Investigating the relationships between environmental stressors and stream condition using Bayesian belief networks

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/92037/1/j.1365-2427.2011.02683.x.pd

Continuous manufacturing via hot-melt extrusion and scale up: regulatory matters

Currently, because globalization, the pharmaceutical industry is facing enormous challenges to comply with regulatory matters. Reduced patent life and overall decreased profitability of newly discovered drugs are also forcing the pharmaceutical industry to shorten the drug development time with maximum throughput. Therefore, continuous manufacturing (CM) processes via hot melt extrusion (HME) can be a promising alternative for achieving these goals. HME offers solvent-free green technology with a process that is easy to scale up. Moreover, CM provides better product quality assurance compared with batch processes, with fewer labor costs and shorter time to development. In this review, we primarily focus on various aspects of CM and the emerging application of HME to bridge the current manufacturing gap in pharmaceutical sphere

A Review on the Mechanical Modeling of Composite Manufacturing Processes

© 2016, The Author(s). The increased usage of fiber reinforced polymer composites in load bearing applications requires a detailed understanding of the process induced residual stresses and their effect on the shape distortions. This is utmost necessary in order to have more reliable composite manufacturing since the residual stresses alter the internal stress level of the composite part during the service life and the residual shape distortions may lead to not meeting the desired geometrical tolerances. The occurrence of residual stresses during the manufacturing process inherently contains diverse interactions between the involved physical phenomena mainly related to material flow, heat transfer and polymerization or crystallization. Development of numerical process models is required for virtual design and optimization of the composite manufacturing process which avoids the expensive trial-and-error based approaches. The process models as well as applications focusing on the prediction of residual stresses and shape distortions taking place in composite manufacturing are discussed in this study. The applications on both thermoset and thermoplastic based composites are reviewed in detail

Dynamic response analysis of floating wind turbines with emphasis on vertical axis rotors

Large floating wind turbines are feasible for offshore application. Due to the commercial success onshore and nearshore, floating horizontal axis wind turbines (HAWTs) are now being widely studied. However, floating vertical axis wind turbines (VAWTs) have an excellent potential in the cost of energy reduction compared with floating HAWTs. This paper deals with the integrated modeling and dynamic response analysis of typical floating VAWT concepts. A fully coupled aero-hydro-servo-elastic method is presented for numerical modeling and dynamic response analysis of floating wind turbine systems. Considering a two-bladed 5 MW Darrieus rotor, the dynamic response characteristics of typical floating VAWT concepts are studied. In addition, comparative studies of floating HAWTs and VAWTs are performed