12 research outputs found
Mitochondrial DNA Manipulations Affect Tau Oligomerization
- Author
- Publication venue
- 'IOS Press'
- Publication date
- 20/01/2022
- Field of study
Background:Mitochondrial dysfunction and tau aggregation occur in Alzheimer’s disease (AD), and exposing cells or rodents to mitochondrial toxins alters their tau. Objective:To further explore how mitochondria influence tau, we measured tau oligomer levels in human neuronal SH-SY5Y cells with different mitochondrial DNA (mtDNA) manipulations. Methods:Specifically, we analyzed cells undergoing ethidium bromide-induced acute mtDNA depletion, ρ0 cells with chronic mtDNA depletion, and cytoplasmic hybrid (cybrid) cell lines containing mtDNA from AD subjects. Results:We found cytochrome oxidase activity was particularly sensitive to acute mtDNA depletion, evidence of metabolic re-programming in the ρ0 cells, and a relatively reduced mtDNA content in cybrids generated through AD subject mitochondrial transfer. In each case tau oligomer levels increased, and acutely depleted and AD cybrid cells also showed a monomer to oligomer shift. Conclusion:We conclude a cell’s mtDNA affects tau oligomerization. Overlapping tau changes across three mtDNA-manipulated models establishes the reproducibility of the phenomenon, and its presence in AD cybrids supports its AD-relevance
Famílies botàniques de plantes medicinals
- Author
- Alcoverro Godoy Carmen
- Alles Pascual Roser
- Alvarez Lorenzo Paula
- Anglí Herrero Oriol
- Bagan Perez Nuria
- Balaguer Pi Nuria
- Balcells Mestre Maria
- Ballesté Márquez Jéssica
- Bartolomé Schneider Carla
- Batlle de Balle Mercadé Laura
- Belmonte Llorens Judit
- Bujedo Moreno Sergi
- Caballero Roman Aitor
- Calafat Gestoso Mario
- Camps Vilar Nuria
- Cardús Agra Aida
- Casas Serrano Rut
- Castanheira Margarida
- Castilla i Amorós Laia
- Castro de la Cortina Laia
- Chavero Pieres Marta
- Ciocia Nicola
- Collado Lorenzo Jessica
- Corominas Auguets Mònica
- Costa Santamaria Berta
- Dalmases Gener Marc de
- Dios Regadera Montserrat de
- Domingo Gesteiro Adrián
- Dorado Cordero Desirée
- Escrigas Albó Helena Evangelista
- Farré Carrera Laia
- Farré Segura Jordi
- Fernández Catalán Miren
- Fernández Martínez Gerard
- Ferreras Barrero Oriol
- Forcen Arenas Meritxell
- Formiga Ribas Estel
- Fragüet Español Beatriz
- Fuertes Flores Lara
- Fàbregas Vàzquez Júlia
- Garcia i Salvador Nestor
- García Marquina Cristian
- Garrell Soler Gemma
- Garrido Lopez Ainoa
- Giménez García del Moral María
- Gispert Latorre Laia
- Gomez de la Peña Celia
- Gomez-Guiu Hormigos Ma. Lourdes
- Grau Calzada Victoria
- Grau Ortiz Miquel
- Grima Arcos Núria
- Gómez Fusté Clàudia Maria
- Herráez Nieto Silvia
- Hurtado Espino Silvia
- Iglesias Rodrigo Mireia
- Izquierdo Pérez Noelia
- Kaichouh Agrirch Mimoun
- Labraña Sánchez Carme
- Lara Arteaga Maria Dolores
- Lasurt Barés Claudia
- Llarden Mediavilla Arnau
- Llibre Perez Monica
- Llibre Perez Sandra
- Llorca Lorenzo Sonia
- Llorente Lopez Xavier
- Luque Castro Adrià
- Luque Salvat Marc
- López Alonso Javier
- López Ruiz Sergio
- Madurell i Blanes Laura
- Manouchehri Aminian S.
- March Rodríguez Elena
- Martell Alonso Clàudia
- Martinez Alguacil Helena
- Martinez Bosch Laia
- Martínez Riveros Héctor
- Martínez Samitier Àlex
- Mas Rincón Irene
- Matas Ayala Anaïs
- Miranda Jimenez Cristina
- Molas Casellas Júlia
- Molina Trullàs Júlia
- Moner Gomez Sofia
- Moral Anter David
- Morera Nadal Júlia
- Moya Martinez Mari Carmen
- Munte Jesus Guillem
- Nadal Serrano Maria de Lluc
- Narvaez Serrano Daniel Lluis
- Navarro Pinin Laura
- Nevado Maza Sara
- Oliver Sintes Cristóbal
- Oros Olondriz Alberto
- Ortega Herrero Natalia
- Ortega Moreno Angel
- Pachón Díaz Carles
- Pagans Llivina Silvia
- Pau Parra Alba
- Perez Prats Marc
- Pino Alamos Maria Pilar
- Pons Hospital Santiago
- Pucuji Tierra Lizeth Estefaní
- Puig Puig Júlia
- Raventós Aymar Cristina
- Redondo Vahle Ana
- Reyner Parra Andrés Joaquím
- Riba Baqués Marta
- Rio Martinez Helena
- Rodriguez Isidro Pol
- Roig Rossello Mariona
- Roig Turner Gemma
- Rojas Ligeron John Henry
- Ros Peña Alba
- Rosendo Masià Cristina
- Rubio Petit Núria
- Ruiz Avila Genesis
- Ruíz Mateo Héctor
- Sanchez Perez Cristina
- Santomà Cardús Alex
- Sanz Peñalver Sara
- Soler Mallart Guillem
- Tanyà Rovira Anna
- Thorson Bofarull Leif
- Torres Solera Olga
- Torres Vila Maria
- Turu Pedrola Marta
- Vega Rodríguez Laura
- Veiret Duart Gabriel
- Vela Pérez Miriam
- Ventura Molina Pere
- Vidal Bernaltes Marta
- Vintu Stefan Silviu
- Ye Wenxi
- Publication venue
- Publication date
- 01/09/2014
- Field of study
Facultat de Farmàcia, Universitat de Barcelona. Ensenyament: Grau de Farmàcia, Assignatura: Botànica Farmacèutica, Curs: 2013-2014, Coordinadors: Joan Simon, Cèsar Blanché i
Maria Bosch.Els materials que aquí es presenten són els recull de 175 treballs d’una família botànica d’interès medicinal realitzats de manera individual. Els treballs han estat realitzat
per la totalitat dels estudiants dels grups M-2 i M-3 de l’assignatura Botànica Farmacèutica
durant els mesos d’abril i maig del curs 2013-14. Tots els treballs s’han dut a terme a través de la plataforma de GoogleDocs i han estat tutoritzats pel professor de l’assignatura i revisats i finalment co-avaluats entre els propis estudiants. L’objectiu principal de l’activitat ha estat fomentar l’aprenentatge autònom i col·laboratiu en Botànica farmacèutica
Patient-reported outcomes and quality of life in PMM2-CDG
- Author
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2022
- Field of study
Differential Body Composition Effects of Protease Inhibitors Recommended for Initial Treatment of HIV Infection: A Randomized Clinical Trial
- Author
- A. Aguilar
- A. Antela
- A. Curran
- A. González-Cordón
- A. Lamas
- A. Pejenaute
- A. Prieto
- Aberg
- Adrià Curran
- Ana Gonzalez-Cordon
- Andrea Pejenaute
- Bentué-Ferrer
- Boffito
- C. Robledano
- C. Viladés
- Capel
- D. Dalmau
- D. Garcia
- D. Podzamczer
- Daar
- Daniel Podzamczer
- David Garcia
- DeJesus
- Dekker
- Division of AIDS (DAIDS)
- E. Ferrer
- E. Losada
- E. Martínez
- E. Negredo
- E. Ribera
- Elena Ferrer
- Esteban Martinez
- Esteban Martínez
- Esteban Ribera
- Eugenia Negredo
- European AIDS Clinical Society Guidelines
- F. Dronda
- F. Gutiérrez
- F. Vidal
- Felix Gutierrez
- Ferrer
- Friedewald
- Fukunaga
- G. Barrera
- Guaraldi
- H. Beleta
- Hammond
- Helena Beleta
- I. Pérez
- I. Santos
- Ignacio Perez
- Ignacio Pérez
- Ignacio Santos
- J. A. Arnaiz
- J. Murillas
- J. Peraire
- J. Pich
- J. Portilla
- J. Puig
- J. Sanz
- J.A. Cartón
- J.I. Bernardino
- J.M. Castro
- J.M. Gatell
- J.R. Arribas
- J.R. Blanco
- J.R. Ramos
- Javier Murillas
- Joaquim Peraire
- Joaquin Portilla
- Jones
- Jose A. Carton
- Jose I. Bernardino
- Jose M. Gatell
- José M. Gatell
- Juan A. Arnaiz
- Judit Pich
- Judit Pich
- Kuritzkes
- L. Giner
- Lennox
- Levey
- Lin
- M. Cairó
- M. Crespo
- M. G. Mateo
- M. Gutierrez
- M. Masiá
- M. Pampliega
- M. Saumoy
- M. Vargas
- Martinez
- Matthews
- McComsey
- McDonald
- McLaughlin
- Moher
- Molina
- Moyle
- Moyle
- N. Ramos
- N. Rozas
- Nolan
- Nuria Ramos
- Ortiz
- P. Arcaina
- P. Domingo
- P. Martí-Belda
- P. Velli
- Panel de expertos de GeSIDA y Plan Nacional sobre el Sida
- Panel on Antiretroviral Guidelines for Adults and Adolescents
- Patel
- Pere Domingo
- Porter
- Puls
- Ramon Deulofeu
- S. Moya
- S. Padilla
- Samaras
- Saumoy
- Taylor
- Tomaka
- V. Asensi
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- Field of study
Effects of once-weekly exenatide on cardiovascular outcomes in type 2 diabetes
- Author
- Abayomi Osunkoya
- Abderrahim Oulhaj
- Abraham Salacata
- Adam DeVore
- Adi Butnaru
- Aditya Mandawat
- Adolphus Anekwe
- Adriaan Kooy
- Adrian Cruciani
- Adrian Schnall
- Adriana Costa e Forti
- Adriana Philippiova
- Adriana Villarino
- Adriano Truffa
- Agatha Wilhase
- Agnes-Anette Himpel Boenninghoff
- Ajay Labroo
- Alain Taylon
- Alan Bell
- Alan Forker
- Alan Kravitz
- Alan Marcus
- Alan Tannenbaum
- Alan Wine
- Albert Lecube
- Albert LeCube Torello
- Alejandro Orozco Linares
- Alessandro Cavarape
- Alessandro Salvioni
- Alexander Dreval
- Alexander Higgins
- Alexander Khokhlov
- Alexander Sherenkov
- Alexander Tong-Boon Tan
- Alexander V Dreval
- Alexey Repin
- Alfonso Soto
- Alice Pik Shan Kong
- Alison Dawson
- Allegra Stone
- Allen Greenspoon
- Amanda Adler
- Amir Bashkin
- Amorin Remus Popa
- Amrit Takhar
- Amritanshu Pandey
- Ana Zazula
- Anand Rohatgi
- Anat Jaffe
- Andras Nagy
- Andras Papp
- Andras Taller
- Andrea Ferch
- Andrea Mölle
- Andrea On Yan Luk
- Andrea Tisch
- Andreas Hamann
- Andreas Mugge
- Andreas Pfutzner
- Andrej Dzupina
- Andrej Levinger
- Andrew Hamer
- Andrew Johnson
- Andrew McWilliams
- Andrew Woodall
- Andrey Obrezan
- Andrian Yakov
- Andrés Alvarisqueta
- Ann Verhaegen
- Anna Chang
- Anna Grabowska
- Anna Mikolajczyk-Swatko
- Anne Chang
- Anne Kilvert
- Anne Milward
- Anthony Bartkowiak Jr
- Anthony Vo
- Anthony White
- Anthony Wright
- Anton Luger
- Antonio Chacra
- Anuj Bhargava
- Araceli Panelo
- Aranka Kovacs
- Arthur Jimenez
- Arvind Cavale
- Asha Thomas
- Asma Khan
- Attila Palinkas
- Audrone Augusteniene
- Audrone Velaviciene
- Axel Akerblom
- Axel Schaefer
- Aysha Badat
- B van Bemmel
- Bankim Bhatt
- Barbara Cylkowska
- Barry Reicher
- Basil Akpunonu
- Basil Lewis
- Benito Garbelini
- Benjamin Field
- Berhane Seyoum
- Bernard Erickson
- Bernard Man-Yeung Cheung
- Bernd Becker
- Bernhard Landers
- Bernhard Paulweber
- Bethel M. A.
