Virtual Dance Floors: Shall We Dance or Fly?

When attending these environments, the psyvatars (Simão and Guerra 2016) point out limitations to the virtual dance floors, namely: the lack of human warmth, the direct interaction between pairs, the lack of movement and dance ritual, the resignation of the body (not in the sense of alienation or psychedelic experience, but in terms of physical perception) and the lack of multisensory experience. On the other hand, others argue that the objective of the party is reached as long they have the fundamental-the music. The subjects who are more connected virtually are often more connected physically or in person (Wellman et al. 2006) and in these SL communities (even smaller than other EM and EDM communities), the feeling of belonging and empathy between the virtual members is quite evident. Beyond these similarities there are other parallels between the conventional and the virtual dance floor: musical aesthetics, empathy between members, the figure of the DJ and the centrality of the dance floor, decor and visual expressions, clothing, accessories and recreational consumptions, among others. It is also important to mention the constant concern in recreating the main elements of the physical parties. More than a simulacrum, these events are thus framing their own place and identity. This imposed digital migration has clearly intensified the virtual dynamics, as well as boosting the hybridism of these digital incubators, but even though these virtual dance floors and online music events in general have proliferated in the first months of 2020, it is more prudent to consider them viable alternatives than effective replacements. Today we are living in the territories of the future surrendered to the permeability and fluidity of the cyber-era (Wilson and Atkinson 2005), listening and dancing to electronic and algorithmic music, but are we prepared to give up the real-physical-offline-sweaty dance floors? In the coexistence of isolation and crowds, the dance floor warriors must resist becoming purely egovatars of cyberspace and keep festivals and rave culture alive (Simão and Guerra 2016)

Rare autosomal dominant hereditary hemochromatosis associated with SLC40A1 gene: ferroportin disease or type 4 hereditary hemochromatosis?

Ferroportin (FPN1), encoded by the SLC40A1 gene, is the unique cellular iron exporter identified in mammals. FPN1 transfers iron from the intestine and macrophages into the bloodstream. This function is negatively regulated by hepcidin. Mutations in SLC40A1 may affect FPN1 function, originating distinct autosomal dominant diseases: (i) the Ferroportin Disease (FD), due to loss-of-function mutations, is characterized by decreased iron export from enterocytes and severely affected iron transfer in macrophages, giving rise to a marked iron accumulation in spleen and liver; and (ii) the Type 4 Hereditary Hemochromatosis (HH), resulting from gain-of-function mutations conferring resistance to hepcidin-mediated FPN1 degradation and consequently high cellular iron export. In this study, 335 individuals suspected of having non-classic HH were enrolled. Six genes related with iron metabolism were analysed by SSCP, dHPLC or NGS. The latter used TruSeq or Nextera XT libraries and a MiSeq platform (Illumina). Genetic variants found were validated by Sanger sequencing. Predictive consequences at protein level were evaluated using Polyphen-2 and SIFT softwares. From all patients analysed, three SLC40A1 pathogenic variants were detected in heterozygosity in three women: two missense, c.238G>A, p.Gly80Ser and c.610G>A, p.Gly204Ser; and one deletion, c.485_487delTTG; p.Val162del. These variants had been reported in public databases, but they were not known to be present in the Portuguese population. The p.Gly80Ser and the p.Val162del are FPN1 loss-of-function mutations and were found associated with hyperferritinemia and low transferrin saturation (FD). In contrast, the p.Gly204Ser induced a gain of FPN1 function with a full iron export capacity giving the patient a type 4-HH phenotype, which includes iron overload, hyperferritinemia and high transferrin saturation. Detailed clinical evaluation of the suspected patients are useful to unravel the effect of different mutations in FPN1 function, expression and regulation.This work was partially supported by INSA_2013DGH910 and GenomePT (POCI-01-0145-FEDER-022184).info:eu-repo/semantics/publishedVersio

