Caso edificio Space

The Space building was a residential complex located in the city of Medellín (Colombia), which was divided into six stages or towers. In the last stage of the project, tower six suffered a structural failure that caused its collapse, which led to the demolition of the other towers. The main issues discussed are related to the design of structures, columns, beams, and loads that a structure can withstand given the terrain and the materials used for construction. In addition, the study carried out by the Universidad de Los Andes, which was the main source of information in the investigation of the collapse and its aftermath, will be presented. This article will collect and show information on this case in the areas directly related to civil engineering and what happened to those involved in the project.El edificio Space fue un conjunto residencial ubicado en la ciudad de Medellín (Colombia), el cual se dividía en seis etapas o torres. En la última etapa del proyecto, la torres seis, sufrió una falla estructural que produjo el colapso de esta, y esto llevó a la demolición de las demás torres. Los problemas principales que se trataron están relacionados con el diseño de estructuras, columnas, vigas y cargas que puede soportar una estructura dadas las situaciones del terreno y los materiales utilizados para la construcción. Además, se dará a conocer el estudio realizado por la Universidad de Los Andes la cual fue la principal fuente de información en la investigación del colapso y posteriormente a este. El presente artículo recolectará y mostrará información de este caso en los ámbitos ligados directamente a la ingeniería civil y lo ocurrido con los implicados en el proyecto

Towards a Rapid Screening of Liver Grafts at the Operating Room Using Mid-Infrared Spectroscopy

The estimation of steatosis in a liver graft is mandatory prior to liver transplantation, as the risk of graft failure increases with the level of infiltrated fat. However, the assessment of liver steatosis before transplantation is typically based on a qualitative or semiquantitative characterization by visual inspection and palpation and histological analysis. Thus, there is an unmet need for transplantation surgeons to have access to a diagnostic tool enabling an in situ fast classification of grafts prior to extraction. In this study, we have assessed an attenuated total reflection−Fourier transform infrared (ATR−FTIR) spectroscopic method compatible with the requirements of an operation room for the evaluation of the lipid content in human livers. A set of human liver biopsies obtained from organs intended for transplantation were analyzed by expert pathologists, ATR−FTIR spectroscopy, lipid biochemical analysis, and UPLC−ESI(+/−)TOFMS for lipidomic profiling. Comparative analysis of multisource data showed strong correlations between ATR−FTIR, clinical, and lipidomic information. Results show that ATR−FTIR captures a global picture of the lipid composition of the liver, along with information for the quantification of the triradylglycerol content in liver biopsies. Although the methodology performance needs to be further validated, results support the applicability of ATR−FTIR for the in situ determination of the grade of liver steatosis at the operation room as a fast, quantitative method, as an alternative to the qualitative and subjective pathological examination

Estimation and trends of the absorption refrigeration global market

This study presents the evolution and economic development of the global market for absorption refrigeration systems. The article reviews trends in demand for high and low-power absorption refrigeration systems. High growth potential was found in low-power absorption refrigeration systems in the global market. An important finding is that the most widely installed systems in the world are those of single effect and double effect, due to their cost/benefit ratio. It also reviews the relations and trends of companies that manufacture this technology

Most mitochondrial dGTP is tightly bound to respiratory complex I through the NDUFA10 subunit

