Análisis de la deserción y la graduación de los estudiantes de la Universidad de la Guajira

Teniendo en cuenta que tanto las altas tasas de deserción como las bajas tasas graduación a término que se presentan en la Universidad de La Guajira reflejan debilitamientos en la calidad y la cobertura de la educación impartida en esta Institución de Educación Superior, el objetivo central de la presente investigación es identificar los determinantes de la deserción y la graduación a tiempo de los estudiantes de la misma, con el fin de proporcionar información relevante para el planteamiento de programas que busquen disminuir la tasa de deserción y aumentar la tasa de graduación a tiempo -- Los resultados de los modelos de elección discreta exteriorizados en la presente investigación dan cuenta que principalmente son aquellos factores económicos y académicos los que influencian en mayor medida dichas problemáticas en el contexto mencionad

Improving the prediction of protein binding sites by combining heterogeneous data and Voronoi diagrams

BACKGROUND: Protein binding site prediction by computational means can yield valuable information that complements and guides experimental approaches to determine the structure of protein complexes. Predictions become even more relevant and timely given the current resolution of protein interaction maps, where there is a very large and still expanding gap between the available information on: (i) which proteins interact and (ii) how proteins interact. Proteins interact through exposed residues that present differential physicochemical properties, and these can be exploited to identify protein interfaces. RESULTS: Here we present VORFFIP, a novel method for protein binding site prediction. The method makes use of broad set of heterogeneous data and defined of residue environment, by means of Voronoi Diagrams that are integrated by a two-steps Random Forest ensemble classifier. Four sets of residue features (structural, energy terms, sequence conservation, and crystallographic B-factors) used in different combinations together with three definitions of residue environment (Voronoi Diagrams, sequence sliding window, and Euclidian distance) have been analyzed in order to maximize the performance of the method. CONCLUSIONS: The integration of different forms information such as structural features, energy term, evolutionary conservation and crystallographic B-factors, improves the performance of binding site prediction. Including the information of neighbouring residues also improves the prediction of protein interfaces. Among the different approaches that can be used to define the environment of exposed residues, Voronoi Diagrams provide the most accurate description. Finally, VORFFIP compares favourably to other methods reported in the recent literature

A holistic in silico approach to predict functional sites in protein structures

Abstract Motivation: Proteins execute and coordinate cellular functions by interacting with other biomolecules. Among these interactions, protein–protein (including peptide-mediated), protein–DNA and protein–RNA interactions cover a wide range of critical processes and cellular functions. The functional characterization of proteins requires the description and mapping of functional biomolecular interactions and the identification and characterization of functional sites is an important step towards this end. Results: We have developed a novel computational method, Multi-VORFFIP (MV), a tool to predicts protein-, peptide-, DNA- and RNA-binding sites in proteins. MV utilizes a wide range of structural, evolutionary, experimental and energy-based information that is integrated into a common probabilistic framework by means of a Random Forest ensemble classifier. While remaining competitive when compared with current methods, MV is a centralized resource for the prediction of functional sites and is interfaced by a powerful web application tailored to facilitate the use of the method and analysis of predictions to non-expert end-users. Availability:  http://www.bioinsilico.org/MVORFFIP Supplementary information:  Supplementary data are available at Bioinformatics online. Contact:  [email protected]; [email protected]</jats:p

Inteligencia emocional y habilidades sociales en alumnos del sexto grado del nivel primario de la I.E 2085 San Agustín en el distrito de Comas – 2015

La investigación titulada inteligencia emocional y habilidades sociales en alumnos del sexto grado del nivel primario de la I.E 2085 San Agustín en el distrito de Comas- 2015 tuvo como objetivo establecer la relación que existe entre la inteligencia emocional y las habilidades sociales. Para tal efecto, se realizó una investigación de tipo no experimental con un diseño correlacional. La muestra es de tipo población muestra total conformada por 120 estudiantes de ambos géneros siendo entre ellos 62 niñas y 58 niños que cursan el sexto grado de primaria a quienes se les aplicó el Inventario de Cociente Emocional de BarOn (ICE) adaptado por Ugarriza y Pajares (2001) y la Lista de Chequeo de Habilidades Sociales de Golstein, siendo ellos instrumentos que cumplen con validez y coeficiente de confiabilidad ya que es un instrumento utilizado a nivel internacional. Para el análisis estadístico se usó el software SPSS, asimismo se organizaron en tablas y figuras para la descripción de resultados y para el análisis inferencial fue utilizado el coeficiente de correlación de Spearman. Los resultados demuestran que existe una relación estadísticamente significativa indicándonos que existe una relación positiva con correlación moderada entre la inteligencia emocional y habilidades sociales. Así mismo, los componentes de las habilidades sociales: primeras habilidades sociales, habilidades sociales avanzadas, habilidades sociales relacionadas a los sentimientos, habilidades sociales alternas a la agresión, habilidades sociales para el manejo de estrés y habilidades sociales de planificación presentaron una relación estadísticamente significativa con la inteligencia emocional. En conclusión, la relación entre la variable inteligencia emocional y habilidades sociales fue establecida, es decir la hipótesis fue confirmada

The Oldest Professions in Revolutionary Times: Madames, Pimps, and Prostitution in Mexico City, 1920 - 1952