Territórios e mobilidades da (transe) virtualidade: a segunda vida dos freaks

Com a emergência do novo paradigma tecnológico, da sociedade em rede e das plataformas digitais, a Electronic Dance Music (EDM) está a ganhar novas configurações. O neo-nomadismo e os movimentos translocais e transglobais, associados a alguns movimentos musicais, desdobram-se numa nova transvirtualidade como resultado da migração digital. O Transe Psicadélico, não apenas enquanto estilo musical específico, mas também produto de uma cena alternativa envolta em atmosferas naturais, tecnológicas, criativas e artísticas, imersivas e simbólicas, está a reconfigurar-se em novos territórios à luz dessa transvirtualidade. Entre o dance-floor, as redes sociais e os ambientes imersivos, os nativos vão (transe)itando entre a imersão física e a imersão digital, a sua cultura produz-se e dissemina-se como nunca antes, e o Transe Psicadélico, renasce.With new technological paradigm, network society and digital platforms emergence, the electronic dance music (EDM) configures itself. Neo-nomad, translocal and transglobal connected to some musical movements unfold a new transvirtuality as result of digital migration. The Psychedelic Trance is not just as a specific musical style but also the product of an alternative scene wrapped in natural, technological, creative, artistic, immersive and symbolic atmospheres, now reconfiguring itself in the transvirtuality of new digital territories. Between dance-floor, social networks and immersive environments, the natives are moving between the physical immersion and digital immersion, their culture disseminates like never has before, and Psytrance reborn

A contabilidade alimenta a gestão: caso prático numa cooperativa agrícola

Resumo Ao longo de todo o meu período de estágio na CALCOB - Cooperativa Agrícola de Oliveira do Bairro e Vagos, C.R.L., tive a oportunidade de desenvolver diversas atividades nos departamentos ligados à área financeira, tendo realizado tarefas relacionadas com os serviços de contabilidade e gestão da cooperativa e efetuado diversas atividades diárias de controlo e registos. No seguimento das atividades efetuadas durante o estágio e no seu respetivo enquadramento com o Mestrado de Gestão de Empresas Agrícolas, que me encontro a finalizar, defini como tema do meu relatório de estágio a análise e compreensão da importância das informações obtidas através contabilidade como suporte para a tomada de decisões por parte da equipa de gestão da CALCOB. É assim objetivo do presente documento compreender até que ponto a prática do registo diário e contabilístico das operações da cooperativa (e a consequente construção de mapas e relatórios de contas) serve de fonte para uma melhor e mais sustentada tomada de decisões por parte dos gestores da cooperativa, tendo como objetivo último o aumento da eficiência e da rentabilidade da cooperativa, garantindo a sua sustentabilidade e a melhoria da qualidade do serviço prestado aos seus parceiros. Palavras-Chave: Contabilidade, Gestão, Serviços Administrativo-Financeiros, Cooperativa Agrícola. Mestrado em Gestão de Empresas Agrícolas Abstrat Throughout my internship at CALCOB - Cooperativa Agrícola de Oliveira do Bairro and Vagos, CRL, I had the opportunity to develop several activities in the administrative/financial department, having performed tasks related to accounting and management services and carried out several daily control activities. Following the activities carried out during the internship and in its respective framework with the Master’s degree in Agricultural Business Management that I am currently finishing, I defined as my internship report’ subject the analysis and understanding of the importance of the information obtained through accounting as a support tool for the decision-making process carried out by CALCOB’s management team. It is therefore the purpose of this document to understand at what extent the practice of daily and accounting operations recording of the cooperative (plus consequent construction of accounting maps and reports) serves as a source for a better and more sustained decision-making process by the cooperative managers, with the ultimate goal of increasing the cooperative efficiency and profitability, guaranteeing its sustainability and improving the quality of service provided to its partners. Keywords: Accounting, Management, Administrative Services, Agricultural Cooperativ