Biochemistry; Molecular medicineBioquímica; Medicina molecularBioquímica; Medicina molecularImbalanced mitochondrial dNTP pools are known players in the pathogenesis of multiple human diseases. Here we show that, even under physiological conditions, dGTP is largely overrepresented among other dNTPs in mitochondria of mouse tissues and human cultured cells. In addition, a vast majority of mitochondrial dGTP is tightly bound to NDUFA10, an accessory subunit of complex I of the mitochondrial respiratory chain. NDUFA10 shares a deoxyribonucleoside kinase (dNK) domain with deoxyribonucleoside kinases in the nucleotide salvage pathway, though no specific function beyond stabilizing the complex I holoenzyme has been described for this subunit. We mutated the dNK domain of NDUFA10 in human HEK-293T cells while preserving complex I assembly and activity. The NDUFA10E160A/R161A shows reduced dGTP binding capacity in vitro and leads to a 50% reduction in mitochondrial dGTP content, proving that most dGTP is directly bound to the dNK domain of NDUFA10. This interaction may represent a hitherto unknown mechanism regulating mitochondrial dNTP availability and linking oxidative metabolism to DNA maintenance.We thank Dr, Luke Formosa (Department of Biochemistry and Molecular Biology, Monash Biomedicine Discovery Institute, Monash University, Melbourne, Australia) for his valuable advice and assistance on NDUFA10 molecular studies and Dr. Francesc Canals and his team (Proteomics Laboratory, Vall d’Hebron Institute of Oncology [VHIO], Universitat Autònoma de Barcelona, Barcelona, Spain) for their assistance with LC-MS/MS analyses. This work was supported by the Spanish Ministry of Industry, Economy and Competitiveness [grants BFU2014-52618-R, SAF2017-87506, and PID2020-112929RB-I00 to Y.C.], by the Spanish Instituto de Salud Carlos III [grants PI21/00554 and PMP15/00025 to R.M.], co-financed by the European Regional Development Fund (ERDF), and by an NHMRC Project grant to M.R. (GNT1164459)

A search for AGN in the most extreme UV-selected starbursts using the European VLBI Network

We have used the European VLBI Network (EVN) to observe a sample of Lyman Break Analogs (LBAs), nearby (z < 0.3) galaxies with properties similar to the more distant Lyman Break Galaxies (LBGs). The study of LBGs may help define the feed-back relationship between black holes (BHs) and their host galaxies. Previous VLA observations have shown that the kpc-scale radio emission from LBAs is dominated by starbursts. The main targets of this VLBI experiment were selected because they possessed emission-line properties between starbursts and Type 2 (obscured) AGN. Eight targets (three star-forming LBAs, four composite LBAs, and one Type 1 AGN) were observed at 5 GHz, four of which were also observed at 1.7 GHz. One star-forming LBA and one composite LBA were detected above 5 \sigma at 1.7 GHz (only), while the AGN was detected at 5 GHz. In both LBAs, the radio luminosity (LR) exceeds that expected from supernovae (remnants) based on a comparison with Arp220, Arp229A and Mrk273, by factors of 2 - 8. The composite LBA exhibits a compact core emitting around 10% of the VLA flux density. The high Tb of 3.5E7 K and excess core L_R with respect to the L_R/L_X relation of radio-quiet AGN indicate that this LBA possesses an obscured AGN (MBH ~ E5-E7 M_sun). While weak AGN may co-exist with the starbursts as shown in at least one of the LBAs, their contribution to the total radio flux is fairly minimal. Our results show that the detection of such weak AGN presents a challenge at radio, X-ray and optical emission-line wavelengths at z ~ 0.2, indicating the great difficulties that need to be overcome in order to study similar processes at high redshift when these types of galaxies were common.Comment: 10 pages, 4 figures, accepted for publication in MNRA

Effect of Raw and Extruded Propionic Acid-Treated Field Beans on Energy and Crude Protein Digestibility (In-Vitro and In-Vivo), Growth and Carcass Quality in Grow-Finisher Pigs

The in-vitro ileal digestibility of dry matter (DM), organic matter (OM), and crude protein (CP) of field beans treated with propionic acid (trFB) and extruded trFB (exFB) was determined in experiment 1. The DE and dCP values of trFB and exFB were determined using the difference method in experiment 2. The effect of replacing SBM with trFB and exFB in grow-finisher diets on growth, carcass quality, apparent ileal digestibility (AiD), and total tract digestibility (ATTD) of DM, OM, gross energy (GE), and CP were investigated in experiment 3. In exp. 1, in-vitro digestibility of exFB compared to trFB was unchanged for DM (p = 0.12), increased for OM (p 0.05).info:eu-repo/semantics/publishedVersio

Crosstalk between Mu-Opioid receptors and neuroinflammation: Consequences for drug addiction and pain

