodirin O
- Aguero Vera M
- Aguzzoli C
- Ahmad A
- Ahmad N
- Ahmad T
- Ahmad T
- Ahmad Y
- Ahmed A
- Ahmed J
- Ai Y
- Aignatoaie M
- Aimoniotou-Georgiou E
- Akanmu O
- Akerman N
- Akinwale M
- Akring I
- Al 'Amri K
- Al Anizi M
- Al hussaini S
- Al-Soudaine Y
- Aladin H
- Alagbe-Briggs O
- Alaman Laguarda G
- Albaj S
- Alcock D
- Alcock L
- Aldecoa C
- Aldecoa C
- Aleixo FB
- Alexander H
- Alexander M
- Alexander-Sefre F
- Alherz F
- Ali H
- Ali M
- Ali S
- Alias A
- Alias AH
- Alias RLR
- Alit MA
- Allen S
- Allen SJ
- Allison J
- Alloj C
- Allorto NL
- Allsop J
- Almeida W
- Alonso E
- Alphonsus C
- Alvares D
- Alves MJ
- Amador JCB
- Ameer Y
- Amendola CP
- Ami N
- Amstrup-Hansen L
- Anagnou A
- Andersen C
- Anderson C
- Anderson C
- Anderson F
- Anderson P
- Andreadaki E
- Andreou A
- Andreou P
- Andrew A
- Andrews E
- Angermair S
- Angus K
- Anillo V
- Antal O
- Antill P
- Antoniadou E
- Antonina W
- Apagaki E
- Apostolou K
- Applewhaite C
- Aquino LPG
- Ar P
- Arawwawala D
- Ardern D
- Argue R
- Arkalaki E
- Armaganidis A
- Armstrong J
- Armstrong R
- Arnaoutoglou C
- Arnaoutoglou E
- Arnold G
- Arrandale L
- Arrich J
- Arrigo M
- Arshad H
- Arshad MA
- Arumugam S
- Arustei M
- Arvaniti K
- Arya A
- Arya S
- Asimakos A
- Asudo F
- Athanasakis E
- Atiku M
- Attrill E
- Attwood C
- Auer P
- Avidan M
- Avila Sanchez FJ
- Avila EJD
- Avis J
- Awad H
- Axioti E
- Ayyaz H
- Azam UAA
- Azambuja P
- Azevedo C
- Aziz FZ
- Baas P
- Baghirzada L
- Bai H-P
- Bai Y
- Baillie S
- Baines D
- Baio TH
- Bairaktari A
- Baker G
- Baker K-A
- Baker P
- Balain B
- Balaji P
- Balajonda N
- Balanescu A
- Balasubramaniam M
- Baldisserotto S
- Baldwin J
- Baldwin M
- Balfoussia D
- Bali C
- Bandeira ME
- Banerjee R
- Bankewitz C
- Banner-Goodspeed V
- Bao Q
- Barcraft-Barnes H
- Barneto L
- Barnett A
- Baroselli A
- Barraclough J
- Barras J-P
- Barrett S
- Barrett WJ
- Basanth S
- Batchelor N
- Bateman B
- Bates A
- Bates S
- Batista HD
- Bauchmuller K
- Bauer M
- Baumgarten G
- Baxter L
- Beaton C
- Beattie S
- Beavis V
- Bechan S
- Bejia T
- Belciu I
- Belda MT
- Bell G
- Bell R
- Bell S
- Bellandi M
- Bello J
- Beloeil H
- Belskiy V
- Ben-Menachem E
- Benavent P
- Benevento A
- Bengeri S
- Bennett C
- Bennett M
- Bennett R
- Bennett V
- Bentley C
- Beretta L
- Berg A
- Bergin C
- Bernard A
- Berntsen E
- Bertram W
- Bester D
- Bester M
- Bettega F
- Bettinelli A
- Bhardwaj N
- Bhatia K
- Bhula C
- Bi Y
- Biais M
- Biccard BM
- Bidd H
- Bidgoli J
- Biffen A
- Bignami E
- Bilolikar A
- Bin Mustapha MT
- Birch J
- Bishop DG
- Biyase T
- Bizios C
- Blackwell C
- Blackwood D
- Blaj M
- Blakemore SP
- Bland M
- Blunt M
- Blyth K
- Bocchino S
- Bodansky D
- Bodger P
- Boer C
- Boereboom C
- Boggiano V
- Bogner G
- Bolaji B
- Bolton D
- Boone M
- Boschi L
- Boshier P
- Botes M
- Botis I
- Bottini C
- Bottrill F
- Bouchez S
- Boulton K
- Bouris V
- Bourner L
- Boutsikos G
- Bouwman A
- Bouwman RA
- Bowrey S
- Boxall L
- Boyd C
- Bradburn M
- Bradley J
- Branagan G
- Branco T
- Brand B
- Brandsborg B
- Breitenstein S
- Brennan A
- Brennan E
- Brenner L
- Brincat M
- Briscoe R
- Bristogiannis S
- Brooke J
- Brookes J
- Brookes M
- Brooks C
- Broomby R
- Brotto AF
- Brown A
- Brown CW
- Brown G
- Brown J
- Brown J
- Brown L
- Brown R
- Brown R
- Browning J
- Bruma D
- Brunete T
- Brunswicker A
- Bryant H
- Bua E
- Buccimazza I
- Buckley S
- Buerkle C
- Buhre W
- Buhre W
- Buhrer T
- Builu PM
- Buise M
- Bullock C
- Bunwarie B
- Burns K
- Burrows L
- Burrows T
- Burston B
- Burtenshaw A
- Burton M
- Busuioc M
- Butryn I
- Butt G
- Byrne K
- Cabezuelo E
- Cabral R