Solubility studies of trans-cinnamic acid in mixed solvents

Phenolic acids are a subclass of phenolic compounds with chemical and biological properties of interest in the pharmaceutical and food industries. The design of their extraction and separation processes includes the knowledge of their thermophysical properties as well as multicomponent solid-liquid equilibria data. For these compounds, even essential solubility data in pure organic solvents and water are scarce. Therefore, in this work, trans-cinnamic acid was chosen as a model compound for which only a few solubility data in pure water and alcohols can be found in the literature [1-3]. The solubility of trans-cinnamic acid in the mixed solvents water + ethanol, and water + methanol was measured, at 298.15 K, using the isothermal shake-flask method and quantitative analysis either by gravimetry or UV spectrophotometry. As can be seen in Fig. 1, the solubility of the acid can significantly increase with the addition of the alcohol, with a more pronounced effect induced by ethanol. In a complementary approach and aiming to search for other methods to increase the aqueous solubility of trans-cinnamic acid, the phase-solubility diagram was determined for systems containing α-cyclodextrin. References [1] J. Li, Z. Zeng, L. Sun, W. Xue, H. Wang, Journal of Chemical and Engineering Data, 61 (2016) 1192−1198. [2] F. Mota, A. Queimada,, S. Pinho, E. Macedo, Industrial and Engineering Chemistry Research, 47 (2008) 5182-5189. [3] Solubilities of Organic Compounds in Organic Solvents, J. Bradley, C. Neylon, R. Guha, A. Williams, B. Hooker, A. Lang, B. Friesen, Open Notebook Science, 2009.This work was financially supported by: Project POCI-01-0145-FEDER-006984 – Associated Laboratory LSRELCM funded by FEDER funds through COMPETE2020 - Programa Operacional Competitividade e Internacionalização (POCI) – and by national funds through FCT - Fundação para a Ciência e a Tecnologia.info:eu-repo/semantics/publishedVersio

Multiple model adaptive control of neuromuscular blockade: Design guidelines and clinical cases

The high level of uncertainty of the dynamic response of patients subject to anaesthesia motivates the use of adaptive control methods. This paper proposes an approach based on Switched Multiple Model Adaptive Control (SMMAC) to tackle this problem in what concerns the control of the neuromuscular blockade level. It is shown how to design the different elements of the SMMAC controller, enhancing the importance of the observer polynomial, that is shown to be instrumental to stabilize the loop. Clinical results using atracurium as blocking agent are reported, thereby illustrating the application of the proposed approach in actual clinical practice

Food tourism in the touristic development pole of the western region – Portugal

Currently, tourism is characterized by significant changes in its supply. These changes are motivated by the need of adjustment to the actual demand, which seek new types of experiences, different sensations and new destinations. Regarding tourist behavior, we can identify that there are profound changes, today, in comparison to previous years. Tourists travel more annually (but with shorter stays), are more knowledgeable about the destinations and products offered (playing, in this case, the internet a very important role) seeking new sensory experiences that are compelling, often to release accumulated labor stress resulting from a competitive urban society. As a result of these changes, niche tourism (also called thematic tourism), has gained an increasing interest from the tourism industry (supply) as well as by the academic community, which particularly in the mid-90s, began to turn more of its attention to this new way of supplying and practicing tourism. Food tourism in academic terms only began to receive greater attention in the beginning of this century. However, it has been relegated, to a secondary plan, in comparison with other types of niche tourism, such as wine tourism, ecotourism or even sports tourism. Therefore, it is easy to understand that all the studies about food tourism are relevant to increment the state of the art. This article results from a research project in the Western Region of Portugal, which had the duration of one year (May 2010 to May 2011) with a team of five investigators and two fulltime research fellows. This region is gastronomically rich, especially on fish, which attracts visitors to the area. Thus, among others, the following objectives were outlined for the study: Assess the potential of food tourism in the Western Touristic Pole; assess the local tourist agents’ perception on food tourism and their sensibility of the same; to profile the food tourist that travels to the Western Touristic Pole; and identify key practices of those who travel, motivated by food. In terms of methodology, the case study approach was used, with field work that resulted in 863 questionnaire surveys on the demand side and 92 questionnaire surveys on the supply side, resulting in a very interesting sample. The conclusions of the project revealed that food can actually be an important factor as a primary attraction, as well as secondary; that although the local agents are aware, the non-structure of a concrete product, results in a predominance of day visitors; there is little promotion of this tourism product; and it was possible to identify the profile of food tourists that visit the region.info:eu-repo/semantics/publishedVersio

