390 research outputs found
Connections between "Extreme Marine Events" and Biological EOVs Report
Identification of local and regional impacts of oxygen, heat and pH related “Extreme Marine Events”: Ocean model data products are overlaid with existing marine biological datasets to identify sensitive areas and organism vulnerabilities
RBD-specific polyclonal F(ab´)2 fragments of equine antibodies in patients with moderate to severe COVID-19 disease: A randomized, multicenter, double-blind, placebo-controlled, adaptive phase 2/3 clinical trial
Background: passive immunotherapy is a therapeutic alternative for patients with COVID-19. Equine polyclonal antibodies (EpAbs) could represent a source of scalable neutralizing antibodies against SARS-CoV-2. Methods: we conducted a double-blind, randomized, placebo-controlled trial to assess efficacy and safety of EpAbs (INM005) in hospitalized adult patients with moderate and severe COVID-19 pneumonia in 19 hospitals of Argentina. Primary endpoint was improvement in at least two categories in WHO ordinal clinical scale at day 28 or hospital discharge (ClinicalTrials.gov number NCT04494984). Findings: between August 1st and October 26th, 2020, a total of 245 patients were enrolled. Enrolled patients were assigned to receive two blinded doses of INM005 (n = 118) or placebo (n = 123). Median age was 54 years old, 65 1% were male and 61% had moderate disease at baseline. Median time from symptoms onset to study treatment was 6 days (interquartile range 5 to 8). No statistically significant difference was noted between study groups on primary endpoint (risk difference [95% IC]: 5 28% [-3 95; 14 50]; p = 0 15). Rate of improvement in at least two categories was statistically significantly higher for INM005 at days 14 and 21 of follow-up. Time to improvement in two ordinal categories or hospital discharge was 14 2 (§ 0 7) days in the INM005 group and 16 3 (§ 0 7) days in the placebo group, hazard ratio 1 31 (95% CI 1 0 to 1 74). Subgroup analyses showed a beneficial effect of INM005 over severe patients and in those with negative baseline antibodies. Overall mortality was 6 9% the INM005 group and 11 4% in the placebo group (risk difference [95% IC]: 0 57 [0 24 to 1 37]). Adverse events of special interest were mild or moderate; no anaphylaxis was reported. Interpretation: Albeit not having reached the primary endpoint, we found clinical improvement of hospitalized patients with SARS-CoV-2 pneumonia, particularly those with severe disease.Fil: Lopardo, Gustavo. Municipalidad de Vicente Lopez (buenos Aires). Hospital Municipal Doctor Bernardo Houssay.; ArgentinaFil: Belloso, Waldo H.. Hospital Italiano; ArgentinaFil: Nannini, Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Colonna, Mariana. Inmunova; ArgentinaFil: Sanguineti, Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Inmunova; ArgentinaFil: Zylberman, Vanesa. Inmunova; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Muñoz, Luciana. Inmunova; ArgentinaFil: Dobarro, Martín. Sanatorio Sagrado Corazón; ArgentinaFil: Lebersztein, Gabriel. Sanatorio Sagrado Corazón; ArgentinaFil: Farina, Javier. Gobierno de la Provincia de Buenos Aires. Hospital de Alta Complejidad Cuenca Alta Doctor Nestor Carlos Kirchner.; ArgentinaFil: Vidiella, Gabriela. Sanatorio Agote. Dr. Luis Agote; ArgentinaFil: Bertetti, Anselmo. Sanatorio Guemes Sociedad Anonima.; ArgentinaFil: Crudo, Favio. Universidad Nacional de San Antonio de