Common variants of ZNF750, RPTOR and TRAF3IP2 genes and psoriasis risk

Psoriasis vulgaris is a genetically heterogenous disease with unclear molecular background. We assessed the association of psoriasis and its main clinical phenotypes with common variants of three potential psoriasis susceptibility genes: ZNF750, RPTOR and TRAF31P2. We genotyped 10 common variants in a cohort of 1,034 case–control individuals using Taqman genotyping assays and sequencing. Minor alleles of all four TRAF3IP2 variants were more frequent among cases. The strongest, significant association was observed for rs33980500 (OR = 2.5, p = 0.01790). Minor allele of this SNP was always present in two haplotypes found to be associated with increased psoriasis risk: rs13196377_G + rs13190932_G + rs33980500_T + rs13210247_A (OR = 2.7, p = 0.0054) and rs13196377_A + rs13190932_A + rs33980500_T + rs13210247_G (OR = 1.8, p = 0.0008). Analyses of clinically relevant phenotypes revealed association of rs33980500 with pustular psoriasis (OR = 1.2, p = 0.0109). We observed significant connection of severity of cutaneous disease with variation at rs13190932 and suggestive with three remaining TRAF3IP2 SNPs. Another positive associations were found between age of onset and familial aggregation of disease: smoking and younger age of onset, smoking and occurrence of pustular psoriasis, nail involvement and arthropatic psoriasis, nail involvement and more severe course of psoriasis. We found no statistically significant differences in the prevalence of the examined variants of RPTOR and ZNF750 genes among our cases and controls. We have replicated the association of TRAF3IP2-_rs33980500 variant with the susceptibility to psoriasis. We have found new associations with clinically relevant subphenotypes such as pustular psoriasis or moderate-to-severe cases. We ascertain no connection of RPTOR and ZNF750 variants with psoriasis or its subphenotypes. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00403-013-1407-9) contains supplementary material, which is available to authorized users

Current challenges and future perspectives in oral absorption research: An opinion of the UNGAP network

Although oral drug delivery is the preferred administration route and has been used for centuries, modern drug discovery and development pipelines challenge conventional formulation approaches and highlight the insufficient mechanistic understanding of processes critical to oral drug absorption. This review presents the opinion of UNGAP scientists on four key themes across the oral absorption landscape: (1) specific patient populations, (2) regional differences in the gastrointestinal tract, (3) advanced formulations and (4) food-drug interactions. The differences of oral absorption in pediatric and geriatric populations, the specific issues in colonic absorption, the formulation approaches for poorly water-soluble (small molecules) and poorly permeable (peptides, RNA etc.) drugs, as well as the vast realm of food effects, are some of the topics discussed in detail. The identified controversies and gaps in the current understanding of gastrointestinal absorption-related processes are used to create a roadmap for the future of oral drug absorption research

Analysis of the impact of sex and age on the variation in the prevalence of antinuclear autoantibodies in Polish population: a nationwide observational, cross-sectional study

The detection of antinuclear autoantibody (ANA) is dependent on many factors and varies between the populations. The aim of the study was first to assess the prevalence of ANA in the Polish adult population depending on age, sex and the cutoff threshold used for the results obtained. Second, we estimated the occurrence of individual types of ANA-staining patterns. We tested 1731 patient samples using commercially available IIFA using two cutoff thresholds of 1:100 and 1:160. We found ANA in 260 participants (15.0%), but the percentage of positive results strongly depended on the cutoff level. For a cutoff threshold 1:100, the positive population was 19.5% and for the 1:160 cutoff threshold, it was 11.7%. The most prevalent ANA-staining pattern was AC-2 Dense Fine speckled (50%), followed by AC-21 Reticular/AMA (14.38%) ANA more common in women (72%); 64% of ANA-positive patients were over 50 years of age. ANA prevalence in the Polish population is at a level observed in other highly developed countries and is more prevalent in women and elderly individuals. To reduce the number of positive results released, we suggest that Polish laboratories should set 1:160 as the cutoff threshold

Assessment of migration potential of youth from peripheral areas in south-east Poland

W artykule opisano jeden z istotnych problemów związanych z migracjami zarobkowymi – zwłaszcza w odniesieniu do regionów peryferyjnych o znaczącym zapóźnieniu cywilizacyjnym, jakim jest zjawisko tzw. „drenażu mózgów” (brain drain). Problem ten dotyczy w głównej mierze absolwentów i osób młodych, które w obliczu rozpoczynania kariery zawodowej napotykają na istotne bariery polskiego rynku pracy. Przeanalizowano potencjalną skalę migracji wewnętrznych i zewnętrznych, oceniono rangę czynników determinujących wybór miejsca migracji oraz znaczenie elementów wpływających na charakter podejmowanej pracy z uwzględnieniem oczekiwań płacowych potencjalnych migrantów.The article describes one of the important problems related to labor migrations, especially in regard to peripheral regions suffering from a considerable civilization gap, i.e. the phenomenon of the so-called “brain drain”. It affects both graduates and young people who, at the start of their professional careers, encounter significant barriers to the Polish labor market. Also the potential scale of internal and external migrations was analyzed and the importance of factors determining the selection of the migration destination as well as the importance of factors affecting the nature of jobs were evaluated, taking into account expectations related to wages and salaries of potential migrants

Social participation type and career adapt-ability among young adults. The mediating effect of promotional and preventive regulatory focus