- Bimal Shah
- Blandine Laferrere
- Boguslaw Okopien
- Brian Katona
- Brian Schactman
- Brian Short
- Brian Webster
- Bruce Boggs
- Bruce Henson
- Bruce Jackson
- Bryan Merrick
- Bryan Ping Yen Yan
- Buse J. B.
- Byung-Hee Oh
- Candice Delcourt
- Carlo Maria Rotella
- Carlos Alberto Cure Cure
- Carlos Alexandre Almeida
- Carlos Arauz-Pacheco
- Carlos Jaramilo
- Carlos Jose Jaramilo Gomez
- Carlos Raffo
- Carol Wysham
- Carolina Gonzaga
- Caryn Baldauf
- Catalina Rua Marin
- Catherine Bain
- Cecelia Jimeno
- Cedrice Davis
- Cesar Zaidman
- Cezar Staniloae
- Chaitanya Ravi
- Chan J. C.
- Chang-Wook Nam
- Changsheng Ma
- Chantal Mathieu
- Chanyu Pan
- Charles Bundy
- Charles Eaton
- Charles Herring
- Cheryl Louw
- Chetan Patel
- Chhavi Chadha
- Chiara Melloni
- Chih-Yuan Wang
- Chiu-Chi Tsang
- Choi J.
- Chong Dang
- Chong-Jin Kim
- Chris Sorli
- Christine Voors-Pette
- Christoph Ebenbichler
- Christoph Schnack
- Chwen-Yi Yang
- Claudia Francesconi
- Claudia Olivares
- Claudio Santibañez
- Clinton Corder
- Colin Helm
- Connie Hess
- Constantin Mlitaru
- Curtis Campbell
- Dace Teterovska
- Dailia Dauksiene
- Dalibor Sosovec
- Damodhar Suresh
- Dan Larson
- Dana Headapohl
- Daniel Donovan
- Daniel George
- Daniel Humiston
- Daniel Pella
- Daniel Wai-Sing Chu
- Daniel Weiss
- Daniela Gabriela Zaharie
- Daniela Vinanska
- Danny Sugimoto
- Danuta Pupek-Musialik
- Dariusz Sowinski
- Darren McGuire
- David Aguliera
- David Chung-Wah Siu
- David Colquhoun
- David Kayne
- David Klonoff
- David Kong
- David MacFarlane
- David O’Neal
- David Price
- David Robbins
- Davida Kruger
- Dayi Hu
- Dean Quinn
- Dedrick Jordan
- Dee Pei
- Denis Crimmins
- Dennis Karounos
- Detlev Kuesters
- Devjit Tripathy
- Dianne Leloudis
- Diego Aizenberg
- Diego Bellido
- Diethelm Tschöpe
- Dimitar Illiev
- Donald Fox
- Dongfang Liu
- Dora Inés Molina de Salazar
- Douglas Denham
- Dzilda Velickiene
- E H Serné
- Edmund Claxton Jr
- Eduardo Márquez-Rodriguez
- Edwin Blumberg
- Efrain Villeda Espinosa
- Egle Urbanaviciene
- Egle Varanauskiene
- Elena Ilieva
- Elena Turova
- Elie Hage-Korban
- Eliezer Klainman
- Elif Oral
- Elizabeth Anne-Fernando Catindig
- Elizabeth Gelersztein
- Elizabeth Paz Pacheco
- Elmer Stout
- Emanuela Pozzi
- Emily Clausen
- Emily Morawski
- Emily Zeitler
- Eniko Dezso
- Eric Hernandez Triana
- Eric Peden
- Erika-Maria Oerter
- Ernesto Ang
- Erno Kis
- Eun Sook Kim
- Eva Peterfai
- Evalda Danyte
- Fabio Rossi
- Faiad Adawi
- Faiez Zannad
- Feixia Shen
- Fernando Lanas
- Fernando Roque
- Flavio De Souza Brito
- Florence Tan
- Francisco Bandeira e Farias
- Francisco Gómez Cerezo
- Francisco José Tinahones
- Francois Dube
- Frank Mikell
- Frank Schoper
- Fred Gorelick
- Fred Whitehouse
- Freddy Eliaschewitz
- Fredrich Hoppichler
- Gabriela Doina Negrisanu
- Gabriella Hodi
- Galina Sheinkova
- Gary Wittert
- Ge Junbo
- George Grunberger
- Georges Argoud
- Georgeta Vacaru
- Georgi Levterov
- Gerald Bloomfield
- Geraldine Ebo
- German Perez Amador
- Gheorgita Aron
- Gilbert Gosselin
- Gilbert Ledesma
- Gladys Josefina Larenas Yanez
- Gloria Rojas-Lingan
- Gordon Golden
- Graham Ellis
- Graham Leese
- Gregory Kaczmarek
- Guiseppe Ambrosio
- Guiseppe Mazza
- Gunter Hergdt
- Guntram Schernthaner
- Guntram Shernthaner
- Gustavo Frechtel
- Gustavson S. M.
- Gwen Bernacki
- Gyozo Vandorfi
- Hal Roseman
- Hamish Simpson
- Hanlie Lottering
- Hanna Mirecka
- Hanna Pogorzelska
- Hans Tillmann
- Hans-Dirk Duengen
- Hans-Robert Schoenherr
- Harald Sourij
- Harold Wessel de Valk
- Heather Lochnan
- Hector Eloy Tamez Perez
- Heidi Anderson
- Heidrun Mehling
- Heinz Drexel
- Helena Rodbard
- Hemantkumar Makan
- Hendrik Nortje
- Henk Swart
- Herbert Goodman
- Herman Josef Strotmann
- Hernandez A. F. EXSCEL Study Group: Robert M Califf
- Hilton Kaplan
- Holly Dushkin
- Holman R. R.
- Hongyan Deng
- Horacio Hidalgo Jr
- Howard Eisen
- Hugo Lisboa
- Hung Fat Tse
- Huo Yong
- I-Chang Hsieh
- Ian Caterson
- Iftikar Ebrahim
- Ihsan Haque
- Ilan Shimon
- Ilka Simon-Wagner
- Ilze Andersone
- Imre Szakal
- Imre Szentpeteri
- In Joo Kim
- In Kyu Lee
- Indra Stelmane
- Ines Bartolacci
- Inese Strautina
- Ingrid Buganova
- Inta Leitane
- Ioan Andrei Veresiu
- Ioannis Dimitropoulos
- Iosif Szilagyi
- Iqbal N.
- Ira Dauber
- Iren Foldesi
- Irene Kennedy
- Irina Bondar
- Isabelle Schenkenberger
- Ismael Aomar
- Istvan Reiber
- Istvan Wittman
- Iurii Rudyk
- Ivan Fushtey
- Ivana Kellinerova
- Ivaylp Nikolov Lefterov
- Ivy Madu
- Iñaki Arguelles
- Jack Misterski
- Jacqueline Hoogendyk
- James Lenhard
- Jan Fedacko
- Jan Murin
- Jan Stevlik
- Jana Havelkova
- Jane Kerr
- Janet McGill
- Janos Penzes
- Janos Takacs
- Jaroslav Jascur
- Jason Pryke
- Jean Francois Yale
- Jean Lucien Rouleau
- Jean-Francois Yale
- Jean-Paul Thissen
- Jeffrey Kingsley
- Jeffrey Overcash
- Jeffrey Wing
- Jelena Sokolova
- Jennifer B Green
- Jennifer Litchfield
- Jennifer Marks
- Jennifer Vincent
- Jeremy Krebs
- Jeremy Soule
- Ji Hu
- Ji Linong
- Jiangzhong Wang
- Jianhua Ma
- Jianping Weng
- Joan Vendrell Ortega
- Joana Nicolau
- JoAnn Sperl-Hillen
- Joanna Niegowska
- Joao Borges
- Joao Felicio
- Jochen Seissler
- Jodi Hawes
- Joel Neutel
- Johan Vanuytsel
- John Adaly Gallegos
- John Amerena
- John Calvert
- John Clark
- John Earl
- John Gilbert
- John Gillies
- John Kessel
- John McKnight
- John McMurray
- John Pullman
- John Reed III
- John Sigalas
- John Tsao
- Jonas Caponis
- Jonathan Wilson
- Jorg Pahl
- Jose Luis Leiva-Pons
- Jose-Luis Leiva-Pons
- Joseph Hargrove
- Joseph Moran
- Joseph Proietto
- Joseph Soufer
- Joshua Cohen
- José Contreras Gilbert
- José Hector Sanchez Mijangos
- José Kerr Saraiva
- José Sabán
- Jozsef Lippai
- Jozsef Takacs
- Juan Garcia Puig
- Juan Godoy
- Juan Mediavilla Garcia
- Judit Simon
- Judith White
- Julian Coronel Arroyo
- Julianna Kiss
- Julie Darbyshire
- Julio Wainstein
- Julius Dean
- June Namgung
- Jung-Fu Chen
- Juraj Selecky
- Jurate Lasiene
- Jyothis George
- János Tibor Kis
- Jörg Nothroff
- Karen Alexander
- Karen Hannan
- Karl-Fredrich Appel
- Karol Micko
- Karoly Nagy
- Karsten Milek
- Katalin Bezzegh
- Katalin Farago
- Katarina Pantikova
- Kathleen Coetzee
- Kathleen Dungan
- Kathleen Wyne
- Kathryn Lucas
- Kee-Sik Kim
- Keith Dombrowski
- Ken Mahaffey
- Kenneth Carr
- Kenny Kung
- Kent Farnsworth
- Keon-Woong Moon
- Kesi Sanders
- Kevin Bybee
- Kevin Cox
- Keyur Patel
- Kingsley Nirmalaraj
- Klaus Busch
- Klaus Kleinertz
- Konstantin Zrahevskiy
- Kristen Hyland
- Kun-Ho Yoon
- Kurt Lesh
- Kyung Mook Choi
- Larry Distiller
- Larry Jackson
- Larry Severa
- Larys Pererva
- Laszlo Futo
- Laura Maffei
- Lauren Bickel
- Lawrence Anastasi
- Lawrence Leiter
- Lawrence Levinson
- Lawrence Phillips
- Leobardo Sauque Reyna
- Leonardo Novaretto
- Leonid Strongin
- Letchuman Ramanathan
- Liga Lagzdina
- Lihui Zhang
- Liliana Monica Angelescu
- Lilya Martynyuk
- Lilyana Mincheva
- Lina Barsiene
- Lina Zabuliene
- Linda Gaudiani
- Lindy Swinkels-Diepenmaat
- Ling Liu
- Linong Ji
- Lisa Abbott
- Liudmyla Prysupa
- Lokhnygina Y.
