Vertigo and positional alcohol nystagmus. The buoyancy mechanism

[ES] El etanol puede producir nistagmo y vértigo por un mecanismo de flotación cupular, planteando el diagnóstico diferencial con vértigos posicionales atípicos o centrales. Presentamos y comentamos el caso de una paciente con una afectación de estas características atribuible al etanol contenido como excipiente en varios preparados medicinales. [EN] Ethanol can cause nistagmus and dizziness by a buoyancy mechanism. Its differential diagnosis includes atypical or central positional vertigo. We report the case of a woman whose positional symptoms were caused by ethanol contained in some mixtures

Vestibular rehabilitation in older people with vestibular dysfunction

[ES] Introducción y objetivo: El mareo y el desequilibrio son síntomas comunes en el anciano y tienen un gran impacto en su calidad de vida. Método: Revisión narrativa. Resultados: Se revisan los principales factores que condicionan la inestabilidad en el anciano, el impacto de las caídas y las exploraciones más rentables desde el punto de vista diagnóstico y terapéutico en estos pacientes. Por último, se incide en la necesidad de un abordaje multidisciplinar destacando la importancia de la rehabilitación vestibular en el tratamiento de estos trastornos. Conclusiones: La inestabilidad en el anciano es de origen multifactorial y no obedece solamente a razones fisiológicas. De ahí la necesidad de identificar los factores precipitantes, tratarlos si es posible y realizar un abordaje multidisciplinar que minimice la morbimortalidad asociada a este proceso y mejorando su calidad de vida. La rehabilitación vestibular puede mejorar significativamente el equilibrio de los ancianos con inestabilidad lo cual conduciría a una reducción significativa de las caídas

Spanish Research Report for 1991

10 páginas, 14 tablasPeer reviewe

Language learning strategy use by spanish efl students: the effect of proficiency level, gender, and motivation

This article aims to investigate the use of Language Learning Strategies (LLSs) by Spanish EFL students, as well as the relationship between that use and other learner variables such as the proficiency level, gender, and motivation. Participants were 206 Spanish students of English from different proficiency levels. The instrument used to collect data was a questionnaire.The results show that the participants use LLSs moderately with a high preference for metacognitive and affective strategies. Proficiency level did not have a significant effect, except in the cognitive category between proficient and basic users groups. In relation to gender, there were not statistically significant differences between male and female students. However, motivation had a paramount effect in the use of LLSs. El propósito de este estudio es investigar el uso de las estrategias de aprendizaje de la lengua extranjera por parte de estudiantes de inglés con distintos niveles de competencia. Además, intenta explorar la relación que ptstros participantes (N=206) hacen un uso moderado de esas estrategias, siendo las más utilizadas las metacognitivas y las afectivas. El nivel de competencia sólo tuvo un impacto significativo en la categoría de estrategias cognitivas entre los estudiantes del nivel más alto y los de los niveles básicos. No se encontraron diferencias significativas entre las mujeres y los hombres en el uso de las estrategias. Sin embargo, el factor motivacional sí arrojó diferencias significativas

Endothelium-dependent vasorelaxation induced by L-carnitine in isolated aorta from normotensive and hypertensive rats

The aim of this work was to investigate the mechanism of the vasodilatory effect induced by L- carnitine. Relaxation produced by L-carnitine was studied in rat aortic rings with and without functional endothelium, pre-contracted with phenylephrine by adding cumulative doses of L- carnitine (10-7 to 10-3 M). The relaxation evoked by L-carnitine reached higher values in aortic rings from spontaneously hypertensive rats than those obtained in arteries from normotensive rats; no relaxation was produced in de-endothelialized arteries. However, in the presence of NG-nitro-L- arginine (3¬10-5 M, a nitric oxide synthase inhibitor), Ro 68070 (10-4 M, a thromboxane synthetase inhibitor–thromboxane A2/prostaglandin H2 receptor antagonist) or ICI 192605 (10- M, a thromboxane A2 receptor antagonist) the relaxant response to L-carnitine was signiicantly inhibited. These results show that L-carnitine induced endothelium-dependent relaxation in the rat aorta and the mechanism of this relaxation appeared to be mostly mediated by endothelial production of nitric oxide but also could involve prevention of the action of cyclooxygenase endothelial products acting on the thromboxane A2/prostaglandin H2 receptor

Respuesta a la suplementación de microminerales a vaquillas en pastoreo de Zacate Estrella de África en la costa norte de Nayarit

En el Campo Experimental Pecuario "El Macho", Tecuala, Nay. México, con clima tropical Aw, fue realizado un estudio para medir la respuesta a la suplementación con microminerales a vaquillas que pastorearon en Estrella de Africa durante 280 días

The acceptance of modern myths about sexual aggression scale: validation for chilean population

