Tune in to your emotions: a robust personalized affective music player

The emotional power of music is exploited in a personalized affective music player (AMP) that selects music for mood enhancement. A biosignal approach is used to measure listeners’ personal emotional reactions to their own music as input for affective user models. Regression and kernel density estimation are applied to model the physiological changes the music elicits. Using these models, personalized music selections based on an affective goal state can be made. The AMP was validated in real-world trials over the course of several weeks. Results show that our models can cope with noisy situations and handle large inter-individual differences in the music domain. The AMP augments music listening where its techniques enable automated affect guidance. Our approach provides valuable insights for affective computing and user modeling, for which the AMP is a suitable carrier application

Development of operating rules for a complex multireservoir system by coupling genetic algorithms and network optimization

This is an Accepted Manuscript of an article published in Hydrological Sciences Journal on MAY 1 2013, available online: http://dx.doi.org/10.1080/02626667.2013.779777[EN] An alternative procedure for assessment of reservoir Operation Rules (ORs) under drought situations is proposed. The definition of ORs for multi-reservoir water resources systems (WRSs) is a topic that has been widely studied by means of optimization and simulation techniques. A traditional approach is to link optimization methods with simulation models. Thus the objective here is to obtain drought ORs for a real and complex WRS: the Júcar River basin in Spain, in which one of the main issues is the resource allocation among agricultural demands in periods of drought. To deal with this problem, a method based on the combined use of genetic algorithms (GA) and network flow optimization (NFO) is presented. The GA used was PIKAIA, which has previously been used in other water resources related fields. This algorithm was linked to the SIMGES simulation model, a part of the AQUATOOL decision support system (DSS). Several tests were developed for defining the parameters of the GA. The optimization of various ORs was analysed with the objective of minimizing short-term and long-term water deficits. The results show that simple ORs produce similar results to more sophisticated ones. The usefulness of this approach in the assessment of ORs for complex multi-reservoir systems is demonstrated.The authors wish to thank the Confederacion Hidrogrofica del Jucar (Spanish Ministry of the Environment) for the data provided in developing this study and the Comision Interministerial de Ciencia y Tecnologia, CICYT (Spanish Ministry of Science and Innovation) for funding the projects INTEGRAME (contract CGL2009-11798) and SCARCE (programme Consolider-Ingenio 2010, project CSD2009-00065). The authors also thank the European Commission (Directorate-General for Research and Innovation) for funding the project DROUGHT-R&SPI (programme FP7-ENV-2011, project 282769) and the Seventh Framework Programme of the European Commission for funding the project SIRIUS (FP7-SPACE-2010-1, project 262902). We are grateful to the reviewers for their valuable comments, which have improved this paper.Lerma Elvira, N.; Paredes Arquiola, J.; Andreu Álvarez, J.; Solera Solera, A. (2013). Development of operating rules for a complex multireservoir system by coupling genetic algorithms and network optimization. Hydrological Sciences Journal. 58(4):797-812. https://doi.org/10.1080/02626667.2013.779777S79781258

Comparative analysis of the genes UL1 through UL7 of the duck enteritis virus and other herpesviruses of the subfamily Alphaherpesvirinae

The nucleotide sequences of eight open reading frames (ORFs) located at the 5' end of the unique long region of the duck enteritis virus (DEV) Clone-03 strain were determined. The genes identified were designated UL1, UL2, UL3, UL4, UL5, UL6 and UL7 homologues of the herpes simplex virus 1 (HSV-1). The DEV UL3.5 located between UL3 and UL4 had no homologue in the HSV-1. The arrangement and transcription orientation of the eight genes were collinear with their homologues in the HSV-1. Phylogenetic trees were constructed based on the alignments of the deduced amino acids of eight proteins with their homologues in 12 alpha-herpesviruses. In the UL1, UL3, UL3.5, UL5 and UL7 proteins trees, the branches were more closely related to the genus Mardivirus. However, the UL2, UL4, and UL6 proteins phylogenetic trees indicated a large distance from Mardivirus, indicating that the DEV evolved differently from other viruses in the subfamily Alphaherpesvirinae and formed a single branch within this subfamily

Epigenetic loss of RNA-methyltransferase NSUN5 in glioma targets ribosomes to drive a stress adaptive translational program