- Cabral TDN
- Cabrini L
- Cacala S
- Cai F
- Cai Y
- Cain H
- Cairns C
- Cakova V
- Calderwood C
- Callaghan M
- Campbell D
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- Campey L
- Camsooksai J
- Cancho D
- Candido K
- Cang J
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- Cardosa J
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- Carmino L
- Carp CP
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- Carrera R
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- Caser E
- Castano Moreira B
- Castano B
- Castle G
- Cavanagh S
- Cawthorn L
- Cernea DD
- Chaddock M
- Chaloulis P
- Chan A
- Chan HMH
- Chan M
- Chan P
- Chan V
- Chan WK
- Chan WKJ
- Chan YL
- Chande S
- Chandler B
- Chandra S
- Chandrasekharan S
- Chang YH
- Chaniotaki F
- Charitos E
- Charlalampidoy A
- Charles R
- Chatterjee D
- Chatterjee J
- Chatzimichali CA
- Chau S
- Chazova E
- Cheah C
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- Cheeseman M
- Cheing Y
- Chen C
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- Chen L-L
- Chen P
- Chen Q
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- Chen S
- Chen S
- Chen S
- Chen Y
- Chen Y
- Chen Y
- Chen Y
- Chen Z
- Cheng B
- Cheng KH
- Cheng Z
- Cheong E
- Cherian R
- Cherrett V
- Chetty RR
- Chew M
- Chhabra A
- Chicken D-W
- Chilinciuc I
- Chin II
- Chirkut S
- Chisbert Cuenca V
- Chlorou D
- Choi H-MD
- Choi S
- Chow L
- Christian R
- Christiansen IC
- Christmas N
- Christodoulidis G
- Christodoulopoulou T
- Christofaki M
- Christoforidis D
- Chronis C
- Chu HM
- Chu S
- Chua P
- Chukkambotla S
- Chung CKE
- Cifra E
- Ciobanu C
- Ciobotaru OR
- Cirstea E
- Clark R
- Clarkson A
- Clarkson R
- Claxton A
- Clemmons K
- Cloro LM
- Clyde A
- Cobzaru I
- Codita A
- Colangelo A
- Colangelo C
- Colling K
- Collins H
- Collins M
- Collins N
- Colvin C
- Commey T
- Comptaer N
- Conde C
- Conradie A
- Constantin K
- Cook T
- Cooper L
- Cooper L
- Cooper M
- Cooper R
- Cooper S
- Copaciu E
- Cope J
- Copetti E
- Copley E
- Copotoiu SM
- Coppens M
- Corneci D
- Cornell J
- Cornish J
- Correia da Silva RFM
- Corti D
- Costanzo E
- Costelloe H
- Cotter R
- Cotterell S
- Cotterill D
- Coughlan E
- Coulter I
- Coulter S
- Coutinho F
- Cowton A
- Cox H
- Cozar OI
- Craig J
- Craven R
- Craw N
- Craw S
- Creary T
- Cripps H
- Critchley R
- Cronje L
- Cruickshank R
- Cruikshanks A
- Cruz S
- Cueva A
- Cunha P
- Curley G
- Currow H
- Czepanski C
- Czeslick E
- D'Andrea R
- da Costa Fischer BF
- Dafnios N
- Dai H
- Dai Q
- Dai Q
- Dai SY
- Daikou P
- Dalamagka M
- Dalampini E
- Dali-Kemmery L
- Dalton E
- Damant R
- Daniel C
- Daniel GD
- Daniel H
- Daniel H
- Daniel S
- Dankl D
- Darko J
- Darwish S
- Das S
- Dasrath A
- Datson A
- Daubeny T
- Daugaard M
- Davari M
- Dave T
- Davies C
- Davies H
- Davies K
- Davies K
- Davies L
- Davies Z
- Davis E
- Davis F
- Davis S
- Daya B
- De Andres Ibanez JA
- de Araujo DM
- De Baerdemaeker L
- de Beer J
- de Boer HD
- De Bruyne A
- de Campos Ferreira MF
- de Fretes J
- de Gasperi J
- De Hert S
- De Jongh K
- De Kegel D
- De Meyer JN
- De Oliveira MC
- de Rudnicki S
- de Swardt M
- de Vasconcellos K
- de Villiers M
- de Wet J
- Deacon M
- Deblaere I
- Dedemadi G
- Deen T
- Deepak S
- Deighton K
- Deja M
- Delgado Garcia DR
- Delgado Navarro C
- Della Rocca G
- Dempsey G
- Dempster A
- den Hoedt M
- Denham S
- Dent K
- Dermitzaki D
- Desbordes J
- Despotidis V
- Diaconescu C
- Dias F
- Dias S
- Dickson J
- Ditai J
- Divatia J
- Dixon L
- do Nascimento Junior P
- Dobson G
- Docherty P
- Dodiyi-Manuel A
- Dodsworth K
- Dolan R
- Dong B
- Donohue R
- Donovan A