- Lon Roberts
- Lorraine Mumtaz
- Louie Tirador
- Louis Luttrell
- Luciana Armaganijan
- Lucrecia Nardone
- Ludger Rose
- Luis Alfonso
- Luis Alvarez
- Luis Garcia Ortiz
- Lynn Perkins
- Lynne Durborow
- Lyubov Sokolova
- Lyudmila Lyubenova
- Lyudmila Suplotova
- László Barkai
- Maggioni A. P.
- Mahfouz El Shahawy
- Mahomed Omar
- Majed Chane
- Mandeep Bajaj
- Manuel Angel Gómez Marcos
- Marcelo Katz
- Marcelo Mallagray
- Marcin Sikorski
- Marco Antonio Alcocer Gamba
- Marek Piepiorka
- Margarita Barrientos Perez
- Margit Mileder
- Maria Angustias Quesada
- Maria Batit
- Maria de Salvo
- Maria Isabel Klyver
- Maria Rosa Ulla
- Marian Denopol
- Mariana Graur
- Marie Magno
- Marijona Sulskiene
- Mark Benson
- Mark Chang
- Mark Davies
- Mark Feinglos
- Mark Graves
- Mark Radbill
- Mark Zimering
- Markolf Hanefeld
- Marso S. P.
- Marta Botella Serrano
- Marta Molnar
- Martin Berk
- Martin Braun
- Martin Grueneberg
- Mary Ann Sellers
- Mary Beth Manning
- Mary Elkins
- Maryna Vlasenko
- Masaya Koshizaka
- Mashra Gani
- Masoud Azizad
- Matt Riddle
- Matt Wilson
- Matthew Roe
- Matyas Keltai
- Mauro Cignarelli
- Maximiliano Sicer
- Mayler Nunes dos Santos
- Meena Rao
- Mentz R. J.
- Mercè Fernández Balsells
- Michael DiGiovanna
- Michael Dulin
- Michael Lehrke
- Michael Lillestol
- Michael McDermott
- Michael Morse
- Michael Shanik
- Michaela Diamant
- Michal Sroka
- Michelle Look
- Michelle Man-Ying Cheung-Wong
- Michelle Masterson
- Miguel Hissa
- Miguel Urina Triana
- Mihaela Biscoveanu
- Mim Mulford
- Mira Baron
- Mircea Munteanu
- Mirela Ioana Culman
- Misra Anoop
- Mithal Ambrish
- Mohamed Omar
- Muhammad Radzi Abu Hassan
- Muhammed Fulat
- Murray Pearce
- Mykola Kopytsya
- Mykola Vatutin
- Myla Custodio
- Myroslava Vayda
- N Jaimeh Asamoah-Owusu
- Nadezhda Izmozherova
- Naftali Stern
- Nancy Luo
- Narendra Godbole
- Naresh Ranjith
- Naseem Jaffrani
- Nasrin Azad
- Natalia Eloisa De La Garza Hernandez
- Naveed Razzaque
- Naveed Sattar
- Naynesh Patel
- Nazira Carim-Ganey
- Neda Rasouli
- Negah Rassouli
- Neha Pagidpati
- Neli Jakuboniene
- Nelson Rassi
- Nemencio Nicodemus Jr
- Nicholas Fisher
- Nicolae Hancu
- Nicoleta Mihaela Mindrescu
- Nizar Elias
- Nora Kesmarki
- Norbert Uy
- Norman Ferrier
- Norman Fishman
- Norman Soler
- Novelette Thompson
- Nuria Sucunza Alfonso
- Ofri Mosenzon
- Ohman P.
- Olakunle Akinboboye
- Oleksandr Larin
- Olena Grishyna
- Olena Koval
- Olena Levchenko
- Olexander Parkhomenko
- Olga Barbarash
- Olga Gyrina
- Olga Koshelskaya
- Olga Smolenskaya
- Orsolva Lovasz
- Oscar Minuchin
- Owais Chaudhri
- P A M Hoogslag
- P C Oldenburg-Ligtenberg
- Pagidipati N. J.
- Pamela Dugano-Daphnis
- Paolo Pozzilli
- Partha Paul
- Pat Gottlieb
- Patricia Guimaraes
- Paul Dixon
- Paul Heal
- Paul Manos
- Paul Rheeder
- Paul Wakefield
- Paula Lavender
- Paulo Rossi
- Pavel Krami
- Peak Mann Mah
- Pedro Barros
- Pedro Barros e Silva
- Pedro Calella
- Perumal Pillai
- Peter Bressler
- Peter Colman
- Peter Dunn
- Peter Fasching
- Peter Harvey
- Peter Olexa
- Peter Reaven
- Peter Voros
- Petr Widimsky
- Petra-Maria Schumm-Draeger
- Petro Kuskalo
- Philip Nicol
- Philip Toth
- Philip Wiles
- Philomena Ukwade
- Piotr Dziemidok
- Piyamitr Sritara
- Poulter N.
- Pravinsagar Mehta
- Priya Dayamani
- Priyanka Batra
- Puvanesveri Naiker
- Qifu Li
- Rafael Canadas
- Rafael Diaz
- Rajbir Athwal
- Rajendra Mehta
- Ramachandran A.
- Rasa Juskiene
- Ray Oelbaum
- Ren Tan
- Renato Lopes
- Rex Force
- Ricardo Cabrera Jardines
- Ricardo Leon De La Fuente
- Richard Bergenstal
- Richard Dumas
- Richard Jackson
- Richard Mills
- Richard Tytus
- Rick Cutfield
- Risa Ozaki
- Rishi Patel
- Rob Harrison
- Robert Busch
- Robert Cuddihy
- Robert Detweiler
- Robert Eckel
- Robert Gagel
- Robert McNeill
- Robert Weiss
- Robert Zimmerman
- Roberto Mirasoi
- Robin Conway
- Robin Kuritsky
- Rodney Ison
- Rodrigo Botero Lopes
- Roger Acheatel
- Roger Estevez
- Rohana Abdul Ghani
- Roman Zaluska
- Romuald Korzeniak
- Ronald Bourgeois
- Ronald D’Agostino
- Ronald Hatheway
- Ronald Sigal
- Rosangela Rea
- Rossitsa Shumkova
- Roxana Reyes Sanchez
- Roza Bobeva
- Rudolf Prager
- Russell Scott
- Russell Struble
- Ruta Eglite
- Ruth Coleman
- Saadiya Seedat
- Sabina Zaharieva
- Sabrina Bernandez
- Salman Khan
- Salphy Mogashoa
- Sam Philip
- Sam Wilson
- Samuel Yeung Shan Wong
- Sana Al-Khatib
- Sandra Macrury
- Santiago Paulino Ramirez Diaz
- Sarah Maxwell
- Schuyler Jones
- Se-Joong Rim
- Sean Pokorney
- Sebastian Schellong
- Sergey Dogadin
- Sergio Leonardi
- Sergio Potthoff
- Sergio Rovner
- Seung Jea Tahk
- Shahin Jaffer
- Sharif Halim
- Sharon Marks
- Shaun Goodman
- Shen Qu
- Shih-Li Su
- Shih-Ting Tseng
- Shuxian Zhou
- Siew Hui Foo
- Sigfrido Miracle Lopes
- Sigita Pastare
- Silviana Constantinescu
- Sim Kui Hian
- Simon Heller
- Simona Tivadar
- Sinikka Green
- Snejina Kovacheva
- Son Giep
- Srikanth Bellary
- Stefanie Schipperen
- Stefano del Prato
- Stefano Genovese
- Stephan Hermes
- Stephanie Powell
- Stephen Aronoff
- Stephen Cheung
- Stuart J Pocock
- Stuart Ross
- Sudesna Chatterjee
- Sudhesh Kumar
- Sunder Raj Mudaliar
- Sung-Hee Choi
- Sungdae Moon
- Susanne Kentgens
- Suzanne Blignaut
- Suzanne Oparil
- Svitlana Panina
- Syed Rizvi
- Talessa Powell
- Tamas Oroszan
- Tamir Bental
- Tania Markovic
- Tao Yang
- Tasso Bieler
- Tejpal Purewal
- Teresa Silwinska
- Teresa Stasinksa
- Terry Flanagan
- Thirumani Govender
- Thomas Barber
- Thomas Coetzer
- Thomas Elliott
- Thomas Forst
- Thomas LeBlanc
- Thomas Linn
- Thomas Pieber
- Thomas VonderHaar
- Thomas Wade
- Thompson V. P.
- Thozhukat Sathayapalan
- Tibor Fulop
- Tim Collier
- Tim Garvey
- Tim Schäufele
- Timothy Hall
- Timothy Woodford
- Tiong Kiam Ong
- Tom Posvic
- Tomas Brychta
- Tommy Herskovits
- Trevenesan Padayachee
- Tsvetalina Tankova
- Ulrich Julius
- Ulrich Meyer-Pannwitt
- Ulrich Schubart
- Vadym Berenfus
- Vadym Vizir
- Vahid Mahabadi
- Vaida Kakariekiene
- Vaidotas Urbanavicius
- Valda Stalte
- Valdis Pirags
- Valentin Ivanov
- Valentina Gushterova
- Valerica Nafornita
- Veita Bland
- Velichka Damyanova
- Venkatesh Nadar
- Vera Adamkova
- Veronica Crawford
- Vicdan Köse
- Vicki Kalen
- Victor Vishlitsky
- Vincent Tok-Fai Yeung
- Vincent Woo
- Vira Tseluyko
- Vitaliy Maslyanko
- Volodymyr Botsyurko
- Vyacheslav Marasaev
- Vyara Videva
- Wanda Lakey
- Wayne Huey Herng Sheu
- Wayne Sheu
- Wee Kooi Cheah
- Wei Gu
- Wen-Ter Lai
- Wilgard Pohl
- Willem Wouter van Kempen
- William Bestermann Jr
- William Jeffries
- William Kirby
- William Nseir
- Winston Gandy
- Wojciech Homenda
- Wolfram Kamke
- Won-Young Lee
- Xiaohui Guo
- Yanbing Li
- Yee Weng Wong
- Yee-Weng Wong
- Yevgen Suprun
- Yi-Jen Hung
- Yiming Mu
- Yingqing Feng
- Ynez Kelfkens
- Yolanda Meadows
- Yong Wang
- Yoon-Nyun Kim
- Youping Dong
- Yulia Samoylova
- Yuming Du
- Yupin Benjasuratwong
- Yves Robitaille
- Zahari Nikitov
- Ziad Gellad
- Zinaida Teliatnikova
- Zinman B.