This dissertation examines the impact of the end of state-regulated prostitution in Mexico City. It analyzes the results of debates on prostitution and the trafficking in women against the backdrop of revolutionary politics and the consolidation of state authority in Mexico in the interwar period. The League of Nations’ resolutions asking for the criminalization of intermediaries, brothels, and call houses prompted global debates and actions. In the capital city prostitutes resulted to be disempowered, madams prosecuted, while authorities and pimps turned more violent towards sex workers and extorted them more often. Through the lens of gender it is argued here that the transition of power from madames to pimps played a central role in the reconfiguration of commercial sex in modern Mexico City. The most important finding of this investigation is that over time, power shifted from women involved in Mexico City’s sex trade —madames and sex workers—to men —pimps, landlords, and cops. This doctoral research contributes to debates on prostitution and labor. It highlights several attempts made by women involved in the sex trade to gain recognition as workers and to be part of the new national project. Another aim of this work is to show the importance of sites of prostitution to the social life of the city, as well as to illuminate the relationship between modernity, urbanization, commercial sex, and different cultural expressions such as literature, cinema, and music. In order to show the complex dynamics of prostitution, this dissertation draws from a wide array of sources: images, film, court records, letters, legislation, memoirs, newspapers, and periodicals show the contested nature of the discourses that shaped legal, cultural, and social notions which ruled commercial sex during the first half of the twentieth century

Análisis del comercio internacional terrestre de 2000 al 2014 entre el Estado Plurinacional de Bolivia y República de Argentina

Bolivia y Argentina que son países limítrofes y que necesariamente están relacionados, y existe un comercio internacional, por ejemplo Argentina importa de Bolivia Gas y Bolivia importa de Argentina: trigo, carne y etc. Bolivia y Argentina en lo que es el tránsito fronterizo terrestre, durante mucho años se dieron diferentes situaciones o problemas como el mercado informal que salió como consecuencia del mal control, la mala aplicación de las leyes y más; este fenómeno del contrabando no solo impacta negativamente en la recaudación impositiva, sino también afecta a la industria nacional y a la salud y seguridad pública . En Bolivia como en Argentina existen leyes, las cuales están tipificadas exclusivamente al fraude marcario, pero es justo y necesario la aplicación o ejecución de las mismas ya que no se llegan a cumplirse, pero en este caso la intervención de los Gobiernos son el punto fundamental. Se dieron varios encuentros entre el Gobierno Argentino como Boliviano para tocar el tema del tránsito fronterizo con respecto a la regulación y control de mercancías, pero falta más rigurosidad o mecanismo alternativos de solución para este problema.Facultad de Ciencias Económica

Effectiveness of neuromuscular electrostimulation in COPD subjects on mechanical ventilation. A systematic review and meta-analysis

Objective: To estimate the effectiveness of Neuromuscular Electrostimulation (NMES) in adults with COPD undergoing MV. Method: A sensitive search was performed in MEDLINE, Embase, CENTRAL, CINAHL and other resources. Randomized Controlled Clinical Trials (RCTs) or non-RCTs that enrolled adults with COPD on MV due to an exacerbation of their disease were included. Two independent reviewers screened, extracted information, and assessed the risk of bias (RoB&nbsp;2 tool) and the certainty of evidence (GRADE approach) from the included studies. Results: Four RCTs (144&nbsp;participants) were included. Subjects who underwent NMES were able to move from bed to chair independently in less time (MD&nbsp;=&nbsp;4.98&nbsp;days less; 95%&nbsp;CI&nbsp;-8.55 to&nbsp;-1.47; 2&nbsp;RCTs; low certainty of the evidence) and they were fewer days on MV (MD&nbsp;=&nbsp;2.89&nbsp;days less; 95%&nbsp;CI&nbsp;-4.58 to&nbsp;-1.21); 3&nbsp;RCTs; low certainty of the evidence) than the control group. However, the effect of NMES on muscle strength is unclear (very low certainty of the evidence). Conclusions: NMES may improve functional independence and decrease MV time in adults with COPD; however, its effectiveness on muscle strength is uncertain. More and better RCTs are needed to determine with greater certainty the effectiveness of NMES in this population

Synthesis and optical characterization of Er-doped bismuth titanate nanoparticles grown by sol-gel hydrothermal method

The Er-doped bismuth titanate (BiTiO, BIT) nanoparticles were synthesized by a combined sol-gel and hydrothermal method under a partial oxygen pressure of 30 bar. The composition and morphology were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM) and Raman scattering. They showed pure and homogeneous spherical BIT nanoparticles with a size below the 30 nm. The incorporation of Er ions showed a strong decrease in the lattice parameters, as well as averaged particle size. The photoluminescence up-conversion (excitation wavelength =1480 nm) showed an enhancement of the infrared emission (980 nm) as Er concentration increased, achieving a maximum for 6% mol, while photoluminescence spectra (excitation wavelength =473 nm) showed a strong green emission (529 and 553 nm) with a maximum at 4% mol

VORFFIP-Driven Dock:V-D ²OCK, a fast, accurate protein docking strategy

The experimental determination of the structure of protein complexes cannot keep pace with the generation of interactomic data, hence resulting in an ever-expanding gap. As the structural details of protein complexes are central to a full understanding of the function and dynamics of the cell machinery, alternative strategies are needed to circumvent the bottleneck in structure determination. Computational protein docking is a valid and valuable approach to model the structure of protein complexes. In this work, we describe a novel computational strategy to predict the structure of protein complexes based on data-driven docking: VORFFIP-driven dock (V-D²OCK). This new approach makes use of our newly described method to predict functional sites in protein structures, VORFFIP, to define the region to be sampled during docking and structural clustering to reduce the number of models to be examined by users. V-D²OCK has been benchmarked using a validated and diverse set of protein complexes and compared to a state-of-art docking method. The speed and accuracy compared to contemporary tools justifies the potential use of VD²OCK for high-throughput, genome-wide, protein docking. Finally, we have developed a web interface that allows users to browser and visualize V-D²OCK predictions from the convenience of their web-browsers