- Douglas J
- Doumos R
- Downes C
- Doyle D
- Dragnea D
- Dragoescu NA
- Drake M
- Drimala M
- Drinkwater Z
- Drummond L
- Du F
- Du F
- Du X
- Duarte C
- Dube NZ
- Duca A
- Dudgeon L
- Dudson R
- Duenser M
- Dumitrascu CO
- Dumitrescu A
- Dunay A
- Dunk N
- Durant E
- Durodola A
- Dursin AN
- Durst A
- Duttchen K
- Dutu M
- Dwyer H
- Dylst D
- Dzhamullaev P
- Dzulkipli N
- Echem R
- Edmond H
- Edwards J
- Edwards M
- Edwards M
- Efthymiadi A
- Egan T
- Eggleston C
- Eichwalder A
- Eikman J
- Ekelund K
- el Manser D
- El-Sayed A
- Elabib A
- Elena G
- Elferink-Vonk R
- Elgasim M
- Ellis J
- Ellis K
- Elna C
- Emma T
- Endersby S
- Eneje P
- Eng K
- English D
- English R
- Epodoi J
- Eskildsen KZ
- Esteves S
- Ethgen S
- Evans A
- Evans C
- Everingham K
- Ewe R
- Ezekiel E
- Ezike H
- Fagerlund MJ
- Faina L
- Falk E
- Fan H
- Fan L
- Fan Y
- Fanfani LC
- Faponle F
- Faria e Maia D
- Faria F
- Farid N
- Farina Z
- Farrell H
- Farrow M
- Fasina O
- Fatungase OM
- Faulds M
- Fei Y
- Fellinger P
- Feng Y
- Fengas L
- Fergey L
- Ferguson M
- Fernandez S
- Ferrando C
- Filipescu D
- Filippopoulos A
- Finch A
- Fiorentza K
- Fischbach N
- Flatt J
- Fleischer A
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- Fleisher LA
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- Flores AAA
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- Flossos A
- Foers W
- Foglia J
- Foley J
- Fonck K
- Foord D
- Foot H
- Foot J
- Ford D
- Forget P
- Forsans E
- Forstner K
- Foster R
- Foubert L
- Fouracres A
- Fowler A
- Fowler C
- Fraga JM
- Fragandreas G
- Francis D
- Franklin J
- Franks R
- Frantzeskos G
- Freeman D
- Freeman V
- Freethy A
- Freitas K
- Freschini A
- Freschini D
- Frewer N
- Fritsch G
- Frost V
- Fu K
- Fu S
- Fu Y
- Fuad A
- Fuentes I
- Fulton G
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- Furtado Paiva AA
- Futier E
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- Gardikou VV
- Gardiner M
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- Garg S
- Garg S
- Garrett E
- Gastaldi C
- Gatke MR
- Gatta A
- Gaudin C
- Gavril L
- Gbolahan O
- Ge X
- Geddoa B
- Geddoa E
- Geisen M
- Geldenhuys J
- Geng W
- Georgakakis G
- George R
- Georgiou G
- Georgopoulou E
- Gercek Y
- Germann R
- Geromarkaki E
- Ghafar FNIA
- Ghignone F
- Ghosh A
- Ghushe N
- Giancarlo L
- Giannaki C
- Gibson-Lapsley H
- Gil Manuel G
- Giles J
- Gill J
- Gill S
- Gill T
- Gille J
- Gillespie D
- Gillies M
- Gilmore J
- Gilmour F
- Gkini K-P
- Gkiokas G
- Gkioni P
- Glasbey J
- Glasgow E
- Glister G
- Glover L
- Goad EHA
- Goebel U
- Goga IE
- Goga R
- Goldberg O
- Golder K
- Gomez Diago L
- Gondo P
- Gong H
- Gordon P
- Goss H
- Gouws H
- Govender K
- Govindasamy V
- Grace A
- Gracia E
- Gradwohl-Matis I
- Granum SN
- Graterol J
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- Greaves R
- Green GM
- Green-Thompson R
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- Gregory P
- Grey B
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- Grigoras I
- Grigoryev E
- Grintescu I
- Grishkowez E
- Grosu R-M
- Grubmueller KG
- Gudaca M
- Guimaraes M
- Guizeline J
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- Guo F
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- Hales D
- Hall AM
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- Halliwell R
- Hambidge O
- Hamdan A
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- Hamzah Z
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- Hariharan V
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- Harrichandparsad R
- Harries R
- Harris B
- Harris C