Areco; ArgentinaFil: Alzogaray, Maria Fernanda. Instituto Medico Platense.; ArgentinaFil: Barcelona, Laura. Municipalidad de Vicente Lopez (buenos Aires). Hospital Municipal Doctor Bernardo Houssay.; ArgentinaFil: Teijeiro, Ricardo. Gobierno de la Ciudad Autónoma de Buenos Aires. Hospital General de Agudos Doctor Ignacio Pirovano; ArgentinaFil: Lambert, Sandra. Provincia de Buenos Aires. Ministerio de Salud. Hospital Alta Complejidad en Red El Cruce Dr. Néstor Carlos Kirchner Samic; ArgentinaFil: Scublinsky, Darío. Clinica Zabala.; ArgentinaFil: Iacono, Marisa. Provincia del Neuquen. Hospital Provincial Neuquen "dr. E. Castro Rendon"; ArgentinaFil: Stanek, Vanina. Hospital Italiano; ArgentinaFil: Solari, Rubén. Gobierno de la Ciudad de Buenos Aires. Hospital de Infecciosas "Dr. Francisco Javier Muñiz"; ArgentinaFil: Cruz, Pablo. No especifíca;Fil: Casas, Marcelo Martín. Clinica Adventista Belgrano; ArgentinaFil: Abusamra, Lorena. Hospital Municipal Dr. Diego Thompson; ArgentinaFil: Luciardi, Héctor Lucas. Provincia de Tucuman. Ministerio de Salud. Sistema Provincial de Salud. Hosp. Centro de Salud "zenon Santillan"; ArgentinaFil: Cremona, Alberto. Hospital Italiano de La Plata; ArgentinaFil: Caruso, Diego. Hospital Español; ArgentinaFil: de Miguel, Bernardo. No especifíca;Fil: Perez Lloret, Santiago. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires"; Argentina. Universidad Abierta Interamericana. Secretaría de Investigación. Centro de Altos Estudios En Ciencias Humanas y de la Salud - Sede Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Millán, Susana. No especifíca;Fil: Kilstein, Yael. No especifíca;Fil: Pereiro, Ana. Fundación Mundo Sano; ArgentinaFil: Sued, Omar. Fundación Huésped; ArgentinaFil: Cahn, Pedro. Fundación Huésped; ArgentinaFil: Spatz, Linus. Inmunova; ArgentinaFil: Goldbaum, Fernando Alberto. Inmunova; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina. Universidad Nacional de San Martin. Centro de Rediseño E Ingenieria de Proteinas.; Argentin
The end of the roman empire in northwestern iberia: Recent research at the site of O Castelo, in Valencia Do Sil (Ourense)
[ES] En este trabajo se presentan los resultados de dos intervenciones arqueológicas realizadas en 2019 en en el
yacimiento de O Castelo, en Valencia do Sil (Ourense),
así como una síntesis analítica de toda la información
disponible sobre el sitio. Se trata de un asentamiento
fortificado que, gracias al análisis estratigráfico y las dataciones radiocarbónicas, podemos situar en los momentos
finales del imperio romano en el noroeste peninsular. Así,
se interpreta el enclave como un espacio de control del
territorio en un momento de gran transformación política
y económica. Las diferentes excavaciones llevadas a cabo
en el sitio han permitido documentar dos entornos domésticos que ofrecen una importante información sobre la
organización social de sus habitantes. El trabajo concluye
con unas reflexiones interpretativas sobre el contexto histórico en el que se insertan este tipo de asentamientos en
el norte peninsular.[EN] In this paper, we present the results of two recent archaeological interventions carried out at the site of O Castelo,
in Valencia do Sil (Ourense), together with an analytic
synthesis of all prior available data. This is a fortified
settlement which, thanks to stratigraphic analyses and
radiocarbon analysis, it can be dated within the final
moments of the Roman Empire in northwestern Iberia.
