A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)

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Contesting the financialization of urban space: Community organizations and the struggle to preserve affordable rental housing in New York City

As cities have become both site and object of capital accumulation in a neoliberal political economy, the challenges to community practice aimed at creating, preserving, and improving affordable housing and neighborhoods have grown. Financial markets and actors are increasingly central to the workings of capitalism, transforming the meaning and significance of mortgage capital in local communities and redrawing the relationship between housing and urban inequality. This article addresses the integration of housing and financial markets through the case of "predatory equity," a wave of aggressive private equity investment in New York City's affordable rental sector during the mid-2000s real estate boom. I consider the potential for community organizations to develop innovative, effective, and progressive practices to contest the impact of predatory equity on affordable housing. Highlighting how organizations employed discursive and empirical tactics as well as tactics that reworked the sites, spaces, and structures of finance, this research speaks to the political possibility of contemporary community practice

The potential predictive value of DEK expression for neoadjuvant chemoradiotherapy response in locally advanced rectal cancer

Abstract Background Limited data are available regarding the ability of biomarkers to predict complete pathological response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. Complete response translates to better patient survival. DEK is a transcription factor involved not only in development and progression of different types of cancer, but is also associated with treatment response. This study aims to analyze the role of DEK in complete pathological response following chemoradiotherapy for locally advanced rectal cancer. Methods Pre-treated tumour samples from 74 locally advanced rectal-cancer patients who received chemoradiation therapy prior to total mesorectal excision were recruited for construction of a tissue microarray. DEK immunoreactivity from all samples was quantified by immunohistochemistry. Then, association between positive stained tumour cells and pathologic response to neoadjuvant treatment was measured to determine optimal predictive power. Results DEK expression was limited to tumour cells located in the rectum. Interestingly, high percentage of tumour cells with DEK positiveness was statistically associated with complete pathological response to neoadjuvant treatment based on radiotherapy and fluoropyrimidine-based chemotherapy and a marked trend toward significance between DEK positiveness and absence of treatment toxicity. Further analysis revealed an association between DEK and the pro-apoptotic factor P38 in the pre-treated rectal cancer biopsies. Conclusions These data suggest DEK as a potential biomarker of complete pathological response to treatment in locally advanced rectal cancer

Tarsometatarsus, eggshells, and the species level identification of large-sized flightless birds from Boyo Paso 2 (Sierras of Córdoba, Argentina)

The article presents the taxonomic study carried out on the Rheidae (Palaeognathae: Ratitae) faunal remains recovered in the open-air archaeological site Boyo Paso 2 dated at approximately 1500–750 years BP (Sierras of Córdoba, Argentina). The study is focused on an adult proximal tarsometatarsus, a juvenile distal tarsometatarsus and 453 eggshell remains. The specimens were identified to its most specific level exploring and describing the diagnostic keys to species/genera level identification in modern reference collections. Two Rheidae species were identified: Rhea cf. R. americana and Rhea cf. R. pennata. However, most specimens were assigned to Rhea sp., including the tarsometatarsus remains. Taxonomic assignments indicate that even with the adoption of plant cultivation approximately 1.500 years BP, a broad spectrum foraging base played a key role for late prehispanic daily subsistence, increasing now the number of identified species added to the subsistence as the one not previously considered R. pennata. Its identification also suggests that the late prehispanic environment presented a higher biodiversity than at present, being the modern landscape a nonaccurate analogue of past conditions. It is concluded that achieving taxonomic identification to the most specific possible level becomes the fundamental pillars to assess the taxonomic diversity of human past subsistence as well as characterize the paleoenvironment, which mixed cultivation and foraging people interacted.Fil: Medina, Matias Eduardo. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. División Arqueología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaFil: Picasso, Mariana Beatriz Julieta. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. División Paleontología Vertebrados; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaFil: Campos, Mailín Rocío. Universidad de Buenos Aires. Facultad de Filosofía y Letras; ArgentinaFil: Avila, Nancy Cecilia. Universidad de Buenos Aires. Facultad de Filosofía y Letras; Argentin

Spatial Variation of Dental Caries in Late Holocene Samples of Southern South America: a Geostatistical Study

Objective: The spatial variation of dental caries in late Holocene Southern South American populationswill be analyzed using geostatistical methods. The existence of a continuous geographical pattern ofdental caries variation will be tested. Methods: The author recorded dental caries in 400 individuals andcollated this information with published caries data from 666 individuals. Then, a Caries Index (CI) wascalculated. The caries spatial distribution was evaluated by means of 2D maps and scatterplots.Geostatistical analyses were performed by calculating Moran´s I, correlograms and a Procrustes analysis.Results: There is a relatively strong latitudinal continuous gradient of dental caries variation, especiallyin the extremes of the distribution. Moreover, the association between dental caries and geography wasrelatively high (m12=0.6). Although Northern and Southern samples had the highest and lowestfrequencies of dental caries respectively, the central ones had the largest variation and, they had lowerrates of caries than expected. Conclusion: The large variation in frequencies of dental caries of thepopulations located in the center of the distribution could be explained by their subsistence strategies,characterized either by the consumption of wild cariogenic plants or cultigens obtained locally or byexchange, a reliance on fishing or the incorporation of plants rich in starch rather than carbohydrates. Itis suggested that dental caries must be considered a multifactorial disease, which results from theinteraction of cultural practices and environmental factors, and can change how we understandsubsistence strategies and how we interpret dental caries rates.Fil: Menendez, Lumila Paula. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. División Arqueología; Argentin

Suppression of soil-borne pathogens of tomato by composts derived from agro-industrial wastes abundant in Mediterranean regions

We studied nine composts derived from wastes and by-products of the olive oil, wine, and Agaricus mushroom agro-industries. They were mixed with peat at 1:3 w w (-1) ratios and comparatively evaluated in pot experiments to assess suppressiveness against soil-borne and foliar pathogens of tomato. All compost amendments demonstrated high levels of suppressiveness against Phytophthora nicotianae Breda de Haan in tomato, when they were applied directly after curing (T0) indicating the occurrence of a "general suppression phenomenon" (81-100% decrease in plant disease incidence). They were, however, relatively less effective when applied 9 months after curing (T1, 55-100% disease decrease). Suppressiveness against Fusarium oxysporum f.sp. radicis-lycopersici Jarvis & Shoemaker was relatively lower and varied widely among composts (8-95% and 22-87% decrease in plant disease incidence for T0 and T1, respectively). Three of the composts conferred induced systemic resistance against the foliar pathogen Septoria lycopersici Speg. Biotic properties were determined, including respiration, fluorescein diacetate hydrolysis, and beta-glucosidase activity of composts. The comparative evaluation of the nine composts revealed no shared critical biotic or abiotic characteristics indicative of their suppressive effects on the soil-borne and foliar pathogens. The complex origin of compost suppressiveness is discussed and the implementation of individual evaluation of each compost product for a specific use is advocated