- Zoltan Czegany
- Zsolt Gaal
- Zsolt Pauker
- Zsolt Ples
- Zsolt Zilahi
- Zsuzsanna Kerenyi
- Zubin Eapen
- Zubin Punthakee
- Zuyi Yuan
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2017
- Field of study
BACKGROUND: The cardiovascular effects of adding once-weekly treatment with exenatide to usual care in patients with type 2 diabetes are unknown. METHODS: We randomly assigned patients with type 2 diabetes, with or without previous cardiovascular disease, to receive subcutaneous injections of extended-release exenatide at a dose of 2 mg or matching placebo once weekly. The primary composite outcome was the first occurrence of death from cardiovascular causes, nonfatal myocardial infarction, or nonfatal stroke. The coprimary hypotheses were that exenatide, administered once weekly, would be noninferior to placebo with respect to safety and superior to placebo with respect to efficacy. RESULTS: In all, 14,752 patients (of whom 10,782 [73.1%] had previous cardiovascular disease) were followed for a median of 3.2 years (interquartile range, 2.2 to 4.4). A primary composite outcome event occurred in 839 of 7356 patients (11.4%; 3.7 events per 100 person-years) in the exenatide group and in 905 of 7396 patients (12.2%; 4.0 events per 100 person-years) in the placebo group (hazard ratio, 0.91; 95% confidence interval [CI], 0.83 to 1.00), with the intention-to-treat analysis indicating that exenatide, administered once weekly, was noninferior to placebo with respect to safety (P<0.001 for noninferiority) but was not superior to placebo with respect to efficacy (P=0.06 for superiority). The rates of death from cardiovascular causes, fatal or nonfatal myocardial infarction, fatal or nonfatal stroke, hospitalization for heart failure, and hospitalization for acute coronary syndrome, and the incidence of acute pancreatitis, pancreatic cancer, medullary thyroid carcinoma, and serious adverse events did not differ significantly between the two groups. CONCLUSIONS: Among patients with type 2 diabetes with or without previous cardiovascular disease, the incidence of major adverse cardiovascular events did not differ significantly between patients who received exenatide and those who received placebo
Ticagrelor in patients with diabetes and stable coronary artery disease with a history of previous percutaneous coronary intervention (THEMIS-PCI) : a phase 3, placebo-controlled, randomised trial
- Author
- Abbott J
- Abe Mitsuru
- Abouglila Kamal
- Abrahamovych Orest
- Abu-Fadel Mazen
- Accini Jose
- Acikel Sadik
- Adhyapak Srilakshmi
- Agaiby John
- Aggarwala Guarav
- Aguilera Roberto M
- Ahn Taehoon
- Aksentiev Sergei
- Akyea-Djamson Ayim
- Al-Amin Jessie
- Al-Faleh Hussam
- Al-Saif Shukri
- Al-Shehri Abdullah
- Al-Zoebi Ayham
- Aladellie Layth
- Albisu Juan
- Alfata Sarab
- Alshehri Halia
- Alvarado Odilon
- Alvarez Jose
- Alvarisqueta Andres
- Amerena John
- Amerena John
- Amin Amit
- Amoroso Giovanni
- Andersson Marielle
- Andersson Marielle
- Andersson Marielle
- Andrawis Nabil
- Andries Alin
- Andrássy Péter
- Angerås Oskar
- Angiolillo Dominick
- Angoulvant Denis
- Ansari Saadat
- Antalik Lubomir
- Aoyama Takahiko
- Appel Karl-Friedrich
- Arana Camilo
- Arat Alev
- Arbanil Hugo
- Arora Satish
- Arriagada German
- Arshad Tamjeed
- Arslan Sakir
- Arvind Moogali
- Arya Ktut
- Asenjo Roberto M
- Asfour Wail
- Askar Alfredo N
- Assanelli Emilio
- Atieh Mahmoud
- Auer Johann
- Avino David
- Babapulle Mohan
- Babilonia Noe
- Babilonia Noe A
- Bae Jang-Whan
- Baglikov Andrey
- Bailey Allan
- Bailey Gordon
- Bain Stephen
- Bakai Judit
- Bakhtari Ladan
- Ballyuzek Marina
- Bander Jeffrey
- Bandh Stellan
- Banerjee Subhash
- Banerjee Supratim
- Banerjee Suvro
- Barabashkina Anna
- Baracioli Luciano
- Barbarash Olga
- Barbas Benny
- Barettella Mark
- Bashkin Amir
- Basiak Marcin
- Baszak Jacek
- Bata Iqbal
- Bauer Michael
- Bayat Junaid
- Bazari Rasha
- Bednarova Jana
- Behnke Thomas
- Bell Alan
- Belle-Isle Jasmin
- Bellotti Sandro
- Belohlavek Jan
- Benczur Bela
- Bennett James
- Berg-Johansen Jan
- Berger Rudolf
- Berrospi Percy
- Bertolet Barry
- Bertrand Olivier
- Bertsch John
- Besada Diego
- Bessoudo Ricardo
- Beth Mary
- Bhargava Anuj
- Bhatt Deepak L
- Bhatt Deepak L
- Bhavsar Janak
- Bijata-Bronisz Renata
- Bittar George
- Bitters J'Cinda
- Black Robert
- Blagden Mark
- Blanco Antonio
- Blick David
- Bochenek Anna
- Boldueva Svetlana
- Bolshoun David
- Bonansea Teresa C
- Bongo Angelo S
- Bordonava Anselmo
- Borges Joao
- Borisov Borislav
- Bortnick Anna
- Bos Robert
- Botelho Roberto
- Botero Rodrigo
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- Butman Samuel
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- Calabrò Paolo
- Cantu Elias G
- Cantú Arnulfo G
- Carda Jiri
- Cardona Jose
- Carell Edgar
- Carnero Gabriela
- Carrasco Jose P
- Carrillo Luis V
- Cartwright Simon
- Castillo Armando G
- Cauthen Brett
- Cayla Guillaume
- Cercato Cintia
- Cermak Ondrej
- Cerqueira Maria J
- Ceyhan Ceyhun
- Cha James
- Cha Kwang S
- Chacon Carolina
- Chae In-Ho
- Chae Jei-Keon
- Chag Milan
- Chai Yingru
- Chamnarnphol Noppadol
- Chan Michael
- Chan Shih-Hung
- Chang Kiyuk
- Chang Kuan-Cheng
- Chatrathi Sridhar
- Chavez Carlos
- Chehayeb Raja
- Cheirif Jorge
- Chen Jersey
- Chen Jersey
- Chen Zhih-Cherng
- Chernyavsky Alexander
- Cheung Deanna
- Cheung Stephen
- Chhabra Anil
- Chiang Chern
- Chiang Chern-En
- Choi Si-Wan
- Choi Young J
- Chompalova Boryana
- Chorin Ehud
- Chouinard Guy
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- Coching Raul M
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- Corbalán Ramón
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- D'Agostino Ronald
- D'Urso Michael
- Dada Fredy T
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- Das Asit
- Dawood Saleem
- de Cosmo Salvatore
- de la Torre Hernández José M
- de Labriolle Axel
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- Domínguez Antonio R
- Dong Xiaolin
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- Ermoshkina Lyudmila
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- Estrada José N
- Ezhov Andrey
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- Fernández Portales Francisco J
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- Fil Wojciech
- Fillat Angel C
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- Fontaine Caroline
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- Fortes Jose A
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- Fox Kim
- Fox Kim
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- Gogov Antoni
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- Goldberg Ronald
- Gomez-Cortes Jose
- Gonzalez Julian
- Gonzalez-Ortiz Elena
- González Juanatey José R
- González Alfonso S
- González Rosa S
- González Vicente B
- Goodfellow Ross
- Gordon Paul
- Gosparini Diego M
- Gossard Denis
- Gosselin Gilbert
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- Gravdal Stein A
- Green Sandy
- Greenberg Gabriel
- Grena Paul
- Greschik István
- Gring Christian
- Grunfeldova Hana
- Guedes Antoine
- Guerra Yamirka D
- Guerrero Diego B
- Guillen Mario
- Guimaraes Fabio
- Guitton Javier
- Gullestad Lars
- Gupta Dinesh
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- Hajek Petr
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- Halperin Frank
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- Hammett Christopher
- Hammond Peter
- Handel Franklin
- Handelsman Yehuda
- Hansen Ole
- Hanson Lenita
- Hanusch Ursula
- Hargrove Joeseph
- Haro Jaime M
- Harrington Robert A
- Harrington Robert A
- Hart Randy
- Hart Terence
- Hartikainen Juha
- Hasegawa Toru
- HASH(0x55aa09b7f480)
- Hata Yoshiki
- Haught W H
- Hawa Zafir
- Hazan Lydie
- He Lanjie
- He Yong
- Hearne Steven
- Heath John
- Hedman Anders
- Hegde Vinayak
- Hei Pak
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- Hella Brent
- Henein Sam
- Hennig Dirk
- Henry Sheldon
- Heredia Javier
- Hernandes Mauro
- Higashiue Shinichi
- Hill Laurie
- Himmelmann Anders
- Himmelmann Anders
- Himmelmann Anders
- Hiotis Louis
- Hirohata Atsushi
- Hissa Miguel
- Hoffer Etienne
- Hoffman David
- Hofseth Ola D
- Hollanders Geert
- Holmvang Lene
- Hominal Miguel
- Hong Soon J
- Honkova Michaela
- Hoosen Farzana
- Horak Adrian
- Horibe Eishun
- Horoshko Olha
- Hotchkiss David
- Hou Charles
- Hsia Chien-Hsun
- Hsieh I-Chang
- Huang Wenjun
- Huber Kurt
- Huber Kurt
- Huling Randall
- Huth Mark
- Huynh Thao T
- Hwang Jin-Yong
- Idogaki Akira
- Iliev Nikolay
- Ilieva Katya
- Ing Douglas
- Iosipescu Laura C
- Isaza Daniel
- Ishiki Ryoji
- Istratoaie Octavian
- Iteld Bruce
- Izzo Mark
- Jaafar Feeroz
- Jaffrani Naseem
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- Jain Ashit
- James Stefan K
- James Stefan K
- Jamil-Copley Shahnaz
- Jamriskova Livia
- Jankowski Maciej
- Janssens Luc
- Jaramillo Nicolás
- Jastrzebski Waldemar
- Javier Julian
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- Jensen Lisette O
- Jeong Myung H
- Jeong Myung H
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- Jesionowski Pawel
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- Johnston Nina
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- Junior Delcio S
- Jurowiecki Jaroslaw
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- Kelberman Michael
- Kelly Allan
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- Király Csaba
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- Kiss Róbert G
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- Kosiborod Mikhail N
- Kosiborod Mikhail N
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- Kosmicki Douglas
- Kostenko Victor
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- Lievano Triana Manuel J
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- Mediavilla García Juan D
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- Wojcik Ronald
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- Wolzt Michael
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- Wong Michelle
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- Woolf Kevin
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- Wozakowska-Kaplon Beata
- Wu Chih-Cheng
- Wu Yen-Wen
- Wujkowski Marek
- Yagensky Andriy
- Yakushin Sergey
- Yalcin Ahmet
- Yamamoto Fumi
- Yaneva Zdravka
- Yeh Hung-I
- Ying Man
- Yokoya Koichi
- Yoon Junghan
- Young Douglas
- Younis Liwa
- Yuan Zuyi
- Zadra Remo
- Zakharov Konstantin
- Zakhary Bosh
- Zaman Azfar
- Zamorano Gómez José L
- Zangroniz Pedro
- Zaniewski Michelle
- Zanini Alejandra
- Zarich Stuart
- Zateyschikova Anna
- Zateyshchikov Dmitry A
- Zebrack James
- Zelazowska Katarzyna
- Zhang Aidong
- Zhang Jian
- Zhang Ningru
- Zhang Wenwu
- Zhao Qiang
- Zhao Qiang
- Zhao Xue-Qiao
- Zharinova Viktoria
- Zidkova Eva
- Zilahi Zsolt
- Zinka Elzbieta
- Zonova Elena
- Zubeeva Galina
- Zucconi-Mazzini Roberto
- Zurakowski Aleksander
- Zólyomi Szilárd
- Édes István
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2019
- Field of study
Background:
Patients with stable coronary artery disease and diabetes with previous percutaneous coronary intervention (PCI), particularly those with previous stenting, are at high risk of ischaemic events. These patients are generally treated with aspirin. In this trial, we aimed to investigate if these patients would benefit from treatment with aspirin plus ticagrelor.
