Classification of product data for a Digital Product Passport in the manufacturing industry

The European Commission set out the goal of carbon neutrality by 2050, which shall be achieved by fostering the twin transition - sustainability through digitalization. A keystone in this transition is the implementation of a prospering Circular Economy (CE). However, product information required to establish a flourishing CE is hardly available or even accessible. The Digital Product Passport (DPP) offers a solution to that problem but in the current discussion, two separate topics are focused on: its architecture and its application on batteries. The content of the DPP has not been an essential part of the discussion, although access to high-quality data about a product's state, composition and ecological footprint is required to enable sustainable decision-making. Therefore, this paper presents a classification of product data for circularity in the manufacturing industry to emphasize the discussion about the DPP's content. Developed through a systematic literature review combined with a case-study-research based on common operational information systems, the classification comprises three levels with 62 data points in four main categories: (1) Product information, (2) Utilization information, (3) Value chain information and (4) Sustainability information. In this paper, the potential content structure of a DPP is demonstrated for a use case in the machinery sector. The contribution to the science and operations community is twofold: Building a guideline for DPP developers that require scientific input from available real-world data points as well as motivating manufacturers to share the presented data points enabling a circular product information management

Festschrift anläßlich der Emeritierung von Prof. Dr.-Ing. Walter Raab

Festschrift zum Festkolloquium am 8. April 1994 anläßlich der Emeritierung von Herrn Prof. Dr.-Ing. Walter Raab, Leiter des Fachgebiets Maschinenlemente und Mechanik an der Technischen Hochschule Darmstadt

Krüppel-like factor 15 regulates BMPER in endothelial cells

Bone morphogenetic proteins (BMPs) are involved in embryonic and adult blood vessel formation in health and disease. Previous studies have shown that BMP endothelial cell precursor-derived regulator (BMPER) plays an important role in endothelial cell function and blood vessel formation. BMPER is a key regulator of BMP4 activity and a prerequisite for BMP pathway activation by BMP4 in endothelial cells. Here, we characterize the BMPER promoter and elucidate mechanisms of BMPER regulation

Advancing the research agenda on food systems governance and transformation

The food systems upon which humanity depends face multiple interdependent environmental, social and economic threats in the 21st Century. Yet, the governance of these systems, which determines to a large extent the ability to adapt and transform in response to these challenges, is underresearched. This perspective piece synthesises the findings of two recent reviews of food systems governance and transformations and proposes a comprehensive research agenda for the coming years. These reviews highlight the influence of governance on food systems, methodological obstacles to explaining the effectiveness of governance in realising food sustainability, and conditions that have historically supported food system transformations. We argue that the following steps are key to improving our knowledge of the role of governance in food systems: (1) developing more comparable research designs for building generalisable explanations of the governance elements that are most effective in realising food systems goals; (2) using the lens of polycentricity to help disentangle complex governance networks; (3) giving greater attention to the conditions and pre-conditions associated with historical food system transformations; (4) identifying adaptations that strengthen or weaken path dependency; and, (5) focusing research on how transformations can be supported by institutions that facilitate collective action and stakeholder agency

The Shahre Javan Community Detailed Plan : Planning for a Climate Responsive and Sustainable Iranian Urban Quarter

Zugleich gedruckt veröffentlicht im Universitätsverlag der TU Berlin unter der ISBN 978-3-7983-2451-0.This report presents the major accomplishments of the ‘Shahre Javan Community’ pilot project as the main pilot project of the German-Iranian Young Cities research project,. ‘Shahre Javan’ is Farsi and stands for ‘Young City’. The pilot project uses an integrated planning and research process to explore aspects of energy and resource efficiency, climate and environmentally conscious solutions for urban form, architecture, landscape planning, transportation planning, water and energy management, and environmental assessment. It is about the upgraded Iranian detailed plan (‘Tarh-e Tafsili’) for a nearly 45 ha large pilot project area in the southern part of the Hashtgerd New Town, Iran. It includes innovations derived during the strategically integrative urban development and research process, in an effort to reach more climate responsive and more sustainable urban development. Thus, several of the presented solutions go above and beyond the standard content of an Iranian detailed plan. Hence, this publication does not present the or an approved formal Iranian detailed plan. Rather, it combines a reflection of research background, approach, and process with a kind of a hybrid detailed plan report which includes common Iranian detailed plan contents and new and innovative elements as well as research findings going beyond the detailed plan scale and content. Printed Version published by Universitätsverlag der TU Berlin (www.univerlag.tu-berlin.de), ISBN 978-3-7983-2451-

Genome-Wide Association and Trans-ethnic Meta-Analysis for Advanced Diabetic Kidney Disease: Family Investigation of Nephropathy and Diabetes (FIND)