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- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2016
- Field of study
BACKGROUND: As global initiatives increase patient access to surgical treatments, there remains a need to understand the adverse effects of surgery and define appropriate levels of perioperative care. METHODS: We designed a prospective international 7-day cohort study of outcomes following elective adult inpatient surgery in 27 countries. The primary outcome was in-hospital complications. Secondary outcomes were death following a complication (failure to rescue) and death in hospital. Process measures were admission to critical care immediately after surgery or to treat a complication and duration of hospital stay. A single definition of critical care was used for all countries. RESULTS: A total of 474 hospitals in 19 high-, 7 middle- and 1 low-income country were included in the primary analysis. Data included 44 814 patients with a median hospital stay of 4 (range 2-7) days. A total of 7508 patients (16.8%) developed one or more postoperative complication and 207 died (0.5%). The overall mortality among patients who developed complications was 2.8%. Mortality following complications ranged from 2.4% for pulmonary embolism to 43.9% for cardiac arrest. A total of 4360 (9.7%) patients were admitted to a critical care unit as routine immediately after surgery, of whom 2198 (50.4%) developed a complication, with 105 (2.4%) deaths. A total of 1233 patients (16.4%) were admitted to a critical care unit to treat complications, with 119 (9.7%) deaths. Despite lower baseline risk, outcomes were similar in low- and middle-income compared with high-income countries. CONCLUSIONS: Poor patient outcomes are common after inpatient surgery. Global initiatives to increase access to surgical treatments should also address the need for safe perioperative care. STUDY REGISTRATION: ISRCTN5181700
Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease
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- A Akyea-Djamson
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- Vogt E
- Vold D
- Volpe M
- Voors C
- Vora K
- Vorster M
- Voyzey Ej
- Vozzhaev A
- Vranckx P
- Vrolix M
- Vuriya Ak
- W Wu
- Wade Rd
- Wadell C
- Wakeling J
- Waksman R
- Walker K
- Walker K
- Wallace K
- Walter I
- Walter J
- Walther I
- Walukiewicz P
- Wanderley Ff
- Wang Cp
- Wang Hc
- Wang J
- Wang Y
- Wang Yl
- Warren M
- Washam M
- Watson B
- Webel R
- Weber Hg
- Wei J
- Wei N
- Weimer J
- Weisnagel Sj
- Wells T
- West M
- Westberg Jc
- Whitaker J
- White A
- White A
- White C
- White J
- Wichterich K
- Wiebusch A
- Wilhoit G
- Wilkins M
- Wilkinson S
- William M
- Willingham K
- Willmerdinger M
- Willner C
- Wilson S
- Wilson V
- Winkelmann B
- Winkler J
- Wise J
- Wistuba T
- Woehrle J
- Woelcke J
- Wohnlich T
- Wolf S
- Woodall S
- Woods A
- Woyczak D
- Wrage P
- Wright J
- Wu J
- Wu J
- Wujkowski M
- Wyss F
- Xavier Jp
- Xu H
- Xu Zj
- Yakovova S
- Yakushin S
- Yamada T
- Yamaguchi E
- Yamamoto H
- Yamamoto T
- Yamane M
- Yan J
- Yanase T
- Yanev T
- Yang Cc
- Yang K
- Yang P
- Yao Z
- Yaoqing H
- Yarows S
- Yasuoka S
- Yasutake M
- Yigit Z
- Yilmaz Mb
- Yim Kh
- Yim S
- Yokoyama M
- Yong H
- Yoshida M
- Yoshimoto E
- Yossen M
- Young A
- Younis L
- Youssef G
- Yuan Z
- Yunoki C
- Yupanqui H
- Z Zhai
- Z Zilahi
- Zadionchenko V
- Zadra R
- Zagozen P
- Zaidman C
- Zalazar L
- Zaman A
- Zangroniz P
- Zarate J
- Zareczky P
- Zarifis I
- Zdrenghea D
- Zebrack J
- Zena N
- Zhang J
- Zhang W
- Zhang Y
- Zhao R
- Zhou H
- Zidova M
- Zielinski M
- Zieve F
- Zineldine A.
