Evaluation of the QTc interval during lenvatinib treatment in radioiodine-refractory differentiated thyroid cancer: reports from the real-life clinical practice.

As for other tyrosine kinase inhibitors, a prolongation of ECG-recorded QTc intervals may be observed during lenvatinib treatment; a warning on this phenomenon has been stated. However, methods and frequency of ECG recordings have seldom been reported in this context. We present two cases of patients treated with lenvatinib for radioiodine-refractory differentiated thyroid cancer in whom the QTc interval was long monitored through a weekly 12-lead ECG registration. Overall, the maximum QTc increase above baseline was 3 and 31 ms in the first and second patient, respectively. QTc interval did not reach the toxicity value for drug withdrawal in either of the patients. These data may provide further information on cardiac safety profile of lenvatinib in a real-life practice

The KLOE-2 experiment at DAΦNE

The KLOE-2 Collaboration succesfully ended its data-taking collecting a total integrated luminosity of 5.5 fb−1 at the peak of the φ(1020) resonance at the DAΦNE collider of the Frascati LNF. New detectors have been added to the KLOE apparatus to improve the detector acceptance, the tracking capability, and also to be able to tag the scattered electrons in γγ processes. By summing the new data sample to the old one of the previous KLOE data-taking ended in 2006, a total of about 8 fb−1 has been collected, corresponding to 24 billions of φ produced. The measurement program of KLOE-2 includes precision studies on kaon and other light mesons, hadronic cross-section, and dark force searches

Multidisciplinary study of biological parameters and fatigue evolution in quay crane operators

In intermodal terminals the handling of containers and the number of accidents still depends on a wide range of human errors due to fatigue despite the automation level reached nowadays. For this reason it is very important to increase knowledge about the factors affecting the propensity of operators to make errors, increasing the chance of accidents happening. The aim of this work is to propose a novel approach to assess fatigue and performance lev els in quay crane operators as a function of physiological parameters and of the many varying boundary conditions encountered in daily work. During their work, quay crane operators have to deal with variable environmental conditions, such as task type, wind speed and direction, lighting conditions that redu ce visibility that can require an exacting level of attention. In the trial eight operators have been examined in a session lastin g four hours. All actual conditions are reproduced through a fully imme rsive quay crane simulator. The operator completes the assigned task (the same for each one) and can see through four wide monito rs a high quality virtual reality view of the simulation. Most biological parameters are acquired using different devices including a Holter ECG monitor, electromyographic monitoring the four trunk muscles most involved in the test, eye tracker and seat - body pressure interface for both seat pan and backrest. Changes in physiological parameters have been monitored during the trial and interesting correlations with performance levels and boundary conditions ha ve been f ound for each operator, in accord ance with their age and skills. The present study can form the basis for further investigations aimed at developing a cost effective, reliable and robust system for monitoring increasing fat igue and for predicting the critical conditions that may result in an acciden

Emergency surgery in a tertiary hospital: The covid-19 experience

Objective: Evaluate the impact of Covid-19 in a critical area and analyze the changes in the daily activities in an Emergency Department of a tertiary COVID-Hospital. Methods: We reported and compared the surgical procedures performed for acute appendicitis and acute cholecystitis between two periods (March and April 2019 and March and April 2020) at Emergency Surgery Department of Parma University Hospital, a tertiary COVID-Hospital. Results: A total of 72 patients underwent surgery between March and April 2019 and 36 between March and April 2020 for acute appendicitis and cholecystitis. The average length of stay was comparable in the two considered years for LA (4.23±1.69 days in 2019 versus 4.5±2.33 days in 2020). The average length of stay in patients with acute cholecystitis was 5.9±3.8 days in 2019 and 8.23±5.5 days in 2020(P=0.038). The average hospitalization was comparable with 2019 data (5.62±3.77 days)n March 2020;whereas, April 2020 was statistically significantly longer 10.5±6 days (P= 0.023). Conclusions: Half of the emergency centers reported a drop in the overall number of urgent cases as confirmed in our department, where the number of total appendicectomy and cholecystectomy was halved comparing the two months in 2019 and 2020, 72 operations in 2019 versus 36 operations in 2020.During the pandemic, the confidence of the population to the healthcare systems was poor, and this can explain the delayed access to the emergency department of patients who suffered from an acute illness. Bangladesh Journal of Medical Science Vol.19(0) 2020 p. S 66-S 6

