Las Vegas Flute Club Teachers\u27 Recital

Program listing performers and works performe

ABT-869, a multitargeted receptor tyrosine kinase inhibitor: inhibition of FLT3 phosphorylation and signaling in acute myeloid leukemia

In 15% to 30% of patients with acute myeloid leukemia (AML), aberrant proliferation is a consequence of a juxtamembrane mutation in the FLT3 gene (FMS-like tyrosine kinase 3–internal tandem duplication [FLT3-ITD]), causing constitutive kinase activity. ABT-869 (a multitargeted receptor tyrosine kinase inhibitor) inhibited the phosphorylation of FLT3, STAT5, and ERK, as well as Pim-1 expression in MV-4-11 and MOLM-13 cells (IC_(50) approximately 1-10 nM) harboring the FLT3-ITD. ABT-869 inhibited the proliferation of these cells (IC_(50) = 4 and 6 nM, respectively) through the induction of apoptosis (increased sub-G_(0)/G_1 phase, caspase activation, and PARP cleavage), whereas cells harboring wild-type (wt)–FLT3 were less sensitive. In normal human blood spiked with AML cells, ABT-869 inhibited phosphorylation of FLT3 (IC_(50) approximately 100 nM), STAT5, and ERK, and decreased Pim-1 expression. In methylcellulose-based colony-forming assays, ABT-869 had no significant effect up to 1000 nM on normal hematopoietic progenitor cells, whereas in AML patient samples harboring both FLT3-ITD and wt-FLT3, ABT-869 inhibited colony formation (IC_(50) = 100 and 1000 nM, respectively). ABT-869 dose-dependently inhibited MV-4-11 and MOLM-13 flank tumor growth, prevented tumor formation, regressed established MV-4-11 xenografts, and increased survival by 20 weeks in an MV-4-11 engraftment model. In tumors, ABT-869 inhibited FLT3 phosphorylation, induced apoptosis (transferase-mediated dUTP nick-end labeling [TUNEL]) and decreased proliferation (Ki67). ABT-869 is under clinical development for AML

LSST: from Science Drivers to Reference Design and Anticipated Data Products

(Abridged) We describe here the most ambitious survey currently planned in the optical, the Large Synoptic Survey Telescope (LSST). A vast array of science will be enabled by a single wide-deep-fast sky survey, and LSST will have unique survey capability in the faint time domain. The LSST design is driven by four main science themes: probing dark energy and dark matter, taking an inventory of the Solar System, exploring the transient optical sky, and mapping the Milky Way. LSST will be a wide-field ground-based system sited at Cerro Pach\'{o}n in northern Chile. The telescope will have an 8.4 m (6.5 m effective) primary mirror, a 9.6 deg$^2$ field of view, and a 3.2 Gigapixel camera. The standard observing sequence will consist of pairs of 15-second exposures in a given field, with two such visits in each pointing in a given night. With these repeats, the LSST system is capable of imaging about 10,000 square degrees of sky in a single filter in three nights. The typical 5$\sigma$ point-source depth in a single visit in $r$ will be $\sim 24.5$ (AB). The project is in the construction phase and will begin regular survey operations by 2022. The survey area will be contained within 30,000 deg$^2$ with $\delta<+34.5^\circ$, and will be imaged multiple times in six bands, $ugrizy$, covering the wavelength range 320--1050 nm. About 90\% of the observing time will be devoted to a deep-wide-fast survey mode which will uniformly observe a 18,000 deg$^2$ region about 800 times (summed over all six bands) during the anticipated 10 years of operations, and yield a coadded map to $r\sim27.5$. The remaining 10\% of the observing time will be allocated to projects such as a Very Deep and Fast time domain survey. The goal is to make LSST data products, including a relational database of about 32 trillion observations of 40 billion objects, available to the public and scientists around the world.Comment: 57 pages, 32 color figures, version with high-resolution figures available from https://www.lsst.org/overvie

How Nineteenth-Century American Literature Got Its Nerve Back

The Politics of Anxiety in Nineteenth-Century American Literature by Justine Murison, Cambridge Studies in American Literature and Culture, gen. ed. Ross Posnock. New York: Cambridge University Press, 2011. Pp. 215. $90.00 cloth

Black Orpheus, Barack Obama’s Governmentality

This essay constitutes a preliminary effort to explain the state fantasy with which Barack Obama hegemonized an alternative to the biopolitical settlement normalizing George W. Bush’s Global War on Terror (Pease 2009). In what follows, I intend to argue that Obama has not utterly displaced Bush’s Homeland State of Exception but that Obama’s governmentality presupposes it as the structuring logic through which he transformed the US state’s relationship with domestic and planetary peoples. I will be interested in particular in the role that Obama’s complex negotiation with the congeries of racial fantasies that he found condensed in the figure and the film Black Orpheus played in Barack Obama’s governmentality

Aboricultural Tree Assessment Springfield East Campus 2010

This is a report in Appendix VII: Previous Aboricultural Maintenance, titled "Aboricultural Tree Assessment Springfield East Campus 2010" and part of the Formal Request to FEMA titled "FEMA-DR-1944-MA Removal Disposal of Debris from the East Campus of Springfield College. This document was part of a binder tilted "Disaster Relief Spring 2012 - FEMA Response to 10/29/11 Snowstorm". The binder was taken apart, though kept in original order, in order to preserve space.. The report was written by Donald Pease and the Northern Tree Service, Inc. and dated March 10, 2010. The entire report is 44 pages long, and listed as page 73 to page 116 of the main FEMA report. The report lists the state of the trees on East Campus and gives recommendations for treatment. There are colored photographs throughout.This document was part of a binder tilted "Disaster Relief Spring 2012 - FEMA Response to 10/29/11 Snowstorm". It was taken apart, though kept in original order, in order to preserve space.

Address given at CWRU Law School / by Congressman Donald J. Pease

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