Educação patrimonial e cultural no exercício do desenho

Relatório da Prática de Ensino Supervisionada, Mestrado em Ensino de Artes Visuais, Universidade de Lisboa, Instituto de Educação, 2019Este projeto, realizado no âmbito da Prática em Ensino Supervisionada, e visando constituir-se como um desafio de consciencialização e de educação patrimonial e cultural nas artes visuais, integrou-se numa metodologia de investigaçãoação sequencial, concretizada com os alunos do 10.º E de Artes Visuais, da Escola Secundária de Casquilhos, no Barreiro, na disciplina de Desenho A. O projeto teve como objeto o edifício do Convento da Madre de Deus da Verderena, localizado no Barreiro, numa perspetiva de valorização e proteção do património local e nacional. No âmbito da educação patrimonial e cultural, pretendeu fomentar-se a observação, a identificação, a interrogação, a reflexão, a interpretação, a apropriação, a experimentação e a resolução de problemas, bem como intervenção e transformação. Estes processos foram apoiados na criação de soluções gráficas próprias, recorrendose a diferentes suportes, materiais, instrumentos e processos, e no pensamento crítico e criativo. Procurou trabalhar-se a iniciativa, a autonomia e o envolvimento, com qualidade e exigência, conciliados com o relacionamento interpessoal positivo e as boas práticas de cidadania. Este processo seguiu as seguintes etapas: (1) abordagem ao projeto e trabalho de pesquisa na biblioteca, (2) realização de inquéritos para diagnóstico e aferição dos resultados do projeto, (3) visita orientada e observação in situ dos processos de degradação do convento, (4) registo fotográfico dos elementos em degradação, (5) realização de dois exercícios de desenho com base nos referentes captados durante a visita, recorrendo-se à reunião de técnicas propostas pelo programa da disciplina, (6) composição de dois painéis com os trabalhos realizados pelos alunos, (7) trabalho interdisciplinar na disciplina de Língua Portuguesa e (8) realização de duas exposições. Mantendo a premissa de educar através da arte, as exposições constituíram-se como um meio de aumentar a abrangência deste projeto de sensibilização patrimonial à comunidade exterior, contribuindo-se para o sentido de identidade local.This project, accomplished within a Supervised Teaching Practice, and aiming to be a challenge of consciousness to the heritage and cultural education in the visual arts, was integrated in a methodology of sequential action-research in the discipline Drawing A, with the students of the 10th E class of Visual Arts, of the Secondary School of Casquilhos, in Barreiro. The case study of this project was the Convent of Madre de Deus da Verderena, located in Barreiro, within a valuing and protection perspective of local and national heritage. In the context of heritage and cultural education, the aim was to promote the observation, identification, interrogation, reflection, interpretation, appropriation, experimentation and problems solving ability, as well as the intervention and transformation. These steps were supported with the creation of single graphical solutions, with the use of several different supports, materials, instruments and processes, and with a creative and critical way of thinking. There was an effort to work with initiative, autonomy and involvement, in a demanding, and rigorous way, conciliating these with positive interpersonal relationships and good practices in citizenship. This process was achieved according to the following steps: (1) introduction to the project and research work in the library, (2) realization of surveys for diagnostic assessment and projects results, (3) guided tour and in situ observation of deterioration processes in the convent, (4) photographic records of deteriorated parts, (5) accomplishment of two drawing exercises made with the techniques proposed by the discipline program, and inspired in the photographic records made during the visit to the convent (6) production of two panels achieved with the reunion of the works done by the students, (7) interdisciplinary work within the Portuguese Language class, (8) accomplishment of two exhibitions. In an attempt to maintain the premise of educating through art, the exhibitions became a mean to increase the scope of this project of heritage consciousness to the outside community, contributing to a sense of local identity

Interface de visibilizaçăo de informaçőes para o sistema integrado de protocolos eletrônicos /

Orientador: Antonio Carlos Ligocki CamposTese (doutorado) - Universidade Federal do Paraná, Setor de Cięncias da Saúde, Programa de Pós-Graduaçăo em Clínica Cirúrgica. Defesa: Curitiba, 2005.Inclui bibliografi