170 research outputs found
Novel strategy for generation of mucosal immune responses against HIV-1 following systemic vaccination
Nitrogen forms affect root structure and water uptake in the hybrid poplar
The study analyses the effects of two different forms of nitrogen fertilisation (nitrate and ammonium) on root structure and water uptake of two hybrid poplar (Populus maximowiczii x P. balsamifera) clones in a field experiment. Water uptake was studied using sap flow gauges on individual proximal roots and coarse root structure was examined by excavating 18 whole-root systems. Finer roots were scanned and analyzed for architecture. Nitrogen forms did not affect coarse-root system development, but had a significant effect on fine-root development. Nitrate-treated trees presented higher fine:coarse root ratios and higher specific root lengths than control or ammonium treated trees. These allocation differences affected the water uptake capacity of the plants as reflected by the higher sapflow rate in the nitrate treatment. The diameter of proximal roots at the tree base predicted well the total root biomass and length. The diameter of smaller lateral roots also predicted the lateral root mass, length, surface area and the number of tips. The effect of nitrogen fertilisation on the fine root structure translated into an effect on the functioning of the fine roots forming a link between form (architecture) and function (water uptake)
Discovery of very high energy gamma rays from PKS 1424+240 and multiwavelength constraints on its redshift
We report the first detection of very-high-energy (VHE) gamma-ray emission
above 140 GeV from PKS 1424+240, a BL Lac object with an unknown redshift. The
photon spectrum above 140 GeV measured by VERITAS is well described by a power
law with a photon index of 3.8 +- 0.5_stat +- 0.3_syst and a flux normalization
at 200 GeV of (5.1 +- 0.9_stat +- 0.5_syst) x 10^{-11} TeV^-1 cm^-2 s^-1, where
stat and syst denote the statistical and systematical uncertainty,
respectively. The VHE flux is steady over the observation period between MJD
54881 and 55003 (2009 February 19 to June 21). Flux variability is also not
observed in contemporaneous high energy observations with the Fermi Large Area
Telescope (LAT). Contemporaneous X-ray and optical data were also obtained from
the Swift XRT and MDM observatory, respectively. The broadband spectral energy
distribution (SED) is well described by a one-zone synchrotron self-Compton
(SSC) model favoring a redshift of less than 0.1. Using the photon index
measured with Fermi in combination with recent extragalactic background light
(EBL) absorption models it can be concluded from the VERITAS data that the
redshift of PKS 1424+240 is less than 0.66.Comment: accepted for publication, Ap
False Heart Rate Feedback and the Perception of Heart Symptoms in Patients with Congenital Heart Disease and Anxiety
Background Little is known about the mechanisms explaining an increased perception of heart symptoms in congenital heart disease (ConHD). In the present study, it was suggested that a combination of high trait anxiety and disease history increases the perception of heart symptoms. Purpose It was tested whether false heart cues will result in an increased perception of heart symptoms in patients with ConHD and anxiety. Method Thirty-six patients with ConHD and 44 healthy controls performed two exercise tasks. During one of the exercise tasks, participants were exposed to a false heart cue consisting of false heart rate feedback (regular or irregular). Perceived heart symptoms were assessed and heart rate, arterial partial pressure of CO2, and respirator rate were monitored continuously. Results In line with the predictions, false heart rate feedback resulted in an increased perception of heart symptoms in high trait anxious patients with ConHD that could not be explained by acute heart dysfunction. However, unexpectedly, this effect was not observed immediately after the false heart rate feedback task but after a second exercise task without false feedback. Conclusion The results suggest that not the sole presence of ConHD but ConHD in combination with high trait anxiety results in a vulnerability to overperceive heart symptom
Acute Effects of Nicotine Amplify Accumbal Neural Responses during Nicotine-Taking Behavior and Nicotine-Paired Environmental Cues
Nicotine self-administration (SA) is maintained by several variables, including the reinforcing properties of nicotine-paired cues and the nicotine-induced amplification of those cue properties. The nucleus accumbens (NAc) is implicated in mediating the influence of these variables, though the underlying neurophysiological mechanisms are not yet understood. In the present study, Long-Evans rats were trained to self-administer nicotine. During SA sessions each press of a lever was followed by an intravenous infusion of nicotine (30 µg/kg) paired with a combined light-tone cue. Extracellular recordings of single-neuron activity showed that 20% of neurons exhibited a phasic change in firing during the nicotine-directed operant, the light-tone cue, or both. The phasic change in firing for 98% of neurons was an increase. Sixty-two percent of NAc neurons additionally or alternatively showed a sustained decrease in average firing during the SA session relative to a presession baseline period. These session decreases in firing were significantly less prevalent in a group of neurons that were activated during either the operant or the cue than in a group of neurons that were nonresponsive during those events (referred to as task-activated and task-nonactivated neurons, respectively). Moreover, the session decrease in firing was dose-dependent for only the task-nonactivated neurons. The data of the present investigation provide supportive correlational evidence for two hypotheses: (1) excitatory neurophysiological mechanisms mediate the NAc role in cue-maintenance of nicotine SA, and (2) a differential nicotine-induced inhibition of task-activated and task-nonactivated neurons mediates the NAc role in nicotine-induced amplification of cue effects on nicotine SA