Methods:
The Effect of Ticagrelor on Health Outcomes in diabEtes Mellitus patients Intervention Study (THEMIS) was a phase 3 randomised, double-blinded, placebo-controlled trial, done in 1315 sites in 42 countries. Patients were eligible if 50 years or older, with type 2 diabetes, receiving anti-hyperglycaemic drugs for at least 6 months, with stable coronary artery disease, and one of three other mutually non-exclusive criteria: a history of previous PCI or of coronary artery bypass grafting, or documentation of angiographic stenosis of 50% or more in at least one coronary artery. Eligible patients were randomly assigned (1:1) to either ticagrelor or placebo, by use of an interactive voice-response or web-response system. The THEMIS-PCI trial comprised a prespecified subgroup of patients with previous PCI. The primary efficacy outcome was a composite of cardiovascular death, myocardial infarction, or stroke (measured in the intention-to-treat population).
Findings:
Between Feb 17, 2014, and May 24, 2016, 11 154 patients (58% of the overall THEMIS trial) with a history of previous PCI were enrolled in the THEMIS-PCI trial. Median follow-up was 3·3 years (IQR 2·8–3·8). In the previous PCI group, fewer patients receiving ticagrelor had a primary efficacy outcome event than in the placebo group (404 [7·3%] of 5558 vs 480 [8·6%] of 5596; HR 0·85 [95% CI 0·74–0·97], p=0·013). The same effect was not observed in patients without PCI (p=0·76, p interaction=0·16). The proportion of patients with cardiovascular death was similar in both treatment groups (174 [3·1%] with ticagrelor vs 183 (3·3%) with placebo; HR 0·96 [95% CI 0·78–1·18], p=0·68), as well as all-cause death (282 [5·1%] vs 323 [5·8%]; 0·88 [0·75–1·03], p=0·11). TIMI major bleeding occurred in 111 (2·0%) of 5536 patients receiving ticagrelor and 62 (1·1%) of 5564 patients receiving placebo (HR 2·03 [95% CI 1·48–2·76], p<0·0001), and fatal bleeding in 6 (0·1%) of 5536 patients with ticagrelor and 6 (0·1%) of 5564 with placebo (1·13 [0·36–3·50], p=0·83). Intracranial haemorrhage occurred in 33 (0·6%) and 31 (0·6%) patients (1·21 [0·74–1·97], p=0·45). Ticagrelor improved net clinical benefit: 519/5558 (9·3%) versus 617/5596 (11·0%), HR=0·85, 95% CI 0·75–0·95, p=0·005, in contrast to patients without PCI where it did not, p interaction=0·012. Benefit was present irrespective of time from most recent PCI.
Interpretation:
In patients with diabetes, stable coronary artery disease, and previous PCI, ticagrelor added to aspirin reduced cardiovascular death, myocardial infarction, and stroke, although with increased major bleeding. In that large, easily identified population, ticagrelor provided a favourable net clinical benefit (more than in patients without history of PCI). This effect shows that long-term therapy with ticagrelor in addition to aspirin should be considered in patients with diabetes and a history of PCI who have tolerated antiplatelet therapy, have high ischaemic risk, and low bleeding risk
Rivaroxaban or aspirin for patent foramen ovale and embolic stroke of undetermined source: a prespecified subgroup analysis from the NAVIGATE ESUS trial
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- Abdelhamid N.
- Abdul Rahman D.
- Abdul-Saheb M.
- Abreu P.
- Abroskina M.
- Abu Ahmad F.
- Accassat S.
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- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2018
- Field of study
Background: Patent foramen ovale (PFO) is a contributor to embolic stroke of undetermined source (ESUS). Subgroup analyses from previous studies suggest that anticoagulation could reduce recurrent stroke compared with antiplatelet therapy. We hypothesised that anticoagulant treatment with rivaroxaban, an oral factor Xa inhibitor, would reduce the risk of recurrent ischaemic stroke compared with aspirin among patients with PFO enrolled in the NAVIGATE ESUS trial. Methods: NAVIGATE ESUS was a double-blinded, randomised, phase 3 trial done at 459 centres in 31 countries that assessed the efficacy and safety of rivaroxaban versus aspirin for secondary stroke prevention in patients with ESUS. For this prespecified subgroup analysis, cohorts with and without PFO were defined on the basis of transthoracic echocardiography (TTE) and transoesophageal echocardiography (TOE). The primary efficacy outcome was time to recurrent ischaemic stroke between treatment groups. The primary safety outcome was major bleeding, according to the criteria of the International Society of Thrombosis and Haemostasis. The primary analyses were based on the intention-to-treat population. Additionally, we did a systematic review and random-effects meta-analysis of studies in which patients with cryptogenic stroke and PFO were randomly assigned to receive anticoagulant or antiplatelet therapy. Findings: Between Dec 23, 2014, and Sept 20, 2017, 7213 participants were enrolled and assigned to receive rivaroxaban (n=3609) or aspirin (n=3604). Patients were followed up for a mean of 11 months because of early trial termination. PFO was reported as present in 534 (7·4%) patients on the basis of either TTE or TOE. Patients with PFO assigned to receive aspirin had a recurrent ischaemic stroke rate of 4·8 events per 100 person-years compared with 2·6 events per 100 person-years in those treated with rivaroxaban. Among patients with known PFO, there was insufficient evidence to support a difference in risk of recurrent ischaemic stroke between rivaroxaban and aspirin (hazard ratio [HR] 0·54; 95% CI 0·22–1·36), and the risk was similar for those without known PFO (1·06; 0·84–1·33; pinteraction=0·18). The risks of major bleeding with rivaroxaban versus aspirin were similar in patients with PFO detected (HR 2·05; 95% CI 0·51–8·18) and in those without PFO detected (HR 2·82; 95% CI 1·69–4·70; pinteraction=0·68). The random-effects meta-analysis combined data from NAVIGATE ESUS with data from two previous trials (PICSS and CLOSE) and yielded a summary odds ratio of 0·48 (95% CI 0·24–0·96; p=0·04) for ischaemic stroke in favour of anticoagulation, without evidence of heterogeneity. Interpretation: Among patients with ESUS who have PFO, anticoagulation might reduce the risk of recurrent stroke by about half, although substantial imprecision remains. Dedicated trials of anticoagulation versus antiplatelet therapy or PFO closure, or both, are warranted. Funding: Bayer and Janssen
Diminishing benefits of urban living for children and adolescents’ growth and development
- Author
- Abarca-Gómez Leandra
- Abdeen Ziad A.
- Abdrakhmanova Shynar
- Abdul Rahim Hanan F.
- Abdurrahmonova Zulfiya
- Abril Guadalupe Longo
- Abu-Rmeileh Niveen M.
- Acosta-Cazares Benjamin
- Adam Ishag
- Adamczyk Marzena
- Adams Robert J.
- Adu-Afarwuah Seth
- Aekplakorn Wichai
- Afsana Kaosar
- Afzal Shoaib
- Agbor Valirie N.
- Agdeppa Imelda A.
- Aghazadeh-Attari Javad
- Aguenaou Hassan
- Aguilar-Salinas Carlos A.
- Agyemang Charles
- Ahmad Mohamad Hasnan
- Ahmad Noor Ani
- Ahmadi Ali
- Ahmadi Naser
- Ahmadi Nastaran
- Ahmed Imran
- Ahmed Soheir H.
- Ahrens Wolfgang
- Aitmurzaeva Gulmira
- Ajlouni Kamel
- Al Hourani Huda M.
- Al Qaoud Nawal M.
- Al-Hazzaa Hazzaa M.
- Al-Lahou Badreya
- Al-Raddadi Rajaa
- Alarouj Monira
- AlBuhairan Fadia
- AlDhukair Shahla
- Aldwairji Maryam A.
- Alexius Sylvia
- Ali Mohamed M.
- Alkandari Abdullah
- Alkerwi Ala’a
- Alkhatib Buthaina M.
- Allin Kristine
- Alvarez-Pedrerol Mar
- Aly Eman
- Amarapurkar Deepak N.
- Amoah John
- Amougou Norbert
- Amouyel Philippe
- Andersen Lars Bo
- Anderssen Sigmund A.
- Androutsos Odysseas
- Anjana Ranjit Mohan
- Ansari-Moghaddam Alireza
- Anufrieva Elena
- Aounallah-Skhiri Hajer
- Araújo Joana
- Ariansen Inger
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- Arku Raphael E.
- Arlappa Nimmathota
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- Manzato Enzo
- Marcil Anie
- Margozzini Paula
- Marina Loreto Santa
- Mariño Joany
- Markaki Anastasia
- Markey Oonagh
- Marques Larissa Pruner
- Marques-Vidal Pedro
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- Martin-Prevel Yves
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- Motta Jorge
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- Movsesyan Yeva
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- Msyamboza Kelias P.
