127 research outputs found
Ab-initio simulations on growth and interface properties of epitaxial oxides on silicon
The replacement of SiO2 by so-called high-k oxides is one of the major
challenges for the semiconductor industry to date. Based on electronic
structure calculations and ab-initio molecular dynamics simulations, we are
able to provide a consistent picture of the growth process of a class of
epitaxial oxides around SrO and SrTiO3. The detailed understanding of the
interfacial binding principles has also allowed us to propose a way to engineer
the band-offsets between the oxide and the silicon substrate.Comment: 6 pages, 6 figures, proceeding for the INFOS2005 conference
(http://www.imec.be/infos/
Plasma Metabolomics Implicate Modified Transfer RNAs and Altered Bioenergetics in the Outcome of Pulmonary Arterial Hypertension.
BACKGROUND: -Pulmonary arterial hypertension (PAH) is a heterogeneous disorder with high mortality. METHODS: -We conducted a comprehensive study of plasma metabolites using ultra-performance liquid chromatography mass-spectrometry to (1) identify patients at high risk of early death, (2) identify patients who respond well to treatment and (3) provide novel molecular insights into disease pathogenesis. RESULTS: -53 circulating metabolites distinguished well-phenotyped patients with idiopathic or heritable PAH (n=365) from healthy controls (n=121) following correction for multiple testing (p<7.3e-5) and confounding factors, including drug therapy, renal and hepatic impairment. A subset of 20/53 metabolites also discriminated PAH patients from disease controls (symptomatic patients without pulmonary hypertension, n=139). 62 metabolites were prognostic in PAH, with 36/62 independent of established prognostic markers. Increased levels of tRNA-specific modified nucleosides (N2,N2-dimethylguanosine, N1-methylinosine), TCA cycle intermediates (malate, fumarate), glutamate, fatty acid acylcarnitines, tryptophan and polyamine metabolites and decreased levels of steroids, sphingomyelins and phosphatidylcholines distinguished patients from controls. The largest differences correlated with increased risk of death and correction of several metabolites over time was associated with a better outcome. Patients who responded to calcium channel blocker therapy had metabolic profiles similar to healthy controls. CONCLUSIONS: -Metabolic profiles in PAH are strongly related to survival and should be considered part of the deep phenotypic characterisation of this disease. Our results support the investigation of targeted therapeutic strategies that seek to address the alterations in translational regulation and energy metabolism that characterize these patients
Cosmic Chronometers: Constraining the Equation of State of Dark Energy. I: H(z) Measurements
We present new determinations of the cosmic expansion history from
red-envelope galaxies. We have obtained for this purpose high-quality spectra
with the Keck-LRIS spectrograph of red-envelope galaxies in 24 galaxy clusters
in the redshift range 0.2 < z < 1.0. We complement these Keck spectra with
high-quality, publicly available archival spectra from the SPICES and VVDS
surveys. We improve over our previous expansion history measurements in Simon
et al. (2005) by providing two new determinations of the expansion history:
H(z) = 97 +- 62 km/sec/Mpc at z = 0.5 and H(z) = 90 +- 40 km/sec/Mpc at z =
0.8. We discuss the uncertainty in the expansion history determination that
arises from uncertainties in the synthetic stellar-population models. We then
use these new measurements in concert with cosmic-microwave-background (CMB)
measurements to constrain cosmological parameters, with a special emphasis on
dark-energy parameters and constraints to the curvature. In particular, we
demonstrate the usefulness of direct H(z) measurements by constraining the
dark- energy equation of state parameterized by w0 and wa and allowing for
arbitrary curvature. Further, we also constrain, using only CMB and H(z) data,
the number of relativistic degrees of freedom to be 4 +- 0.5 and their total
mass to be < 0.2 eV, both at 1-sigma.Comment: Submitted to JCA
Galaxy And Mass Assembly (GAMA): testing galaxy formation models through the most massive galaxies in the Universe