Mu-Opioid Receptors (MORs) are well-known for participating in analgesia, sedation, drug addiction, and other physiological functions. Although MORs have been related to neuroinflammation their biological mechanism remains unclear. It is suggested that MORs work alongside Toll-Like Receptors to enhance the release of pro-inflammatory mediators and cytokines during pathological conditions. Some cytokines, including TNF-α, IL-1β and IL-6, have been postulated to regulate MORs levels by both avoiding MOR recycling and enhancing its production. In addition, Neurokinin-1 Receptor, also affected during neuroinflammation, could be regulating MOR trafficking. Therefore, inflammation in the central nervous system seems to be associated with altered/increased MORs expression, which might regulate harmful processes, such as drug addiction and pain. Here, we provide a critical evaluation on MORs' role during neuroinflammation and its implication for these conditions. Understanding MORs' functioning, their regulation and implications on drug addiction and pain may help elucidate their potential therapeutic use against these pathological conditions and associated disorders

Implementación y configuración de servicios de gestión de infraestructura IT mediante Nethserver

Se implementaron servicios de gestión de infraestructura IT mediante la plataforma Nethserver. La primera fase abarcó la configuración de servicios esenciales como DHCP Server, DNS Server y Controlador de Dominio para permitir el acceso seguro de estaciones de trabajo GNU/Linux. La segunda etapa se centró en desplegar y configurar un Proxy que filtra el acceso a Internet para estaciones GNU/Linux, utilizando el puerto 3128 como punto de control. La tercera fase se dedicó a la implementación de un Cortafuegos que restringe el acceso a sitios de entretenimiento y redes sociales, con pruebas desde una estación GNU/Linux para validar las restricciones. La última fase se concentró en la creación y configuración de una VPN donde se estableció un túnel privado de comunicación con una estación GNU/Linux, demostrando el acceso a un contenido específico.IT infrastructure management services were implemented using the Nethserver platform. The first phase involved configuring essential services such as DHCP Server, DNS Server, and Domain Controller to allow secure access from GNU/Linux workstations. The second stage focused on deploying and configuring a Proxy that filters Internet access for GNU/Linux workstations, using port 3128 as a control point. The third phase was dedicated to implementing a Firewall that restricts access to entertainment sites and social media, with testing from a GNU/Linux workstation to validate the restrictions. The last phase focused on creating and configuring a VPN where a private communication tunnel was established with a GNU/Linux workstation, demonstrating access to specific content

Tele-care and tele-alarms for the elderly: preliminary experiences in Mexico

OBJETIVO Analizar el efecto de un programa piloto de tele-asistencia y tele-alarma en la autopercepción del estado de salud de los adultos mayores y conocer la satisfacción y aceptación del programa. METODOS Estudio transversal que incluyó entrevistas a 378 adultos mayores, 294 cuidadores/familiares y 53 profesionales de la salud, realizado en la Ciudad de México en 2010. Variables sociodemográficas, de autopercepción del estado de salud, satisfacción y aceptación del programa se obtuvieron por medio de cuestionario estandarizado. Se realizó análisis descriptivo y se utilizaron pruebas no paramétricas. RESULTADOS Se observaron efectos significativos en la autopercepción del estado de salud, 6,17 (DE 17,9 p < 0,05) puntos por encima de la media. El programa tuvo una buena aceptación por parte de los adultos mayores, de sus cuidadores familiares y de los profesionales de la salud. CONCLUSIONES El programa contribuye a mantener o mejorar la calidad de vida, permite la atención preventiva y es un medio ideal para dar apoyo psicosocial a los adultos mayores.OBJECTIVE : To analyze the effect of a pilot program of tele-assistance and tele-alarms on the elderly’s self-perception of health status and to identify the satisfaction with and acceptance of the program. METHODS : Cross-sectional study that included interviews with 378 elderly individuals, 294 caretakers/relatives and 53 health care professionals. The program was run in Mexico City in 2010. The variables were socio-demographic characteristics, self-rated health, satisfaction and acceptance of the program. The information was gathered through a standardized questionnaire. The statistical analysis included descriptive analysis and nonparametric tests. RESULTS : Significant effects on self-perception of health were observed, 6.17 (SD 17.9 p < 0.05) points above the average. The program was well received and accepted by the elderly, family caregivers and health professionals. CONCLUSIONS : The program helps to maintain or improve quality of life, allows preventive care and is an ideal means of providing psychosocial support to the elderly