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- Nejatizadeh Azim
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- Nelis Keiu
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- Neovius Martin
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- Nowak-Szczepanska Natalia
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- Nuhoğlu Irfan
- Nunes Baltazar
- Nurk Eha
- Nuwaha Fred
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- Námešná Jana
- Obreja Galina
- Ochimana Caleb
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- Palmieri Luigi
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- Panza Francesco
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- Pascanu Ionela M.
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- Pechlaner Raimund
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- Petkeviciene Janina
- Petrauskiene Ausra
- Petrescu Constanta Huidumac
- Pettenuzzo Emanuela
- Peykari Niloofar
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- Phall Modou Cheyassin
- Pham Son Thai
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- Pierannunzio Daniela
- Pigeot Iris
- Pikhart Hynek
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- Pitakaka Freda
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- Poulimeneas Dimitrios
- Pouraram Hamed
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- Providencia Rui
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- Pudule Iveta
- Puiu Maria
- Punab Margus
- Pérez Cynthia M.
- Qadir Muhammed S.
- Qasrawi Radwan F.
- Qorbani Mostafa
- Quintana Hedley K.
- Quiroga-Padilla Pedro J.
- Rach Stefan
- Radic Ivana
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- Rahimikazerooni Salar
- Rahman Mahfuzar
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- Raitakari Olli
- Raj Manu
- Rajabov Tamerlan
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- Rao Kodavanti Mallikharjuna
- Rao Sudha Ramachandra
- Rarra Vayia
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- Ribas-Barba Lourdes
- Ribeiro Robespierre
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- Roa Reina G.
- Robinson Louise
- Robitaille Cynthia
- Roccaldo Romana
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- Rodriguez-Martinez Andrea
- Rodríguez Andrea Y.
- Rodríguez Inés Sánchez
- Rodríguez-Artalejo Fernando
- Rodríguez-Villamizar Laura A.
- Roggenbuck Ulla
- Rohloff Peter
- Rohner Fabian
- Rojas-Martinez Rosalba
- Rojroongwasinkul Nipa
- Rolandi Gilda Estela Benitez
- Romaguera Dora
- Romeo Elisabetta L.
- Rosario Angelika Schaffrath
- Rosario Rafaela V.
- Rosengren Annika
- Rouse Ian
- Rouzier Vanessa
- Roy Joel G. R.
- Ruano Maira H.
- Rubinstein Adolfo
- Ruidavets Jean-Bernard
- Ruiz-Betancourt Blanca Sandra
- Ruiz-Castell Maria
- Rusakova Iuliia A.
- Russo Paola
- Rust Petra
- Rutkowski Marcin
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- Sabbaghi Hamideh
- Sacchini Elena
- Sachdev Harshpal S.
- Sadjadi Alireza
- Safarpour Ali Reza
- Safi Sare
- Safiri Saeid
- Saghi Mohammad Hossien
- Saidi Olfa
- Saki Nader
- Salanave Benoit
- Saleva Calogero
- Salmerón Diego
- Salomaa Veikko
- Salonen Jukka T.
- Salvetti Massimo
- Samoutian Margarita
- Sandjaja [missing]
- Sans Susana
- Santacruz Ethel
- Santos Diana A.
- Santos Ina S.
- Santos Lèlita C.
- Santos Maria Paula
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- Santos Rute
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- Sardinha Luis B.
- Sarrafzadegan Nizal
- Sathish Thirunavukkarasu
- Saum Kai-Uwe
- Savin Stefan
- Savva Savvas
- Savy Mathilde
- Sawada Norie
- Sbaraini Mariana
- Scazufca Marcia
- Schaan Beatriz D.
- Schargrodsky Herman
- Schienkiewitz Anja
- Schindler Karin
- Schipf Sabine
- Schmidt Carsten O.
- Schmidt Ida Maria
- Schneider Andrea
- Schnohr Peter
- Schramm Sara
- Schramm Stine
- Schröder Helmut
- Schultsz Constance
- Schulze Matthias B.
- Schutte Aletta E.
- Schöttker Ben
- Sebert Sylvain
- Sedaghattalab Moslem
- Selamat Rusidah
- Sember Vedrana
- Sen Abhijit
- Senbanjo Idowu O.
- Sepanlou Sadaf G.
- Sequera Guillermo
- Serra-Majem Luis
- Servais Jennifer
- Shalnova Svetlana
- Shamah-Levy Teresa
- Shamshirgaran Seyed Morteza
- Shanthirani Coimbatore Subramaniam
- Sharafkhah Maryam
- Sharma Sanjib K.
- Shaw Jonathan E.
- Shayanrad Amaneh
- Shayesteh Ali Akbar
- Sheffer Kate E.
- Shengelia Lela
- Shi Zumin
- Shibuya Kenji
- Shimizu-Furusawa Hana
- Shimony Tal
- Shiri Rahman
- Shrestha Namuna
- Si-Ramlee Khairil
- Siani Alfonso
- Siantar Rosalynn
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- Sidossis Labros S.
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- Silva Antonio M.
- Silva Diego Augusto Santos
- Silva Kelly S.
- Sim Xueling
- Simina Iulia Jurca
- Simon Mary
- Simons Judith
- Simons Leon A.
- Singleton Rosie K.
- Sjöberg Agneta
- Sjöström Michael
- Skoblina Natalia A.
- Skodje Gry
- Slazhnyova Tatyana
- Slowikowska-Hilczer Jolanta
- Slusarczyk Przemysław
- Smeeth Liam
- So Hung-Kwan
- Soares Fernanda Cunha
- Sobek Grzegorz
- Sobngwi Eugène
- Sodemann Morten
- Soekatri Moesijanti Y. E.
- Soemantri Agustinus
- Sofat Reecha
- Solano Marta García
- Solfrizzi Vincenzo
- Somi Mohammad Hossein
- Sonestedt Emily
- Song Yi
- Soofi Sajid
- Sophiea Marisa K.
- Sorić Maroje
- Soto-Rojas Victoria E.
- Soumaré Aïcha
- Sousa-Poza Alfonso
- Sovic Slavica
- Sparboe-Nilsen Bente
- Sparrenberger Karen
- Spencer Phoebe R.
- Spinelli Angela
- Spiroski Igor
- Staessen Jan A.
- Stamm Hanspeter
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- Stokwiszewski Jakub
- Stoyanova Ekaterina
- Stratton Gareth
- Stronks Karien
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- Sturua Lela
- Stöckl Doris
- Suka Machi
- Sun Chien-An
- Sun Liang
- Sundström Johan
- Sung Yn-Tz
- Sunyer Jordi
- Suriyawongpaisal Paibul
- Suárez-Medina Ramón
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- Szklo Moyses
- Szponar Lucjan
- Sánchez-Abanto Jose
- Söderberg Stefan
- Sørensen Thorkild I. A.
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- Tabone Lorraine
- Tai E. Shyong
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- Tammesoo Mari-Liis
- Tamosiunas Abdonas
- Tan Eng Joo
- Tang Xun
- Tanrygulyyeva Maya
- Tanser Frank
- Tao Yong
- Tarawneh Mohammed Rasoul
- Tarp Jakob
- Tarqui-Mamani Carolina B.
- Taylor Anne
- Taylor Julie
- Tchibindat Félicité
- Te Velde Saskia
- Tebar William R.
- Tell Grethe S.
- Tello Tania
- Tham Yih Chung
- Thankappan K. R.
- Theobald Holger
- Theodoridis Xenophon
- Thomas Nihal
- Thorand Barbara
- Thuesen Betina H.
- Tichá Ľubica
- Timmermans Erik J.
- Tjandrarini Dwi H.
- Tjonneland Anne
- Tolonen Hanna K.
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- Topór-Mądry Roman
- Torheim Liv Elin
- Tormo María José
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- Torrent Maties
- Torres-Collado Laura
- Toselli Stefania
- Touloumi Giota
- Traissac Pierre
- Tran Thi Tuyet-Hanh
- Tremblay Mark S.
- Triantafyllou Areti
- Trichopoulos Dimitrios
- Trichopoulou Antonia
- Trinh Oanh T. H.
- Trivedi Atul
- Tsao Yu-Hsiang
- Tshepo Lechaba
- Tsigga Maria
- Tsintavis Panagiotis
- Tsugane Shoichiro
- Tuitele John
- Tuliakova Azaliia M.
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- Tuomainen Tomi-Pekka
- Tuomilehto Jaakko
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- Tynelius Per
- Tzala Evangelia
- Tzotzas Themistoklis
- Tzourio Christophe
- Ueda Peter
- Ugel Eunice
- Ukoli Flora A. M.
- Ulmer Hanno
- Unal Belgin
- Usupova Zhamyila
- Uusitalo Hannu M. T.
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- Wang Ningli
- Wang Qian
- Wang Xiangjun
- Wang Ya Xing
- Wang Ying-Wei
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- Wareham Nicholas
- Weber Adelheid
- Webster-Kerr Karen
- Wedderkopp Niels
- Weghuber Daniel
- Wei Wenbin
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- Widyahening Indah S.
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- Wilsgaard Tom
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- Więcek Andrzej
- Wojciech Rusek
- Wojtyniak Bogdan
- Wolf Kathrin
- Wong Andrew
- Wong Emily B.
- Wong Jyh Eiin
- Wong Norazizah Ibrahim
- Wong Tien Yin
- Wong-McClure Roy A.
- Woo Jean
- Woodward Mark
- Wu Frederick C.
- Wu Hon-Yen
- Wu Jianfeng
- Wu Li Juan
- Wu Shouling
- Wyszyńska Justyna
- Xu Haiquan
- Xu Liang
- Yaacob Nor Azwany
- Yamborisut Uruwan
- Yan Weili
- Yang Ling
- Yang Xiaoguang
- Yang Yang
- Yardim Nazan
- Yasuharu Tabara
- Yiallouros Panayiotis K.
- Yngve Agneta
- Yoosefi Moein
- Yoshihara Akihiro
- You Qi Sheng
- You San-Lin
- Younger-Coleman Novie O.
- Yu Yu-Ling
- Yu Yunjiang
- Yusof Safiah Md
- Yusoff Ahmad Faudzi
- Yusoff Muhammad Fadhli Mohd
- Zaccagni Luciana
- Zafiropulos Vassilis
- Zainuddin Ahmad A.
- Zakavi Seyed Rasoul
- Zamani Farhad
- Zambon Sabina
- Zampelas Antonis
- Zamrazilová Hana
- Zapata Maria Elisa
- Zargar Abdul Hamid
- Zaw Ko Ko
- Zayed Ayman A.
- Zdrojewski Tomasz
- Zejglicova Kristyna
- Zeng Yi
- Zhang Luxia
- Zhang Zhen-Yu
- Zhao Dong
- Zhao Ming-Hui
- Zhao Wenhua
- Zhecheva Yanitsa V.