Se planteó una investigación para adaptar y validar la escala Acceptance of Modern Myths about Sexual Aggression (ammsa) en población chilena. En el Estudio 1, 428 participantes respondieron a la adaptación chilena de la escala ammsa. Un análisis factorial confirmatorio mostró que los índices de ajuste no prestaban apoyo empírico al modelo de la escala de 30 ítems; los índices mejoraban tras ajustar el modelo a 14 ítems (α = .90), en el que incrementa la validez sobre el modelo saturado. En el Estudio 2, 212 participantes respondieron a la escala ammsa-14, a una medida de sexismo y una de deseabilidad social. Los resultados revelaron una correlación alta con el sexismo y baja con la deseabilidad social. En conclusión, se validó una medida de los mitos sobre la agresión sexual con la que evaluar a la población chilenaAs for the adaptation and validation of the Acceptance of Modern Myths about Sexual Aggression (ammsa) scale to Chilean population, a research was designed. In Study 1, 428 participants answered to the Chilean adaptation of the ammsa scale. A confi rmatory factorial analysis did not give support to the measurement model of 30 items, improving the indexes after adjusting the model to 14 items (α = .90), and increasing validity over the saturated model. In Study 2, 212 participants endorsed the ammsa-14 scale, as well as sexism and social desirability measures. Results revealed a high correlation with sexism and a low correlation with social desirability. In conclusion, a measurement of the myths about sexual aggression to assess Chilean population was validatedEl Ministerio de Economía, Industria y Competitividad [España] financió, en parte, esta investigación en el marco del proyecto con referencia PSI2017-87278-RS

An X-ray View of Star Formation in the Central 3 kpc of NGC 2403

Archival Chandra observations are used to study the X-ray emission associated with star formation in the central region of the nearby SAB(s)cd galaxy NGC 2403. The distribution of X-ray emission is compared to the morphology visible at other wavelengths using complementary Spitzer, GALEX, and ground-based Halpha imagery. In general, the brightest extended X-ray emission is associated with HII regions and to other star-forming structures but is more pervasive; existing also in regions devoid of strong Halpha and UV emission. This X-ray emission has the spectral properties of diffuse hot gas (kT ~ 0.2keV) whose likely origin is in gas shock-heated by stellar winds and supernovae with < 20% coming from faint unresolved X-ray point sources. This hot gas may be slowly-cooling extra-planar remnants of past outflow events, or a disk component that either lingers after local star formation activity has ended or that has vented from active star-forming regions into a porous interstellar medium.Comment: 25 pages, accepted to A

Prediction of Breast Cancer Proteins Involved in Immunotherapy, Metastasis, and RNA-Binding Using Molecular Descriptors and Artifcial Neural Networks

[Abstract] Breast cancer (BC) is a heterogeneous disease where genomic alterations, protein expression deregulation, signaling pathway alterations, hormone disruption, ethnicity and environmental determinants are involved. Due to the complexity of BC, the prediction of proteins involved in this disease is a trending topic in drug design. This work is proposing accurate prediction classifer for BC proteins using six sets of protein sequence descriptors and 13 machine-learning methods. After using a univariate feature selection for the mix of fve descriptor families, the best classifer was obtained using multilayer perceptron method (artifcial neural network) and 300 features. The performance of the model is demonstrated by the area under the receiver operating characteristics (AUROC) of 0.980±0.0037, and accuracy of 0.936±0.0056 (3-fold cross-validation). Regarding the prediction of 4,504 cancer-associated proteins using this model, the best ranked cancer immunotherapy proteins related to BC were RPS27, SUPT4H1, CLPSL2, POLR2K, RPL38, AKT3, CDK3, RPS20, RASL11A and UBTD1; the best ranked metastasis driver proteins related to BC were S100A9, DDA1, TXN, PRNP, RPS27, S100A14, S100A7, MAPK1, AGR3 and NDUFA13; and the best ranked RNA-binding proteins related to BC were S100A9, TXN, RPS27L, RPS27, RPS27A, RPL38, MRPL54, PPAN, RPS20 and CSRP1. This powerful model predicts several BC-related proteins that should be deeply studied to fnd new biomarkers and better therapeutic targets. Scripts can be downloaded at https://github.com/muntisa/ neural-networks-for-breast-cancer-proteins.This work was supported by a) Universidad UTE (Ecuador), b) the Collaborative Project in Genomic Data Integration (CICLOGEN) PI17/01826 funded by the Carlos III Health Institute from the Spanish National plan for Scientific and Technical Research and Innovation 2013-2016 and the European Regional Development Funds (FEDER) - “A way to build Europe”; c) the General Directorate of Culture, Education and University Management of Xunta de Galicia ED431D 2017/16 and “Drug Discovery Galician Network” Ref. ED431G/01 and the “Galician Network for Colorectal Cancer Research” (Ref. ED431D 2017/23); d) the Spanish Ministry of Economy and Competitiveness for its support through the funding of the unique installation BIOCAI (UNLC08-1E-002, UNLC13-13-3503) and the European Regional Development Funds (FEDER) by the European Union; e) the Consolidation and Structuring of Competitive Research Units - Competitive Reference Groups (ED431C 2018/49), funded by the Ministry of Education, University and Vocational Training of the Xunta de Galicia endowed with EU FEDER funds; f) research grants from Ministry of Economy and Competitiveness, MINECO, Spain (FEDER CTQ2016-74881-P), Basque government (IT1045-16), and kind support of Ikerbasque, Basque Foundation for Science; and, g) Sociedad Latinoamericana de Farmacogenómica y Medicina Personalizada (SOLFAGEM)Xunta de Galicia; ED431D 2017/16Xunta de Galicia; ED431G/01Xunta de Galicia; ED431D 2017/23Xunta de Galicia; ED431C 2018/49Gobierno Vasco; IT1045-1

Paroxysmal bradyarrhythmias are frequent among heart transplant recipients with unexplained syncope: a study based on implantable loop recorders

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