The Citizen Artist : 20 Years of Art in the Public Arena : An Anthology from High Performance Magazine 1978-1998, Vol. I

An anthology of articles from High Performance Magazine published between 1978 and 1998, comprised mainly of interviews with artists grouped under three themes: the art/life experiment, the artist as activist, and the artist as citizen. Durland claims the groupings reflect the evolution of the magazine’s editorial concerns, from performance art to activist art to community-based art. Each text, he notes, is linked by the desire to reach beyond the traditional forms, content, and context of the arts to engage with a broader community. Biographical notes. Bibl. 4 p

Host resistance to endotoxic shock requires the neuroendocrine regulation of group 1 innate lymphoid cells

International audienceUpon infection, the immune system produces inflammatory mediators important for pathogen clearance. However, inflammation can also have deleterious effect on the host and is tightly regulated. Immune system-derived cytokines stimulate the hypothalamic-pituitary-adrenal (HPA) axis, triggering endogenous glucocorticoid production. Through interaction with ubiquitously expressed glucocorticoid receptors (GRs), this steroid hormone has pleiotropic effects on many cell types. Using a genetic mouse model in which the gene encoding the GR is selectively deleted in NKp46(+) innate lymphoid cells (ILCs), we demonstrated a major role for the HPA pathway in host resistance to endotoxin-induced septic shock. GR expression in group 1 ILCs is required to limit their IFN-gamma production, thereby allowing the development of IL-10-dependent tolerance to endotoxin. These findings suggest that neuroendocrine axes are crucial for tolerization of the innate immune system to microbial endotoxin exposure through direct corticosterone-mediated effects on NKp46-expressing innate cells, revealing a novel strategy of host protection from immunopathology