- Zhen Shiqi
- Zheng Wei
- Zheng Yingfeng
- Zholdin Bekbolat
- Zhou Bin
- Zhou Maigeng
- Zhu Dan
- Zins Marie
- Zitt Emanuel
- Zocalo Yanina
- Zoghlami Nada
- Zuziak Monika
- Ängquist Lars
- Čapková Naděžda
- Łuszczki Edyta
- Šalaj Sanja
- Ševčíková Ľudmila
- Żegleń Magdalena
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2023
- Field of study
Optimal growth and development in childhood and adolescence is crucial for lifelong health and well-being1–6. Here we used data from 2,325 population-based studies, with measurements of height and weight from 71 million participants, to report the height and body-mass index (BMI) of children and adolescents aged 5–19 years on the basis of rural and urban place of residence in 200 countries and territories from 1990 to 2020. In 1990, children and adolescents residing in cities were taller than their rural counterparts in all but a few high-income countries. By 2020, the urban height advantage became smaller in most countries, and in many high-income western countries it reversed into a small urban-based disadvantage. The exception was for boys in most countries in sub-Saharan Africa and in some countries in Oceania, south Asia and the region of central Asia, Middle East and north Africa. In these countries, successive cohorts of boys from rural places either did not gain height or possibly became shorter, and hence fell further behind their urban peers. The difference between the age-standardized mean BMI of children in urban and rural areas was <1.1 kg m–2 in the vast majority of countries. Within this small range, BMI increased slightly more in cities than in rural areas, except in south Asia, sub-Saharan Africa and some countries in central and eastern Europe. Our results show that in much of the world, the growth and developmental advantages of living in cities have diminished in the twenty-first century, whereas in much of sub-Saharan Africa they have amplified
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
- Author
- Abdel-Aziz Amal Kamal
- Abdelfatah Sara
- Abdellatif Mahmoud
- Abdoli Asghar
- Abel Steffen
- Abeliovich Hagai
- Abildgaard Marie H
- Abudu Yakubu Princely
- Acevedo-Arozena Abraham
- Adamopoulos Iannis E
- Adeli Khosrow
- Adolph Timon E
- Adornetto Annagrazia
- Aflaki Elma
- Afshar Elham Ghasemipour
- Agam Galila
- Agarwal Anupam
- Aggarwal Bharat B
- Agnello Maria
- Agostinis Patrizia
- Agrewala Javed N
- Agrotis Alexander
- Aguilar Patricia V
- Ahmad S Tariq
- Ahmed Zubair M
- Ahumada-Castro Ulises
- Aits Sonja
- Aizawa Shu
- Akkoc Yunus
- Akoumianaki Tonia
- Akpinar Hafize Aysin
- Al-Abd Ahmed M
- Al-Akra Lina
- Al-Bari M Abdul Alim
- Al-Gharaibeh Abeer
- Alaoui-Jamali Moulay A
- Alberti Simon
- Alcocer-Gomez Elisabet
- Alcon Soledad Porte
- Alessandri Cristiano
- Ali Muhammad
- Aliwaini Saeb
- Alizadeh Javad
- Almacellas Eugenia
- Almasan Alexandru
- Alonso Alicia
- Alonso Guillermo D
- Altan-Bonnet Nihal
- Altieri Dario C
- Alvarez Elida MC
- Alves Sara
- Alzaharna Mazen M
- Amadio Marialaura
- Amantini Consuelo
- Amaral Cristina
- Ambrosio Susanna
- Amer Amal O
- Ammanathan Veena
- An Zhenyi
- Andersen Stig U
- Andrabi Shaida A
- Andrade-Silva Magaiver
- Andres Allen M
- Angelini Sabrina
- Ann David
- Anozie Uche C
- Ansari Mohammad Y
- Antas Pedro
- Antebi Adam
- Anton Zurine
- Anwar Tahira
- Apetoh Lionel
- Apostolova Nadezda
- Araki Toshiyuki
- Araki Yasuhiro
- Arasaki Kohei
- Araujo Thais Fenz
- Araujo Wagner L
- Araya Jun
- Arden Catherine
- Arevalo Maria-Angeles
- Arguelles Sandro
- Arias Esperanza
- Arikkath Jyothi
- Arimoto Hirokazu
- Ariosa Aileen R
- Armstrong-James Darius
- Arnaune-Pelloquin Laetitia
- Aroca Angeles
- Arroyo Daniela S
- Arsov Ivica
- Artero Ruben
- Asaro Dalia Maria Lucia
- Aschner Michael
- Ashrafizadeh Milad
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- Chiurchiu Valerio
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- Choi Mary E
- Choudhury Kamalika Roy
- Chow Norman S
- Chu Charleen T
- Chua Jason P
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- Germain Kyla
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- Giampietri Claudia
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- Golab Jakub
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- Gunther Andreas
- Guntur Anyonya R
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- Hamann Andrea
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- Horos Rastislav
- Hoshida Yujin
- Hsin I-Lun
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- Ji Jing
- Jia Lijun
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- Johnston Simon A
- Jokitalo Eija
- Jolly Mohit Kumar
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- Jr Robert C Bast
- Ju Dianwen
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- Judith Delphine
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- Jun Youngsoo
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- Jung SungChul
- Jung Yong Keun
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- Sahni Sumit
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- Saito Shigeru
- Saito Tsunenori
- Sakai Ryohei
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- Spector Stephen A
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- Stenmark Harald
- Sterneckert Jared
- Stevens Craig
- Stoka Veronika
- Storch Stephan
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- Stupack Dwayne G
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- Sun Jun
- Sun Kang
- Sun Meng-xiang
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- Sweeney Gary
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- Tacke Frank
- Taegtmeyer Heinrich
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- Tai Haoran
- Tait Stephen WG
- Takahashi Yoshinori
- Takats Szabolcs
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- Tamura Atsushi
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- Tanaka Motomasa
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- Tanida Isei
- Tao Zhipeng
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- Teixeira Natercia
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- Thirumalaikumar VP
- Thomas Sufi Mary
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- Torriglia Alicia
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- Van den Berghe Greet
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- van Loosdregt Jorg
- van Wijk Sjoerd JL
- Vandenberghe Wim
- Vanhorebeek Ilse
- Vannier-Santos Marcos A
- Vannini Nicola
- Vanrell M Cristina
- Vantaggiato Chiara
- Varano Gabriele
- Varela-Nieto Isabel
- Varga Mate
- Vasconcelos M Helena
- Vats Somya
- Vavvas Demetrios G
- Vega-Rubin-de-Celis Silvia
- VegaNaredo Ignacio
- Velasco Guillermo
- Velazquez Ariadna P
- Vellai Tibor
- Vellenga Edo
- Velotti Francesca
- Verdier Mireille
- Verginis Panayotis
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- Vidal Michel
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- Villalba Jose M
- Villalobo Antonio
- Villarejo-Zori Beatriz
- Villarroya Francesc
- Villarroya Joan
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- Vocadlo David J
- Voitsekhovskaja Olga V
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- Vooijs Marc A
- Voos Wolfgang
- Vucicevic Ljubica
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- Waguri Satoshi
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- Wandosell Francisco G
- Wang Bo
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- Wang Hao
- Wang Hexiang
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- Wang Jiou
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- Wang Ping
- Wang Ping
- Wang Qing
- Wang Qing Jun
- Wang Qing Kenneth
- Wang Qiong A
- Wang Wen-Tao
- Wang Wuyang
- Wang Xinnan
- Wang Xuejun
- Wang Yan
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- Wang Zhenyu
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- Warnes Gary
- Warnsmann Verena
- Watada Hirotaka
- Watanabe Eizo
- Watchon Maxinne
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- Wehman Ann M
- Wei Huafeng
- Wei Lei
- Wei Taotao
- Wei Yongjie
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- Wen Runxia H
- Wen Xin
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- Weykopf Beatrice
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- Wilson Richard A
- Winner Beate
- Winsor Nathaniel J
- Witkin Steven S
- Wodrich Harald
- Woehlbier Ute
- Wollert Thomas
- Wong Esther
- Wong Jack Ho
- Wong Richard W
- Wong Vincent Kam Wai
- Wong W Wei-Lynn
- Wu An-Guo
- Wu Chengbiao
- Wu Jian
- Wu Junfang
- Wu Kenneth K
- Wu Min
- Wu Shan-Ying
- Wu Shengzhou
- Wu Shufang
- Wu ShuYan
- Wu William KK
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- Wu Yao-Wen
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- Xie Chuan-Ming
- Xie Min
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- Xie Zhiping
- Xie Zhonglin
- Xilouri Maria
- Xu Congfeng
- Xu En
- Xu Haoxing
- Xu Jing