Altres ajuts: This work was supported by the Obra Social "La Caixa" (to M. Esteller).Tumors have aberrant proteomes that often do not match their corresponding transcriptome profiles. One possible cause of this discrepancy is the existence of aberrant RNA modification landscapes in the so-called epitranscriptome. Here, we report that human glioma cells undergo DNA methylation-associated epigenetic silencing of NSUN5, a candidate RNA methyltransferase for 5-methylcytosine. In this setting, NSUN5 exhibits tumor-suppressor characteristics in vivo glioma models. We also found that NSUN5 loss generates an unmethylated status at the C3782 position of 28S rRNA that drives an overall depletion of protein synthesis, and leads to the emergence of an adaptive translational program for survival under conditions of cellular stress. Interestingly, NSUN5 epigenetic inactivation also renders these gliomas sensitive to bioactivatable substrates of the stress-related enzyme NQO1. Most importantly, NSUN5 epigenetic inactivation is a hallmark of glioma patients with long-term survival for this otherwise devastating disease

Tribology of improved transformation-toughened ceramics-heat engine test

A short term study has been carried out to evaluate the suitability as cam roller followers of three ceria zirconia toughened aluminas and two yttria stabilized tetragonal zirconias (YTZPs) previously enhanced in programs supported by ORNL. Norton Si{sub 3}N{sub 4} (NBD-100) was also included in this study as a reference material, because it was known from work at Northwestern University that Si{sub 3}N{sub 4} to experienced little or no wear in this application, and NBD-100 is currently a successful commercial bearing material. The tribological studies were subcontracted to the Torrington Company. They found that in cam roller follower simulated tests that there was essentially no wear after 1 hour and 5 hours of testing detectable by weighing and concluded that all of these ceramics are, therefore, candidate materials. Because of the minute amounts of wear it was not possible to identify the wear mechanism or to make any correlations with the other physical properties which were evaluated such as MOR, K{sub IC} hardness, density and grain size. Phase transformation during rolling has been of interest in the tribology of zirconia contain materials. The least stable of the ceria zirconia toughened aluminas resulted in as much as 33% monoclinic phase after testing whereas the yttria stabilized (TTZ) contained very little of this transformed phase. The results of this study show that oxide materials can now be considered as candidates for cam roller followers in heat engines

Spatial distribution of helium isotopes in volcanic gases and thermal waters along the Vanuatu (New Hebrides) volcanic arc

International audienceWe report the first helium isotope survey of volcanic gases, hot springs and some olivine phenocrysts along the Vanuatu island arc, from Tanna in the south to Vanua Lava in the north. Low CO2 content and low 3He/4He ratios in thermal fluids of Epi (4.0 ± 0.1 Ra), Efate (4.5 ± 0.1 Ra) and Pentecost (5.3 ± 0.5 Ra) islands coherently indicate reduced mantle gas leakage and crustal contamination by radiogenic helium on these extinct volcanic systems of the former (Pliocene) arc. Instead, presently active Vanuatu volcanoes display 3He/4He and C/3He ratios typical of subduction-related volcanic arcs: 3He/4He ratios range from 6.4 ± 0.5 Ra in southernmost Tanna and 7.23 ± 0.09 Ra in northernmost Vanua Lava to typical MORB values in the central islands of Gaua (7.68 ± 0.06 Ra), Ambrym (7.6 ± 0.8 Ra) and Ambae (7 ± 2 Ra in groundwaters, 7.9 ± 1.4 Ra in olivine phenocrysts, and 8.0 ± 0.1 Ra in summit fumaroles of Aoba volcano). On Ambrym, however, we discover that hydrothermal manifestations separated by only 10–15 km on both sides of a major E–W transverse fault zone crossing the island are fed by two distinct helium sources, with different 3He/4He signatures: while fluids in southwest Ambrym (Baiap and Sesivi areas) have typical arc ratios (7.6 ± 0.8 Ra), fluids on the northwest coast (Buama Bay area) display both higher 3He/4He ratios (9.8 ± 0.2 Ra in waters to 10.21 ± 0.08 Ra in bubbling gases) and lower C/3He ratios that evidence a hotspot influence. We thus infer that the influx of Indian MORB mantle beneath the central Vanuatu arc, from which Ambrym magmas originate, also involves a 3He-rich hotspot component, possibly linked to a westward influx of Samoan hotspot material or another yet unknown local source. This duality in magmatic He source at Ambrym fits with the bimodal composition and geochemistry of the erupted basalts, implying two distinct magma sources and feeding systems. More broadly, the wide He isotopic variations detected along the Vanuatu arc further verify the complex tectonic and magmatic framework of this intra-oceanic island arc