A meta-analysis on age-associated changes in blood DNA methylation: Results from an original analysis pipeline for Infinium 450k data

open18noAging is characterized by a profound remodeling of the epigenetic architecture in terms of DNA methylation patterns. To date the most effective tool to study genome wide DNA methylation changes is Infinium HumanMethylation450 BeadChip (Infinium 450k). Despite the wealth of tools for Infinium 450k analysis, the identification of the most biologically relevant DNA methylation changes is still challenging. Here we propose an analytical pipeline to select differentially methylated regions (DMRs), tailored on microarray architecture, which is highly effective in highlighting biologically relevant results. The pipeline groups microarray probes on the basis of their localization respect to CpG islands and genic sequences and, depending on probes density, identifies DMRs through a single-probe or a regioncentric approach that considers the concomitant variation of multiple adjacent CpG probes. We successfully applied this analytical pipeline on 3 independent Infinium 450k datasets that investigated age-associated changes in blood DNA methylation. We provide a consensus list of genes that systematically vary in DNA methylation levels from 0 to 100 years and that have a potentially relevant role in the aging process.This work was supported by the European Union's Seventh Framework Programme (grant agreement no. 259679 “IDEAL”, grant agreement no. 266486 “NU-AGE”, grant agreement no. 305280), by CARISBO foundation and by the Italian Ministry of Health, Progetto Ricerca Finalizzata 2008, convenzione 35: “An integrated approach to identify functional, biochemical and genetic markers for diagnostic and prognostic purposes in the elderly, in the centenarians and in people with dementia, Alzheimer's disease, mild cognitive impairment”.openBacalini MG; Boattini A; Gentilini D; Giampieri E; Pirazzini C; Giuliani C; Fontanesi E; Remondini D; Capri M; Del Rio A; Luiselli D; Vitale G; Mari D; Castellani G; Di Blasio AM; Salvioli S; Franceschi C; Garagnani P.Bacalini MG; Boattini A; Gentilini D; Giampieri E; Pirazzini C; Giuliani C; Fontanesi E; Remondini D; Capri M; Del Rio A; Luiselli D; Vitale G; Mari D; Castellani G; Di Blasio AM; Salvioli S; Franceschi C; Garagnani P

European Headache Federation (EHF) consensus on the definition of effective treatment of a migraine attack and of triptan failure

BACKGROUND: Triptans are migraine-specific acute treatments. A well-accepted definition of triptan failure is needed in clinical practice and for research. The primary aim of the present Consensus was to provide a definition of triptan failure. To develop this definition, we deemed necessary to develop as first a consensus definition of effective treatment of an acute migraine attack and of triptan-responder. MAIN BODY: The Consensus process included a preliminary literature review, a Delphi round and a subsequent open discussion. According to the Consensus Panel, effective treatment of a migraine attack is to be defined on patient well-being featured by a) improvement of headache, b) relief of non-pain symptoms and c) absence of adverse events. An attack is considered effectively treated if patient's well-being, as defined above, is restored within 2 hours and for at least 24 hours. An individual with migraine is considered as triptan-responder when the given triptan leads to effective acute attack treatment in at least three out of four migraine attacks. On the other hand, an individual with migraine is considered triptan non-responder in the presence of failure of a single triptan (not matching the definition of triptan-responder). The Consensus Panel defined an individual with migraine as triptan-resistant in the presence of failure of at least 2 triptans; triptan refractory, in the presence of failure to at least 3 triptans, including subcutaneous formulation; triptan ineligibile in the presence of an acknowledged contraindication to triptan use, as specified in the summary of product characteristics. CONCLUSIONS: The novel definitions can be useful in clinical practice for the assessment of acute attack treatments patients with migraine. They may be helpful in identifying people not responding to triptans and in need for novel acute migraine treatments. The definitions will also be of help in standardizing research on migraine acute care.info:eu-repo/semantics/publishedVersio

Open Universe for Blazars: A new generation of astronomical products based on 14 years of Swift -XRT data

