Enhancement of πA→ππA\pi A \to \pi\pi A Threshold Cross Sections by In-Medium ππ\pi\pi Final State Interactions

We address the problem of pion production in low energy $\pi$-nucleus collisions. For the production mechanism we assume a simple model consisting of a coherent sum of single pion exchange and the excitation---followed by the decay into two pions and a nucleon---of the $N^*(1440)$ resonance. The production amplitude is modified by the final state interaction between the pions calculated using the chirally improved J\"ulich meson exchange model including the polarization of the nuclear medium by the pions. The model reproduces well the experimentally observed $\pi A \to \pi\pi A$ cross sections, especially the enhancement with increasing $A$ of the $\pi^+\pi^-$ mass distribution in the threshold region.Comment: 5 pages RevTeX, 3-eps figure

Asthma Prevalence, Knowledge, and Perceptions among Secondary School Pupils in Rural and Urban Costal Districts in Tanzania.

Asthma is a common chronic disease of childhood that is associated with significant morbidity and mortality. We aimed to estimate the prevalence of asthma among secondary school pupils in urban and rural areas of coast districts of Tanzania. The study also aimed to describe pupils' perception towards asthma, and to assess their knowledge on symptoms, triggers, and treatment of asthma. A total of 610 pupils from Ilala district and 619 pupils from Bagamoyo district formed the urban and rural groups, respectively. Using a modified International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire, a history of "diagnosed" asthma or the presence of a wheeze in the previous 12 months was obtained from all the studied pupils, along with documentation of their perceptions regarding asthma. Pupils without asthma or wheeze in the prior 12 months were subsequently selected and underwent a free running exercise testing. A >= 20% decrease in the post-exercise Peak Expiratory Flow Rate (PEFR) values was the criterion for diagnosing exercise-induced asthma. The mean age of participants was 16.8 (+/-1.8) years. The prevalence of wheeze in the past 12 months was 12.1% in Bagamoyo district and 23.1% in Ilala district (p < 0.001). Self-reported asthma was found in 17.6% and 6.4% of pupils in Ilala and Bagamoyo districts, respectively (p < 0.001). The prevalence of exercise-induced asthma was 2.4% in Bagamoyo, and 26.3% in Ilala (P < 0.002). In both districts, most information on asthma came from parents, and there was variation in symptoms and triggers of asthma reported by the pupils. Non-asthmatic pupils feared sleeping, playing, and eating with their asthmatic peers. The prevalence rates of self-reported asthma, wheezing in the past 12 months, and exercise-induced asthma were significantly higher among urban than rural pupils. Although bronchial asthma is a common disease, pupils' perceptions about asthma were associated with fear of contact with their asthmatic peers in both rural and urban schools

Systematic review of economic evaluations and cost analyses of guideline implementation strategies

Objectives To appraise the quality of economic studies undertaken as part of evaluations of guideline implementation strategies; determine their resources use; and recommend methods to improve future studies. Methods Systematic review of economic studies undertaken alongside robust study designs of clinical guideline implementation strategies published (1966-1998). Studies assessed against the BMJ economic evaluations guidelines for each stage of the guideline process (guideline development, implementation and treatment). Results 235 studies were identified, 63 reported some information on cost. Only 3 studies provided evidence that their guideline was effective and efficient. 38 reported the treatment costs only, 12 implementation and treatment costs, 11 implementation costs alone, and two guideline development, implementation and treatment costs. No study gave reasonably complete information on costs. Conclusions Very few satisfactory economic evaluations of guideline implementation strategies have been performed. Current evaluations have numerous methodological defects and rarely consider all relevant costs and benefits. Future evaluations should focus on evaluating the implementation of evidence based guidelines. Keywords: Cost-effectiveness analysis, physician (or health care professional) behaviour, practice guidelines, quality improvement, systematic review.Peer reviewedAuthor versio

\pi\pi, K\pi and \pi N potential scattering and a prediction of a narrow \sigma meson resonance

Low energy scattering and bound state properties of the \pi N, \pi\pi and K\pi systems are studied as coupled channel problems using inversion potentials of phase shift data. In a first step we apply the potential model to explain recent measurements of pionic hydrogen shift and width. Secondly, predictions of the model for pionium lifetime and shift confirm a well known and widely used effective range expression. Thirdly, as extension of this confirmation, we predict an unexpected medium effect of the pionium lifetime which shortens by several orders of magnitude. The \sigma meson shows a narrow resonance structure as a function of the medium modified mass with the implication of being essentially energy independent. Similarly, we see this medium resonance effect realized for the K\pi system. To support our findings we present also results for the \rho meson and the \Delta(1232) resonance.Comment: 42 pages, 17 PS figures, REFTeX, epsfig.sty needed, submitted to Phys. Re

TERF Wars: Introduction

No abstract available

The chemokine receptor CXCR2 and coronavirus-induced neurologic disease.

Inoculation with the neurotropic JHM strain of mouse hepatitis virus (MHV) into the central nervous system (CNS) of susceptible strains of mice results in an acute encephalomyelitis in which virus preferentially replicates within glial cells while excluding neurons. Control of viral replication during acute disease is mediated by infiltrating virus-specific T cells via cytokine secretion and cytolytic activity, however sterile immunity is not achieved and virus persists resulting in chronic neuroinflammation associated with demyelination. CXCR2 is a chemokine receptor that upon binding to specific ligands promotes host defense through recruitment of myeloid cells to the CNS as well as protecting oligodendroglia from cytokine-mediated death in response to MHV infection. These findings highlight growing evidence of the diverse and important role of CXCR2 in regulating neuroinflammatory diseases