18 research outputs found
Entanglement growth and simulation efficiency in one-dimensional quantum lattice systems
We study the evolution of one-dimensional quantum lattice systems when the
ground state is perturbed by altering one site in the middle of the chain. For
a large class of models, we observe a similar pattern of entanglement growth
during the evolution, characterized by a moderate increase of significant
Schmidt coefficients in all relevant bipartite decompositions of the state. As
a result, the evolution can be accurately described by a matrix product state
and efficiently simulated using the time-evolving block decimation algorithm.Comment: 6 pages, 5 figure
Excitations in two-component Bose-gases
In this paper, we study a strongly correlated quantum system that has become
amenable to experiment by the advent of ultracold bosonic atoms in optical
lattices, a chain of two different bosonic constituents. Excitations in this
system are first considered within the framework of bosonization and Luttinger
liquid theory which are applicable if the Luttinger liquid parameters are
determined numerically. The occurrence of a bosonic counterpart of fermionic
spin-charge separation is signalled by a characteristic two-peak structure in
the spectral functions found by dynamical DMRG in good agreement with
analytical predictions. Experimentally, single-particle excitations as probed
by spectral functions are currently not accessible in cold atoms. We therefore
consider the modifications needed for current experiments, namely the
investigation of the real-time evolution of density perturbations instead of
single particle excitations, a slight inequivalence between the two
intraspecies interactions in actual experiments, and the presence of a
confining trap potential. Using time-dependent DMRG we show that only
quantitative modifications occur. With an eye to the simulation of strongly
correlated quantum systems far from equilibrium we detect a strong dependence
of the time-evolution of entanglement entropy on the initial perturbation,
signalling limitations to current reasonings on entanglement growth in
many-body systems
Time evolution of 1D gapless models from a domain-wall initial state: SLE continued?
We study the time evolution of quantum one-dimensional gapless systems
evolving from initial states with a domain-wall. We generalize the
path-integral imaginary time approach that together with boundary conformal
field theory allows to derive the time and space dependence of general
correlation functions. The latter are explicitly obtained for the Ising
universality class, and the typical behavior of one- and two-point functions is
derived for the general case. Possible connections with the stochastic Loewner
evolution are discussed and explicit results for one-point time dependent
averages are obtained for generic \kappa for boundary conditions corresponding
to SLE. We use this set of results to predict the time evolution of the
entanglement entropy and obtain the universal constant shift due to the
presence of a domain wall in the initial state.Comment: 27 pages, 10 figure
Pck1 Gene Silencing in the Liver Improves Glycemia Control, Insulin Sensitivity, and Dyslipidemia in db/db Mice
OBJECTIVE—Cytosolic phosphoenolpyruvate carboxykinase (PEPCK-C; encoded by Pck1) catalyzes the first committed step in gluconeogenesis. Extensive evidence demonstrates a direct correlation between PEPCK-C activity and glycemia control. Therefore, we aimed to evaluate the metabolic impact and their underlying mechanisms of knocking down hepatic PEPCK-C in a type 2 diabetic model
Activation of the Unfolded Protein Response (UPR) Is Associated with Cholangiocellular Injury, Fibrosis and Carcinogenesis in an Experimental Model of Fibropolycystic Liver Disease
Fibropolycystic liver disease is characterized by hyperproliferation of the biliary epithelium and the formation of multiple dilated cysts, a process associated with unfolded protein response (UPR). In the present study, we aimed to understand the mechanisms of cyst formation and UPR activation in hepatocytic c-Jun N-terminal kinase 1/2 (Jnk1/2) knockout mice. Floxed JNK1/2 (Jnkf/f) and Jnk∆hepa animals were sacrificed at different time points during progression of liver disease. Histological examination of specimens evidenced the presence of collagen fiber deposition, increased α-smooth muscle actin (αSMA), infiltration of CD45, CD11b and F4/80 cells and proinflammatory cytokines (Tnf, Tgfβ1) and liver injury (e.g., ALT, apoptosis and Ki67-positive cells) in Jnk∆hepa compared with Jnkf/f livers from 32 weeks of age. This was associated with activation of effectors of the UPR, including BiP/GRP78, CHOP and spliced XBP1. Tunicamycin (TM) challenge strongly induced ER stress and fibrosis in Jnk∆hepa animals compared with Jnkf/f littermates. Finally, thioacetamide (TAA) administration to Jnk∆hepa mice induced UPR activation, peribiliary fibrosis, liver injury and markers of biliary proliferation and cholangiocarcinoma (CCA). Orthoallografts of DEN/CCl4-treated Jnk∆hepa liver tissue triggered malignant CCA. Altogether, these results suggest that activation of the UPR in conjunction with fibrogenesis might trigger hepatic cystogenesis and early stages of CCA