Developmental differences in children’s interpersonal emotion regulation
Previous research on interpersonal emotion regulation (ER) in childhood has been rather unsystematic, focusing mainly on children’s prosocial behaviour, and has been conducted in the absence of an integrative emotion theoretical framework. The present research relied on the interpersonal affect classification proposed by Niven, Totterdell, and Holman (2009) to investigate children’s use of different interpersonal ER strategies. The study drew on two samples: 180 parents of children aged between 3 and 8 years reported about a situation where their child was able to change what another person was feeling in order to make them feel better. In addition, 126 children between 3- and 8-years old answered two questions about how they could improve others’ mood. Results from both samples showed age differences in children’s use of interpersonal ER strategies. As expected, ‘affective engagement’ (i.e., focusing on the person or the problem) and ‘cognitive engagement’ (i.e., appraising the situation from a different perspective) were mainly used by 7-8 years-old, whereas ‘attention’ (i.e., distracting and valuing) was most used by 3-4 and 5-6 years-old. ‘Humor’ (i.e., laughing with the target) remained stable across the different age groups. The present research provides more information about the developmental patterns for each specific interpersonal emotion regulation strategy
Galactic Gradients, Postbiological Evolution and the Apparent Failure of SETI
Motivated by recent developments impacting our view of Fermi's paradox
(absence of extraterrestrials and their manifestations from our past light
cone), we suggest a reassessment of the problem itself, as well as of
strategies employed by SETI projects so far. The need for such reevaluation is
fueled not only by the failure of searches thus far, but also by great advances
recently made in astrophysics, astrobiology, computer science and future
studies, which have remained largely ignored in SETI practice. As an example of
the new approach, we consider the effects of the observed metallicity and
temperature gradients in the Milky Way on the spatial distribution of
hypothetical advanced extraterrestrial intelligent communities. While,
obviously, properties of such communities and their sociological and
technological preferences are entirely unknown, we assume that (1) they operate
in agreement with the known laws of physics, and (2) that at some point they
typically become motivated by a meta-principle embodying the central role of
information-processing; a prototype of the latter is the recently suggested
Intelligence Principle of Steven J. Dick. There are specific conclusions of
practical interest to be drawn from coupling of these reasonable assumptions
with the astrophysical and astrochemical structure of the Galaxy. In
particular, we suggest that the outer regions of the Galactic disk are most
likely locations for advanced SETI targets, and that intelligent communities
will tend to migrate outward through the Galaxy as their capacities of
information-processing increase, for both thermodynamical and astrochemical
reasons. This can also be regarded as a possible generalization of the Galactic
Habitable Zone, concept currently much investigated in astrobiology.Comment: 30 pages, 2 figure
‘Back to our Roots?’ Re-visiting psychoanalytically-informed baby and young child observation in the education of student social workers
Postmortem Analyses Unveil the Poor Efficacy of Decontamination, Anti-Inflammatory and Immunosuppressive Therapies in Paraquat Human Intoxications
studies resulting from human PQ poisonings have assessed the relationship of these therapeutic measures with PQ toxicokinetics and related histopathological lesions, these being the aims of the present study.For that purpose, during 2008, we collected human fluids and tissues from five forensic autopsies following fatal PQ poisonings. PQ levels were measured by gas chromatography-ion trap mass spectrometry. Structural inflammatory lesions were evaluated by histological and immunohistochemistry analysis. The samples of cardiac blood, urine, gastric and duodenal wall, liver, lung, kidney, heart and diaphragm, showed quantifiable levels of PQ even at 6 days post-intoxication. Structural analysis showed diffused necrotic areas, intense macrophage activation and leukocyte infiltration in all analyzed tissues. By immunohistochemistry it was possible to observe a strong nuclear factor kappa-B (NF-κB) activation and excessive collagen deposition.Considering the observed PQ levels in all analyzed tissues and the expressive inflammatory reaction that ultimately leads to fibrosis, we conclude that the therapeutic protocol usually performed needs to be reviewed, in order to increase the efficacy of PQ elimination from the body as well as to diminish the inflammatory process
- …