Aims. Open Universe for Blazars is a set of high-transparency multi-frequency data products for blazar science, and the tools designed to generate them. Blazars are drawing growing interest following the consolidation of their position as the most abundant type of source in the extragalactic very high-energy γ-ray sky, and because of their status as prime candidate sources in the nascent field of multi-messenger astrophysics. As such, blazar astrophysics is becoming increasingly data driven, depending on the integration and combined analysis of large quantities of data from the entire span of observational astrophysics techniques. The project was therefore chosen as one of the pilot activities within the United Nations Open Universe Initiative, whose objective is to stimulate a large increase in the accessibility and ease of utilisation of space science data for the worldwide benefit of scientific research, education, capacity building, and citizen science. Methods. Our aim is to deliver innovative data science tools for multi-messenger astrophysics. In this work we report on a data analysis pipeline called Swift-DeepSky based on the Swift XRTDAS software and the XIMAGE package, encapsulated into a Docker container. Swift-DeepSky downloads and reads low-level data, generates higher level products, detects X-ray sources, and estimates several intensity and spectral parameters for each detection, thus facilitating the generation of complete and up-to-date science-ready catalogues from an entire space-mission data set. Results. As a first application of our innovative approach, we present the results of a detailed X-ray image analysis based on Swift-DeepSky that was run on all Swift-XRT observations including a known blazar, carried out during the first 14 years of operations of the Neil Gehrels Swift Observatory. Short exposures executed within one week of each other have been added to increase sensitivity, which ranges between ∼1 × 10-12 and ∼1 × 10-14 erg cm-2 s-1 (0.3-10.0 keV). After cleaning for problematic fields, the resulting database includes over 27 000 images integrated in different X-ray bands, and a catalogue, called 1OUSXB, that provides intensity and spectral information for 33 396 X-ray sources, 8896 of which are single or multiple detections of 2308 distinct blazars. All the results can be accessed online in a variety of ways, from the Open Universe portal through Virtual Observatory services, via the VOU-Blazar tool and the SSDC SED builder. One of the most innovative aspects of this work is that the results can be easily reproduced and extended by anyone using the Docker version of the Swift-DeepSky pipeline, which runs on Linux, Mac, and Windows machines, and does not require any specific experience in X-ray data analysis.Fil: Giommi, Paolo. Università di Roma; Italia. International Center For Relativistic Astrophysics; Italia. Universitat Technical Zu Munich; AlemaniaFil: Brandt, C. H.. International Center For Relativistic Astrophysics; Italia. Jacobs University; AlemaniaFil: Barres de Almeida, U.. International Center For Relativistic Astrophysics; Italia. Centro Brasileiro de Pesquisas Físicas; BrasilFil: Pollock, A. M. T.. University of Sheffield; Reino UnidoFil: Arneodo, F.. New York University Abu Dhabi; Arabia SauditaFil: Chang, Y. L.. International Center For Relativistic Astrophysics; ItaliaFil: Civitarese, Enrique Osvaldo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; ArgentinaFil: de Angelis, Maria Cruz. Università di Roma; ItaliaFil: D'Elia, V.. Space Science Data Center; Italia. Osservatorio Astronomico di Roma; ItaliaFil: Del Rio Vera, J.. United Nations Office for Outer Space Affairs; AustraliaFil: Di Pippo, S.. United Nations Office for Outer Space Affairs; AustraliaFil: Middei, Riccardo. Università di Roma; ItaliaFil: Penacchioni, Ana Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; ArgentinaFil: Perri, M.. Osservatorio Astronomico di Roma; Italia. Space Science Data Center; ItaliaFil: Ruffini, Remo. International Center For Relativistic Astrophysics; ItaliaFil: Sahakyan, Narek. International Centre For Relativistic Astrophysics Network; ArmeniaFil: Turriziani, Sara. Computational Astrophysics Laboratory; Japó

Toward a Comprehensive and Integrated Strategy of the European Marine Research Infrastructures for Ocean Observations

Research Infrastructures (RIs) are large-scale facilities encompassing instruments, resources, data and services used by the scientific community to conduct high-level research in their respective fields. The development and integration of marine environmental RIs as European Research Vessel Operators [ERVO] (2020) is the response of the European Commission (EC) to global marine challenges through research, technological development and innovation. These infrastructures (EMSO ERIC, Euro-Argo ERIC, ICOS-ERIC Marine, LifeWatch ERIC, and EMBRC-ERIC) include specialized vessels, fixed-point monitoring systems, Lagrangian floats, test facilities, genomics observatories, bio-sensing, and Virtual Research Environments (VREs), among others. Marine ecosystems are vital for life on Earth. Global climate change is progressing rapidly, and geo-hazards, such as earthquakes, volcanic eruptions, and tsunamis, cause large losses of human life and have massive worldwide socio-economic impacts. Enhancing our marine environmental monitoring and prediction capabilities will increase our ability to respond adequately to major challenges and efficiently. Collaboration among European marine RIs aligns with and has contributed to the OceanObs’19 Conference statement and the objectives of the UN Decade of Ocean Science for Sustainable Development (2021–2030). This collaboration actively participates and supports concrete actions to increase the quality and quantity of more integrated and sustained observations in the ocean worldwide. From an innovation perspective, the next decade will increasingly count on marine RIs to support the development of new technologies and their validation in the field, increasing market uptake and produce a shift in observing capabilities and strategies.Peer reviewe