New records of the Neotropical genus Phaonantho Albuquerque (Diptera: Anthomyiidae)

The genus Phaonantho Albuquerque (Anthomyiidae) comprises three species: P. mallochi (Curran), P. benevola Couri, and P. sordilloae Pamplona & Couri. These species are distributed in the neotropics. In this study, we updated the distributional knowledge for Phaonantho species, including the first record of the genus in Bolivia, Paraguay, Peru, and Mexico, and additional new records to Brazil

A força pública e o policiamento do estado republicano em Minas Gerais

Análise do policiamento do estado de Minas Gerais sob a responsabilidade da força pública mineira tendo como foco o ponto de vista dos comandantes da força pública e dos chefes de polícia entre 1894 e1922. Aprincipal documentação utilizada é um conjunto de relatórios de gestão da Secretaria de Polícia que contêm análises anuais da administração policial, elaboradas por delegados, comandantes e bacharéis que dirigiram a chefia de polícia. A abordagem privilegia o estudo das representações sobre os soldados e oficiais da força pública mineira. Tais representações dialogaram com um imaginário mais amplo sobre o caráter pacífico e ordeiro da população mineira, partilhado entre as elites do estado. A presença dos militares nos municípios, a formação de soldados e oficiais e a questão da indisciplina estiveram interligadas em torno do problema da gestão moderna do policiamento do estado mineiro. Os projetos de policiamento do estado mantiveram relações com os projetos políticos das elites para a sociedade brasileira, mas encontraram entraves no próprio cotidiano da instituição

REPRESENTAÇÕES DO COMPORTAMENTO FEMININO EM BELO HORIZONTE (1920-1930) * REPRESENTATIONS OF FEMALE BEHAVIOUR IN BELO HORIZONTE (1920-1930)

Os impressos contribuíram para a difusão de representações, de diferenciações e de classificações sociais do comportamento feminino. Durante as décadas de 1920 e 1930 em Belo Horizonte, Minas Gerais, os jornais publicaram diversos textos dispersos dirigidos às mulheres e aos seus comportamentos que são uma importante série documental para a análise das distinções a partir da interseccionalidade do gênero com as dimensões raciais e sexuais (morais). Essas representações produziram e foram produzidas pela dicotomia entre “mulher honesta” e “mulher decaída”. Argumento que essa situação é parte de um amplo processo de construção de diferentes mecanismos de normatização dos comportamentos femininos que se relacionam com as distinções sociais e de gênero que marcaram a sociedade brasileira.*The press contributed to the production and dissemination of social representation, differentiation and classifications of female behaviour. The 1920’s and 1930’s newspapers in Belo Horizonte, Minas Gerais, Brazil, have published several dispersed texts addressed to women and their behaviour. They form an important series of documents to the analysis of social distinctions from intersectionality of gender with the racial, social and sexual (moral) dimensions. These representations forged and have been shaped by the dichotomy between the “honest woman” and the “fallen woman”. I argue that this situation is part of a large process of production of different arrangements of standardisation of female performance that are related with the social and gender distinctions of the Brazilian society

Discovery of novel mechanisms of centrosome amplification and their therapeutic value in cancer

Genomic instability is a hallmark of cancer cells that generates the genetic diversity that makes possible the acquisition of all the other hallmarks. Thus, the maintenance of genome stability is critical for proper cell function. Centrosomes, the major microtubule-organising centres of animal cells, are the main subcellular organelles implicated in the maintenance of genome stability. It is therefore not surprising that centrosome amplification (CA) – the presence of more than one centrosome in a cell – is a common feature in cancer. Recent work from the Bettencourt-Dias Lab has identified a new recurrent feature of cancer cells: centriole over-elongation (COE), which also promotes CA. Those abnormalities are specific features of cancer cells and hence appealing targets in cancer therapy. However, their origins and therapeutic value remain poorly understood, preventing their use in the clinic. We have screened the NCI-60 panel of human cancer cell lines for centriole number and individual length to test their frequency and interdependence. We have thereby also generated a metric capturing each abnormality level per cell line that we then correlated with the publicly available molecular (particularly transcriptomic and proteomic) and drug-sensitivity quantitative profiles for that panel. Our work showed lower frequency of COE compared to CA and lung and skin as the primary cancer tissues with higher centriole length heterogeneity. However, the two features are not independent, with overly-longer centrioles being more common in cells with CA. Our single-cell analyses have also suggested that cells apparently do not control their overall centriolar mass when the centriole number increases. Moreover, cancer cell lines with longer centrioles proliferated slower due to an accumulation of cells in G1 phase, suggesting that centriole length defects could lead to a cell cycle delay in G1. In addition, our original genomewide approach highlighted putative mechanisms associated with both abnormalities in cancer, such as the PRKACA kinase promoting COE and the proteasome protecting cells from CA. Correlation with drug activity have both associated CA with higher sensitivity to compound activity and also identified some compounds as potential therapeutic options to selectively target cells with higher incidence of centriole abnormalities. This work provides the first single-centriole-level portrait of centriole abnormalities in cancer and contributes to the understanding of their molecular origins, namely by revealing novel molecular mechanisms in cell cycle biology. Given the cancer-specificity of these abnormalities, the identified compounds will inspire the development of clinical applications based on selectively targeting these Achilles’ heels of cancer cells

A ESCUTA DO OUTRO EM TEMPOS DISSONANTES

Resenha do livro HERMETO, Miriam; AMATO, Gabriel; DELLAMORE, Carolina. Alteridades em tempos de (in)certezas: escutas sensíveis. São Paulo: Letra e Voz, 2019. 180p. &nbsp