- Xu JinRong
- Xu Liang
- Xu Wen Wen
- Xu Xiulong
- Xue Yu
- Yakhine-Diop Sokhna MS
- Yamaguchi Masamitsu
- Yamaguchi Osamu
- Yamamoto Ai
- Yamashina Shunhei
- Yan Shengmin
- Yan Shian-Jang
- Yan Zhen
- Yanagi Yasuo
- Yang Chuanbin
- Yang Dun-Sheng
- Yang Huan
- Yang Huang-Tian
- Yang Hui
- Yang Jin-Ming
- Yang Jing
- Yang Jingyu
- Yang Ling
- Yang Liu
- Yang Ming
- Yang Pei-Ming
- Yang Qian
- Yang Seungwon
- Yang Shu
- Yang Shun-Fa
- Yang Wannian
- Yang Wei Yuan
- Yang Xiaoyong
- Yang Xuesong
- Yang Yi
- Yang Ying
- Yao Honghong
- Yao Shenggen
- Yao Xiaoqiang
- Yao Yong-Gang
- Yao Yong-Ming
- Yasui Takahiro
- Yazdankhah Meysam
- Yen Paul M
- Yi Cong
- Yin Xiao-Ming
- Yin Yanhai
- Yin Zhangyuan
- Yin Ziyi
- Ying Meidan
- Ying Zheng
- Yip Calvin K
- Yiu Stephanie Pei Tung
- Yoo Young H
- Yoshida Kiyotsugu
- Yoshii Saori R
- Yoshimori Tamotsu
- Yousefi Bahman
- Yu Boxuan
- Yu Haiyang
- Yu Jun
- Yu Jun
- Yu Li
- Yu Ming-Lung
- Yu Seong-Woon
- Yu Victor C
- Yu W Haung
- Yu Zhengping
- Yu Zhou
- Yuan Junying
- Yuan Ling-Qing
- Yuan Shilin
- Yuan Shyng-Shiou F
- Yuan Yanggang
- Yuan Zengqiang
- Yue Jianbo
- Yue Zhenyu
- Yun Jeanho
- Yung Raymond L
- Zacks David N
- Zaffagnini Gabriele
- Zambelli Vanessa O
- Zanella Isabella
- Zang Qun S
- Zanivan Sara
- Zappavigna Silvia
- Zaragoza Pilar
- Zarbalis Konstantinos S
- Zarebkohan Amir
- Zarrouk Amira
- Zeitlin Scott O
- Zeng Jialiu
- Zeng Ju-deng
- Zerovnik Eva
- Zhan Lixuan
- Zhang Bin
- Zhang Donna D
- Zhang Hanlin
- Zhang Hong
- Zhang Hong
- Zhang Honghe
- Zhang Huafeng
- Zhang Huaye
- Zhang Hui
- Zhang Hui-Ling
- Zhang Jianbin
- Zhang Jianhua
- Zhang Jing-Pu
- Zhang Kalin YB
- Zhang Leshuai W
- Zhang Lin
- Zhang Lisheng
- Zhang Lu
- Zhang Luoying
- Zhang Menghuan
- Zhang Peng
- Zhang Sheng
- Zhang Wei
- Zhang Xiangnan
- Zhang Xiao-Wei
- Zhang Xiaolei
- Zhang Xiaoyan
- Zhang Xin
- Zhang Xinxin
- Zhang Xu Dong
- Zhang Yang
- Zhang Yanjin
- Zhang Yi
- Zhang Ying-Dong
- Zhang Yingmei
- Zhang Yuan-Yuan
- Zhang Yuchen
- Zhang Zhe
- Zhang Zhengguang
- Zhang Zhibing
- Zhang Zhihai
- Zhang Zhiyong
- Zhang Zili
- Zhao Haobin
- Zhao Lei
- Zhao Shuang
- Zhao Tongbiao
- Zhao Xiao-Fan
- Zhao Ying
- Zhao Yongchao
- Zhao Yongliang
- Zhao Yuting
- Zheng Guoping
- Zheng Kai
- Zheng Ling
- Zheng Shizhong
- Zheng Xi-Long
- Zheng Yi
- Zheng Zu-Guo
- Zhivotovsky Boris
- Zhong Qing
- Zhou Ao
- Zhou Ben
- Zhou Cefan
- Zhou Gang
- Zhou Hao
- Zhou Hong
- Zhou Hongbo
- Zhou Jie
- Zhou Jing
- Zhou Jing
- Zhou Jiyong
- Zhou Kailiang
- Zhou Rongjia
- Zhou Xu-Jie
- Zhou Yanshuang
- Zhou Yinghong
- Zhou Yubin
- Zhou Zheng-Yu
- Zhou Zhou
- Zhu Binglin
- Zhu Changlian
- Zhu Guo-Qing
- Zhu Haining
- Zhu Hongxin
- Zhu Hua
- Zhu WeiGuo
- Zhu Yanping
- Zhu Yushan
- Zhuang Haixia
- Zhuang Xiaohong
- Zientara-Rytter Katarzyna
- Zimmermann Christine M
- Ziviani Elena
- Zoladek Teresa
- Zong Wei-Xing
- Zorov Dmitry B
- Zorzano Antonio
- Zou Weiping
- Zou Zhen
- Zou Zhengzhi
- Zuryn Steven
- Zwerschke Werner
- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2021
- Field of study
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field
Analysis of Outcomes in Ischemic vs Nonischemic Cardiomyopathy in Patients With Atrial Fibrillation A Report From the GARFIELD-AF Registry
- Author
- A'Court Christine
- Abdel-Qader Muwafeg
- Abe Masahiko
- Abe Masatake
- Abe Mitsunori
- Abe Sumihisa
- Abe Yukihiko
- Abhayaratna Walter
- Accogli Michele
- Adachi Susumu
- Adachi Toru
- Adak Dhriti
- Adam Matthew
- Adriaansen Henk
- Aegerter Emanuel
- Ageta Masato
- Aggarwala Anil
- Agnelli Giancarlo
- AgnieszkaMetzgier-Gumiela AgnieszkaMetzgier-Gumiela
- Ahlmark Hakan
- Ahmad Kamran
- Ahmad Shahid
- Ahmed Fayzal
- Ahn Jung Joo
- Akers Lori
- Akiyama Masahiro
- Al Mahmeed Wael
- Al-Khalili Faris
- Alberts Mark
- Alborough Elizabeth
- Aldegather Jehad
- Aleksandrova Elena
- Alexandre Almeida Carlos
- Ali Amar
- Ali Gholam
- Alia Pilar Montero
- Allasia Bartolomeo
- Alonso Carmela
- Alonso Concepcion
- Altun Armagan
- Alunni Massimo
- Alvarez Garcia Pere
- Alvarez Douglas
- Alvarez Miguel
- Alzogaray Maria Fernanda
- Amarenco Pierre
- Amaro Marisol
- Ambicka Monika
- Ambrosino Pasquale
- Ambrosio Giuseppe
- Amin Joseph
- Amrhein Diana
- Amstutz Daniela
- An Hae Jung
- Andere Natalia
- Andersson Agneta
- Andersson Lisbeth
- Ando Hiroshi
- Ando Shinichi
- Andrzejewski Dariusz
- Angaran Paul
- Ansoult Nadege
- Antonova Petra
- Antonsen Hege
- Aoki Kenji
- Aoyama Takuma
- Appleby Nigel
- Appleby Nigel
- Aracil Villar Joaquin
- Arai Hidekazu
- Araminowicz Joanna
- Aras Funda
- Arcocha Torres Maria Fe
- Argena Antonio
- Arima Shinichi
- Armangau Pauline
- Arstall Margaret
- Asafu-Adjaye Nana
- Asano Hiroshi
- Asano Taku
- Ashraf M. Javed
- Assagay Maharajh S.
- Assouline Serge
- Astridge Penny
- Atar Dan
- Atar Dan
- Ausen Karin
- Austria Aileen
- Aves Theresa
- Avinc Gamze
- Avinc Gamze
- Avinc Gamze
- Axthelm Christoph
- Ayar Ozge
- Aydinlar Ali
- Ayres Bronte
- Azakami Shiro
- Aziz Michael
- Azuma Junya
- Baba Takao
- Babjakova Zuzana
- Babyesiza Adyeri
- Bae Sang Cheol
- Baek Ae Lee
- Baglioni Gregorio
- Bai Chunlin
- Baksh Farisha
- Balaraju Swathi
- Ball Kelly
- Bamungpong Panthipa
- Banfi Elena
- Barbarash Olga
- Barbeira Pablo Saleta
- Barkowski Timothy
- Barnes Dylan
- Barnes Dylan
- Baron Esquivias Gonzalo
- Barraquer Feu Edelmira
- Barreau Angeline
- Barreda Maria
- Barretto Antonio Carlos Pereira
- Barrow Susan
- Barry Lisa
- Bartkowiak Radoslaw
- Bartlett Melialoha
- Bartnik Jerzy
- Basiak Marcin
- Basily Wagdy
- Bassand Jean-Pierre
- Bassand Jean-Pierre
- Bassand Jean-Pierre
- Bassand Jean-Pierre
- Bastani Lisa
- Baszak Jacek
- Batalov Roman
- Batlle Javier
- Batta Claire
- Batta Claire
- Baumbach Sylvia
- Baumgartner Philipp
- Baweja Paramdeep
- Bayat Junaid
- Beattie Andre
- Becerra Munoz Victor
- Begum Haseena
- Bekieszczuk Ewa
- Belenkova Yulia
- Belenky Dmitry
- Bengtsberg Daniel
- Bennett James
- Berardi Mario
- Berg-Johansen Berg-Johansen
- Berge Eivind
- Berge Trude
- Berit Anne
- Berman Sofia Graciela
- Bernat Lukasz
- Berneau Jean-Baptiste
- Best Peggy
- Beton Osman
- Betsuyaku Tetsuo
- Beveridge Rosemary
- Bezrodna Larysa
- Bhargava Kartikeya
- Biagioli Viviana
- Bianchi Alfredo
- Biedrzycka Malgorzata
- Biedrzycka Malgorzata
- Biedrzycki Lukasz
- Biernacka Anita
- Bigcanoe Julie
- Bignell Nanci
- Bilas Roman
- Bilecen Sinan
- Billger Annelie
- Bindig Hans-Walter
- Binnekamp Maurits
- Bird Nigel
- Bireciklioglu Mustafa Fehmi
- Birhan MEHMET BİRHAN
- Bitakova Fatima
- Black Andrew
- Blenkhorn Adam
- Blinkova Marina
- Blombery Peter
- Blumberg Edwin
- Bockova Lucie
- Boda Zoltan
- Boehme Stefanie
- Boen Rigmor
- Boersma Misannia
- Boggian Giulio
- Bonet Jorge
- Bongaerts Maarten
- Bongiorni Maria Grazia
- Bonin Kerstin
- Bonkowski Grzegorz
- Bonner Michelle
- Bonnetain Anne
- Boon Jannie
- Boonyapisit Warangkana
- Boos Laura
- Booysen Maria
- Borjesson Ulf
- Borras Ana Domenech
- Boshoff Cecilia
- Bosman Femmy
- Bosschaert Mike
- Bossolasco Pierdomenico
- Botha Margo
- Bottarelli Maria Luisa
- Bouzamayor Maria Belen Lage
- Bowen-Simpkins Emma
- Bowers Suzanne
- Boys Janice
- Bradshaw Colin
- Braham Simon
- Brauer Gunter
- Bray Bryan
- Breakwell Lynn
- Bremmelgaard Arne
- Breschi Marco
- Breukel Laura
- Briceno Hinojo Ana
- Brimley Jennifer
- Broad Oulton
- Brodmann Marianne
- Bronisz Marek
- Broton Elzbieta
- Brotons Cuixart Carles
- Browne Debbie
- Bruegger Jasmine
- Brugnaux Jean Philippe
- Bruin Sandra
- Brusorio Stefania
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- Mantovani Lorenzo G.
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- Yamamoto Kunihiko
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- Yamasawa Masanori
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- Yamazoe Masahiro
- Yang Jingshan
- Yang Lingli
- Yang Zhiming
- Yawila Suree
- Yildirim Rifat
- Yilmaz Faruk
- Yilmaz Ozcan
- Yokota Naoto
- Yokoyama Yasuhiro
- Yoon Eunji
- Yoon Jung Han
- Yoshida Keiki
- Yoshida Tetsuro
- Yoshida Tomohiro
- Yoshida Tomoki
- Yoshimura Akira
- Yoshizawa Naoto
- Yu HyunJu
- Yu Ting
- Yusuf Huma
- Yuyang Tan
- Zaatout Eman
- Zaitsu Ryuji
- Zak Jan
- Zakutynska-Kowalczyk Karolina
- Zaluska Roman
- Zaman Kashif
- Zateyshchikov Dmitry
- Zauzig Heinz-Dieter
- Zdrowotnej Zespol Opieki
- Zecca Cinzia
- Zemlianskaia Oksana
- Zhai Hong
- Zhan Qiong
- Zhang Guoshan
- Zhang Huaiqin
- Zhang Ran
- Zhang Yi
- Zhao Yusheng
- Zhuravleva Evgeniya
- Zidek Milan
- Zidkova Eva
- Zika Jiri
- Zillo Mariana
- Zimmett Leon
- Zimny Hans-Hermann
- Zincke Stephanie
- Zinka Elzbieta
- Zinka Elzbieta
- Zotova Irina
- Zubeeva Galina
- Zuber Mathieu
- Zutz Stefan
- Zwenkau Schwarz
- Zyczynska Malgorzata
- Publication venue
- 'American Medical Association (AMA)'
- Publication date
- 01/06/2019
- Field of study
IMPORTANCE Congestive heart failure (CHF) is commonly associated with nonvalvular atrial fibrillation (AF), and their combination may affect treatment strategies and outcomes