We have analysed the growth of Brightest Group Galaxies and Brightest Cluster Galaxies (BGGs/BCGs) over the last 3 billion years using a large sample of 883 galaxies from the Galaxy And Mass Assembly survey. By comparing the stellar mass of BGGs and BCGs in groups and clusters of similar dynamical masses, we find no significant growth between redshift z = 0.27 and 0.09. We also examine the number of BGGs/BCGs that have line emission, finding that approximately 65 per cent of BGGs/BCGs show Hα in emission. From the galaxies where the necessary spectroscopic lines were accurately recovered (54 per cent of the sample), we find that half of this (i.e. 27 per cent of the sample) harbour ongoing star formation with rates up to 10âMâ yrâ1, and the other half (i.e. 27 per cent of the sample) have an active nucleus (AGN) at the centre. BGGs are more likely to have ongoing star formation, while BCGs show a higher fraction of AGN activity. By examining the position of the BGGs/BCGs with respect to their host dark matter halo, we find that around 13 per cent of them do not lie at the centre of the dark matter halo. This could be an indicator of recent clusterâcluster mergers. We conclude that BGGs and BCGs acquired their stellar mass rapidly at higher redshifts as predicted by semi-analytic models, mildly slowing down at low redshifts
The First Magnetic Fields
We review current ideas on the origin of galactic and extragalactic magnetic
fields. We begin by summarizing observations of magnetic fields at cosmological
redshifts and on cosmological scales. These observations translate into
constraints on the strength and scale magnetic fields must have during the
early stages of galaxy formation in order to seed the galactic dynamo. We
examine mechanisms for the generation of magnetic fields that operate prior
during inflation and during subsequent phase transitions such as electroweak
symmetry breaking and the quark-hadron phase transition. The implications of
strong primordial magnetic fields for the reionization epoch as well as the
first generation of stars is discussed in detail. The exotic, early-Universe
mechanisms are contrasted with astrophysical processes that generate fields
after recombination. For example, a Biermann-type battery can operate in a
proto-galaxy during the early stages of structure formation. Moreover, magnetic
fields in either an early generation of stars or active galactic nuclei can be
dispersed into the intergalactic medium.Comment: Accepted for publication in Space Science Reviews. Pdf can be also
downloaded from http://canopus.cnu.ac.kr/ryu/cosmic-mag1.pd
Traffic exposures, air pollution and outcomes in pulmonary arterial hypertension: A United Kingdom cohort study analysis
While traffic and air pollution exposure is associated with increased mortality in numerous diseases, its association with disease severity and outcomes in pulmonary arterial hypertension (PAH) remains unknown.Exposure to particulate matter â€2.5â
ÎŒm3 (PM2.5), nitrogen dioxide (NO2) and indirect measures of traffic-related air pollution (distance to main road and length of roads within buffer zones surrounding residential addresses) were estimated for 301 patients with idiopathic/heritable PAH recruited in the UK PAH national Cohort study. Associations with transplant-free survival and pulmonary hemodynamic severity at baseline were assessed, adjusting for confounding variables defined a priori.Higher estimated exposure to PM2.5 was associated with higher risk of death or lung transplant (Unadjusted hazard ratio (HR) 2.68; 95% CI 1.11-6.47 per 3â
ÎŒg·m-3, p=0.028). This association remained similar when adjusted for potential confounding variables (HR 4.38; 95% CI 1.44-13.36 per 3â
ÎŒg·m-3, p=0.009). No associations were found between NO2 exposure or other traffic pollution indicators and transplant-free survival Conversely, indirect measures of exposure to traffic-related air pollution within the 500-1000â
m buffer zones correlated with the ERS/ESC risk categories as well as pulmonary hemodynamics at baseline. This association was strongest for pulmonary vascular resistance.In idiopathic/heritable PAH, indirect measures of exposure to traffic-related air pollution were associated with disease severity at baseline, whereas higher PM2.5 exposure may independently predict shorter transplant-free survival
History of clinical transplantation
How transplantation came to be a clinical discipline can be pieced together by perusing two volumes of reminiscences collected by Paul I. Terasaki in 1991-1992 from many of the persons who were directly involved. One volume was devoted to the discovery of the major histocompatibility complex (MHC), with particular reference to the human leukocyte antigens (HLAs) that are widely used today for tissue matching.1 The other focused on milestones in the development of clinical transplantation.2 All the contributions described in both volumes can be traced back in one way or other to the demonstration in the mid-1940s by Peter Brian Medawar that the rejection of allografts is an immunological phenomenon.3,4 © 2008 Springer New York
Efeitos ambientais e genĂ©ticos sobre peso, perĂmetro escrotal e escores de avaliação visual Ă desmama em bovinos da raça Canchim
Galaxy And Mass Assembly (GAMA): data release 4 and the z < 0.1 total and z < 0.08 morphological galaxy stellar mass functions
Galaxie
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