Traços Patológicos e Adaptabilidade como Preditores do Engajamento

This study aimed to test the predictive capacity of pathological traits of personality and career adaptability on four constructs that compose the well-being at work: work engagement, job satisfaction, burnout, and workaholism. A total of 204 Brazilian working adults (M age = 34.02, SD = 10.39) participated in the study, which responded to scales measuring pathological traits, career adaptability resources, and well-being components at work. Our findings indicate that pathological traits are, in general, negatively related to job satisfaction and work engagement and positively associated with burnout and workaholism. After the insertion of career adaptability, there was an increase in most of the models' explanation. The contribution of adaptability was significant only for job satisfaction prediction.Este estudo teve como objetivo testar a capacidade preditiva de traços patológicos da personalidade e adaptabilidade de carreira sobre quatro construtos que compõem o bem-estar no trabalho: engajamento no trabalho, satisfação no trabalho, burnout e workaholism. Participaram 204 adultos brasileiros trabalhadores (M idade = 34,02; DP = 10,39) que responderam instrumentos que mensuram traços patológicos, recursos de adaptabilidade de carreira e componentes do bem-estar no trabalho. Nossos achados indicaram que os traços patológicos estão, de modo geral, relacionados negativamente com satisfação no trabalho e engajamento no trabalho e positivamente com burnout e workaholism. Após a inserção da adaptabilidade de carreira houve aumento da explicação na maioria dos modelos, sendo que a contribuição única de adaptabilidade foi significativa apenas para predição de satisfação no trabalho

Acurácia Diagnóstica da Escala Baptista de Depressão: Versões Adulto e Triagem

This study aimed to investigate the diagnostic accuracy of the Baptista Depression Scale adult and screening versions (EBADEP-A and EBADEP-screening) for discrimination of people with a major depressive episode (MDE) or major depressive disorder (MDD) and to compare discriminative capacities. Participants were 187 people, 52 patients, and 135 non-clinical individuals. Results indicated sensitivity equal to 0.92 and specificity equal to 0.88 for EBADEP-A (cut-off = 54), and 0.96 and 0.82, respectively, for EBADEP-screening (cut-off = 17). Findings suggest equivalence between the two versions of EBADEP to discriminate people with MDE or MDD. Results indicate that the two versions can provide a correct diagnostic indicative for MDE and MDD.O objetivo da presente investigação foi verificar a acurácia diagnóstica da Escala Baptista de Depressão adulto e triagem (EBADEP-A e EBADEP- triagem) para discriminação de pessoas com episódio depressivo maior (EDM) e/ou transtorno depressivo maior (TDM), e comparar suas capacidades discriminativas. Participaram 187 pessoas, 52 pacientes e 135 do grupo não clínico. Os resultados indicaram sensibilidade igual a 0,92 e especificidade igual a 0,88 para a EBADEP-A (ponto de corte igual a 54), e 0,96 e 0,82, respectivamente, para a EBADEP-triagem (ponto de corte igual a 17). Os achados sugerem equivalência entre as duas versões da EBADEP para discriminação de pessoas com EDM e/ou TDM. Os resultados indicam que as duas versões podem fornecer um indicativo diagnóstico correto para EDM e TDM

Phytochemical study and antioxidant activity of Dalbergia ecastaphyllum

The chemical profile of Dalbergia ecastaphyllum has been indicated as the botanical origin of Brazilian red propolis, an apicultural product with proven therapeutic properties. However, few studies have investigated this plant species. This study evaluated and compared microbiological quality, chemical composition, and antioxidant activity of stem and leaf samples of D. ecastaphyllum. The samples were collected in February 2015, in the southern region of the state of Bahia, Brazil. We performed the microbiological analyses, determined the contents of fatty acid, total phenol and flavonoid, and identified the chemical profile and antioxidant activit. Escherichia coli, Salmonella spp. and sulfite reducing clostridial spores were not detected in the samples. Acids of the family ω3 were recorded in the stems and ω6 in the leaves. The leaves presented better nutritional quality of the fraction, better antioxidant capacity in the tests by the DPPH method and β-carotene bleaching. There were 49 chemical compounds, of which 38 belonged to the class of flavonoids. The results indicate that stems and leaves of D. ecastaphyllum have biological properties. Leaves particularly are better for functional food formulation and as natural antioxidant.info:eu-repo/semantics/publishedVersio

PLANT RESIDUES AS AN ALTERNATIVE FOR SUBSTRATE COMPOSITION IN THE PRODUCTION OF Eucalyptus grandis SEEDLINGS

Selecting constituents for substrate formulations is of fundamental importance for the production of quality seedlings. The objective of this work was to evaluate the initial growth of Eucalyptus grandis seedlings, using carbonized and fresh coffee husks, cattle manure, coconut fiber and carbonized rice husks as substrate constituents, in different combinations. As a control treatment, the commercial substrate Maxfértil was used. The experiment was set in a nursery, in a randomized block design, consisting of eight treatments and four replications, with a sample unit of 16 seedlings. To evaluate the quality of the seedlings formed, the biometric variables, and plant biomass were quantified and the characterization of the physical and chemical properties of the formulated substrates was also carried out, regarding the characteristics of the seedlings produced. Qualitative analyses were used, where the ease of removing the seedlings from the tube and the aggregation of the roots to the substrate were assessed. After data analysis, it was found that the use of coffee husks was adequate for the production of Eucalyptus grandis seedlings for most of the analyzed variables, with higher values than the seedlings formed in the control treatment. Thus, coffee husks are indicated as an alternative constituent of substrates for the production of seedlings of the referred specie