The significance of cephalopod beaks as a research tool: An update
The use of cephalopod beaks in ecological and population dynamics studies has allowed major advances of our knowledge on the role of cephalopods in marine ecosystems in the last 60 years. Since the 1960's, with the pioneering research by Malcolm Clarke and colleagues, cephalopod beaks (also named jaws or mandibles) have been described to species level and their measurements have been shown to be related to cephalopod body size and mass, which permitted important information to be obtained on numerous biological and ecological aspects of cephalopods in marine ecosystems. In the last decade, a range of new techniques has been applied to cephalopod beaks, permitting new kinds of insight into cephalopod biology and ecology. The workshop on cephalopod beaks of the Cephalopod International Advisory Council Conference (Sesimbra, Portugal) in 2022 aimed to review the most recent scientific developments in this field and to identify future challenges, particularly in relation to taxonomy, age, growth, chemical composition (i.e., DNA, proteomics, stable isotopes, trace elements) and physical (i.e., structural) analyses. In terms of taxonomy, new techniques (e.g., 3D geometric morphometrics) for identifying cephalopods from their beaks are being developed with promising results, although the need for experts and reference collections of cephalopod beaks will continue. The use of beak microstructure for age and growth studies has been validated. Stable isotope analyses on beaks have proven to be an excellent technique to get valuable information on the ecology of cephalopods (namely habitat and trophic position). Trace element analyses is also possible using beaks, where concentrations are significantly lower than in other tissues (e.g., muscle, digestive gland, gills). Extracting DNA from beaks was only possible in one study so far. Protein analyses can also be made using cephalopod beaks. Future challenges in research using cephalopod beaks are also discussed.info:eu-repo/semantics/publishedVersio
The significance of cephalopod beaks as a research tool: An update
The use of cephalopod beaks in ecological and population dynamics studies has allowed major advances of our knowledge on the role of cephalopods in marine ecosystems in the last 60 years. Since the 1960’s, with the pioneering research by Malcolm Clarke and colleagues, cephalopod beaks (also named jaws or mandibles) have been described to species level and their measurements have been shown to be related to cephalopod body size and mass, which permitted important information to be obtained on numerous biological and ecological aspects of cephalopods in marine ecosystems. In the last decade, a range of new techniques has been applied to cephalopod beaks, permitting new kinds of insight into cephalopod biology and ecology. The workshop on cephalopod beaks of the Cephalopod International Advisory Council Conference (Sesimbra, Portugal) in 2022 aimed to review the most recent scientific developments in this field and to identify future challenges, particularly in relation to taxonomy, age, growth, chemical composition (i.e., DNA, proteomics, stable isotopes, trace elements) and physical (i.e., structural) analyses. In terms of taxonomy, new techniques (e.g., 3D geometric morphometrics) for identifying cephalopods from their beaks are being developed with promising results, although the need for experts and reference collections of cephalopod beaks will continue. The use of beak microstructure for age and growth studies has been validated. Stable isotope analyses on beaks have proven to be an excellent technique to get valuable information on the ecology of cephalopods (namely habitat and trophic position). Trace element analyses is also possible using beaks, where concentrations are significantly lower than in other tissues (e.g., muscle, digestive gland, gills). Extracting DNA from beaks was only possible in one study so far. Protein analyses can also be made using cephalopod beaks. Future challenges in research using cephalopod beaks are also discussed
On Charge Carrier Recombination in Sb2S3 and Its Implication for the Performance of Solar Cells
International audienceSb2S3 is widely considered to be an attractive photovoltaic material based on abundant, nontoxic elements. However, the maximum efficiency reported for solar cells based on this semiconductor does not exceed 6.5%. We have measured light intensity-dependent J-V curves, transient microwave photoconductivity, steady-state photocurrent grating, modulated photocurrent, and photoconductivity on Sb2S3-based samples. All techniques converge toward the same observation: the main recombination route controlling the density of charge carriers in the absorber is of an order greater than one and appears to stem from an exponentially decaying density of tail states within the conduction band of the material. This conclusion has direct and drastic implications for the performance of Sb2S3-based solar cells