Therefore, we interpret the site as a territorial control nucleus in a period of great political and economic
changes. Different excavations have uncovered two large
domestic areas which offer quite important information
on the social organization of its inhabitants. This paper
concludes with some interpretative thoughts on the historic context in which this type of sites are inserted in
northwestern Iberia.SIEste trabajo ha sido realizado en el marco del Proyecto «Agencia campesina y complejidad sociopolítica en el noroeste de la Península Ibérica en época medieval» (Ministerio de Economía, Industria y Competitividad, AEI/FEDER UE HUM2016-76094-C4-2-R), del Grupo de Investigación en Arqueología Medieval, Patrimonialización y Paisajes Culturales / ErdiArokoArkeologia, Ondaregintza eta KulturPaisaiakIkerketaTaldea(Gobierno Vasco, IT1193-19) y del Grupo de Estudios Rurales (Unidad Asociada UPV/EHU-CSIC)
Clathrin regulates lymphocyte migration by driving actin accumulation at the cellular leading edge
Lymphocyte migration, which is essential for effective immune responses, belongs to the so-called amoeboid migration. The lymphocyte migration is up to 100 times faster than between mesenchymal and epithelial cell types. Migrating lymphocytes are highly polarized in three well-defined structural and functional zones: uropod, medial zone, and leading edge (LE). The actiomyosin-dependent driving force moves forward the uropod, whereas massive actin rearrangements protruding the cell membrane are observed at the LE. These actin rearrangements resemble those observed at the immunological synapse driven by clathrin, a protein normally involved in endocytic processes. Here, we used cell lines as well as primary lymphocytes to demonstrate that clathrin and clathrin adaptors colocalize with actin at the LE of migrating lymphocytes, but not in other cellular zones that accumulate both clathrin and actin. Moreover, clathrin and clathrin adaptors, including Hrs, the clathrin adaptor for multivesicular bodies, drive local actin accumulation at the LE. Clathrin recruitment at the LE resulted necessary for a complete cell polarization and further lymphocyte migration in both 2D and 3D migration models. Therefore, clathrin, including the clathrin population associated to internal vesicles, controls lymphocyte migration by regulating actin rearrangements occurring at the LE.This work was supported by the grants from the Spanish Ministry of Science and Technology (MICINN; BFU2011-29450 to E.V.) and Ministry of Economy and Competitiveness (MINECO; SAF2014-56716-REDT and BFU2014-59585-R to E.V., SAF2011-25834 to F.S.M., SAF2014-58895-JIN to A.C.A and BFU2014-54181-P to J.L.C.), the Madrid regional government (INDISNET-S2011/BMD-2332 to F.S.M.) and the European Research Council (ERC-2011-AdG 294340-GENTRIS to F.S.M.). We are grateful to the “Centro de Transfusión” of the “Comunidad Autónoma de Madrid” for providing the Buffy Coats
Whole genome sequencing of turbot (Scophthalmus maximus; Pleuronectiformes):a fish adapted to demersal life
12 páginas, 5 figuras.-- Antonio Figueras ... et al.-- This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly citedThe turbot is a flatfish (Pleuronectiformes) with increasing commercial value, which has prompted active genomic research aimed at more efficient selection. Here we present the sequence and annotation of the turbot genome, which represents a milestone for both boosting breeding programmes and ascertaining the origin and diversification of flatfish. We compare the turbot genome with model fish genomes to investigate teleost chromosome evolution. We observe a conserved macrosyntenic pattern within Percomorpha and identify large syntenic blocks within the turbot genome related to the teleost genome duplication. We identify gene family expansions and positive selection of genes associated with vision and metabolism of membrane lipids, which suggests adaptation to demersal lifestyle and to cold temperatures, respectively. Our data indicate a quick evolution and diversification of flatfish to adapt to benthic life and provide clues for understanding their controversial origin. Moreover, we investigate the genomic architecture of growth, sex determination and disease resistance, key traits for understanding local adaptation and boosting turbot production, by mapping candidate genes and previously reported quantitative trait loci. The genomic architecture of these productive traits has allowed the identification of candidate genes and enriched pathways that may represent useful information for future marker-assisted selection in turbotThis work was funded by the Spanish Government: projects Consolider
Ingenio: Aquagenomics (CSD2007-00002) and Metagenoma
de la Península Ibérica (CSD2007-00005), Ministerio de Economía
y Competitividad and European Regional Development Funds
(AGL2012-35904), and Ministerio de Economía y Competitividad
(AGL2014-51773 and AGL2014-57065-R); and Local Government
Xunta de Galicia (GRC2014/010). P.P. and D.R. gratefully acknowledge
the Spanish Ministerio de Educación for their FPU fellowships
(AP2010-2408, AP2012-0254). Funding to pay the Open Access publication
charges for this article was provided by the Ministerio de
Economía y Competitividad (AGL2014-51773) and Xunta de Galicia
(GRC2014/010)Peer reviewe
Multidifferential study of identified charged hadron distributions in -tagged jets in proton-proton collisions at 13 TeV
Jet fragmentation functions are measured for the first time in proton-proton