The aim of the presented study was to investigate the relationship between the career adapt-ability and the implementation of developmental tasks by young adults with regard to life orientation type, and to check whether self-regulation is a mediator in the relationship between life orientation and career adapt-ability. In total, 435 young adults (274 women and 160 men) aged 18 to 34 years were included (M = 23.76; SD = 3.37). The study used the Social Participation Questionnaire (Kwestionariusz Partycypacji Społecznej – KPS) by Brzezińska, Hejmanowska and Rękosiewicz, based on the theoretical approach to life orientation by Reinders, Bergs-Winkels, Butz and Claßen, as well as the Social Participation Self-Regulation Scale by Kolańczyk, Bąk and Brzezińska, based on Higgins, and the Polish version of the CareerAdapt-Abilities Scale-5 by Savickas and Portfeli (five-factor version by Nye and colleagues). This analysis was aimed at verifying the following hypotheses: Hypothesis 1: The type of life orientation is significantly related to the type of social participation and career adapt-ability. It is assumed that a transitive orientation, as well as the assimilation and integration of social participation types, are positively associated with all dimensions of career adapt-ability, while the moratorium orientation, as well as the marginalization and segregation types, are negatively associated. Hypothesis 2: A significant relationship exists between self-regulation and the components of career adapt-ability: Hypothesis 2a: in the case of promotional standards, this relationship will be positive Hypothesis 2b: In the case of preventive standards, this relationship will be negative Hypothesis 3: A significant relationship exists between self-regulation and life orientations Hypothesis 3a: in the case of promotional standards, there will be a positive relationship with a transitive orientation and a negative relationship with a moratorium one Hypothesis 3b: in the case of preventive standards, there will be a positive relationship with a moratorium orientation and a negative relationship with a transitive one Hypothesis 4: Self-regulation mediates the relationship between life orientation and career adapt-ability. Due to the young age of the respondents, a significant mediation effect can be expected from promotional standards, because they are activated by the needs of growth and development and focus the individual on achieving positive results

Modyfikacja sposobu punktacji wybranych elementów wierzchniowego wariantu próby dzielności koników polskich

The aim of the study was to elaborate a new scoring system of chosen elements in performance test of Polish Konik horse. In the analysis, 42 horses were included. Test scores of two approaches were statistically elaborated: of the system in force and obtained on the basis of new intervals divided according to their mean values and SD. Multifactorial analysis of variance and T-Tukey test were performed. Low variation of individual performance test scores suggests a necessity for modification of the score system in force. The necessity also results from the change of score level in effect of using the new scoring system. The method of estimating the following traits is particularly controversial: behaviour, step length in walk, return of breath frequency to standard and effort test which belong to elements usually maximally scored. In consequence, they do not function as selection criteria

Social Participation Type and Career Adaptability among Young Adults: An Examination of the Mediation Effect of Promotional and Preventive Regulatory Focus

The aim of the presented study was to investigate the relationship between the career adapt-ability and the implementation of developmental tasks by young adults with regard to life orientation type, and to check whether self-regulation is a mediator in the relationship between life orientation and career adapt-ability. In total, 435 young adults (274 women and 160 men) aged 18 to 34 years were included (M = 23.76; SD = 3.37). The study used the Social Participation Questionnaire (Kwestionariusz Partycypacji Społecznej – KPS) by Brzezińska, Hejmanowska and Rękosiewicz, based on the theoretical approach to life orientation by Reinders, Bergs-Winkels, Butz and Claßen, as well as the Social Participation Self-Regulation Scale by Kolańczyk, Bąk and Brzezińska, based on Higgins, and the Polish version of the CareerAdapt-Abilities Scale-5 by Savickas and Portfeli (five-factor version by Nye and colleagues). This analysis was aimed at verifying the following hypotheses: Hypothesis 1: The type of life orientation is significantly related to the type of social participation and career adapt-ability. It is assumed that a transitive orientation, as well as the assimilation and integration of social participation types, are positively associated with all dimensions of career adapt-ability, while the moratorium orientation, as well as the marginalization and segregation types, are negatively associated.Hypothesis 2: A significant relationship exists between self-regulation and the components of career adapt-ability: Hypothesis 2a: in the case of promotional standards, this relationship will be positive Hypothesis 2b: In the case of preventive standards, this relationship will be negative Hypothesis 3: A significant relationship exists between self-regulation and life orientations Hypothesis 3a: in the case of promotional standards, there will be a positive relationship with a transitive orientation and a negative relationship with a moratorium one Hypothesis 3b: in the case of preventive standards, there will be a positive relationship with a moratorium orientation and a negative relationship with a transitive oneHypothesis 4: Self-regulation mediates the relationship between life orientation and career adapt-ability. Due to the young age of the respondents, a significant mediation effect can be expected from promotional standards, because they are activated by the needs of growth and development and focus the individual on achieving positive results.THIS DATASET IS ARCHIVED AT DANS/EASY, BUT NOT ACCESSIBLE HERE. TO VIEW A LIST OF FILES AND ACCESS THE FILES IN THIS DATASET CLICK ON THE DOI-LINK ABOV

Assessment of Service Life of HCM12 Steel After 100 000 Hrs of Service

The subject of the research was a material in the form of a ϕ38×4 pipe from HCM12 steel used for steam superheater coils in power boilers with supercritical and ultra-supercritical steam parameters. This article presents results of investigations of mechanical properties and microstructure of material of the examined tube in the as-received condition and after 100,000 h service at 585°C under creep conditions. Creep tests were carried out for the material after 100,000 h service to determine the disposable residual life. The impact of changes in mechanical properties and degradation of the microstructure on the loss of creep resistance compared to the as-received condition was assessed. The investigations have revealed that the examined steel after 100,000 h service meets the requirements for this steel in the as-received condition with regard to strength properties at room and elevated temperature. The creep tests have revealed a significant loss of creep resistance, which was estimated at around 60-70% compared to the as-received condition