- Zirlik A
- Zucchetti C
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2017
- Field of study
Background: Experimental and clinical data suggest that reducing inflammation without affecting lipid levels may reduce the risk of cardiovascular disease. Yet, the inflammatory hypothesis of atherothrombosis has remained unproved. Methods: We conducted a randomized, double-blind trial of canakinumab, a therapeutic monoclonal antibody targeting interleukin-1β, involving 10,061 patients with previous myocardial infarction and a high-sensitivity C-reactive protein level of 2 mg or more per liter. The trial compared three doses of canakinumab (50 mg, 150 mg, and 300 mg, administered subcutaneously every 3 months) with placebo. The primary efficacy end point was nonfatal myocardial infarction, nonfatal stroke, or cardiovascular death. RESULTS: At 48 months, the median reduction from baseline in the high-sensitivity C-reactive protein level was 26 percentage points greater in the group that received the 50-mg dose of canakinumab, 37 percentage points greater in the 150-mg group, and 41 percentage points greater in the 300-mg group than in the placebo group. Canakinumab did not reduce lipid levels from baseline. At a median follow-up of 3.7 years, the incidence rate for the primary end point was 4.50 events per 100 person-years in the placebo group, 4.11 events per 100 person-years in the 50-mg group, 3.86 events per 100 person-years in the 150-mg group, and 3.90 events per 100 person-years in the 300-mg group. The hazard ratios as compared with placebo were as follows: in the 50-mg group, 0.93 (95% confidence interval [CI], 0.80 to 1.07; P = 0.30); in the 150-mg group, 0.85 (95% CI, 0.74 to 0.98; P = 0.021); and in the 300-mg group, 0.86 (95% CI, 0.75 to 0.99; P = 0.031). The 150-mg dose, but not the other doses, met the prespecified multiplicity-adjusted threshold for statistical significance for the primary end point and the secondary end point that additionally included hospitalization for unstable angina that led to urgent revascularization (hazard ratio vs. placebo, 0.83; 95% CI, 0.73 to 0.95; P = 0.005). Canakinumab was associated with a higher incidence of fatal infection than was placebo. There was no significant difference in all-cause mortality (hazard ratio for all canakinumab doses vs. placebo, 0.94; 95% CI, 0.83 to 1.06; P = 0.31). Conclusions: Antiinflammatory therapy targeting the interleukin-1β innate immunity pathway with canakinumab at a dose of 150 mg every 3 months led to a significantly lower rate of recurrent cardiovascular events than placebo, independent of lipid-level lowering. (Funded by Novartis; CANTOS ClinicalTrials.gov number, NCT01327846.
Echium Oil Reduces Plasma Triglycerides by Increasing Intravascular Lipolysis in apoB100-Only Low Density Lipoprotein (LDL) Receptor Knockout Mice
- Author
- Publication venue
- Publication date
- 01/01/2013
- Field of study
nutrient
FTICR
- Author
- Publication venue
- Publication date
- 15/03/2018
- Field of study
MALDI FTICR IMS of a mouse section containing an infectious foci. The FTICR was used to obtain accurate mass measurements from the MALDI IMS data in order to have confidence in protein identifications
ICP Mn Reporter
- Author
- Publication venue
- Publication date
- 15/03/2018
- Field of study
These are LA-ICP IMS data from the kidney of mice infected with S. aureus. This stain of S. aureus is responsive to manganese. Mice were analyzed at 4, 7, and 10 days post infection
ICP Iron Reporter
- Author
- Publication venue
- Publication date
- 15/03/2018
- Field of study
These data are LA-ICP IMS data corresponding to mouse kidneys infected with S.aureus. These mice were infected with a, iron-reporter. Mice were analyzed at three time points post infection: 4, 7, and 10 day
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