collisions for charged pions, kaons, and protons within jets recoiling against
a boson. The charged-hadron distributions are studied longitudinally and
transversely to the jet direction for jets with transverse momentum 20 GeV and in the pseudorapidity range . The
data sample was collected with the LHCb experiment at a center-of-mass energy
of 13 TeV, corresponding to an integrated luminosity of 1.64 fb. Triple
differential distributions as a function of the hadron longitudinal momentum
fraction, hadron transverse momentum, and jet transverse momentum are also
measured for the first time. This helps constrain transverse-momentum-dependent
fragmentation functions. Differences in the shapes and magnitudes of the
measured distributions for the different hadron species provide insights into
the hadronization process for jets predominantly initiated by light quarks.Comment: All figures and tables, along with machine-readable versions and any
supplementary material and additional information, are available at
https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2022-013.html (LHCb
public pages
Study of the decay
The decay is studied
in proton-proton collisions at a center-of-mass energy of TeV
using data corresponding to an integrated luminosity of 5
collected by the LHCb experiment. In the system, the
state observed at the BaBar and Belle experiments is
resolved into two narrower states, and ,
whose masses and widths are measured to be where the first uncertainties are statistical and the second
systematic. The results are consistent with a previous LHCb measurement using a
prompt sample. Evidence of a new
state is found with a local significance of , whose mass and width
are measured to be and , respectively. In addition, evidence of a new decay mode
is found with a significance of
. The relative branching fraction of with respect to the
decay is measured to be , where the first
uncertainty is statistical, the second systematic and the third originates from
the branching fractions of charm hadron decays.Comment: All figures and tables, along with any supplementary material and
additional information, are available at
https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2022-028.html (LHCb
public pages
Measurement of the ratios of branching fractions and
The ratios of branching fractions
and are measured, assuming isospin symmetry, using a
sample of proton-proton collision data corresponding to 3.0 fb of
integrated luminosity recorded by the LHCb experiment during 2011 and 2012. The
tau lepton is identified in the decay mode
. The measured values are
and
, where the first uncertainty is
statistical and the second is systematic. The correlation between these
measurements is . Results are consistent with the current average
of these quantities and are at a combined 1.9 standard deviations from the
predictions based on lepton flavor universality in the Standard Model.Comment: All figures and tables, along with any supplementary material and
additional information, are available at
https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2022-039.html (LHCb
public pages
O movemento Kepleriano perturbado
Traballo Fin de Grao en Matemáticas. Curso 2020-2021.[GL] Neste traballo trataremos o tema do movemento kepleriano perturbado, un tipo de movemento
orbital que ten como base o movemento kepleriano do Problema de dous corpos,
que xorde por pequenas alteracións destas órbitas keplerianas, provocadas por diferentes
causas. O obxectivo consiste en explicar cando aparece este movemento e saber en que
medida afecta ao modelo teórico, exemplificando este modelo na órbita dun satélite arti-
ficial, perturbada por causa do achatamento da Terra. Tamén faremos un percorrido polo
Problema de tres corpos e un caso particular do Problema de n corpos, dado que a través
do sistema Sol-Terra-Lúa, que é un caso do Problema de tres corpos xerarquizado, comezou
a desenvolverse toda unha teoría de perturbacións, onde se tiña en conta a influencia dos
demais corpos no movemento da Lúa. Finalmente, tamén introduciremos o Problema restrinxido
de tres corpos (circular plano) pois tamén nos permitirá analizar como evoluciona
un caso particular de tres corpos cando un deles non é influínte no movemento dos outros
corpos, como ocorre por exemplo cun exoplaneta que se move baixo a acción gravitacional
dunha estrela binaria.[EN] In this work, we will deal with the subject of disturbed Keplerian Movement, a type
of orbital movement, like the Keplerian movement of the Two-Body Problem, which is
developed by small alteration of these Keplerian orbits, caused by different factors. The
objective is to explain when this movement appears and to know to what extent it can
affect the theoretical Keplerian model, exemplifying this model in the orbit of an artificial
satellite, which is disturbed by the flattening of the Earth. We will also take into account
the Three-Body Problem, a particular case of n-body Problem, because, through the Sun-
Earth-Moon system (it can be classified as a hierarchical three-body movement), it began to
unfold a whole theory of perturbations where the influence of other bodies was considered
for studying the Moon movement. Finally, we will introduce the Restricted (Circular Plane)
three-body Problem, since it allows us to analyse an especial case that evolves when the
orbiting body, due to its small mass, it does not influe on the movement of the other two
bodies, as occurs with an exoplanet moving around a binary star
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