Diabetic kidney disease (DKD) is the most common etiology of chronic kidney disease (CKD) in the industrialized world and accounts for much of the excess mortality in patients with diabetes mellitus. Approximately 45% of U.S. patients with incident end-stage kidney disease (ESKD) have DKD. Independent of glycemic control, DKD aggregates in families and has higher incidence rates in African, Mexican, and American Indian ancestral groups relative to European populations. The Family Investigation of Nephropathy and Diabetes (FIND) performed a genome-wide association study (GWAS) contrasting 6,197 unrelated individuals with advanced DKD with healthy and diabetic individuals lacking nephropathy of European American, African American, Mexican American, or American Indian ancestry. A large-scale replication and trans-ethnic meta-analysis included 7,539 additional European American, African American and American Indian DKD cases and non-nephropathy controls. Within ethnic group meta-analysis of discovery GWAS and replication set results identified genome-wide significant evidence for association between DKD and rs12523822 on chromosome 6q25.2 in American Indians (P = 5.74x10-9). The strongest signal of association in the trans-ethnic meta-analysis was with a SNP in strong linkage disequilibrium with rs12523822 (rs955333; P = 1.31x10-8), with directionally consistent results across ethnic groups. These 6q25.2 SNPs are located between the SCAF8 and CNKSR3 genes, a region with DKD relevant changes in gene expression and an eQTL with IPCEF1, a gene co-translated with CNKSR3. Several other SNPs demonstrated suggestive evidence of association with DKD, within and across populations. These data identify a novel DKD susceptibility locus with consistent directions of effect across diverse ancestral groups and provide insight into the genetic architecture of DKD

Eine empirische Untersuchung forensischer Gutachten unter besonderer Berücksichtigung von Persönlichkeitsstörungen und Rückfälligkeit nach Vollverbüßung

Softcover, 17x24Die Arbeit beruht auf Daten aus dem DFG-geförderten Projekt „Gefährlichkeit von Strafentlassenen nach langen Jugendstrafen“, das in Deutschland in dieser Form bisher einmalig ist. Sie führt eine vertiefte Analyse forensischer Begutachtung im Zusammenhang mit langjährigen Jugendstrafen durch. Mittels einer leitfadengeführten Strafaktenauswertung werden empirische Erkenntnisse über die Praxis forensischer Begutachtung in drei Verfahrensstadien gewonnen: Die Begutachtung im Erkenntnisverfahren in Ansehung der Bezugstat der langen Jugendstrafe, die Begutachtung während des Vollzuges und schließlich, bei rückfälligen Probanden, die Begutachtung im Zusammenhang mit der Rückfalltat. Auf diese Weise stellt die Arbeit drei Querschnittsuntersuchungen und eine Längsschnittuntersuchung forensischer Begutachtungspraxis bei langen Jugendstrafen dar. Neben dem Aspekt, welche Motive die beteiligten Akteure in der Justiz dazu veranlassen, ein Gutachten einzuholen und wie treffsicher die Einschätzungen der Gutachter in Bezug auf die Gefährlichkeit der Probanden sind, stehen bei der vorliegenden Untersuchung psychische Störungen, insbesondere die Persönlichkeitsstörungen, im Zentrum der Betrachtung. Die diagnostizierten Persönlichkeitsstörungen werden – unter Abgrenzung zu Prävalenzraten in der Allgemeinbevölkerung – im Zusammenhang mit Ergebnissen der Schuldfähigkeitsbegutachtungen sowie der Gefährlichkeitsprognosen betrachtet. Ferner können im Rahmen der Längsschnittuntersuchung auch Aussagen zur Stabilität dieser Diagnose getroffen werden

Untersuchung perturbativer und nichtperturbativer Struktur der Momente hadronischer Ereignisformvariablen mit den Experimenten JADE und OPAL

In Hadronproduktionsdaten der e+e− - Vernichtungsexperimente JADE und OPAL messen wir die ersten f¨unf Momente von zw¨olf hadronischen Ereignisformvariablen bei Schwerpunktsenergien von 14 bis 207GeV. Aus dem Vergleich der QCD NLO-Vorhersage mit den mittels MC-Modellen um Hadronisierung korrigierten Daten erhalten wir den Referenzwert der starken Kopplung αs(MZ0) = 0.1254 ± 0.0007(stat.) ± 0.0010(exp.)+0.0009 −0.0023(had.)+0.0069 −0.0053(theo.) . F¨ur einige, insbesondere h¨ohere, Momente sind systematische Unzul¨anglichkeiten in der QCD NLO-Vorhersage erkenntlich. Simultane Fits an zwei Momente unter Annahme identischer Renormierungsskalen ergeben Skalenwerte von xμ=0.057 bis xμ=0.196 . Wir pr¨ufen Vorhersagen verschiedener nichtperturbativer Modelle. Aus der Single Dressed Gluon - N¨aherung ergibt sich eine perturbative Vorhersage in O(α5 s ) mit zu vernachl¨assigender Energiepotenzkorrektur, die den Mittelwert von Thrust auf Hadronniveau gut beschreibt mit αs(MZ0) = 0.1186 ± 0.0007(stat.) ± 0.0017(exp.)+0.0033 −0.0028(theo.) . Die Varianz der Ereignisformvariablen wird gemessen und mit Modellen sowie Vorhersagen verglichen